Protein: LIS1
Platelet-activating factor acetylhydrolase IB subunit beta (Lissencephaly-1 protein) (LIS-1) (PAF acetylhydrolase 45 kDa subunit) (PAF-AH 45 kDa subunit) (PAF-AH alpha) (PAFAH alpha)

Gene: LIS1, PAFAH1B1
Organism: Homo sapiens
Interactions: 185
UniProt ID: P43034

Gene Ontology (top 5):
GO:0000132 - establishment of mitotic spindle orientation
GO:0000226 - microtubule cytoskeleton organization
GO:0000235 - astral microtubule
GO:0000776 - kinetochore
GO:0001667 - ameboidal-type cell migration

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

792984

DYHC1
Cytoplasmic dynein 1 heavy chain 1

11

7

Small-scale

0.979

High

792971

PA1B2
Platelet-activating factor acetylhydrolase IB subunit alpha2

6

2

Small-scale

0.952

High

792935

LIS1
Platelet-activating factor acetylhydrolase IB subunit beta

5

16

Small-scale

0.932

High

792989

PA1B3
Platelet-activating factor acetylhydrolase IB subunit alpha1

5

2

Small-scale

0.924

High

792979

DC1I2
Cytoplasmic dynein 1 intermediate chain 2

3

16

High-throughput

0.861

High

148046

DC1I1
Cytoplasmic dynein 1 intermediate chain 1

3

17

Small-scale

0.827

High

793028

NDEL1
Nuclear distribution protein nudE-like 1

11

19

Small-scale

0.759

High

792967

RACK1
Small ribosomal subunit protein RACK1

2

16

High-throughput

0.754

High

793043

NUDC
Nuclear migration protein nudC

5

16

Small-scale

0.727

High

793026

KTNB1
Katanin p80 WD40 repeat-containing subunit B1

1

18

Small-scale

0.724

High

793036

NDE1
Nuclear distribution protein nudE homolog 1

5

14

Small-scale

0.718

High

675131

CLIP1
CAP-Gly domain-containing linker protein 1

4

16

Small-scale

0.710

High

792947

ACTB
Actin, cytoplasmic 1

1

10

High-throughput

0.691

High

792968

ACTG
Actin, cytoplasmic 2

1

10

High-throughput

0.691

High

792983

DCTN1
Dynactin subunit 1

4

14

Small-scale

0.676

High

793049

DC1L1
Cytoplasmic dynein 1 light intermediate chain 1

3

2

High-throughput

0.667

High

793034

DISC1
Disrupted in schizophrenia 1 protein

3

1

High-throughput

0.658

High

793035

GID8
Glucose-induced degradation protein 8 homolog

1

0

High-throughput

0.656

High

431630

HS90A
Heat shock protein HSP 90-alpha

2

11

Small-scale

0.650

High

226765

PRKN
E3 ubiquitin-protein ligase parkin

3

18

High-throughput

0.640

High

792991

MARE1
Microtubule-associated protein RP/EB family member 1

2

4

High-throughput

0.628

High

282843

CIAO1
Probable cytosolic iron-sulfur protein assembly protein CIAO1

1

20

High-throughput

0.618

High

231469

KIF1B
Kinesin-like protein KIF1B

1

6

High-throughput

0.618

High

362915

FINC
Fibronectin

1

6

High-throughput

0.618

High

631108

RS12
Small ribosomal subunit protein eS12

1

2

High-throughput

0.618

High

674357

UFO
Tyrosine-protein kinase receptor UFO

1

7

High-throughput

0.618

High

792953

RS16
Small ribosomal subunit protein uS9

1

7

High-throughput

0.618

High

792959

RL7A
Large ribosomal subunit protein eL8

1

10

High-throughput

0.618

High

793011

AHI1
Jouberin

1

18

High-throughput

0.618

High

793031

CIA2A
Cytosolic iron-sulfur assembly component 2A

1

2

High-throughput

0.618

High

793045

CIA2B
Cytosolic iron-sulfur assembly component 2B

