HitPredict

Interactor 1: RBBP4 (Q09028)
Histone-binding protein RBBP4 (Chromatin assembly factor 1 subunit C) (CAF-1 subunit C) (Chromatin assembly factor I p48 subunit) (CAF-I 48 kDa subunit) (CAF-I p48) (Nucleosome-remodeling factor subunit RBAP48) (Retinoblastoma-binding protein 4) (RBBP-4) (Retinoblastoma-binding protein p48)
Gene: RBBP4

Interactor 2: PHF12 (Q96QT6)
PHD finger protein 12 (PHD factor 1) (Pf1)
Gene: PHF12

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.74	0.60	0.667

Property	Details
Experiments	24981860, 33961781, 37689310
Identification Methods	affinity chromatography technology, proximity labelling technology, tandem affinity purification, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0045892 - negative regulation of DNA-templated transcription GO:0070822 - Sin3-type complex
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 425 Hs			1 1004
+	Hs
		1083354 RBBP7_HUMAN (1-425): 3.63e-115: 345: 89.20		PHF12_HUMAN (1-1004): 0: 1360: 100.00
+	Hs
		997694 RBBP4_HUMAN (1-425): 4.3e-124: 367: 100.00		BPTF_HUMAN (43-264): 2.26e-31: 135: 19.28
+	Hs
		1083425 RBBP7_HUMAN (1-425): 3.63e-115: 345: 89.20		BAZ2B_HUMAN (3-239): 3.57e-37: 154: 17.07
+	Hs
		1017306 RBBP7_HUMAN (1-425): 3.63e-115: 345: 89.20		BPTF_HUMAN (43-264): 2.26e-31: 135: 19.28
+	Hs
		997824 RBBP4_HUMAN (1-425): 4.3e-124: 367: 100.00		CHD5_HUMAN (15-166): 1.47e-20: 100: 16.77
+	Hs
		997726 RBBP4_HUMAN (1-425): 4.3e-124: 367: 100.00		CHD4_HUMAN (52-166): 3.04e-20: 99.6: 19.23
+	Hs
		997695 RBBP4_HUMAN (1-425): 4.3e-124: 367: 100.00		CHD3_HUMAN (11-166): 1.58e-19: 97.3: 16.96
+	Hs
		1083322 RBBP7_HUMAN (1-425): 3.63e-115: 345: 89.20		CHD5_HUMAN (15-166): 1.47e-20: 100: 16.77
+	Hs
		1059641 RBBP7_HUMAN (1-425): 3.63e-115: 345: 89.20		CHD4_HUMAN (52-166): 3.04e-20: 99.6: 19.23
+	Hs
		1018507 RBBP7_HUMAN (1-425): 3.63e-115: 345: 89.20		CHD3_HUMAN (11-166): 1.58e-19: 97.3: 16.96
+	Hs
		903374 WDR5_HUMAN (267-425): 7.48e-35: 133: 25.61		KMT2C_HUMAN (48-281): 6.78e-29: 128: 14.35
+	Mm
		903669 WDR5_MOUSE (267-425): 7.48e-35: 133: 25.61		KMT2C_MOUSE (48-281): 4.03e-29: 128: 13.92
+	Dm
		332768 CAF1_DROME (226-419): 3.68e-29: 119: 18.36		CHDM_DROME (50-278): 8.02e-29: 127: 16.47
+	Dm
		1099182 CAF1_DROME (226-419): 3.68e-29: 119: 18.36		NU301_DROME (49-202): 9.45e-27: 120: 25.28
+	Hs
		903234 WDR5_HUMAN (267-425): 7.48e-35: 133: 25.61		CHD4_HUMAN (52-166): 3.04e-20: 99.6: 19.23
+	Hs
		1059830 GRWD1_HUMAN (263-425): 3.54e-26: 111: 23.56		CHD4_HUMAN (52-166): 3.04e-20: 99.6: 19.23
+	Hs
		1302684 NLE1_HUMAN (8-106): 1.77e-21: 98.3: 10.58		RSF1_HUMAN (53-191): 9.33e-24: 110: 21.66
+	Ce
		954000 LIN53_CAEEL (272-421): 6.33e-22: 99.1: 21.52		CHD3_CAEEL (6-278): 1.12e-22: 107: 14.05
+	Ce
		104626 LIN53_CAEEL (272-421): 6.33e-22: 99.1: 21.52		LE418_CAEEL (6-278): 1.56e-20: 100: 14.29
+	Hs
		1018714 NLE1_HUMAN (8-106): 1.77e-21: 98.3: 10.58		CHD3_HUMAN (11-166): 1.58e-19: 97.3: 16.96