Protein: NC2B
Protein Dr1 (Down-regulator of transcription 1) (Negative cofactor 2-beta) (NC2-beta) (TATA-binding protein-associated phosphoprotein)

Gene: NC2B, DR1
Organism: Homo sapiens
Interactions: 121
UniProt ID: Q01658

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0003677 - DNA binding
GO:0005654 - nucleoplasm
GO:0006355 - regulation of DNA-templated transcription
GO:0006357 - regulation of transcription by RNA polymerase II

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

966144

NC2A
Dr1-associated corepressor

14

20

Small-scale

0.983

High

966205

DPOE3
DNA polymerase epsilon subunit 3

5

10

High-throughput

0.924

High

589834

TBP
TATA-box-binding protein

5

4

Small-scale

0.917

High

966142

NFYC
Nuclear transcription factor Y subunit gamma

3

20

High-throughput

0.861

High

267645

TADA3
Transcriptional adapter 3

5

2

Small-scale

0.714

High

903138

WDR5
WD repeat-containing protein 5

4

2

Small-scale

0.694

High

966184

SGF29
SAGA-associated factor 29

4

2

Small-scale

0.694

High

966207

MBIP1
MAP3K12-binding inhibitory protein 1

4

2

Small-scale

0.694

High

266340

TAD2A
Transcriptional adapter 2-alpha

4

5

Small-scale

0.686

High

966179

KAT2A
Histone acetyltransferase KAT2A

4

11

Small-scale

0.686

High

966213

YETS2
YEATS domain-containing protein 2

3

5

Small-scale

0.674

High

966149

Q32MN6
TATA-box-binding protein

1

4

High-throughput

0.665

High

966156

H3C
Histone H3.3C

1

2

High-throughput

0.665

High

966180

KAT2B
Histone acetyltransferase KAT2B

3

9

Small-scale

0.656

High

828195

CENPA
Histone H3-like centromeric protein A

1

2

High-throughput

0.618

High

966165

ZZZ3
ZZ-type zinc finger-containing protein 3

2

2

High-throughput

0.611

High

966155

CE162
Centrosomal protein of 162 kDa

2

1

High-throughput

0.571

High

966161

SRCAP
Helicase SRCAP

1

4

High-throughput

0.536

High

966195

ARP6
Actin-related protein 6

1

1

High-throughput

0.536

High

966199

CSR2B
Cysteine-rich protein 2-binding protein

1

4

High-throughput

0.536

High

346554

MYC
Myc proto-oncogene protein

1

1

High-throughput

0.515

High

394556

A4
Amyloid-beta precursor protein

1

1

High-throughput

0.515

High

803492

BAG6
Large proline-rich protein BAG6

1

1

High-throughput

0.515

High

885442

VSX2
Visual system homeobox 2

1

2

High-throughput

0.515

High

966140

CBLB
E3 ubiquitin-protein ligase CBL-B

1

1

High-throughput

0.515

High

966153

PHF19
PHD finger protein 19

1

4

High-throughput

0.515

High

966154

DCAF8
DDB1- and CUL4-associated factor 8

1

3

High-throughput

0.515

High

966169

ZSCA1
Zinc finger and SCAN domain-containing protein 1

1

1

High-throughput

0.515

High

966178

DPF1
Zinc finger protein neuro-d4

1

1

High-throughput

0.515

High

966194

PBX4
Pre-B-cell leukemia transcription factor 4

1

3

High-throughput

0.515

High

966203

HES4
Transcription factor HES-4

1

1

High-throughput

0.515

High

966208

ZN581
Zinc finger protein 581

1

2

High-throughput

0.515

High

966211

KLF15
Krueppel-like factor 15

1

4

High-throughput

0.515

High

455332

PARP1
Poly [ADP-ribose] polymerase 1

1

0

High-throughput

0.513

High

891703

ACTB
Actin, cytoplasmic 1

1

0

High-throughput

0.513

High

966167

MIER1
Mesoderm induction early response protein 1

1

0

High-throughput

0.513

High

966204

DMAP1
DNA methyltransferase 1-associated protein 1

1

0

High-throughput

0.513

High

966214

RUVB2
