HitPredict

Interactor 1: LGG1 (Q09490)
Protein lgg-1
Gene: lgg-1

Interactor 2: ATG42 (Q9U1N6)
Cysteine protease atg-4.2 (EC 3.4.22.-) (Autophagy-related protein 4 homolog 2)
Gene: atg-4.2

Species: Caenorhabditis elegans

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	30880001
Identification Methods	enzymatic study
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	ATG8~Peptidase_C54
Common GO terms	GO:0000045 - autophagosome assembly GO:0005737 - cytoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 123 Ce			1 521
+	Hs
		891203 GBRL2_HUMAN (1-116): 8.75e-59: 178: 57.76		ATG4D_HUMAN (41-496): 6.7e-163: 472: 28.69
+	Hs
		306219 GBRAP_HUMAN (1-116): 1.56e-57: 175: 83.62		ATG4D_HUMAN (41-496): 6.7e-163: 472: 28.69
+	Hs
		1198603 GBRL1_HUMAN (1-116): 5.58e-57: 173: 78.45		ATG4D_HUMAN (41-496): 6.7e-163: 472: 28.69
+	Hs
		306269 GBRAP_HUMAN (1-116): 1.56e-57: 175: 83.62		ATG4C_HUMAN (112-519): 9.62e-155: 451: 24.68
+	Hs
		1288559 GBRL1_HUMAN (1-116): 5.58e-57: 173: 78.45		ATG4C_HUMAN (112-519): 9.62e-155: 451: 24.68
+	Hs
		891370 GBRL2_HUMAN (1-116): 8.75e-59: 178: 57.76		ATG4B_HUMAN (140-492): 1.15e-131: 389: 28.50
+	Hs
		306368 GBRAP_HUMAN (1-116): 1.56e-57: 175: 83.62		ATG4B_HUMAN (140-492): 1.15e-131: 389: 28.50
+	Hs
		891248 GBRL2_HUMAN (1-116): 8.75e-59: 178: 57.76		ATG4A_HUMAN (133-499): 3.61e-130: 386: 27.86
+	Hs
		1328075 GBRL1_HUMAN (1-116): 5.58e-57: 173: 78.45		ATG4B_HUMAN (140-492): 1.15e-131: 389: 28.50
+	Hs
		306253 GBRAP_HUMAN (1-116): 1.56e-57: 175: 83.62		ATG4A_HUMAN (133-499): 3.61e-130: 386: 27.86
+	Hs
		1264549 GBRL1_HUMAN (1-116): 5.58e-57: 173: 78.45		ATG4A_HUMAN (133-499): 3.61e-130: 386: 27.86
+	Mm
		1206409 MLP3A_MOUSE (5-116): 3.26e-46: 146: 35.09		ATG4B_MOUSE (140-501): 6.33e-134: 395: 30.05
+	Hs
		1315816 MLP3C_HUMAN (5-116): 5.23e-46: 147: 38.60		ATG4B_HUMAN (140-492): 1.15e-131: 389: 28.50
+	Hs
		1264550 MLP3A_HUMAN (5-116): 3.26e-46: 146: 35.09		ATG4A_HUMAN (133-499): 3.61e-130: 386: 27.86
+	Ce
		111920 LGG1_CAEEL (1-123): 4.26e-61: 184: 100.00		ATG41_CAEEL (128-502): 1.06e-113: 346: 25.29
+	Dm
		1372164 Q9W2S2_DROME (1-116): 5.32e-59: 179: 85.35		Q9VPW2_DROME (144-465): 3.69e-113: 342: 32.52
+	Dm
		114224 Q9VEG5_DROME (1-116): 1.65e-55: 170: 74.14		M9PBM3_DROME (144-465): 3.07e-113: 343: 32.52
+	Dm
		1179054 Q7K1J3_DROME (1-116): 1.36e-55: 171: 74.14		Q9VPW2_DROME (144-465): 3.69e-113: 342: 32.52
+	Dm
		1364631 Q9VEG5_DROME (1-116): 1.65e-55: 170: 74.14		Q9VPW2_DROME (144-465): 3.69e-113: 342: 32.52
+	Sc
		746022 ATG8_YEAST (1-116): 7.26e-60: 181: 53.45		ATG4_YEAST (163-475): 4.89e-79: 257: 23.26