Protein: UB2E1
Ubiquitin-conjugating enzyme E2 E1 (EC 2.3.2.23) ((E3-independent) E2 ubiquitin-conjugating enzyme E1) (EC 2.3.2.24) (E2 ubiquitin-conjugating enzyme E1) (UbcH6) (Ubiquitin carrier protein E1) (Ubiquitin-protein ligase E1)

Gene: UB2E1, UBE2E1
Organism: Homo sapiens
Interactions: 160
UniProt ID: P51965

Gene Ontology (top 5):
GO:0000151 - ubiquitin ligase complex
GO:0000209 - protein polyubiquitination
GO:0004842 - ubiquitin-protein transferase activity
GO:0005524 - ATP binding
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

607028

UBA1
Ubiquitin-like modifier-activating enzyme 1

9

20

Small-scale

0.969

High

808057

NEDD4
E3 ubiquitin-protein ligase NEDD4

7

20

Small-scale

0.967

High

851868

OTUB1
Ubiquitin thioesterase OTUB1

6

11

Small-scale

0.938

High

851885

RN167
E3 ubiquitin-protein ligase RNF167

5

20

Small-scale

0.928

High

851863

RNF25
E3 ubiquitin-protein ligase RNF25

4

14

High-throughput

0.912

High

734564

TRI23
E3 ubiquitin-protein ligase TRIM23

4

17

Small-scale

0.896

High

851808

TRI32
E3 ubiquitin-protein ligase TRIM32

4

20

Small-scale

0.896

High

851908

CHIP
E3 ubiquitin-protein ligase CHIP

4

14

Small-scale

0.888

High

851877

RING2
E3 ubiquitin-protein ligase RING2

3

20

Small-scale

0.873

High

175654

TRI18
E3 ubiquitin-protein ligase Midline-1

3

20

Small-scale

0.870

High

851828

RN111
E3 ubiquitin-protein ligase Arkadia

3

20

High-throughput

0.867

High

749256

BRCA1
Breast cancer type 1 susceptibility protein

3

20

Small-scale

0.865

High

851801

RNF4
E3 ubiquitin-protein ligase RNF4

3

20

Small-scale

0.857

High

851849

ZNRF1
E3 ubiquitin-protein ligase ZNRF1

2

20

High-throughput

0.849

High

851795

UB2E1
Ubiquitin-conjugating enzyme E2 E1

3

17

Small-scale

0.845

High

851871

ITCH
E3 ubiquitin-protein ligase Itchy homolog

3

20

Small-scale

0.845

High

851901

RNF14
E3 ubiquitin-protein ligase RNF14

2

20

Small-scale

0.812

High

851802

XIAP
E3 ubiquitin-protein ligase XIAP

2

20

Small-scale

0.812

High

851836

GOLI
E3 ubiquitin-protein ligase RNF130

2

20

Small-scale

0.800

High

851860

MUL1
Mitochondrial ubiquitin ligase activator of NFKB 1

2

20

Small-scale

0.800

High

851883

TRIM2
Tripartite motif-containing protein 2

2

20

Small-scale

0.800

High

851893

RNF12
E3 ubiquitin-protein ligase RLIM

2

20

Small-scale

0.800

High

851898

RN181
E3 ubiquitin-protein ligase RNF181

2

20

Small-scale

0.800

High

851914

RN114
E3 ubiquitin-protein ligase RNF114

2

20

Small-scale

0.800

High

851807

RING1
E3 ubiquitin-protein ligase RING1

2

20

Small-scale

0.793

High

851806

UBE3A
Ubiquitin-protein ligase E3A

2

20

Small-scale

0.793

High

851903

IPO11
Importin-11

2

3

Small-scale

0.793

High

851879

RNF5
E3 ubiquitin-protein ligase RNF5

2

20

Small-scale

0.785

High

226922

PRKN
E3 ubiquitin-protein ligase parkin

2

20

Small-scale

0.778

High

851875

NED4L
E3 ubiquitin-protein ligase NEDD4-like

2

20

Small-scale

0.778

High

851910

RNF11
RING finger protein 11

1

20

High-throughput

0.776

High

317660

CNOT4
CCR4-NOT transcription complex subunit 4

2

11

Small-scale

0.754

High

851850

ZNRF2
E3 ubiquitin-protein ligase ZNRF2

2

20

Small-scale

0.754

High

851904

HERC5
E3 ISG15--protein ligase HERC5

2

20

Small-scale

0.743

High

610307

CBL
E3 ubiquitin-protein ligase CBL

1

11

Small-scale

0.740

High

851912

TRAF6
TNF receptor-associated factor 6

1

20

High-throughput

0.735

High

851821

BRE1A
E3 ubiquitin-protein ligase BRE1A

1

13

Small-scale

0.724

High

851905

TRIM1
Probable E3 ubiquitin-protein ligase MID2

1

20

Small-scale

0.713

High

584910

RO52
E3 ubiquitin-protein ligase TRIM21

1

20

Small-scale

0.710

High

207548

RNF13
E3 ubiquitin-protein ligase RNF13

1

20

High-throughput

0.698

High

230127

MGRN1
E3 ubiquitin-protein ligase MGRN1

1

6

High-throughput

0.698

High

301043

RNF37
RING finger protein 37

1

5

High-throughput

0.698

High

312522

ARI2
E3 ubiquitin-protein ligase ARIH2

1

20

High-throughput

0.698

High

851809

MKRN3
Probable E3 ubiquitin-protein ligase makorin-3

1

14

High-throughput

0.698

High

851822

RNF43
E3 ubiquitin-protein ligase RNF43

1

20

High-throughput

0.698

High

851824

RFWD3
E3 ubiquitin-protein ligase RFWD3

1

20

High-throughput

0.698

High

851826

LRSM1
E3 ubiquitin-protein ligase LRSAM1

1

6

High-throughput

0.698

High

851829

ARK2C
E3 ubiquitin-protein ligase ARK2C

