Protein: ICLN
Methylosome subunit pICln (Chloride channel, nucleotide sensitive 1A) (Chloride conductance regulatory protein ICln) (I(Cln)) (Chloride ion current inducer protein) (ClCI) (Reticulocyte pICln)

Gene: ICLN, CLNS1A
Organism: Homo sapiens
Interactions: 149
UniProt ID: P54105

Gene Ontology (top 5):
GO:0000387 - spliceosomal snRNP assembly
GO:0003723 - RNA binding
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005681 - spliceosomal complex

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

867411

SMD3
Small nuclear ribonucleoprotein Sm D3

10

10

Small-scale

0.980

High

867409

SMD1
Small nuclear ribonucleoprotein Sm D1

8

10

Small-scale

0.979

High

867410

SMD2
Small nuclear ribonucleoprotein Sm D2

8

2

Small-scale

0.976

High

867408

LSM6
U6 snRNA-associated Sm-like protein LSm6

7

7

High-throughput

0.972

High

538876

RSMB
Small nuclear ribonucleoprotein-associated proteins B and B'

7

3

Small-scale

0.968

High

867406

RUXG
Small nuclear ribonucleoprotein G

6

10

Small-scale

0.958

High

867492

LSM2
U6 snRNA-associated Sm-like protein LSm2

6

10

High-throughput

0.953

High

867405

RUXF
Small nuclear ribonucleoprotein F

5

7

Small-scale

0.942

High

867404

RUXE
Small nuclear ribonucleoprotein E

5

2

Small-scale

0.939

High

867407

LSM3
U6 snRNA-associated Sm-like protein LSm3

5

6

High-throughput

0.935

High

867413

RSMN
Small nuclear ribonucleoprotein-associated protein N

2

3

High-throughput

0.811

High

867495

LSM4
U6 snRNA-associated Sm-like protein LSm4

2

10

High-throughput

0.811

High

153615

ANM5
Protein arginine N-methyltransferase 5

9

1

Small-scale

0.759

High

867458

LSM10
U7 snRNA-associated Sm-like protein LSm10

1

11

Small-scale

0.724

High

867478

GAR1
H/ACA ribonucleoprotein complex subunit 1

5

0

High-throughput

0.691

High

867465

MEP50
Methylosome protein WDR77

5

0

Small-scale

0.689

High

204636

E41L2
Band 4.1-like protein 2

3

6

High-throughput

0.675

High

299251

FARP2
FERM, ARHGEF and pleckstrin domain-containing protein 2

3

6

High-throughput

0.675

High

867491

E41L3
Band 4.1-like protein 3

3

6

High-throughput

0.675

High

198863

RFOX2
RNA binding protein fox-1 homolog 2

3

2

High-throughput

0.667

High

550677

RS2
Small ribosomal subunit protein uS5

3

0

High-throughput

0.638

High

867466

RIOK1
Serine/threonine-protein kinase RIO1

3

0

High-throughput

0.638

High

505591

EPB41
Protein 4.1

2

7

High-throughput

0.631

High

867467

E41L1
Band 4.1-like protein 1

2

6

High-throughput

0.628

High

167672

LSM1
U6 snRNA-associated Sm-like protein LSm1

1

8

High-throughput

0.618

High

867415

LSM11
U7 snRNA-associated Sm-like protein LSm11

2

0

Small-scale

0.612

High

867438

