HitPredict

Interactor 1: EP300 (Q09472)
Histone acetyltransferase p300 (p300 HAT) (EC 2.3.1.48) (E1A-associated protein p300) (Histone butyryltransferase p300) (EC 2.3.1.-) (Histone crotonyltransferase p300) (EC 2.3.1.-) (Protein 2-hydroxyisobutyryltransferase p300) (EC 2.3.1.-) (Protein lactyltransferas p300) (EC 2.3.1.-) (Protein propionyltransferase p300) (EC 2.3.1.-)
Gene: EP300

Interactor 2: HIF1A (Q16665)
Hypoxia-inducible factor 1-alpha (HIF-1-alpha) (HIF1-alpha) (ARNT-interacting protein) (Basic-helix-loop-helix-PAS protein MOP1) (Class E basic helix-loop-helix protein 78) (bHLHe78) (Member of PAS protein 1) (PAS domain-containing protein 8)
Gene: HIF1A

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.99 1.00 0.997

The method score is based on:

Property Details
Experiments 25192544, 16847340, 17906695, 22684029, 19680224, 12042299, 19589782, 22219185, 12588875, 8917528, 22807441, 23746844, 22735262, 22908229, 15280364, 26135796, 18047470, 23448368, 15342390, 27320910 and 41 others

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Identification Methods affinity chromatography technology, pull down, two hybrid, unspecified method, fluorescent resonance energy transfer, enzymatic study, x-ray crystallography, anti tag coimmunoprecipitation, anti bait coimmunoprecipitation, competition binding and 1 others

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Interaction Type physical association, direct interaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains HIF-1a_CTAD~zf-TAZ
Common GO terms GO:0000785 - chromatin
GO:0001223 - transcription coactivator binding
GO:0001666 - response to hypoxia
GO:0002039 - p53 binding
GO:0005634 - nucleus
and 8 others

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Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 2414
Hs

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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024