1

2

High-throughput

0.618

High

792964

DYL1
Dynein light chain 1, cytoplasmic

2

3

Small-scale

0.611

High

208248

DCX
Neuronal migration protein doublecortin

2

0

Small-scale

0.603

High

793038

TNIK
TRAF2 and NCK-interacting protein kinase

2

13

High-throughput

0.576

High

793017

NUDC2
NudC domain-containing protein 2

1

16

Small-scale

0.565

High

265395

KTNA1
Katanin p60 ATPase-containing subunit A1

1

8

Small-scale

0.561

High

792977

PDE4D
3',5'-cyclic-AMP phosphodiesterase 4D

1

3

Small-scale

0.561

High

793032

CCSE2
Serine-rich coiled-coil domain-containing protein 2

2

0

High-throughput

0.559

High

792949

WDR5
WD repeat-containing protein 5

1

17

Small-scale

0.553

High

793003

TRI67
Tripartite motif-containing protein 67

1

16

High-throughput

0.553

High

793030

PKHA4
Pleckstrin homology domain-containing family A member 4

1

19

High-throughput

0.553

High

792986

SYK
Lysine--tRNA ligase

1

7

High-throughput

0.541

High

198230

DC1L2
Cytoplasmic dynein 1 light intermediate chain 2

1

2

High-throughput

0.536

High

254560

CLAP2
CLIP-associating protein 2

1

3

High-throughput

0.536

High

496503

TAU
Microtubule-associated protein tau

1

17

High-throughput

0.536

High

683188

1433B
14-3-3 protein beta/alpha

1

16

High-throughput

0.536

High

792940

CAPZB
F-actin-capping protein subunit beta

1

3

High-throughput

0.536

High

792944

DYLT3
Dynein light chain Tctex-type 3

1

3

High-throughput

0.536

High

792950

1433G
14-3-3 protein gamma

1

16

High-throughput

0.536

High

792954

1433E
14-3-3 protein epsilon

1

1

High-throughput

0.536

High

792963

1433Z
14-3-3 protein zeta/delta

1

16

High-throughput

0.536

High

792965

DYLT1
Dynein light chain Tctex-type 1

1

3

High-throughput

0.536

High

792969

TBB4B
Tubulin beta-4B chain

1

14

High-throughput

0.536

High

792974

1433F
14-3-3 protein eta

1

16

High-throughput

0.536

High

793006

CLAP1
CLIP-associating protein 1

1

9

High-throughput

0.536

High

793048

SAR1B
Small COPII coat GTPase SAR1B

1

6

High-throughput

0.536

High

790233

THIM
3-ketoacyl-CoA thiolase, mitochondrial

2

5

High-throughput

0.533

High

793010

NUDC3
NudC domain-containing protein 3

1

16

Small-scale

0.528

High

792987

IQCB1
IQ calmodulin-binding motif-containing protein 1

1

0

High-throughput

0.513

High

793016

DLRB2
Dynein light chain roadblock-type 2

1

0

High-throughput

0.513

High

793021

TANK
TRAF family member-associated NF-kappa-B activator

1

0

High-throughput

0.513

High

269123

DAB1
Disabled homolog 1

1

3

Small-scale

0.501

High

358724

CRYAA
Alpha-crystallin A chain

1

2

High-throughput

0.501

High

792970

CSK21
Casein kinase II subunit alpha

1

14

Small-scale

0.501

High

793005

TBA1A
Tubulin alpha-1A chain

1

10

Small-scale

0.501

High

793046

FBX7
F-box only protein 7

1

1

High-throughput

0.501

High

571094

EGLN
Endoglin

1

2

High-throughput

0.489

High

792981

DCTN2
Dynactin subunit 2

1

1

Small-scale

0.481

High

135989

ACACB
Acetyl-CoA carboxylase 2

1

12

High-throughput

0.479

High

166894

ANR28
Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A

1

3

High-throughput

0.479

