HitPredict

Interactor 1: SYGP1 (F6SEU4)
Ras/Rap GTPase-activating protein SynGAP (Neuronal RasGAP) (Synaptic Ras GTPase-activating protein 1) (Synaptic Ras-GAP 1)
Gene: Syngap1

Interactor 2: 1433Z (P63101)
14-3-3 protein zeta/delta (Protein kinase C inhibitor protein 1) (KCIP-1) (SEZ-2)
Gene: Ywhaz

Species: Mus musculus

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.80	0.60	0.694

Property	Details
Experiments	27507650, 28706196, 28671696, 16959763
Identification Methods	affinity chromatography technology, anti bait coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0019901 - protein kinase binding GO:0098978 - glutamatergic synapse
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1340 Mm			1 245
+	Mm
		99940 SYGP1_MOUSE (1-1340): 0: 1075: 100.00		1433E_MOUSE (2-241): 9.9e-144: 403: 68.18
+	Hs
		927424 SYGP1_HUMAN (1-1340): 0: 1065: 98.59		1433Z_HUMAN (1-245): 1.67e-144: 405: 99.59
+	Hs
		909931 SYGP1_HUMAN (1-1340): 0: 1065: 98.59		1433E_HUMAN (2-241): 9.9e-144: 403: 68.18
+	Hs
		647202 SYGP1_HUMAN (1-1340): 0: 1065: 98.59		1433T_HUMAN (1-245): 2.6e-140: 395: 80.00
+	Hs
		683638 SYGP1_HUMAN (1-1340): 0: 1065: 98.59		1433B_HUMAN (1-242): 9.01e-140: 393: 88.02
+	Mm
		99939 SYGP1_MOUSE (1-1340): 0: 1075: 100.00		1433G_MOUSE (1-240): 8.4e-109: 315: 74.59
+	Mm
		99953 SYGP1_MOUSE (1-1340): 0: 1075: 100.00		1433F_MOUSE (2-240): 5.1e-108: 313: 74.07
+	Hs
		905008 SYGP1_HUMAN (1-1340): 0: 1065: 98.59		1433G_HUMAN (1-240): 8.4e-109: 315: 74.59
+	Hs
		982401 SYGP1_HUMAN (1-1340): 0: 1065: 98.59		1433F_HUMAN (2-240): 5.21e-108: 313: 74.49
+	Hs
		927150 DAB2P_HUMAN (97-1339): 0: 859: 47.63		1433Z_HUMAN (1-245): 1.67e-144: 405: 99.59
+	Hs
		909664 DAB2P_HUMAN (97-1339): 0: 859: 47.63		1433E_HUMAN (2-241): 9.9e-144: 403: 68.18
+	Hs
		646987 DAB2P_HUMAN (97-1339): 0: 859: 47.63		1433T_HUMAN (1-245): 2.6e-140: 395: 80.00
+	Hs
		683429 DAB2P_HUMAN (97-1339): 0: 859: 47.63		1433B_HUMAN (1-242): 9.01e-140: 393: 88.02
+	Mm
		935486 Q0VAV5_MOUSE (17-1338): 0: 890: 43.23		1433F_MOUSE (2-240): 5.1e-108: 313: 74.07
+	Hs
		647363 NGAP_HUMAN (84-1338): 0: 800: 43.48		1433T_HUMAN (1-245): 2.6e-140: 395: 80.00
+	Hs
		683798 NGAP_HUMAN (84-1338): 0: 800: 43.48		1433B_HUMAN (1-242): 9.01e-140: 393: 88.02
+	Hs
		904695 DAB2P_HUMAN (97-1339): 0: 859: 47.63		1433G_HUMAN (1-240): 8.4e-109: 315: 74.59
+	Hs
		982121 DAB2P_HUMAN (97-1339): 0: 859: 47.63		1433F_HUMAN (2-240): 5.21e-108: 313: 74.49
+	Hs
		905231 NGAP_HUMAN (84-1338): 0: 800: 43.48		1433G_HUMAN (1-240): 8.4e-109: 315: 74.59
+	Hs
		684382 NGAP_HUMAN (84-1338): 0: 800: 43.48		1433S_HUMAN (1-237): 2.52e-103: 301: 71.55