RuvB-like 2

1

0

High-throughput

0.513

High

966147

NFIL3
Nuclear factor interleukin-3-regulated protein

1

3

Small-scale

0.501

High

177490

NVL
Nuclear valosin-containing protein-like

1

0

High-throughput

0.493

High

235806

HNRPQ
Heterogeneous nuclear ribonucleoprotein Q

1

0

High-throughput

0.493

High

265189

SAP30
Histone deacetylase complex subunit SAP30

1

0

High-throughput

0.493

High

271074

UBP2
Ubiquitin carboxyl-terminal hydrolase 2

1

0

High-throughput

0.493

High

485166

ZSC22
Zinc finger and SCAN domain-containing protein 22

1

0

High-throughput

0.493

High

583693

RPAB1
DNA-directed RNA polymerases I, II, and III subunit RPABC1

1

0

High-throughput

0.493

High

771918

VHL
von Hippel-Lindau disease tumor suppressor

1

0

High-throughput

0.493

High

822243

KC1D
Casein kinase I isoform delta

1

0

High-throughput

0.493

High

893538

SEM1
26S proteasome complex subunit SEM1

1

0

High-throughput

0.493

High

914929

RS4X
Small ribosomal subunit protein eS4, X isoform

1

0

High-throughput

0.493

High

966139

RED
Protein Red

1

0

High-throughput

0.493

High

966143

LPIN1
Phosphatidate phosphatase LPIN1

1

0

High-throughput

0.493

High

966150

ZN829
Zinc finger protein 829

1

0

High-throughput

0.493

High

966160

ASCL4
Achaete-scute homolog 4

1

0

High-throughput

0.493

High

966168

RYBP
RING1 and YY1-binding protein

1

0

High-throughput

0.493

High

966173

BAHD1
Bromo adjacent homology domain-containing 1 protein

1

0

High-throughput

0.493

High

966174

SPP2B
Signal peptide peptidase-like 2B

1

0

High-throughput

0.493

High

966175

MAGC3
Melanoma-associated antigen C3

1

0

High-throughput

0.493

High

966176

JADE3
Protein Jade-3

1

0

High-throughput

0.493

High

966181

RNF34
E3 ubiquitin-protein ligase RNF34

1

0

High-throughput

0.493

High

966187

ZN488
Zinc finger protein 488

1

0

High-throughput

0.493

High

966188

ANM1
Protein arginine N-methyltransferase 1

1

0

High-throughput

0.493

High

966190

RPP25
Ribonuclease P protein subunit p25

1

0

High-throughput

0.493

High

966210

ZN219
Zinc finger protein 219

1

0

High-throughput

0.493

High

966193

PAR6B
Partitioning defective 6 homolog beta

1

1

High-throughput

0.489

High

966212

DNM3L
DNA

1

0

Small-scale

0.480

High

569608

CEBPB
CCAAT/enhancer-binding protein beta

1

3

High-throughput

0.479

High

917130

H4
Histone H4

1

2

High-throughput

0.479

High

966146

TAF9
Transcription initiation factor TFIID subunit 9

1

1

High-throughput

0.479

High

966158

EDC4
Enhancer of mRNA-decapping protein 4

1

2

High-throughput

0.479

High

966163

TAD2B
Transcriptional adapter 2-beta

1

5

High-throughput

0.479

High

966171

NUP43
Nucleoporin Nup43

1

3

High-throughput

0.479

High

966201

TAF9B
Transcription initiation factor TFIID subunit 9B

1

1

High-throughput

0.479

High

966206

STRN4
Striatin-4

1

3

High-throughput

0.470

High

966218

EMIL1
EMILIN-1

1

1

High-throughput

0.470

High

173951

ATX7
Ataxin-7

1

0

High-throughput

0.458

High

201306

M3K7
Mitogen-activated protein kinase kinase kinase 7

1

0

Small-scale

0.458

High

266476

SUPT3
Transcription initiation protein SPT3 homolog

1

0

High-throughput

0.458

High

297903

ST65G
STAGA complex 65 subunit gamma

1

0

High-throughput

0.458

High

501035

IRF1
Interferon regulatory factor 1

1

0

Small-scale

0.458

High

572927

PRS6A
26S proteasome regulatory subunit 6A

1

0