High

317218

PCNT
Pericentrin

1

15

High-throughput

0.479

High

383677

ERBB2
Receptor tyrosine-protein kinase erbB-2

1

12

High-throughput

0.479

High

384438

NTRK1
High affinity nerve growth factor receptor

1

13

High-throughput

0.479

High

397828

ISG15
Ubiquitin-like protein ISG15

1

12

High-throughput

0.479

High

398334

PCCB
Propionyl-CoA carboxylase beta chain, mitochondrial

1

16

High-throughput

0.479

High

414806

CDK1
Cyclin-dependent kinase 1

1

6

High-throughput

0.479

High

436191

RHOC
Rho-related GTP-binding protein RhoC

1

5

Small-scale

0.479

High

445307

RSSA
Small ribosomal subunit protein uS2

1

2

High-throughput

0.479

High

449217

LEG1
Galectin-1

1

6

High-throughput

0.479

High

456818

FURIN
Furin

1

1

High-throughput

0.479

High

499599

CH60
60 kDa heat shock protein, mitochondrial

1

10

High-throughput

0.479

High

508856

TOP2A
DNA topoisomerase 2-alpha

1

7

High-throughput

0.479

High

538141

ENPL
Endoplasmin

1

11

High-throughput

0.479

High

551632

DESP
Desmoplakin

1

17

High-throughput

0.479

High

597996

FLNA
Filamin-A

1

13

High-throughput

0.479

High

602811

TGM2
Protein-glutamine gamma-glutamyltransferase 2

1

2

High-throughput

0.479

High

603388

FBRL
rRNA 2'-O-methyltransferase fibrillarin

1

4

High-throughput

0.479

High

616170

RS3
Small ribosomal subunit protein uS3

1

5

High-throughput

0.479

High

622391

CCND1
G1/S-specific cyclin-D1

1

7

Small-scale

0.479

High

623899

THIL
Acetyl-CoA acetyltransferase, mitochondrial

1

5

High-throughput

0.479

High

625202

CDK2
Cyclin-dependent kinase 2

1

6

High-throughput

0.479

High

636838

ATPA
ATP synthase subunit alpha, mitochondrial

1

6

High-throughput

0.479

High

671159

RL12
Large ribosomal subunit protein uL11

1

3

High-throughput

0.479

High

671742

PDIA3
Protein disulfide-isomerase A3

1

7

High-throughput

0.479

High

676650

AL1B1
Aldehyde dehydrogenase X, mitochondrial

1

2

High-throughput

0.479

High

708826

MCM7
DNA replication licensing factor MCM7

1

8

High-throughput

0.479

High

722328

RL22
Large ribosomal subunit protein eL22

1

4

High-throughput

0.479

High

736295

RL4
Large ribosomal subunit protein uL4

1

4

High-throughput

0.479

High

759918

RL3
Large ribosomal subunit protein uL3

1

7

High-throughput

0.479

High

773261

RL13A
Large ribosomal subunit protein uL13

1

5

High-throughput

0.479

High

782977

SYIC
Isoleucine--tRNA ligase, cytoplasmic

1

8

High-throughput

0.479

High

792936

PRS6B
26S proteasome regulatory subunit 6B

1

7

High-throughput

0.479

High

792937

RL27A
Large ribosomal subunit protein uL15

1

5

High-throughput

0.479

High

792938

RL21
Large ribosomal subunit protein eL21

1

2

High-throughput

0.479

High

792939

RS9
Small ribosomal subunit protein uS4

1

5

High-throughput

0.479

High

792942

TCPG
T-complex protein 1 subunit gamma

1

20

High-throughput

0.479

High

792943

EFTU
Elongation factor Tu, mitochondrial

1

6

High-throughput

0.479

High

792945

GDIR1
Rho GDP-dissociation inhibitor 1

1

1

Small-scale

0.479

High

792948

RL26
Large ribosomal subunit protein uL24

1

5

High-throughput

0.479

High

792951

PRS8
