HitPredict

Interactor 1: RBBP4 (Q09028)
Histone-binding protein RBBP4 (Chromatin assembly factor 1 subunit C) (CAF-1 subunit C) (Chromatin assembly factor I p48 subunit) (CAF-I 48 kDa subunit) (CAF-I p48) (Nucleosome-remodeling factor subunit RBAP48) (Retinoblastoma-binding protein 4) (RBBP-4) (Retinoblastoma-binding protein p48)
Gene: RBBP4

Interactor 2: HDAC2 (Q92769)
Histone deacetylase 2 (HD2) (EC 3.5.1.98) (Protein deacylase HDAC2) (EC 3.5.1.-)
Gene: HDAC2

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.96 0.60 0.762

The method score is based on:

Property Details
Experiments 27705803, 12943729, 12091390, 31435636, 33961781, 34518534, 35271311, 17827154, 21670149, 12493763, 9804427, 24981860, 20388487, 9885572, 21258344
Identification Methods affinity chromatography technology, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, tandem affinity purification
Interaction Type physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains -
Common GO terms GO:0000118 - histone deacetylase complex
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000781 - chromosome, telomeric region
GO:0000785 - chromatin
GO:0005634 - nucleus
and 16 others

more...
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 425
Hs

1 488
+ Hs
+ Mm
+ Mm
+ Hs
+ Mm
+ Hs
+ Hs
+ Hs
+ Hs
+ At
+ At
+ At
+ Hs
+ Dm
+ Dm
+ Hs
+ Hs
+ At
+ At
+ Hs

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024