HitPredict

Interactor 1: SRSF4 (Q08170)
Serine/arginine-rich splicing factor 4 (Pre-mRNA-splicing factor SRP75) (SRP001LB) (Splicing factor, arginine/serine-rich 4)
Gene: SRSF4

Interactor 2: PPIE (Q9UNP9)
Peptidyl-prolyl cis-trans isomerase E (PPIase E) (EC 5.2.1.8) (Cyclophilin E) (Cyclophilin-33) (Rotamase E)
Gene: PPIE

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	27684187
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Pro_isomerase~RRM_1, RRM_1~RRM_1
Common GO terms	GO:0000398 - mRNA splicing, via spliceosome GO:0003723 - RNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm and 1 others more... GO:0016607 - nuclear speck
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 494 Hs			1 301
+	Hs
		1029160 SRSF6_HUMAN (1-180): 4.52e-52: 181: 78.50		PPIE_HUMAN (1-301): 5.5e-108: 317: 100.00
+	Hs
		1028634 SRSF9_HUMAN (3-216): 2.36e-52: 178: 36.53		PPIE_HUMAN (1-301): 5.5e-108: 317: 100.00
+	Hs
		1028873 SRSF5_HUMAN (3-256): 1.26e-49: 172: 53.85		PPIE_HUMAN (1-301): 5.5e-108: 317: 100.00
+	At
		1340387 SR30_ARATH (4-253): 1.45e-54: 185: 36.33		CYP63_ARATH (134-299): 1.18e-89: 279: 58.62
+	Hs
		516744 PABP1_HUMAN (1-189): 4.04e-31: 128: 19.50		PPIE_HUMAN (1-301): 5.5e-108: 317: 100.00
+	At
		186870 SR34_ARATH (4-293): 7.04e-36: 137: 35.22		CYP63_ARATH (134-299): 1.18e-89: 279: 58.62