HitPredict

Interactor 1: SRSF4 (Q08170)
Serine/arginine-rich splicing factor 4 (Pre-mRNA-splicing factor SRP75) (SRP001LB) (Splicing factor, arginine/serine-rich 4)
Gene: SRSF4

Interactor 2: SRRM2 (Q9UQ35)
Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803)
Gene: SRRM2

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	0.60	0.625

Property	Details
Experiments	22365833, 33961781
Identification Methods	two hybrid, affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000398 - mRNA splicing, via spliceosome GO:0003723 - RNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0016607 - nuclear speck
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 494 Hs			1 2752
+	Hs
		992995 SRSF1_HUMAN (3-166): 2.36e-57: 192: 41.42		SRRM2_HUMAN (1-2752): 2.88e-178: 615: 100.00
+	Hs
		1029163 SRSF6_HUMAN (1-180): 4.52e-52: 181: 78.50		SRRM2_HUMAN (1-2752): 2.88e-178: 615: 100.00
+	Hs
		1028876 SRSF5_HUMAN (3-256): 1.26e-49: 172: 53.85		SRRM2_HUMAN (1-2752): 2.88e-178: 615: 100.00
+	Hs
		516749 PABP1_HUMAN (1-189): 4.04e-31: 128: 19.50		SRRM2_HUMAN (1-2752): 2.88e-178: 615: 100.00
+	Hs
		1029046 SRSF6_HUMAN (1-180): 4.52e-52: 181: 78.50		CIC_HUMAN (216-2751): 1.9e-62: 240: 8.98
+	Hs
		993735 SRSF4_HUMAN (1-468): 4.56e-48: 174: 100.00		PRC2B_HUMAN (640-2750): 5.74e-64: 245: 9.36
+	Hs
		516546 PABP1_HUMAN (1-189): 4.04e-31: 128: 19.50		PRC2B_HUMAN (640-2750): 5.74e-64: 245: 9.36
+	Hs
		1029050 SRSF6_HUMAN (1-180): 4.52e-52: 181: 78.50		MINT_HUMAN (709-2695): 5.55e-37: 157: 9.30
+	Hs
		992912 SRSF1_HUMAN (3-166): 2.36e-57: 192: 41.42		DIDO1_HUMAN (13-1216): 9.01e-11: 70.1: 10.22
+	Hs
		993011 SRSF1_HUMAN (3-166): 2.36e-57: 192: 41.42		PRC2C_HUMAN (1360-2752): 9.55e-11: 70.1: 9.11
+	Hs
		516609 PABP1_HUMAN (1-189): 4.04e-31: 128: 19.50		TITIN_HUMAN (26-1299): 8.38e-20: 100: 7.11
+	Hs
		516406 PABP1_HUMAN (1-189): 4.04e-31: 128: 19.50		PRC2A_HUMAN (8-1230): 6.75e-14: 80.5: 10.65
+	Hs
		516766 PABP1_HUMAN (1-189): 4.04e-31: 128: 19.50		PRC2C_HUMAN (1360-2752): 9.55e-11: 70.1: 9.11
+	Hs
		516595 PABP1_HUMAN (1-189): 4.04e-31: 128: 19.50		KMT2C_HUMAN (1760-2747): 2.06e-09: 65.9: 9.01
+	Hs
		965152 PABP3_HUMAN (3-189): 1.09e-28: 121: 19.19		ANK2_HUMAN (1488-2676): 2.26e-09: 65.6: 13.23
+	Hs
		1031405 PABP4_HUMAN (100-185): 3.19e-11: 67.7: 19.78		TITIN_HUMAN (26-1299): 8.38e-20: 100: 7.11
+	Hs
		820908 PABP4_HUMAN (100-185): 3.19e-11: 67.7: 19.78		PRC2A_HUMAN (8-1230): 6.75e-14: 80.5: 10.65
+	Hs
		820889 TIAR_HUMAN (96-188): 2.66e-10: 63.8: 16.67		PRC2A_HUMAN (8-1230): 6.75e-14: 80.5: 10.65
+	Hs
		1308748 RBM4B_HUMAN (3-104): 4.68e-11: 66.1: 23.08		DIDO1_HUMAN (13-1216): 9.01e-11: 70.1: 10.22