Protein: SIM43
Small integral membrane protein 43 (Nodal enhanced mesendoderm micropeptide) (NEMEP)

Gene: SIM43, Smim43
Organism: Mus musculus
Interactions: 207
UniProt ID: A0A286YD83

Gene Ontology (top 5):
GO:0005886 - plasma membrane
GO:0010828 - positive regulation of D-glucose transmembrane transport
GO:0044325 - transmembrane transporter binding
GO:0048382 - mesendoderm development

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

46488

GTR1
Solute carrier family 2, facilitated glucose transporter member 1

1

5

High-throughput

0.536

High

46495

GTR3
Solute carrier family 2, facilitated glucose transporter member 3

1

5

High-throughput

0.536

High

46450

DESP
Desmoplakin

1

1

High-throughput

0.479

High

46481

IGHM
Immunoglobulin heavy constant mu [Cleaved into: Mu' chain

1

1

High-throughput

0.479

High

46485

GLUT4
Solute carrier family 2, facilitated glucose transporter member 4

1

5

High-throughput

0.479

High

46486

GTR2
Solute carrier family 2, facilitated glucose transporter member 2

1

5

High-throughput

0.479

High

46427

SIM43
Small integral membrane protein 43

1

0

High-throughput

0.458

High

46442

D3Z111
Acyl-protein thioesterase 1

1

0

High-throughput

0.458

High

46453

E9QPI5
PDS5 cohesin associated factor A

1

0

High-throughput

0.458

High

46474

AIP
AH receptor-interacting protein

1

0

High-throughput

0.458

High

46483

ITB1
Integrin beta-1

1

0

High-throughput

0.458

High

46508

PP4C
Serine/threonine-protein phosphatase 4 catalytic subunit

1

0

High-throughput

0.458

High

46519

Q3TIP8
Chloride intracellular channel protein

1

0

High-throughput

0.458

High

46521

Q3TJF3
Maternal embryonic leucine zipper kinase

1

0

High-throughput

0.458

High

46541

PLSI
Plastin-1

1

0

High-throughput

0.458

High

46570

PTK7
Inactive tyrosine-protein kinase 7

1

0

High-throughput

0.458

High

46577

SPICE
Spindle and centriole-associated protein 1

1

0

High-throughput

0.458

High

46580

FAD1
FAD synthase

1

0

High-throughput

0.458

High

46588

LZTS2
Leucine zipper putative tumor suppressor 2

1

0

High-throughput

0.458

High

46592

RTN4
Reticulon-4

1

0

High-throughput

0.458

High

46593

LGUL
Lactoylglutathione lyase

1

0

High-throughput

0.458

High

351

A0A075B5P4
Immunoglobulin heavy constant gamma 1

1

1

High-throughput

0.437

High

3004

A0A0G2JFY0
AFG2 AAA ATPase homolog A

1

1

High-throughput

0.437

High

3005

A0A0G2JG00
Far upstream element-binding protein 1

1

1

High-throughput

0.437

High

46458

F7BTP8
DnaJ heat shock protein family

1

1

High-throughput

0.437

High

46459

F7BX26
Serine/threonine-protein phosphatase

1

1

High-throughput

0.437

High

46470

I3ITR1
Iron-sulfur cluster assembly 1 homolog, mitochondrial

1

1

High-throughput

0.437

High

46479

KV2A6
Ig kappa chain V-II region 7S34.1

1

1

High-throughput

0.437

High

46480

KV3A1
Ig kappa chain V-III region PC 2880/PC 1229

1

1

High-throughput

0.437

High

46487

H12
Histone H1.2

1

2

High-throughput

0.437

High

46489

K1C19
Keratin, type I cytoskeletal 19

1

7

High-throughput

0.437

High

46494

DESM
Desmin

1

2

High-throughput

0.437

High

46497

H14
Histone H1.4

1

2

High-throughput

0.437

High

46506

RAD50
DNA repair protein RAD50

1

1

High-throughput

0.437

High

46511

TERA
Transitional endoplasmic reticulum ATPase

1

1

High-throughput

0.437

High

46514

Q1WWK3
Hist1h1b protein

1

2

High-throughput

0.437

High

46515

Q3T9Y8
Eukaryotic translation initiation factor 3 subunit I

1

1

High-throughput

0.437

High

46517

Q3THQ5
Stress-induced-phosphoprotein 1

1

1

High-throughput

0.437

High

46528

FUBP2
Far upstream element-binding protein 2

1

1

High-throughput

0.437

High

46529

Q3U3A7
Metastasis-associated protein MTA3

1

1

High-throughput

0.437

High

46530

Q3U480
Nucleolar protein 9

1

1

High-throughput

0.437

High

46533

Q3UDZ8
Metastasis-associated protein MTA2

1

1

High-throughput

0.437

High

46537

MCCB
Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial

1

1

High-throughput

0.437

High

46548

K1C15