High-throughput

0.458

High

652819

APEX1
DNA repair nuclease/redox regulator APEX1

1

0

High-throughput

0.458

High

966138

TAF10
Transcription initiation factor TFIID subunit 10

1

0

High-throughput

0.458

High

966170

SP20H
Transcription factor SPT20 homolog

1

0

High-throughput

0.458

High

966182

TADA1
Transcriptional adapter 1

1

0

High-throughput

0.458

High

966192

DDA1
DET1- and DDB1-associated protein 1

1

0

High-throughput

0.458

High

966215

TRRAP
Transformation/transcription domain-associated protein

1

0

High-throughput

0.458

High

717715

BMI1
Polycomb complex protein BMI-1

1

0

High-throughput

0.426

High

162642

XPO1
Exportin-1

1

0

Small-scale

0.391

High

966164

ZDH17
Palmitoyltransferase ZDHHC17

1

0

High-throughput

0.282

High

686164

GLPK
Glycerol kinase

1

0

High-throughput

0.279

Low

966141

MTMR2
Myotubularin-related protein 2

1

0

High-throughput

0.279

Low

966159

CP087
UPF0547 protein C16orf87

1

0

High-throughput

0.279

Low

46666

A0A384ME25
Epididymis secretory sperm binding protein

1

0

High-throughput

0.268

Low

58402

A2RU56
LOC401296 protein

1

0

High-throughput

0.268

Low

208561

TIM44
Mitochondrial import inner membrane translocase subunit TIM44

1

0

High-throughput

0.268

Low

316421

MPC2
Mitochondrial pyruvate carrier 2

1

0

High-throughput

0.268

Low

533973

ANXA8
Annexin A8

1

0

High-throughput

0.268

Low

966145

MLC1
Membrane protein MLC1

1

0

High-throughput

0.268

Low

966148

FA98C
Protein FAM98C

1

0

High-throughput

0.268

Low

966151

CP100
Cilia- and flagella-associated protein 100

1

0

High-throughput

0.268

Low

966152

ZC21C
Zinc finger C2HC domain-containing protein 1C

1

0

High-throughput

0.268

Low

966157

F117B
Protein FAM117B

1

0

High-throughput

0.268

Low

966162

DPP9
Dipeptidyl peptidase 9

1

0

High-throughput

0.268

Low

966166

FAM9A
Protein FAM9A

1

0

High-throughput

0.268

Low

966172

SPT22
Spermatogenesis-associated protein 22

1

0

High-throughput

0.268

Low

966177

LAR4B
La-related protein 4B

1

0

High-throughput

0.268

Low

966183

RN183
E3 ubiquitin-protein ligase RNF183

1

0

High-throughput

0.268

Low

966185

GMPPA
Mannose-1-phosphate guanyltransferase alpha

1

0

High-throughput

0.268

Low

966186

CH048
Uncharacterized protein C8orf48

1

0

High-throughput

0.268

Low

966189

TACO1
Translational activator of cytochrome c oxidase 1

1

0

High-throughput

0.268

Low

966191

RUSC1
AP-4 complex accessory subunit RUSC1

1

0

High-throughput

0.268

Low

966196

MKRN2
E3 ubiquitin-protein ligase makorin-2

1

0

High-throughput

0.268

Low

966197

Q9H669
cDNA: FLJ22558 fis, clone HSI01557

1

0

High-throughput

0.268

Low

966198

AUNIP
Aurora kinase A- and ninein-interacting protein

1

0

High-throughput

0.268

Low

966200

CN093
Uncharacterized protein C14orf93

1

0

High-throughput

0.268

Low

966202

GGA2B
Putative golgin subfamily A member 2B

1

0

High-throughput

0.268

Low

966209

SPMA2
Sperm microtubule associated protein 2

1

0

High-throughput

0.268

Low

966216

GPSM3
G-protein-signaling modulator 3

1

0

High-throughput

0.268

Low

966217

RAI2
Retinoic acid-induced protein 2

1

0

High-throughput

0.268

Low

148695

CTRO
Citron Rho-interacting kinase

1

0

High-throughput

0.249

Low

590853

BTF3
Transcription factor BTF3

1

0

High-throughput

0.249

Low


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Last updated: 15 Jul 2024