FRMD7
FERM domain-containing protein 7

2

6

High-throughput

0.606

High

867400

RL15
Large ribosomal subunit protein eL15

2

0

High-throughput

0.602

High

867421

CIRBP
Cold-inducible RNA-binding protein

2

0

High-throughput

0.602

High

867474

COPRS
Coordinator of PRMT5 and differentiation stimulator

2

0

High-throughput

0.602

High

68405

RUXGL
Putative small nuclear ribonucleoprotein G-like protein 15

1

10

High-throughput

0.575

High

867443

NFE4
Transcription factor NF-E4

2

0

Small-scale

0.569

High

384552

NTRK1
High affinity nerve growth factor receptor

2

0

High-throughput

0.559

High

235058

DOK2
Docking protein 2

2

0

High-throughput

0.547

High

592177

RAB5A
Ras-related protein Rab-5A

2

0

High-throughput

0.547

High

657813

ELK4
ETS domain-containing protein Elk-4

2

0

High-throughput

0.547

High

867414

CSK21
Casein kinase II subunit alpha

1

0

High-throughput

0.545

High

439935

ITA2B
Integrin alpha-IIb

1

0

Small-scale

0.537

High

682745

HNRH1
Heterogeneous nuclear ribonucleoprotein H

1

1

High-throughput

0.536

High

851400

NEK4
Serine/threonine-protein kinase Nek4

1

1

High-throughput

0.536

High

867397

HNRH2
Heterogeneous nuclear ribonucleoprotein H2

1

1

High-throughput

0.536

High

867426

SMN
Survival motor neuron protein

1

1

High-throughput

0.536

High

867452

DP13B
DCC-interacting protein 13-beta

1

1

High-throughput

0.536

High

867453

GEMI5
Gem-associated protein 5

1

2

High-throughput

0.536

High

867455

DDX1
ATP-dependent RNA helicase DDX1

1

1

High-throughput

0.536

High

867464

VRK1
Serine/threonine-protein kinase VRK1

1

1

High-throughput

0.536

High

867469

AGO3
Protein argonaute-3

1

1

High-throughput

0.536

High

867473

WDR6
tRNA

1

2

High-throughput

0.536

High

867477

RFOX1
RNA binding protein fox-1 homolog 1

1

2

High-throughput

0.536

High

867482

DDX20
Probable ATP-dependent RNA helicase DDX20

1

3

High-throughput

0.536

High

128981

PLK4
Serine/threonine-protein kinase PLK4

1

0

High-throughput

0.513

High

235767

HNRPQ
Heterogeneous nuclear ribonucleoprotein Q

1

0

High-throughput

0.513

High

261981

PEX14
Peroxisomal membrane protein PEX14

1

0

High-throughput

0.513

High

321736

WIZ
Protein Wiz

1

0

High-throughput

0.513

High

362968

FINC
Fibronectin

1

0

High-throughput

0.513

High

685858

ARRB2
Beta-arrestin-2

1

0

High-throughput

0.513

High

867398

GEMI4
Gem-associated protein 4

1

0

High-throughput

0.513

High

867425

NUMA1
Nuclear mitotic apparatus protein 1

1

0

High-throughput

0.513

High

867428

TSR1
Pre-rRNA-processing protein TSR1 homolog

1

0

High-throughput

0.513

High

867441

CSN6
COP9 signalosome complex subunit 6

1

0