Keratin, type I cytoskeletal 15

1

7

High-throughput

0.437

High

46551

K1C14
Keratin, type I cytoskeletal 14

1

7

High-throughput

0.437

High

46552

Q61782
Keratin, type I cytoskeletal 14

1

8

High-throughput

0.437

High

46553

KT33B
Keratin, type I cuticular Ha3-II

1

7

High-throughput

0.437

High

46554

K1C42
Keratin, type I cytoskeletal 42

1

7

High-throughput

0.437

High

46555

K2C72
Keratin, type II cytoskeletal 72

1

1

High-throughput

0.437

High

46559

NEST
Nestin

1

4

High-throughput

0.437

High

46609

ISCA2
Iron-sulfur cluster assembly 2 homolog, mitochondrial

1

1

High-throughput

0.437

High

46613

K1C17
Keratin, type I cytoskeletal 17

1

7

High-throughput

0.437

High

46617

K1C16
Keratin, type I cytoskeletal 16

1

7

High-throughput

0.437

High

372

A0A075DCI0
ATP synthase complex subunit 8

1

0

High-throughput

0.249

Low

375

A0A087WP01
E2 ubiquitin-conjugating enzyme

1

0

High-throughput

0.249

Low

2041

A0A0A6YX02
Ragulator complex protein LAMTOR1

1

0

High-throughput

0.249

Low

2042

A0A0A6YX05
Sodium/potassium-transporting ATPase subunit beta

1

0

High-throughput

0.249

Low

3001

A0A0G2JE25
small monomeric GTPase

1

0

High-throughput

0.249

Low

3172

A0A0J9YUQ8
Gelsolin

1

0

High-throughput

0.249

Low

3206

A0A0R4J260
OTU domain-containing protein 4

1

0

High-throughput

0.249

Low

4745

A0A1B0GR99
5-hydroxyisourate hydrolase

1

0

High-throughput

0.249

Low

4818

A0A1D5RLY6
Microtubule-associated protein 1S

1

0

High-throughput

0.249

Low

45887

A0A1L1SRV0
Calponin

1

0

High-throughput

0.249

Low

46428

A2A6G6
LIM and SH3 protein 1

1

0

High-throughput

0.249

Low

46429

A2AFN3
Trophinin

1

0

High-throughput

0.249

Low

46430

B0R1E3
Histidine triad nucleotide binding protein 1

1

0

High-throughput

0.249

Low

46431

B1ATL6
mitogen-activated protein kinase kinase

1

0

High-throughput

0.249

Low

46432

B1AWE0
Clathrin light chain

1

0

High-throughput

0.249

Low

46433

B2RWX5
Centrosomal protein 250

1

0

High-throughput

0.249

Low

46434

C5IGX4
Cyclin b1 variant 1

1

0

High-throughput

0.249

Low

46435

D3YTP6
Chromatin assembly factor 1 subunit B

1

0

High-throughput

0.249

Low

46436

D3YTP8
U6 snRNA-associated Sm-like protein LSm4

1

0

High-throughput

0.249

Low

46437

D3YVH4
Splicing factor 1

1

0

High-throughput

0.249

Low

46438

D3YVZ9
Mitochondrial ribosomal protein S21

1

0

High-throughput

0.249

Low

46439

D3YWS3
Profilin

1

0

High-throughput

0.249

Low

46440

D3Z0M9
Probable ATP-dependent RNA helicase DDX23

1

0

High-throughput

0.249

Low

46441

D3Z0S9
Tumor susceptibility gene 101

1

0

High-throughput

0.249

Low

46443

D3Z158
Glutamine--tRNA ligase

1

0

High-throughput

0.249

Low

46444

D3Z3F1
Pre-mRNA 3'-end-processing factor FIP1

1

0

High-throughput

0.249

Low

46445

D3Z4W5
Serine protease 59

1

0

High-throughput

0.249

Low

46446

D3Z7Q8
DNA-directed RNA polymerases I and III subunit RPAC1

1

0

High-throughput

0.249

Low

46447

E9PUB7
Protein misato homolog 1

1

0

High-throughput

0.249

Low

46448

E9PWY6
Glycine C-acetyltransferase

1

0

High-throughput

0.249

Low

46449

NU153
Nuclear pore complex protein Nup153

1

0

High-throughput

0.249

Low

46451

E9Q6M7
Pumilio homolog 1

1

0

High-throughput

0.249

Low

46452

E9QND8
Atlastin GTPase 2

1

0

High-throughput

0.249

Low

46454

F6QTS1
COP9 signalosome complex subunit 4

1

0

High-throughput

0.249

Low

46455

F6RJV6
LanC-like protein 2

1

0

High-throughput

0.249

Low

46456

F6VF36
Signal recognition particle receptor alpha

1

0

High-throughput

0.249

Low

46457

F6WYM0
Septin-2

1

0

High-throughput

0.249

Low

46460

F8VQJ3
Laminin subunit gamma-1

1

0

High-throughput

0.249

Low

46461

F8WGT2
Transmembrane protein 209

1

0

High-throughput

0.249

Low

46462

F8WH46
RIKEN cDNA 0610010K14 gene

1

0

High-throughput

0.249

Low

46463

G3UXB4
Cytoplasmic tRNA 2-thiolation protein 2

1

0

High-throughput

0.249

Low

46464

G3UY98
Methyltransferase 3, N6-adenosine-methyltransferase complex catalytic subunit

