Protein: SMHD1
Structural maintenance of chromosomes flexible hinge domain-containing protein 1 (SMC hinge domain-containing protein 1) (EC 3.6.1.-)

Gene: SMHD1, SMCHD1
Organism: Homo sapiens
Interactions: 174
UniProt ID: A6NHR9

Gene Ontology (top 5):
GO:0001740 - Barr body
GO:0003677 - DNA binding
GO:0005524 - ATP binding
GO:0006302 - double-strand break repair
GO:0009048 - dosage compensation by inactivation of X chromosome

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

62916

H31
Histone H3.1

4

2

High-throughput

0.676

High

62856

MYC
Myc proto-oncogene protein

3

1

High-throughput

0.640

High

62915

H2B1C
Histone H2B type 1-C/E/F/G/I

3

2

High-throughput

0.640

High

62945

LRIF1
Ligand-dependent nuclear receptor-interacting factor 1

2

0

Small-scale

0.602

High

62968

AURKB
Aurora kinase B

2

0

High-throughput

0.602

High

62914

H4
Histone H4

2

0

High-throughput

0.559

High

62931

KCC1A
Calcium/calmodulin-dependent protein kinase type 1

1

1

High-throughput

0.536

High

62942

H2B2E
Histone H2B type 2-E

1

2

High-throughput

0.536

High

62947

KDM4D
Lysine-specific demethylase 4D

1

1

High-throughput

0.536

High

62954

STING
Stimulator of interferon genes protein

1

1

High-throughput

0.536

High

63000

KCC2A
Calcium/calmodulin-dependent protein kinase type II subunit alpha

1

1

High-throughput

0.536

High

62868

ANDR
Androgen receptor

2

3

High-throughput

0.533

High

62869

PRPS2
Ribose-phosphate pyrophosphokinase 2

1

0

High-throughput

0.513

High

62903

DGKG
Diacylglycerol kinase gamma

1

0

High-throughput

0.513

High

62906

NEK4
Serine/threonine-protein kinase Nek4

1

0

High-throughput

0.513

High

62934

NOLC1
Nucleolar and coiled-body phosphoprotein 1

1

0

High-throughput

0.513

High

62972

CDC5L
Cell division cycle 5-like protein

1

0

High-throughput

0.513

High

62986

MAGF1
Melanoma-associated antigen F1

1

0

High-throughput

0.513

High

62965

OPTN
Optineurin

1

1

High-throughput

0.489

High

62983

KDM4C
Lysine-specific demethylase 4C

1

1

High-throughput

0.489

High

62917

SRPK2
SRSF protein kinase 2

1

0

High-throughput

0.480

High

62835

TAF4
Transcription initiation factor TFIID subunit 4

1

1

High-throughput

0.479

High

62846

SOX15
Transcription factor SOX-15

1

3

High-throughput

0.479

High

62848

H2B1K
Histone H2B type 1-K

1

2

High-throughput

0.479

High

62863

MYCN
N-myc proto-oncogene protein

1

1

High-throughput

0.479

High

62867

PARP1
Poly [ADP-ribose] polymerase 1

1

1

High-throughput

0.479

High

62872

RFA2
Replication protein A 32 kDa subunit

1

1

High-throughput

0.479

High

62873

CEBPB
CCAAT/enhancer-binding protein beta

1

1

High-throughput

0.479

High

62885

PML
Protein PML

1

1

High-throughput

0.479

High

62890

SOX6
Transcription factor SOX-6

1

4

High-throughput

0.479

High

62892

BRCA1
Breast cancer type 1 susceptibility protein

1

2

High-throughput

0.479

High

62898

SOX2
Transcription factor SOX-2

1

4

High-throughput

0.479

High

62901

CENPA
Histone H3-like centromeric protein A

1

2

High-throughput

0.479

High

62912

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

1

High-throughput

0.479

High

62919

H33
Histone H3.3

1

2

High-throughput

0.479

High

62925

RFA4
Replication protein A 30 kDa subunit

1

1

High-throughput

0.479

High

62946

RIF1
Telomere-associated protein RIF1

1

1

High-throughput

0.479

High

62957

SLX4
Structure-specific endonuclease subunit SLX4

1

1

High-throughput

0.479

High

62961

ESR2
Estrogen receptor beta

1

3

High-throughput

0.479

High

62985

WDR76
WD repeat-containing protein 76

1

1

High-throughput

0.479

High

