Protein: DHB4
Peroxisomal multifunctional enzyme type 2 (MFE-2) (17-beta-hydroxysteroid dehydrogenase 4) (17-beta-HSD 4) (D-bifunctional protein) (DBP) (Multifunctional protein 2) (MFP-2) (Short chain dehydrogenase/reductase family 8C member 1) [Cleaved into: (3R)-hydroxyacyl-CoA dehydrogenase (EC 1.1.1.n12); Enoyl-CoA hydratase 2 (EC 4.2.1.107) (EC 4.2.1.119) (3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholest-24-enoyl-CoA hydratase)]

Gene: DHB4, HSD17B4
Organism: Homo sapiens
Interactions: 135
UniProt ID: P51659

Gene Ontology (top 5):
GO:0000038 - very long-chain fatty acid metabolic process
GO:0001649 - osteoblast differentiation
GO:0003857 - 3-hydroxyacyl-CoA dehydrogenase activity
GO:0004300 - enoyl-CoA hydratase activity
GO:0004303 - estradiol 17-beta-dehydrogenase [NAD(P)+] activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

825905

FAS
Fatty acid synthase

1

1

High-throughput

0.691

High

606958

SCP2
Sterol carrier protein 2

1

1

High-throughput

0.665

High

849083

DHB4
Peroxisomal multifunctional enzyme type 2

1

17

Small-scale

0.647

High

840238

PEX5
Peroxisomal targeting signal 1 receptor

3

5

Small-scale

0.631

High

841098

CDK7
Cyclin-dependent kinase 7

2

1

High-throughput

0.614

High

849100

IKZF1
DNA-binding protein Ikaros

2

0

High-throughput

0.602

High

261978

PEX14
Peroxisomal membrane protein PEX14

2

1

Small-scale

0.588

High

373365

CATA
Catalase

2

3

High-throughput

0.588

High

849119

TBA1A
Tubulin alpha-1A chain

2

2

High-throughput

0.588

High

116559

ADAS
Alkyldihydroxyacetonephosphate synthase, peroxisomal

2

2

High-throughput

0.584

High

226912

PRKN
E3 ubiquitin-protein ligase parkin

2

5

High-throughput

0.584

High

322359

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

2

1

High-throughput

0.584

High

835594

GSK3B
Glycogen synthase kinase-3 beta

2

1

High-throughput

0.584

High

849108

ITSN1
Intersectin-1

2

0

High-throughput

0.547

High

849096

TIAM1
Rho guanine nucleotide exchange factor TIAM1

1

1

High-throughput

0.541

High

345371

FOS
Protein c-Fos

1

1

High-throughput

0.536

High

528803

CFTR
Cystic fibrosis transmembrane conductance regulator

1

3

High-throughput

0.536

High

666560

LTK
Leukocyte tyrosine kinase receptor

1

5

High-throughput

0.536

High

849116

LRSM1
E3 ubiquitin-protein ligase LRSAM1

1

1

High-throughput

0.536

High

849136

UBA5
Ubiquitin-like modifier-activating enzyme 5

1

1

High-throughput

0.536

High

800729

MK08
Mitogen-activated protein kinase 8

1

0

High-throughput

0.518

High

849127

NDRG1
Protein NDRG1

1

1

Small-scale

0.515

High

156665

PAHX
Phytanoyl-CoA dioxygenase, peroxisomal

1

0

High-throughput

0.513

High

728594

PPM1A
Protein phosphatase 1A

1

0

High-throughput

0.513

High

739038

ODO2
Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial

1

0

High-throughput

0.513

High

849089

HNRPU
Heterogeneous nuclear ribonucleoprotein U

1

0

High-throughput

0.513

High

849098

G3BP1
Ras GTPase-activating protein-binding protein 1

1

0

High-throughput

0.513

High

849103

HNRPD
Heterogeneous nuclear ribonucleoprotein D0

1

0

High-throughput

0.513

High

849133

SORT
Sortilin

1

0

High-throughput

0.513

High

849137

RGAP1
Rac GTPase-activating protein 1

1

0

High-throughput

0.513

High

517936

CO6A1

1

0

High-throughput

0.493

High

440426

ODPA
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial

1

3

High-throughput

0.489

High

440938

PLEK
Pleckstrin

1

2

Small-scale

0.484

High

59143

VWA8
von Willebrand factor A domain-containing protein 8

1

1

High-throughput

0.479

High

309786

MRP6
ATP-binding cassette sub-family C member 6

1

1

Small-scale

0.479

High

377194

GCR
Glucocorticoid receptor

1

8

Small-scale

0.479

High

383701

ERBB2
Receptor tyrosine-protein kinase erbB-2

1

3

High-throughput

0.479

High

384520

NTRK1
High affinity nerve growth factor receptor

1

6

High-throughput

0.479

High

386347

P53
Cellular tumor antigen p53