26S proteasome regulatory subunit 8

1

8

High-throughput

0.479

High

792952

RS8
Small ribosomal subunit protein eS8

1

3

High-throughput

0.479

High

792955

RS14
Small ribosomal subunit protein uS11

1

5

High-throughput

0.479

High

792956

RS18
Small ribosomal subunit protein uS13

1

2

High-throughput

0.479

High

792957

RS13
Small ribosomal subunit protein uS15

1

3

High-throughput

0.479

High

792958

RS11
Small ribosomal subunit protein uS17

1

5

High-throughput

0.479

High

792960

RS6
Small ribosomal subunit protein eS6

1

3

High-throughput

0.479

High

792961

RS25
Small ribosomal subunit protein eS25

1

3

High-throughput

0.479

High

792962

RL11
Large ribosomal subunit protein uL5

1

3

High-throughput

0.479

High

792966

RL38
Large ribosomal subunit protein eL38

1

3

High-throughput

0.479

High

792973

CENPE
Centromere-associated protein E

1

3

High-throughput

0.479

High

792975

RL18
Large ribosomal subunit protein eL18

1

4

High-throughput

0.479

High

792976

PDE4B
3',5'-cyclic-AMP phosphodiesterase 4B

1

3

Small-scale

0.479

High

792980

SQSTM
Sequestosome-1

1

3

High-throughput

0.479

High

792985

GANAB
Neutral alpha-glucosidase AB

1

1

High-throughput

0.479

High

792988

PDIA6
Protein disulfide-isomerase A6

1

9

High-throughput

0.479

High

792990

MARE2
Microtubule-associated protein RP/EB family member 2

1

4

High-throughput

0.479

High

792992

H31T
Histone H3.1t

1

10

High-throughput

0.479

High

792993

PCKGM
Phosphoenolpyruvate carboxykinase [GTP], mitochondrial

1

3

High-throughput

0.479

High

792994

TSR1
Pre-rRNA-processing protein TSR1 homolog

1

4

High-throughput

0.479

High

792997

CP135
Centrosomal protein of 135 kDa

1

13

High-throughput

0.479

High

792998

H2A2A
Histone H2A type 2-A

1

6

High-throughput

0.479

High

792999

CAVN1
Caveolae-associated protein 1

1

1

High-throughput

0.479

High

793000

C1TM
Monofunctional C1-tetrahydrofolate synthase, mitochondrial

1

3

High-throughput

0.479

High

793002

LMTK1
Serine/threonine-protein kinase LMTK1

1

18

High-throughput

0.479

High

793004

CE128
Centrosomal protein of 128 kDa

1

19

High-throughput

0.479

High

793009

ARMC8
Armadillo repeat-containing protein 8

1

7

High-throughput

0.479

High

793014

BICD2
Protein bicaudal D homolog 2

1

14

Small-scale

0.479

High

793015

DLG5
Disks large homolog 5

1

2

High-throughput

0.479

High

793018

DYT2B
Dynein light chain Tctex-type protein 2B

1

3

High-throughput

0.479

High

793020

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

2

High-throughput

0.479

High

793023

DYL2
Dynein light chain 2, cytoplasmic

1

3

High-throughput

0.479

High

793025

SNX27
Sorting nexin-27

1

4

High-throughput

0.479

High

793029

TOLIP
Toll-interacting protein

1

1

High-throughput

0.479

High

793033

MCCB
Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial

1

16

High-throughput

0.479

High

793040

CHIP
E3 ubiquitin-protein ligase CHIP

1

14

Small-scale

0.479

High

793044

NINL
Ninein-like protein

1

15

High-throughput

0.479

High

793047

RL36
Large ribosomal subunit protein eL36

1

3

High-throughput

0.479

High

80915

B6ZDN3
Doublecortin domain containing 1

