HitPredict

Interactor 1: SRSF4 (Q08170)
Serine/arginine-rich splicing factor 4 (Pre-mRNA-splicing factor SRP75) (SRP001LB) (Splicing factor, arginine/serine-rich 4)
Gene: SRSF4

Interactor 2: YTDC1 (Q96MU7)
YTH domain-containing protein 1 (Splicing factor YT521) (YT521-B)
Gene: YTHDC1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000398 - mRNA splicing, via spliceosome GO:0003723 - RNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0016607 - nuclear speck
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 494 Hs			1 727
+	Hs
		1029043 SRSF6_HUMAN (1-180): 4.52e-52: 181: 78.50		YTDC1_HUMAN (1-673): 0: 567: 100.00
+	Hs
		516767 PABP1_HUMAN (1-189): 4.04e-31: 128: 19.50		YTHD2_HUMAN (300-520): 2.5e-88: 290: 23.71
+	Hs
		516575 PABP1_HUMAN (1-189): 4.04e-31: 128: 19.50		YTHD3_HUMAN (300-503): 4.24e-83: 276: 22.48
+	Hs
		516679 PABP1_HUMAN (1-189): 4.04e-31: 128: 19.50		YTHD1_HUMAN (300-521): 7.77e-81: 270: 22.55
+	Hs
		1029095 SRSF6_HUMAN (1-180): 4.52e-52: 181: 78.50		YTDC2_HUMAN (253-493): 1.34e-53: 202: 35.22
+	Hs
		1031506 PABP4_HUMAN (100-185): 3.19e-11: 67.7: 19.78		YTHD2_HUMAN (300-520): 2.5e-88: 290: 23.71
+	Sc
		742085 NOP4_YEAST (1-492): 1.19e-52: 190: 11.82		MDN1_YEAST (2-347): 6.94e-39: 158: 13.30
+	Hs
		1031376 PABP4_HUMAN (100-185): 3.19e-11: 67.7: 19.78		YTHD3_HUMAN (300-503): 4.24e-83: 276: 22.48
+	Hs
		963542 TIAR_HUMAN (96-188): 2.66e-10: 63.8: 16.67		YTHD3_HUMAN (300-503): 4.24e-83: 276: 22.48
+	Hs
		1031449 PABP4_HUMAN (100-185): 3.19e-11: 67.7: 19.78		YTHD1_HUMAN (300-521): 7.77e-81: 270: 22.55
+	Hs
		1308769 RBM4B_HUMAN (3-104): 4.68e-11: 66.1: 23.08		YTDC2_HUMAN (253-493): 1.34e-53: 202: 35.22