1

2

High-throughput

0.479

High

428979

ADRB2
Beta-2 adrenergic receptor

1

1

High-throughput

0.479

High

475499

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

3

High-throughput

0.479

High

719420

MERL
Merlin

1

1

High-throughput

0.479

High

724187

MSX2
Homeobox protein MSX-2

1

2

High-throughput

0.479

High

849087

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

1

High-throughput

0.479

High

849088

GRB2
Growth factor receptor-bound protein 2

1

2

High-throughput

0.479

High

849090

RELB
Transcription factor RelB

1

1

High-throughput

0.479

High

849093

KIF23
Kinesin-like protein KIF23

1

3

High-throughput

0.479

High

849099

SKP2
S-phase kinase-associated protein 2

1

2

Small-scale

0.479

High

849101

BIRC3
Baculoviral IAP repeat-containing protein 3

1

2

High-throughput

0.479

High

849102

CUL4B
Cullin-4B

1

1

High-throughput

0.479

High

849107

KIF14
Kinesin-like protein KIF14

1

1

High-throughput

0.479

High

849115

CDC73
Parafibromin

1

1

High-throughput

0.479

High

849117

FGD5
FYVE, RhoGEF and PH domain-containing protein 5

1

2

High-throughput

0.479

High

849122

LMTK2
Serine/threonine-protein kinase LMTK2

1

4

High-throughput

0.479

High

849142

ECT2
Protein ECT2

1

1

High-throughput

0.479

High

849143

RC3H2
Roquin-2

1

1

Small-scale

0.479

High

849146

BIRC6
Baculoviral IAP repeat-containing protein 6

1

2

Small-scale

0.479

High

849148

DUS22
Dual specificity protein phosphatase 22

1

2

High-throughput

0.479

High

849151

ZRAN1
Ubiquitin thioesterase ZRANB1

1

5

High-throughput

0.479

High

849152

ANC2
Anaphase-promoting complex subunit 2

1

2

High-throughput

0.479

High

849153

LOXL2
Lysyl oxidase homolog 2

1

2

High-throughput

0.479

High

849121

TRI59
Tripartite motif-containing protein 59

1

4

High-throughput

0.470

High

849084

CASP9
Caspase-9

1

0

High-throughput

0.460

High

849109

BAK
Bcl-2 homologous antagonist/killer

1

0

High-throughput

0.460

High

122575

MEN1
Menin

1

0

High-throughput

0.458

High

294554

RECQ4
ATP-dependent DNA helicase Q4

1

0

High-throughput

0.458

High

348583

RASN
GTPase NRas

1

0

High-throughput

0.458

High

381874

G3P
Glyceraldehyde-3-phosphate dehydrogenase

1

0

High-throughput

0.458

High

456313

LOX5
Polyunsaturated fatty acid 5-lipoxygenase

1

0

Small-scale

0.458

High

503717

HSP7C
Heat shock cognate 71 kDa protein

1

0

High-throughput

0.458

High

684541

STIP1
Stress-induced-phosphoprotein 1

1

0

High-throughput

0.458

High

849085

PEX3
Peroxisomal biogenesis factor 3

1

0

High-throughput

0.458

High

849095

NFX1
Transcriptional repressor NF-X1

1

0

High-throughput

0.458

High

849105

CUL7
Cullin-7

1

0

High-throughput

0.458

High

849106

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

0

High-throughput

0.458

High

849112

MIDN
Midnolin

1

0

High-throughput

0.458

High

849120

DYR2
Dihydrofolate reductase 2, mitochondrial

1

0

High-throughput

0.458

High

849123

MIRO2
Mitochondrial Rho GTPase 2

1

0

High-throughput

0.458

High

849124

SLX4
Structure-specific endonuclease subunit SLX4

1

0

High-throughput

0.458

High

849125

NHLC2
NHL repeat-containing protein 2

1

0

High-throughput

0.458

High

849126

BICD2
Protein bicaudal D homolog 2

1

0

High-throughput

0.458

High

849129

SGK3
Serine/threonine-protein kinase Sgk3

1

0

Small-scale

0.458

High

849134

BAG1
BAG family molecular chaperone regulator 1

1

0

High-throughput

0.458

High

849139

CCDC8
Coiled-coil domain-containing protein 8

1

0

High-throughput

0.458

High

849141

EGLN3
Prolyl hydroxylase EGLN3

1

0

High-throughput

0.458

High

849144

NMRL1
NmrA-like family domain-containing protein 1

1

0

High-throughput

0.458

High

849145

ANLN
Anillin

1

0

High-throughput

0.458

High

849147

PXMP2
Peroxisomal membrane protein 2

1

0

High-throughput

0.458

High

306036

GBRAP
Gamma-aminobutyric acid receptor-associated protein

1

1

