HitPredict

Interactor 1: ESA1 (Q08649)
Histone acetyltransferase ESA1 (EC 2.3.1.48) (Protein 2-hydroxyisobutyryltransferase ESA1) (EC 2.3.1.-) (Protein acetyltransferase ESA1) (EC 2.3.1.-) (Protein crotonyltransferase ESA1) (EC 2.3.1.-)
Gene: ESA1

Interactor 2: H2AZ (Q12692)
Histone H2A.Z
Gene: HTZ1

Species: Saccharomyces cerevisiae S288C

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.585

Property	Details
Experiments	16543219, 21179020
Identification Methods	enzymatic study, tandem affinity purification
Interaction Type	direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000785 - chromatin GO:0000786 - nucleosome GO:0003682 - chromatin binding GO:0005634 - nucleus GO:0006357 - regulation of transcription by RNA polymerase II
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 445 Sc			1 134
+	Sc
		392220 ESA1_YEAST (1-445): 0: 608: 100.00		H2A1_YEAST (23-133): 7.94e-52: 162: 62.50
+	Sc
		392593 ESA1_YEAST (1-445): 0: 608: 100.00		H2A2_YEAST (23-133): 1.36e-51: 161: 62.50
+	Sp
		293417 ESA1_SCHPO (1-445): 0: 561: 55.44		H2AZ_SCHPO (18-130): 1.98e-47: 151: 73.45
+	Dm
		137453 MOF_DROME (30-438): 4.32e-179: 523: 37.04		H2A_DROME (24-130): 7.69e-52: 161: 62.04
+	Hs
		309706 KAT7_HUMAN (50-434): 1.1e-178: 514: 39.55		H2A2C_HUMAN (7-134): 6.76e-52: 162: 55.04
+	Hs
		309651 KAT7_HUMAN (50-434): 1.1e-178: 514: 39.55		H2AZ_HUMAN (10-134): 6.73e-41: 134: 67.72
+	Hs
		391906 KAT8_HUMAN (22-434): 0: 525: 40.10		H2A1B_HUMAN (8-126): 5.7e-31: 108: 60.83
+	Hs
		309643 KAT7_HUMAN (50-434): 1.1e-178: 514: 39.55		H2A1B_HUMAN (8-126): 5.7e-31: 108: 60.83
+	Hs
		470113 KAT6A_HUMAN (92-439): 1.21e-154: 484: 42.74		H2AZ_HUMAN (10-134): 6.73e-41: 134: 67.72
+	Sc
		710460 SAS3_YEAST (91-439): 1.16e-131: 401: 34.53		H2AZ_YEAST (1-134): 2.81e-53: 165: 100.00
+	Sc
		392094 SAS3_YEAST (91-439): 1.16e-131: 401: 34.53		H2A1_YEAST (23-133): 7.94e-52: 162: 62.50
+	Sc
		392379 SAS3_YEAST (91-439): 1.16e-131: 401: 34.53		H2A2_YEAST (23-133): 1.36e-51: 161: 62.50
+	Dm
		446320 TIP60_DROME (1-127): 2.12e-22: 101: 20.61		H2AV_DROME (10-129): 3.97e-52: 163: 69.67
+	Dm
		950439 TIP60_DROME (1-127): 2.12e-22: 101: 20.61		H2A_DROME (24-130): 7.69e-52: 161: 62.04
+	Hs
		1087124 MO4L1_HUMAN (20-180): 8.97e-13: 71.2: 11.50		H2A2C_HUMAN (7-134): 6.76e-52: 162: 55.04
+	Hs
		470116 KAT5_HUMAN (17-165): 3.96e-19: 91.7: 27.27		H2AZ_HUMAN (10-134): 6.73e-41: 134: 67.72
+	Mm
		470234 KAT5_MOUSE (17-165): 4.14e-19: 91.7: 27.27		H2AZ_MOUSE (10-134): 6.73e-41: 134: 67.72
+	Mm
		1111884 KAT5_MOUSE (17-165): 4.14e-19: 91.7: 27.27		H2AV_MOUSE (10-134): 1.67e-40: 133: 67.72
+	Hs
		470191 MO4L1_HUMAN (20-180): 8.97e-13: 71.2: 11.50		H2AZ_HUMAN (10-134): 6.73e-41: 134: 67.72
+	Hs
		391828 KAT5_HUMAN (17-165): 3.96e-19: 91.7: 27.27		H2A1B_HUMAN (8-126): 5.7e-31: 108: 60.83