1

0

Small-scale

0.458

High

337213

AATM
Aspartate aminotransferase, mitochondrial

1

0

High-throughput

0.458

High

793012

NHLC2
NHL repeat-containing protein 2

1

0

High-throughput

0.458

High

793022

ENTR1
Endosome-associated-trafficking regulator 1

1

0

High-throughput

0.458

High

793037

DCTN4
Dynactin subunit 4

1

0

High-throughput

0.458

High

239840

HCN1
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

1

2

High-throughput

0.445

High

264279

GGYF1
GRB10-interacting GYF protein 1

1

5

High-throughput

0.445

High

437971

HS90B
Heat shock protein HSP 90-beta

1

12

High-throughput

0.445

High

503614

HSP7C
Heat shock cognate 71 kDa protein

1

15

High-throughput

0.445

High

792995

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

11

High-throughput

0.445

High

793007

TLK2
Serine/threonine-protein kinase tousled-like 2

1

10

High-throughput

0.445

High

793027

ZDHC5
Palmitoyltransferase ZDHHC5

1

5

High-throughput

0.445

High

169397

BET1
BET1 homolog

1

1

High-throughput

0.437

High

214131

SPOP
Speckle-type POZ protein

1

5

High-throughput

0.437

High

346159

MYC
Myc proto-oncogene protein

1

20

High-throughput

0.437

High

533423

ETFA
Electron transfer flavoprotein subunit alpha, mitochondrial

1

2

High-throughput

0.437

High

559595

H12
Histone H1.2

1

9

High-throughput

0.437

High

572595

VGFR1
Vascular endothelial growth factor receptor 1

1

5

High-throughput

0.437

High

609202

FGFR3
Fibroblast growth factor receptor 3

1

12

High-throughput

0.437

High

687180

P5CR1
Pyrroline-5-carboxylate reductase 1, mitochondrial

1

5

High-throughput

0.437

High

735876

ATPG
ATP synthase subunit gamma, mitochondrial

1

2

High-throughput

0.437

High

738171

FLT3
Receptor-type tyrosine-protein kinase FLT3

1

5

High-throughput

0.437

High

778064

ECHA
Trifunctional enzyme subunit alpha, mitochondrial

1

1

High-throughput

0.437

High

792946

P5CS
Delta-1-pyrroline-5-carboxylate synthase

1

6

High-throughput

0.437

High

792972

RNF4
E3 ubiquitin-protein ligase RNF4

1

7

High-throughput

0.437

High

792978

TIF1B
Transcription intermediary factor 1-beta

1

18

High-throughput

0.437

High

792982

CUL4A
Cullin-4A

1

20

High-throughput

0.437

High

792996

MRP7
ATP-binding cassette sub-family C member 10

1

1

High-throughput

0.437

High

793008

GOLI
E3 ubiquitin-protein ligase RNF130

1

3

High-throughput

0.437

High

793013

LNX1
E3 ubiquitin-protein ligase LNX

1

2

Small-scale

0.437

High

793019

H1X
Histone H1.10

1

3

High-throughput

0.437

High

793024

SUCB2
Succinate--CoA ligase [GDP-forming] subunit beta, mitochondrial

1

2

High-throughput

0.437

High

793039

CPSF3
Cleavage and polyadenylation specificity factor subunit 3

1

3

High-throughput

0.437

High

793041

AP4E1
AP-4 complex subunit epsilon-1

1

4

High-throughput

0.437

High

793042

SRRM2
Serine/arginine repetitive matrix protein 2

1

19

High-throughput

0.437

High

792941

UCRI
Cytochrome b-c1 complex subunit Rieske, mitochondrial

1

0

High-throughput

0.249

Low

793001

SOSD1
Sclerostin domain-containing protein 1

1

0

Small-scale

0.249

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024