HitPredict

Interactor 1: EP300 (Q09472)
Histone acetyltransferase p300 (p300 HAT) (EC 2.3.1.48) (E1A-associated protein p300) (Histone butyryltransferase p300) (EC 2.3.1.-) (Histone crotonyltransferase p300) (EC 2.3.1.-) (Protein 2-hydroxyisobutyryltransferase p300) (EC 2.3.1.-) (Protein lactyltransferas p300) (EC 2.3.1.-) (Protein propionyltransferase p300) (EC 2.3.1.-)
Gene: EP300

Interactor 2: NANOG (Q9H9S0)
Homeobox protein NANOG (Homeobox transcription factor Nanog) (hNanog)
Gene: NANOG

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	23708658
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000785 - chromatin GO:0003677 - DNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 2414 Hs			1 305
+	Hs
		641388 EP300_HUMAN (1-2414): 0: 1113: 100.00		PAX6_HUMAN (49-293): 3.5e-30: 119: 14.17
+	Hs
		679102 EP300_HUMAN (1-2414): 0: 1113: 100.00		TLX1_HUMAN (26-221): 2.65e-30: 118: 23.47
+	Hs
		211845 EP300_HUMAN (1-2414): 0: 1113: 100.00		TLX3_HUMAN (88-157): 1.29e-25: 104: 42.86
+	Dm
		116025 M9PH39_DROME (430-2323): 0: 769: 36.52		Q9W1H7_DROME (81-193): 9.17e-35: 127: 18.58
+	Hs
		1334444 TRI33_HUMAN (604-1201): 1.37e-44: 180: 14.50		NANOG_HUMAN (1-305): 3.02e-64: 206: 100.00
+	Hs
		641617 NCOA3_HUMAN (1849-2386): 7.64e-52: 204: 21.89		PAX6_HUMAN (49-293): 3.5e-30: 119: 14.17
+	Hs
		679202 NCOA3_HUMAN (1849-2386): 7.64e-52: 204: 21.89		TLX1_HUMAN (26-221): 2.65e-30: 118: 23.47
+	Mm
		88353 D3YZC7_MOUSE (522-1196): 3.52e-41: 168: 14.49		NANOG_MOUSE (1-303): 7.62e-40: 143: 54.98
+	Hs
		212008 NCOA3_HUMAN (1849-2386): 7.64e-52: 204: 21.89		TLX3_HUMAN (88-157): 1.29e-25: 104: 42.86
+	Mm
		1194645 BRD8_MOUSE (442-1175): 6.73e-37: 154: 14.71		NANOG_MOUSE (1-303): 7.62e-40: 143: 54.98
+	Mm
		101537 F8VQD1_MOUSE (1081-1354): 5.61e-11: 70.6: 17.92		NANOG_MOUSE (1-303): 7.62e-40: 143: 54.98
+	Hs
		641391 BPTF_HUMAN (2011-2413): 1.11e-14: 82.9: 12.86		PAX6_HUMAN (49-293): 3.5e-30: 119: 14.17
+	Hs
		641583 CHD7_HUMAN (69-452): 4.51e-13: 77.9: 12.02		PAX6_HUMAN (49-293): 3.5e-30: 119: 14.17
+	Hs
		679182 CHD7_HUMAN (69-452): 4.51e-13: 77.9: 12.02		TLX1_HUMAN (26-221): 2.65e-30: 118: 23.47
+	Hs
		641482 KMT2C_HUMAN (416-1078): 1.02e-10: 70.1: 11.13		PAX6_HUMAN (49-293): 3.5e-30: 119: 14.17
+	Hs
		679137 KMT2C_HUMAN (416-1078): 1.02e-10: 70.1: 11.13		TLX1_HUMAN (26-221): 2.65e-30: 118: 23.47
+	Hs
		213398 CHD7_HUMAN (69-452): 4.51e-13: 77.9: 12.02		TLX2_HUMAN (76-157): 1.26e-27: 110: 37.35
+	Hs
		211986 CHD7_HUMAN (69-452): 4.51e-13: 77.9: 12.02		TLX3_HUMAN (88-157): 1.29e-25: 104: 42.86
+	Hs
		213358 KMT2C_HUMAN (416-1078): 1.02e-10: 70.1: 11.13		TLX2_HUMAN (76-157): 1.26e-27: 110: 37.35
+	Hs
		211919 KMT2C_HUMAN (416-1078): 1.02e-10: 70.1: 11.13		TLX3_HUMAN (88-157): 1.29e-25: 104: 42.86