62966

SGTB
Small glutamine-rich tetratricopeptide repeat-containing protein beta

1

2

High-throughput

0.470

High

62952

PEG10
Retrotransposon-derived protein PEG10

1

0

High-throughput

0.460

High

62975

BARD1
BRCA1-associated RING domain protein 1

1

0

High-throughput

0.460

High

62837

CTRO
Citron Rho-interacting kinase

1

0

High-throughput

0.458

High

62844

ACTN4
Alpha-actinin-4

1

0

High-throughput

0.458

High

62847

NUPR1
Nuclear protein 1

1

0

High-throughput

0.458

High

62849

PAGE4
P antigen family member 4

1

0

High-throughput

0.458

High

62854

UFL1
E3 UFM1-protein ligase 1

1

0

High-throughput

0.458

High

62858

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

0

High-throughput

0.458

High

62861

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

0

High-throughput

0.458

High

62864

NTRK1
High affinity nerve growth factor receptor

1

0

High-throughput

0.458

High

62870

XRCC6
X-ray repair cross-complementing protein 6

1

0

High-throughput

0.458

High

62876

RO52
E3 ubiquitin-protein ligase TRIM21

1

0

High-throughput

0.458

High

62879

TYY1
Transcriptional repressor protein YY1

1

0

High-throughput

0.458

High

62880

PAX6
Paired box protein Pax-6

1

0

High-throughput

0.458

High

62881

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.458

High

62882

APEX1
DNA repair nuclease/redox regulator APEX1

1

0

High-throughput

0.458

High

62883

TEAD1
Transcriptional enhancer factor TEF-1

1

0

High-throughput

0.458

High

62888

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.458

High

62902

UBE2A
Ubiquitin-conjugating enzyme E2 A

1

0

High-throughput

0.458

High

62908

P5CS
Delta-1-pyrroline-5-carboxylate synthase

1

0

High-throughput

0.458

High

62921

HSF1
Heat shock factor protein 1

1

0

High-throughput

0.458

High

62922

MECOM
Histone-lysine N-methyltransferase MECOM

1

0

High-throughput

0.458

High

62924

FOXC1
Forkhead box protein C1

1

0

High-throughput

0.458

High

62933

MDC1
Mediator of DNA damage checkpoint protein 1

1

0

High-throughput

0.458

High

62956

SMC5
Structural maintenance of chromosomes protein 5

1

0

High-throughput

0.458

High

62988

SIR7
NAD-dependent protein deacetylase sirtuin-7

1

0

High-throughput

0.458

High

62909

PTEN
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

1

1

High-throughput

0.457

High

62865

JUN
Transcription factor Jun

1

1

High-throughput

0.445

High

62995

TNIK
TRAF2 and NCK-interacting protein kinase

1

0

High-throughput

0.438

High

62841

TNC18
Trinucleotide repeat-containing gene 18 protein

1

1

High-throughput

0.437

High

62842

RPA34
DNA-directed RNA polymerase I subunit RPA34

1

1

High-throughput

0.437

High

62845

SGTA
Small glutamine-rich tetratricopeptide repeat-containing protein alpha

1

2

Small-scale

0.437

High

62850

BRD4
Bromodomain-containing protein 4

1

2

High-throughput

0.437

High

62852

EED
Polycomb protein EED

1

2

High-throughput

0.437

High

62860

ESR1
Estrogen receptor

1

3

High-throughput

0.437

High

62862

GCR
Glucocorticoid receptor

1

3

Small-scale

0.437

High

62878

BRD2
Bromodomain-containing protein 2

1

2

High-throughput

0.437

High

62886

ELF1
ETS-related transcription factor Elf-1

1

3

High-throughput

0.437

High

62889

SOX5
Transcription factor SOX-5

1

4

High-throughput

0.437

High

62893

ETV3
ETS translocation variant 3

1

3

High-throughput

0.437

High

62894

ELK3
ETS domain-containing protein Elk-3

1

3

High-throughput

0.437

High

62897

YAP1
Transcriptional coactivator YAP1

1

1

High-throughput

0.437

High

62930

SPTN1
Spectrin alpha chain, non-erythrocytic 1

1

1