1

0

High-throughput

0.249

Low

46465

G3UYC5
Serine/threonine-protein kinase Chk1

1

0

High-throughput

0.249

Low

46466

G3UZW7
Mago homolog B, exon junction complex core component

1

0

High-throughput

0.249

Low

46467

G3UZX6
Small ubiquitin-like modifier 3

1

0

High-throughput

0.249

Low

46468

H3BJA3
Glutamate--cysteine ligase regulatory subunit

1

0

High-throughput

0.249

Low

46469

H3BJW0
CCN family member 2

1

0

High-throughput

0.249

Low

46471

M0QWK9
Eukaryotic translation initiation factor 2D

1

0

High-throughput

0.249

Low

46472

M0QWS4
Ubiquitin-fold modifier-conjugating enzyme 1

1

0

High-throughput

0.249

Low

46473

THOC4
THO complex subunit 4

1

0

High-throughput

0.249

Low

46475

OST48
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit

1

0

High-throughput

0.249

Low

46476

SPT5H
Transcription elongation factor SPT5

1

0

High-throughput

0.249

Low

46477

PFD2
Prefoldin subunit 2

1

0

High-throughput

0.249

Low

46478

DYR
Dihydrofolate reductase

1

0

High-throughput

0.249

Low

46482

PDIA4
Protein disulfide-isomerase A4

1

0

High-throughput

0.249

Low

46484

COX5A
Cytochrome c oxidase subunit 5A, mitochondrial

1

0

High-throughput

0.249

Low

46490

COX5B
Cytochrome c oxidase subunit 5B, mitochondrial

1

0

High-throughput

0.249

Low

46491

GSTA4
Glutathione S-transferase A4

1

0

High-throughput

0.249

Low

46492

MAP4
Microtubule-associated protein 4

1

0

High-throughput

0.249

Low

46493

PLAP
Phospholipase A-2-activating protein

1

0

High-throughput

0.249

Low

46496

HMGCL
Hydroxymethylglutaryl-CoA lyase, mitochondrial

1

0

High-throughput

0.249

Low

46498

RAGP1
Ran GTPase-activating protein 1

1

0

High-throughput

0.249

Low

46499

FOLC
Folylpolyglutamate synthase, mitochondrial

1

0

High-throughput

0.249

Low

46500

PDCD5
Programmed cell death protein 5

1

0

High-throughput

0.249

Low

46501

KLF16
Krueppel-like factor 16

1

0

High-throughput

0.249

Low

46502

RS20
Small ribosomal subunit protein uS10

1

0

High-throughput

0.249

Low

46503

NTF2
Nuclear transport factor 2

1

0

High-throughput

0.249

Low

46504

TIM13
Mitochondrial import inner membrane translocase subunit Tim13

1

0

High-throughput

0.249

Low

46505

PEBP1
Phosphatidylethanolamine-binding protein 1

1

0

High-throughput

0.249

Low

46507

MCL1
Induced myeloid leukemia cell differentiation protein Mcl-1 homolog

1

0

High-throughput

0.249

Low

46509

THUM3
tRNA

1

0

High-throughput

0.249

Low

46510

PSB4
Proteasome subunit beta type-4

1

0

High-throughput

0.249

Low

46512

Q05BD4
Phosphoribosyl pyrophosphate synthase-associated protein 2

1

0

High-throughput

0.249

Low

46513

Q05BH6
Tcof1 protein

1

0

High-throughput

0.249

Low

46516

Q3TGV3
Survival of motor neuron-related-splicing factor 30

1

0

High-throughput

0.249

Low

46518

Q3TIF7
Histone-lysine N-methyltransferase SMYD3

1

0

High-throughput

0.249

Low

46520

ZC3HF
Zinc finger CCCH domain-containing protein 15

1

0

High-throughput

0.249

Low

46522

Q3TLK4
Uncharacterized protein

1

0

High-throughput

0.249

Low

46523

Q3TN42
U3 small nucleolar RNA-associated protein 15 homolog

