HitPredict

Interactor 1: EP300 (Q09472)
Histone acetyltransferase p300 (p300 HAT) (EC 2.3.1.48) (E1A-associated protein p300) (Histone butyryltransferase p300) (EC 2.3.1.-) (Histone crotonyltransferase p300) (EC 2.3.1.-) (Protein 2-hydroxyisobutyryltransferase p300) (EC 2.3.1.-) (Protein lactyltransferas p300) (EC 2.3.1.-) (Protein propionyltransferase p300) (EC 2.3.1.-)
Gene: EP300

Interactor 2: KLF1 (Q13351)
Krueppel-like factor 1 (Erythroid krueppel-like transcription factor) (EKLF)
Gene: KLF1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	21670263
Identification Methods	pull down, isothermal titration calorimetry
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000785 - chromatin GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0031648 - protein destabilization GO:0045893 - positive regulation of DNA-templated transcription
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 2414 Hs			1 362
+	Hs
		204170 EP300_HUMAN (1-2414): 0: 1113: 100.00		KLF4_HUMAN (258-362): 5.56e-44: 160: 79.05
+	Hs
		999260 EP300_HUMAN (1-2414): 0: 1113: 100.00		KLF2_HUMAN (262-362): 1.97e-44: 158: 82.18
+	Hs
		998688 EP300_HUMAN (1-2414): 0: 1113: 100.00		KLF5_HUMAN (263-361): 1.07e-38: 145: 73.00
+	Hs
		316867 EP300_HUMAN (1-2414): 0: 1113: 100.00		KLF8_HUMAN (248-361): 3.01e-38: 141: 60.53
+	Hs
		884141 EP300_HUMAN (1-2414): 0: 1113: 100.00		KLF3_HUMAN (273-362): 2.16e-34: 131: 71.11
+	Hs
		999184 EP300_HUMAN (1-2414): 0: 1113: 100.00		KLF15_HUMAN (279-361): 2.11e-30: 121: 67.47
+	Hs
		157893 EP300_HUMAN (1-2414): 0: 1113: 100.00		KLF11_HUMAN (275-362): 5.94e-28: 116: 61.36
+	Hs
		999055 EP300_HUMAN (1-2414): 0: 1113: 100.00		KLF16_HUMAN (278-361): 1.58e-29: 115: 63.10
+	Hs
		970912 EP300_HUMAN (1-2414): 0: 1113: 100.00		SP3_HUMAN (258-361): 4.44e-27: 114: 51.89
+	Hs
		435071 EP300_HUMAN (1-2414): 0: 1113: 100.00		SP1_HUMAN (267-361): 9.06e-27: 113: 56.84
+	Hs
		999239 EP300_HUMAN (1-2414): 0: 1113: 100.00		KLF13_HUMAN (276-361): 2.79e-26: 107: 61.63
+	Hs
		204247 NCOA3_HUMAN (1849-2386): 7.64e-52: 204: 21.89		KLF4_HUMAN (258-362): 5.56e-44: 160: 79.05
+	Hs
		1046781 NCOA3_HUMAN (1849-2386): 7.64e-52: 204: 21.89		KLF5_HUMAN (263-361): 1.07e-38: 145: 73.00
+	Hs
		317049 NCOA3_HUMAN (1849-2386): 7.64e-52: 204: 21.89		KLF8_HUMAN (248-361): 3.01e-38: 141: 60.53
+	Hs
		1158957 TRI33_HUMAN (604-1201): 1.37e-44: 180: 14.50		ZFP1_HUMAN (104-255): 3.64e-39: 145: 9.87
+	Hs
		1355818 NCOA3_HUMAN (1849-2386): 7.64e-52: 204: 21.89		KLF15_HUMAN (279-361): 2.11e-30: 121: 67.47
+	Hs
		317033 TRI33_HUMAN (604-1201): 1.37e-44: 180: 14.50		KLF8_HUMAN (248-361): 3.01e-38: 141: 60.53
+	Hs
		316791 BRD2_HUMAN (1035-1159): 9.57e-30: 131: 31.20		KLF8_HUMAN (248-361): 3.01e-38: 141: 60.53
+	Hs
		631572 BRD2_HUMAN (1035-1159): 9.57e-30: 131: 31.20		KLF16_HUMAN (278-361): 1.58e-29: 115: 63.10
+	Hs
		316987 BRD8_HUMAN (965-1183): 9.91e-16: 86: 19.18		KLF8_HUMAN (248-361): 3.01e-38: 141: 60.53