High-throughput

0.437

High

62937

BRD3
Bromodomain-containing protein 3

1

2

High-throughput

0.437

High

62949

TRI67
Tripartite motif-containing protein 67

1

1

High-throughput

0.437

High

62955

CHERP
Calcium homeostasis endoplasmic reticulum protein

1

2

High-throughput

0.437

High

62971

CIC
Protein capicua homolog

1

4

High-throughput

0.437

High

62973

RING2
E3 ubiquitin-protein ligase RING2

1

3

High-throughput

0.437

High

62974

ELF4
ETS-related transcription factor Elf-4

1

3

High-throughput

0.437

High

62996

HECD1
E3 ubiquitin-protein ligase HECTD1

1

1

High-throughput

0.437

High

62997

FZR1
Fizzy-related protein homolog

1

1

High-throughput

0.437

High

62999

CC14A
Dual specificity protein phosphatase CDC14A

1

1

High-throughput

0.437

High

62884

MK01
Mitogen-activated protein kinase 1

1

0

High-throughput

0.426

High

62904

CEBPA
CCAAT/enhancer-binding protein alpha

1

1

High-throughput

0.408

High

62857

TSHB
Thyrotropin subunit beta

2

0

High-throughput

0.328

High

62959

TP4AP
Short transient receptor potential channel 4-associated protein

2

0

High-throughput

0.328

High

62836

BIN1
Myc box-dependent-interacting protein 1

2

0

High-throughput

0.316

High

62910

SUMO2
Small ubiquitin-related modifier 2

2

0

High-throughput

0.314

High

62926

CBX3
Chromobox protein homolog 3

2

0

High-throughput

0.313

High

62833

HNRC2
Heterogeneous nuclear ribonucleoprotein C-like 2

1

0

High-throughput

0.279

Low

62840

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

1

0

High-throughput

0.279

Low

62843

SRGP3
SLIT-ROBO Rho GTPase-activating protein 3

1

0

High-throughput

0.279

Low

62853

MPDZ
Multiple PDZ domain protein

1

0

High-throughput

0.279

Low

62859

FINC
Fibronectin

1

0

High-throughput

0.279

Low

62874

RL35A
Large ribosomal subunit protein eL33

1

0

High-throughput

0.279

Low

62896

NOTC1
Neurogenic locus notch homolog protein 1

1

0

High-throughput

0.279

Low

62918

HMGN5
High mobility group nucleosome-binding domain-containing protein 5

1

0

High-throughput

0.279

Low

62927

NMI
N-myc-interactor

1

0

High-throughput

0.279

Low

62951

SPRE2
Sprouty-related, EVH1 domain-containing protein 2

1

0

High-throughput

0.279

Low

62960

IASPP
RelA-associated inhibitor

1

0

High-throughput

0.279

Low

62963

EFMT3
EEF1A lysine methyltransferase 3

1

0

High-throughput

0.279

Low

62970

CEP19
Centrosomal protein of 19 kDa

1

0

High-throughput

0.279

Low

63004

MB212
Protein mab-21-like 2

1

0

High-throughput

0.279

Low

63005

WIF1
Wnt inhibitory factor 1

1

0

High-throughput

0.279

Low

62940

SEPT7
Septin-7

1

0

High-throughput

0.269

Low

62944

DACT2
Dapper homolog 2

1

0

High-throughput

0.269

Low

62967

PHIPL
Phytanoyl-CoA hydroxylase-interacting protein-like

1

0

High-throughput

0.269

Low

62834

LEG9
Galectin-9

1

0

High-throughput

0.249

Low

62838

SR140
U2 snRNP-associated SURP motif-containing protein

1

0

High-throughput

0.249

Low

62839

PER2
Period circadian protein homolog 2

1

0

Small-scale

0.249

Low

62851

OBSL1
Obscurin-like protein 1

1

0

High-throughput

0.249

Low

62855

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

0

High-throughput

0.249

Low

62866

F16P1
Fructose-1,6-bisphosphatase 1

1

0

High-throughput

0.249

Low

62871

ITA4
Integrin alpha-4

1

0

High-throughput

0.249

Low

62877

SAHH
Adenosylhomocysteinase

1

0

High-throughput

0.249

Low

62887

GLYM
Serine hydroxymethyltransferase, mitochondrial

1

0

High-throughput

0.249

Low

62891

SYUA
Alpha-synuclein

1

0

High-throughput

0.249

Low

62895

MATR3
Matrin-3

1

0

High-throughput