High-throughput

0.445

High

849114

PKHA7
Pleckstrin homology domain-containing family A member 7

1

4

High-throughput

0.445

High

849138

GBRL1
Gamma-aminobutyric acid receptor-associated protein-like 1

1

1

High-throughput

0.445

High

214151

SPOP
Speckle-type POZ protein

1

3

Small-scale

0.437

High

308519

KI20A
Kinesin-like protein KIF20A

1

4

High-throughput

0.437

High

552278

RFA2
Replication protein A 32 kDa subunit

1

1

High-throughput

0.437

High

572604

VGFR1
Vascular endothelial growth factor receptor 1

1

5

High-throughput

0.437

High

607925

FGFR4
Fibroblast growth factor receptor 4

1

5

High-throughput

0.437

High

609218

FGFR3
Fibroblast growth factor receptor 3

1

4

High-throughput

0.437

High

650719

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

1

High-throughput

0.437

High

720016

RFA3
Replication protein A 14 kDa subunit

1

1

High-throughput

0.437

High

738180

FLT3
Receptor-type tyrosine-protein kinase FLT3

1

5

High-throughput

0.437

High

798807

GATA4
Transcription factor GATA-4

1

1

High-throughput

0.437

High

849086

WDR5
WD repeat-containing protein 5

1

2

High-throughput

0.437

High

849091

ROR1
Inactive tyrosine-protein kinase transmembrane receptor ROR1

1

5

High-throughput

0.437

High

849094

MERTK
Tyrosine-protein kinase Mer

1

3

High-throughput

0.437

High

849097

DUS4
Dual specificity protein phosphatase 4

1

3

High-throughput

0.437

High

849110

CLPP
ATP-dependent Clp protease proteolytic subunit, mitochondrial

1

3

Small-scale

0.437

High

849113

RC3H1
Roquin-1

1

1

Small-scale

0.437

High

849118

TRI67
Tripartite motif-containing protein 67

1

6

High-throughput

0.437

High

849128

ESR2
Estrogen receptor beta

1

8

High-throughput

0.437

High

849140

PKHA4
Pleckstrin homology domain-containing family A member 4

1

2

High-throughput

0.437

High

849150

HECW2
E3 ubiquitin-protein ligase HECW2

1

3

High-throughput

0.437

High

330918

PAK4
Serine/threonine-protein kinase PAK 4

1

0

High-throughput

0.426

High

496601

TAU
Microtubule-associated protein tau

1

0

High-throughput

0.426

High

786280

STAT1
Signal transducer and activator of transcription 1-alpha/beta

1

0

Small-scale

0.426

High

849111

TYSD1
Peroxisomal leader peptide-processing protease

1

0

Small-scale

0.426

High

849135

ZDHC5
Palmitoyltransferase ZDHHC5

1

0

High-throughput

0.426

High

346275

MYC
Myc proto-oncogene protein

1

2

High-throughput

0.407

High

742139

SYUA
Alpha-synuclein

1

0

Small-scale

0.391

High

831121

CEBPA
CCAAT/enhancer-binding protein alpha

1

0

High-throughput

0.391

High

452686

DLDH
Dihydrolipoyl dehydrogenase, mitochondrial

1

0

High-throughput

0.279

Low

677907

SDHA
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial

1

0

High-throughput

0.279

Low

224768

DHX16
Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16

1

0

High-throughput

0.269

Low

49712

ANO9
Anoctamin-9

1

0

High-throughput

0.249

Low

182625

R113A
E3 ubiquitin-protein ligase RNF113A

1

0

High-throughput

0.249

Low

277998

PIAS1
E3 SUMO-protein ligase PIAS1

1

0

High-throughput

0.249

Low

823727

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

0

High-throughput

0.249

Low

849104

RBM39
RNA-binding protein 39

1

0

High-throughput

0.249

Low

849130

DDRGK
DDRGK domain-containing protein 1

1

0

High-throughput

0.249

Low

849131

RPGR1
X-linked retinitis pigmentosa GTPase regulator-interacting protein 1

1

0

High-throughput

0.249

Low

849132

IMP2L
Mitochondrial inner membrane protease subunit 2

1

0

High-throughput

0.249

Low

849149

PD1L1
Programmed cell death 1 ligand 1

1

0

High-throughput

0.249

Low

321021

PTBP3
Polypyrimidine tract-binding protein 3

1

0

High-throughput

0.232

Low

401671

JUN
Transcription factor Jun

1

0

High-throughput

0.232

Low

849092

TAGL
Transgelin

1

0

High-throughput

0.232

Low


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Last updated: 15 Jul 2024