HitPredict

Interactor 1: SMC5 (Q08204)
Structural maintenance of chromosomes protein 5
Gene: SMC5

Interactor 2: SMT3 (Q12306)
Ubiquitin-like protein SMT3
Gene: SMT3

Species: Saccharomyces cerevisiae S288C

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.78	0.60	0.685

Property	Details
Experiments	25764370, 19995966, 15590687, 18719252
Identification Methods	pull down, anti tag coimmunoprecipitation, affinity chromatography technology, two hybrid
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0016925 - protein sumoylation
Homologous interactions	12

Homologous interactions

Color coding for hit scores

	1 1093 Sc			1 101
+	Hs
		902660 SMC5_HUMAN (16-1076): 2.66e-85: 301: 23.96		SUMO2_HUMAN (9-98): 2.32e-36: 120: 42.86
+	Hs
		928131 SMC5_HUMAN (16-1076): 2.66e-85: 301: 23.96		SUMO1_HUMAN (1-98): 2.09e-33: 112: 44.44
+	Sc
		1015436 SMC6_YEAST (34-1052): 8.61e-47: 184: 12.17		SMT3_YEAST (1-101): 1.79e-40: 130: 100.00
+	Sc
		700812 SMC1_YEAST (40-1051): 2.14e-45: 180: 12.13		SMT3_YEAST (1-101): 1.79e-40: 130: 100.00
+	Hs
		902813 SMC3_HUMAN (40-986): 3.81e-46: 183: 12.10		SUMO2_HUMAN (9-98): 2.32e-36: 120: 42.86
+	Sc
		1015401 SMC4_YEAST (197-1048): 2.8e-38: 158: 11.60		SMT3_YEAST (1-101): 1.79e-40: 130: 100.00
+	Hs
		902772 SMC4_HUMAN (87-1067): 1.34e-41: 168: 9.15		SUMO2_HUMAN (9-98): 2.32e-36: 120: 42.86
+	At
		878967 SMC1_ARATH (37-1038): 2.77e-44: 177: 11.27		SUMO1_ARATH (11-96): 1.49e-32: 110: 45.98
+	Ce
		823187 DPY27_CAEEL (115-1067): 3.29e-36: 151: 9.23		SUMO_CAEEL (12-98): 3.17e-32: 109: 39.77
+	Hs
		311521 SMC2_HUMAN (150-1050): 5.68e-32: 137: 10.22		SUMO2_HUMAN (9-98): 2.32e-36: 120: 42.86
+	Hs
		902586 SMC1A_HUMAN (162-1050): 5.4e-31: 134: 10.29		SUMO2_HUMAN (9-98): 2.32e-36: 120: 42.86
+	Rn
		1140357 MYH9_RAT (602-986): 1.03e-13: 78.2: 9.09		SUMO3_RAT (9-98): 1.04e-35: 119: 43.96