0.249

Low

62899

IDHP
Isocitrate dehydrogenase [NADP], mitochondrial

1

0

High-throughput

0.249

Low

62900

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

0

High-throughput

0.249

Low

62905

LHX2
LIM/homeobox protein Lhx2

1

0

High-throughput

0.249

Low

62907

UBP14
Ubiquitin carboxyl-terminal hydrolase 14

1

0

High-throughput

0.249

Low

62911

WDR5
WD repeat-containing protein 5

1

0

High-throughput

0.249

Low

62913

CNBP
CCHC-type zinc finger nucleic acid binding protein

1

0

High-throughput

0.249

Low

62920

VIGLN
Vigilin

1

0

High-throughput

0.249

Low

62923

SF3A3
Splicing factor 3A subunit 3

1

0

High-throughput

0.249

Low

62928

BIRC3
Baculoviral IAP repeat-containing protein 3

1

0

High-throughput

0.249

Low

62929

SNW1
SNW domain-containing protein 1

1

0

High-throughput

0.249

Low

62932

NBR1
Next to BRCA1 gene 1 protein

1

0

High-throughput

0.249

Low

62935

CUL7
Cullin-7

1

0

High-throughput

0.249

Low

62936

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

0

High-throughput

0.249

Low

62938

SF3A1
Splicing factor 3A subunit 1

1

0

High-throughput

0.249

Low

62939

EZH2
Histone-lysine N-methyltransferase EZH2

1

0

High-throughput

0.249

Low

62941

IF16
Gamma-interferon-inducible protein 16

1

0

High-throughput

0.249

Low

62943

PDCD4
Programmed cell death protein 4

1

0

High-throughput

0.249

Low

62948

LRC31
Leucine-rich repeat-containing protein 31

1

0

High-throughput

0.249

Low

62950

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

0

High-throughput

0.249

Low

62953

NAA40
N-alpha-acetyltransferase 40

1

0

High-throughput

0.249

Low

62958

CMTR1
Cap-specific mRNA

1

0

High-throughput

0.249

Low

62962

FGF11
Fibroblast growth factor 11

1

0

High-throughput

0.249

Low

62964

DCPS
m7GpppX diphosphatase

1

0

High-throughput

0.249

Low

62969

DDRGK
DDRGK domain-containing protein 1

1

0

High-throughput

0.249

Low

62976

ERP44
Endoplasmic reticulum resident protein 44

1

0

High-throughput

0.249

Low

62977

DERL1
Derlin-1

1

0

Small-scale

0.249

Low

62978

LGR4
Leucine-rich repeat-containing G-protein coupled receptor 4

1

0

High-throughput

0.249

Low

62979

KLF16
Krueppel-like factor 16

1

0

High-throughput

0.249

Low

62980

FACD2
Fanconi anemia group D2 protein

1

0

High-throughput

0.249

Low

62981

TOLIP
Toll-interacting protein

1

0

High-throughput

0.249

Low

62982

CCDC8
Coiled-coil domain-containing protein 8

1

0

High-throughput

0.249

Low

62984

PKHA4
Pleckstrin homology domain-containing family A member 4

1

0

High-throughput

0.249

Low

62987

ANLN
Anillin

1

0

High-throughput

0.249

Low

62989

FBX6
F-box only protein 6

1

0

High-throughput

0.249

Low

62990

GNL3L
Guanine nucleotide-binding protein-like 3-like protein

1

0

High-throughput

0.249

Low

62991

TE2IP
Telomeric repeat-binding factor 2-interacting protein 1

1

0

High-throughput

0.249

Low

62992

HECW2
E3 ubiquitin-protein ligase HECW2

1

0

High-throughput

0.249

Low

62993

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.249

Low

62994

MKRN1
E3 ubiquitin-protein ligase makorin-1

1

0

High-throughput

0.249

Low

62998

UBQL1
Ubiquilin-1

1

0

High-throughput

0.249

Low

63001

E41L3
Band 4.1-like protein 3

1

0

High-throughput

0.249

Low

63002

ZN330
Zinc finger protein 330

1

0

High-throughput

0.249

Low

63003

TRRAP
Transformation/transcription domain-associated protein

1

0

High-throughput

0.249

Low

46888

PNT87
Transcriptional regulator PINT87aa

1

0

Small-scale

0.232

Low

62875

VCAM1
Vascular cell adhesion protein 1

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024