1

0

High-throughput

0.249

Low

46524

Q3TN61
Transforming protein RhoA

1

0

High-throughput

0.249

Low

46525

Q3TQL4
MICOS complex subunit MIC60

1

0

High-throughput

0.249

Low

46526

Q3TQP7
Acetyl-CoA acetyltransferase, mitochondrial

1

0

High-throughput

0.249

Low

46527

Q3TUM0
Lin-7 homolog A, crumbs cell polarity complex component

1

0

High-throughput

0.249

Low

46531

Q3U9H4
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A

1

0

High-throughput

0.249

Low

46532

Q3UCQ7
Lysine--tRNA ligase

1

0

High-throughput

0.249

Low

46534

Q3UEG7
Uncharacterized protein

1

0

High-throughput

0.249

Low

46535

Q3UGJ7
Nuclear pore glycoprotein p62

1

0

High-throughput

0.249

Low

46536

SMU1
WD40 repeat-containing protein SMU1

1

0

High-throughput

0.249

Low

46538

Q3UQD0
Mitochondrial import receptor subunit TOM40 homolog

1

0

High-throughput

0.249

Low

46539

Q3USC0
HEAT repeat-containing protein 3

1

0

High-throughput

0.249

Low

46540

Q3UYZ6
Baculoviral IAP repeat-containing protein 6

1

0

High-throughput

0.249

Low

46542

LRC47
Leucine-rich repeat-containing protein 47

1

0

High-throughput

0.249

Low

46543

Q5EBK8
Dynlt1 protein

1

0

High-throughput

0.249

Low

46544

UBP28
Ubiquitin carboxyl-terminal hydrolase 28

1

0

High-throughput

0.249

Low

46545

TSR1
Pre-rRNA-processing protein TSR1 homolog

1

0

High-throughput

0.249

Low

46546

ACACA
Acetyl-CoA carboxylase 1

1

0

High-throughput

0.249

Low

46547

HCFC1
Host cell factor 1

1

0

High-throughput

0.249

Low

46549

HCDH
Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial

1

0

High-throughput

0.249

Low

46550

FSCN1
Fascin

1

0

High-throughput

0.249

Low

46556

Q6J4Q0
C2-H2 zinc finger protein

1

0

High-throughput

0.249

Low

46557

Q6NSS8
Mpp6 protein

1

0

High-throughput

0.249

Low

46558

HELB
DNA helicase B

1

0

High-throughput

0.249

Low

46560

Q6PAS9
Rae1 protein homolog

1

0

High-throughput

0.249

Low

46561

HERC4
Probable E3 ubiquitin-protein ligase HERC4

1

0

High-throughput

0.249

Low

46562

AEDO
2-aminoethanethiol dioxygenase

1

0

High-throughput

0.249

Low

46563

Q6ZPS0
Ribosome-binding protein 1

1

0

High-throughput

0.249

Low

46564

VIP2
Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2

1

0

High-throughput

0.249

Low

46565

RL35
Large ribosomal subunit protein uL29

1

0

High-throughput

0.249

Low

46566

Q791X1
Cyclin-dependent kinase inhibitor 1C

1

0

High-throughput

0.249

Low

46567

CGBP1
CGG triplet repeat-binding protein 1

1

0

High-throughput

0.249

Low

46568

Q8BK00
Glucosamine-6-phosphate isomerase

1

0

High-throughput

0.249

Low

46569

Q8BK66
Probable ATP-dependent RNA helicase DDX56

1

0

High-throughput

0.249

Low

46571

RBGPR
Rab3 GTPase-activating protein non-catalytic subunit

1

0

High-throughput

0.249

Low

46572

Q8BNA5
Src substrate cortactin

1

0

High-throughput

0.249

Low

46573

Q8BX21
Protein kinase domain-containing protein

1

0

High-throughput

0.249

Low

46574

NUAK2
NUAK family SNF1-like kinase 2

1

0

High-throughput

0.249

Low

46575

Q8C1L7
40S ribosomal protein S21