High-throughput

0.513

High

867442

KDM3B
Lysine-specific demethylase 3B

1

0

High-throughput

0.513

High

867444

THOC4
THO complex subunit 4

1

0

High-throughput

0.513

High

867449

LRC47
Leucine-rich repeat-containing protein 47

1

0

High-throughput

0.513

High

867450

EIF1A
Probable RNA-binding protein EIF1AD

1

0

High-throughput

0.513

High

867451

FA98A
Protein FAM98A

1

0

High-throughput

0.513

High

867457

FGF11
Fibroblast growth factor 11

1

0

High-throughput

0.513

High

867485

NOB1
RNA-binding protein NOB1

1

0

High-throughput

0.513

High

867487

WDR3
WD repeat-containing protein 3

1

0

High-throughput

0.513

High

867489

RTRAF
RNA transcription, translation and transport factor protein

1

0

High-throughput

0.513

High

867490

CDYL
Chromodomain Y-like protein

1

0

High-throughput

0.513

High

867494

MTCL1
Microtubule cross-linking factor 1

1

0

High-throughput

0.513

High

867403

1433E
14-3-3 protein epsilon

1

0

Small-scale

0.493

High

867419

G3BP1
Ras GTPase-activating protein-binding protein 1

1

0

High-throughput

0.493

High

475517

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

0

High-throughput

0.480

High

226958

PRKN
E3 ubiquitin-protein ligase parkin

1

1

High-throughput

0.479

High

509564

UBL4A
Ubiquitin-like protein 4A

1

1

High-throughput

0.479

High

640225

PTN3
Tyrosine-protein phosphatase non-receptor type 3

1

6

High-throughput

0.479

High

757520

IF4A3
Eukaryotic initiation factor 4A-III

1

1

High-throughput

0.479

High

867433

RC3H1
Roquin-1

1

1

High-throughput

0.479

High

867434

RN123
E3 ubiquitin-protein ligase RNF123

1

1

High-throughput

0.479

High

867437

TRI67
Tripartite motif-containing protein 67

1

1

High-throughput

0.479

High

867447

VRK3
Serine/threonine-protein kinase VRK3

1

1

High-throughput

0.479

High

867463

ANM1
Protein arginine N-methyltransferase 1

1

1

High-throughput

0.479

High

867470

RC3H2
Roquin-2

1

2

High-throughput

0.479

High

182632

R113A
E3 ubiquitin-protein ligase RNF113A

1

0

High-throughput

0.458

High

200375

HS12A
Heat shock 70 kDa protein 12A

1

0

High-throughput

0.458

High

242029

PAGE4
P antigen family member 4

1

0

High-throughput

0.458

High

244166

BRD4
Bromodomain-containing protein 4

1

0

High-throughput

0.458

High

294574

RECQ4
ATP-dependent DNA helicase Q4

1

0

High-throughput

0.458

High

298314

UFL1
E3 UFM1-protein ligase 1

1

0

High-throughput

0.458

High

325670

LATS1
Serine/threonine-protein kinase LATS1

1

0

High-throughput

0.458

High

326531

SNAI1
Zinc finger protein SNAI1

1

0

High-throughput

0.458

High

351318

TGFB1
Transforming growth factor beta-1 proprotein [Cleaved into: Latency-associated peptide

1

0

High-throughput

0.458

High

369242

ESR1
Estrogen receptor

1

0

High-throughput

0.458

High

501867

BIP
Endoplasmic reticulum chaperone BiP

1

0

High-throughput

0.458

High

506941

LAMP1
Lysosome-associated membrane glycoprotein 1

1

0

High-throughput

0.458

High

569454

CEBPB
CCAAT/enhancer-binding protein beta

1

0

High-throughput

0.458

High

617092

PTPRG
Receptor-type tyrosine-protein phosphatase gamma

1

0

High-throughput

0.458

High

632225

TNR6
Tumor necrosis factor receptor superfamily member 6

1

0

High-throughput

0.458

High

653147

DCK
Deoxycytidine kinase

1

0

Small-scale

0.458

High

718465

NOS2
Nitric oxide synthase, inducible

1

0

High-throughput

0.458

High

841108

CDK7
Cyclin-dependent kinase 7

1

0

High-throughput

0.458

High

867399

UBC12
NEDD8-conjugating enzyme Ubc12

1

0

High-throughput

0.458

High

867401

MGN
Protein mago nashi homolog

1

0

High-throughput

0.458

High

867402

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

0

High-throughput

0.458

High

867416

EP300
Histone acetyltransferase p300

1

0

High-throughput

0.458

High

867417

TP4A2
Protein tyrosine phosphatase type IVA 2

1

0

High-throughput

0.458

High

867418

CACO2
Calcium-binding and coiled-coil domain-containing protein 2

1

0

High-throughput

0.458

High

867420

CUL3
Cullin-3

1

0

High-throughput

0.458

High

867422

TRI14
Tripartite motif-containing protein 14

1

0

High-throughput

0.458

High

867424

GRM2
Metabotropic glutamate receptor 2

1

0

High-throughput

0.458

High

867427

DUS5
Dual specificity protein phosphatase 5

1

0

High-throughput

0.458

High

867429

LARP7
La-related protein 7

1

0

High-throughput

0.458

High

867430

PAN2
PAN2-PAN3 deadenylation complex catalytic subunit PAN2

1

0

High-throughput

0.458

High

867435

VIR
Protein virilizer homolog

1

0

High-throughput

0.458

High

867440

MEPCE
7SK snRNA methylphosphate capping enzyme

1

0

High-throughput

0.458

High

867454

NUDC2
NudC domain-containing protein 2

1

0

High-throughput

0.458

High

867456

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

0

High-throughput

0.458

High

867459

CDCA5
Sororin

1

0

High-throughput

0.458

High

867460

ALKB3
Alpha-ketoglutarate-dependent dioxygenase alkB homolog 3

1

0

Small-scale

0.458

High

867461

CIC
Protein capicua homolog

1

0

High-throughput

0.458

High

867462

CRBN
Protein cereblon

1

0

Small-scale

0.458

High

867471

NMRL1
NmrA-like family domain-containing protein 1

1

0

High-throughput

0.458

High

867472

SMUF1
E3 ubiquitin-protein ligase SMURF1

1

0

High-throughput

0.458

High

867475

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

1

0

High-throughput

0.458

High

867476

FBX6
F-box only protein 6

1

0

High-throughput

0.458

High

867480

KS6B2
Ribosomal protein S6 kinase beta-2

1

0

High-throughput

0.458

High

867481

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.458

High

867486

FZR1
Fizzy-related protein homolog

1

0

High-throughput

0.458

High

867493

WIPI4
WD repeat domain phosphoinositide-interacting protein 4

1

0

Small-scale

0.458

High

867423

IF4A2
Eukaryotic initiation factor 4A-II

1

1

High-throughput

0.457

High

46554

A0A2R8Y783
Erythrocyte membrane protein band 4.1

1

3

High-throughput

0.445

High

867436

PKHA7
Pleckstrin homology domain-containing family A member 7

1

1

High-throughput

0.445

High

867448

ULK2
Serine/threonine-protein kinase ULK2

1

1

High-throughput

0.445

High

867484

AGO2
Protein argonaute-2

1

1

High-throughput

0.445

High

275391

PR15A
Protein phosphatase 1 regulatory subunit 15A

1

0

High-throughput

0.426

High

496632

TAU
Microtubule-associated protein tau

1

0

High-throughput

0.426

High

867412

RS30
Ubiquitin-like FUBI-ribosomal protein eS30 fusion protein

1

0

High-throughput

0.426

High

867432

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

0

High-throughput

0.426

High

867439

NEK10
Serine/threonine-protein kinase Nek10

1

1

High-throughput

0.407

High

326916

DDAH2
Putative hydrolase DDAH2

3

0

High-throughput

0.347

High

577456

PACA
Pituitary adenylate cyclase-activating polypeptide

3

0

High-throughput

0.347

High

867431

FBLN7
Fibulin-7

2

0

High-throughput

0.318

High

867468

RDD1
Required for drug-induced death protein 1

1

0

High-throughput

0.279

Low

867479

F135A
Protein FAM135A

1

0

High-throughput

0.279

Low

867483

ZNHI2
Zinc finger HIT domain-containing protein 2

1

0

High-throughput

0.279

Low

867488

AGAP1
Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1

1

0

High-throughput

0.279

Low

867445

TMM17
Transmembrane protein 17

1

0

High-throughput

0.249

Low

867446

GOLI
E3 ubiquitin-protein ligase RNF130

1

0

High-throughput

0.249

Low


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Last updated: 15 Jul 2024