1

0

High-throughput

0.249

Low

46576

Q8C6K6
Cleavage and polyadenylation specificity factor subunit 2

1

0

High-throughput

0.249

Low

46578

SMC4
Structural maintenance of chromosomes protein 4

1

0

High-throughput

0.249

Low

46579

MYL6B
Myosin light chain 6B

1

0

High-throughput

0.249

Low

46581

HMCES
Abasic site processing protein HMCES

1

0

High-throughput

0.249

Low

46582

MCMBP
Mini-chromosome maintenance complex-binding protein

1

0

High-throughput

0.249

Low

46583

Q8R3F7
Aladin

1

0

High-throughput

0.249

Low

46584

UBP15
Ubiquitin carboxyl-terminal hydrolase 15

1

0

High-throughput

0.249

Low

46585

ASPC1
Tether containing UBX domain for GLUT4

1

0

High-throughput

0.249

Low

46586

SYYC
Tyrosine--tRNA ligase, cytoplasmic

1

0

High-throughput

0.249

Low

46587

Q91YK6
Large ribosomal subunit protein uL23

1

0

High-throughput

0.249

Low

46589

UBXN1
UBX domain-containing protein 1

1

0

High-throughput

0.249

Low

46590

MAOM
NAD-dependent malic enzyme, mitochondrial

1

0

High-throughput

0.249

Low

46591

HSP7E
Heat shock 70 kDa protein 14

1

0

High-throughput

0.249

Low

46594

DECR
2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing], mitochondrial

1

0

High-throughput

0.249

Low

46595

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.249

Low

46596

TIM16
Mitochondrial import inner membrane translocase subunit TIM16

1

0

High-throughput

0.249

Low

46597

Q9CRS5
RNA-binding protein EWS

1

0

High-throughput

0.249

Low

46598

Q9CT18
protein-tyrosine-phosphatase

1

0

High-throughput

0.249

Low

46599

Q9CT23
PCI domain-containing protein

1

0

High-throughput

0.249

Low

46600

NDUF7
Protein arginine methyltransferase NDUFAF7, mitochondrial

1

0

High-throughput

0.249

Low

46601

Q9D096
Isochorismatase domain-containing protein 1

1

0

High-throughput

0.249

Low

46602

PSRC1
Proline/serine-rich coiled-coil protein 1

1

0

High-throughput

0.249

Low

46603

CNDP2
Cytosolic non-specific dipeptidase

1

0

High-throughput

0.249

Low

46604

TBCB
Tubulin-folding cofactor B

1

0

High-throughput

0.249

Low

46605

RM53
Large ribosomal subunit protein mL53

1

0

High-throughput

0.249

Low

46606

RL34
Large ribosomal subunit protein eL34

1

0

High-throughput

0.249

Low

46607

RL22L
Ribosomal protein eL22-like 1

1

0

High-throughput

0.249

Low

46608

ARP5L
Actin-related protein 2/3 complex subunit 5-like protein

1

0

High-throughput

0.249

Low

46610

NDUA8
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8

1

0

High-throughput

0.249

Low

46611

GLRX1
Glutaredoxin-1

1

0

High-throughput

0.249

Low

46612

Q9QWJ3
Alpha-1-globin

1

0

High-throughput

0.249

Low

46614

DCTP1
dCTP pyrophosphatase 1

1

0

High-throughput

0.249

Low

46615

AIFM1
Apoptosis-inducing factor 1, mitochondrial

1

0

High-throughput

0.249

Low

46616

SUCB1
Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial

1

0

High-throughput

0.249

Low

46618

Q9Z2L2
Truncated hsp25

1

0

High-throughput

0.249

Low

46619

Z4YKV1
Guanine nucleotide-binding protein G(s) subunit alpha

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025