1

20

High-throughput

0.698

High

851838

DTX1
E3 ubiquitin-protein ligase DTX1

1

20

High-throughput

0.698

High

851839

DZIP3
E3 ubiquitin-protein ligase DZIP3

1

20

High-throughput

0.698

High

851843

RNF10
E3 ubiquitin-protein ligase RNF10

1

20

High-throughput

0.698

High

851846

RN152
E3 ubiquitin-protein ligase RNF152

1

20

High-throughput

0.698

High

851847

DTX3
Probable E3 ubiquitin-protein ligase DTX3

1

20

High-throughput

0.698

High

851852

DTX3L
E3 ubiquitin-protein ligase DTX3L

1

20

High-throughput

0.698

High

851856

ZNRF4
E3 ubiquitin-protein ligase ZNRF4

1

20

High-throughput

0.698

High

851861

RN166
E3 ubiquitin-protein ligase RNF166

1

20

High-throughput

0.698

High

851866

CHFR
E3 ubiquitin-protein ligase CHFR

1

20

High-throughput

0.698

High

851869

RMD5B
E3 ubiquitin-protein transferase RMND5B

1

6

High-throughput

0.698

High

851870

RN185
E3 ubiquitin-protein ligase RNF185

1

20

High-throughput

0.698

High

851874

BIRC8
Baculoviral IAP repeat-containing protein 8

1

20

High-throughput

0.698

High

851907

RN150
RING finger protein 150

1

20

High-throughput

0.698

High

851913

RN115
E3 ubiquitin-protein ligase RNF115

1

20

High-throughput

0.698

High

851851

COP1
E3 ubiquitin-protein ligase COP1

1

10

High-throughput

0.691

High

282582

RNF8
E3 ubiquitin-protein ligase RNF8

1

20

Small-scale

0.680

High

851831

DET1
DET1 homolog

3

3

Small-scale

0.667

High

851881

RNF26
E3 ubiquitin-protein ligase RNF26

1

20

High-throughput

0.656

High

125263

WWP2
NEDD4-like E3 ubiquitin-protein ligase WWP2

1

20

Small-scale

0.647

High

256229

BRE1B
E3 ubiquitin-protein ligase BRE1B

1

13

Small-scale

0.647

High

262163

TRIM3
Tripartite motif-containing protein 3

1

20

Small-scale

0.647

High

475504

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

20

Small-scale

0.647

High

782203

UBA7
Ubiquitin-like modifier-activating enzyme 7

1

20

Small-scale

0.647

High

851800

RBX1
E3 ubiquitin-protein ligase RBX1

1

20

Small-scale

0.647

High

851803

MDM2
E3 ubiquitin-protein ligase Mdm2

1

14

Small-scale

0.647

High

851811

TIF1B
Transcription intermediary factor 1-beta

1

20

Small-scale

0.647

High

851812

CUL3
Cullin-3

1

16

Small-scale

0.647

High

851827

NHLC1
E3 ubiquitin-protein ligase NHLRC1

1

20

Small-scale

0.647

High

851840

RN168
E3 ubiquitin-protein ligase RNF168

1

7

Small-scale

0.647

High

851848

RN169
E3 ubiquitin-protein ligase RNF169

1

20

Small-scale

0.647

High

851853

RN128
E3 ubiquitin-protein ligase RNF128

1

20

Small-scale

0.647

High

851854

UBS3B
Ubiquitin-associated and SH3 domain-containing protein B

1

6

Small-scale

0.647

High

851859

RNF34
E3 ubiquitin-protein ligase RNF34

1

20

Small-scale

0.647

High

851865

RNF31
E3 ubiquitin-protein ligase RNF31

1

20

Small-scale

0.647

High

851891

TOPRS
E3 ubiquitin-protein ligase Topors

1

6

Small-scale

0.647

High

851858

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

2

5

Small-scale

0.634

High

851796

ATX1
Ataxin-1

2

1

Small-scale

0.631

High

851857

TRIB2
Tribbles homolog 2

2

4

High-throughput

0.628

High

851876

TRIB1
Tribbles homolog 1

2

5

High-throughput

0.628

High

122257

RN103
E3 ubiquitin-protein ligase RNF103

1

20

Small-scale

0.621

High

851837

TRI50
E3 ubiquitin-protein ligase TRIM50

1

20

Small-scale

0.621

High

851864

BIRC7
Baculoviral IAP repeat-containing protein 7

1

20

Small-scale

0.621

High

851886

TRI45
E3 ubiquitin-protein ligase TRIM45

1

20

Small-scale

0.621

High

851915

TRI17
E3 ubiquitin-protein ligase TRIM17

1

20

Small-scale

0.621

High

851889

TRI39
E3 ubiquitin-protein ligase TRIM39

2

20

High-throughput

0.619

High

851799

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

17

High-throughput

0.618

High

851832

PCGF5
Polycomb group RING finger protein 5

1

20

Small-scale

0.618

High

851896

DTL
Denticleless protein homolog

1

9

Small-scale

0.618

High

304080

UBR5
E3 ubiquitin-protein ligase UBR5

1

20

High-throughput

0.590

High

851820

RN220
E3 ubiquitin-protein ligase RNF220

1

7

High-throughput

0.590

High

851899

MBD5
Methyl-CpG-binding domain protein 5

2

0

High-throughput

0.585

High

851888

RN122
RING finger protein 122

1

20

Small-scale

0.579

High

851845

UBR7
Putative E3 ubiquitin-protein ligase UBR7

2

0

Small-scale

0.577

High

851844

PAF1
RNA polymerase II-associated factor 1 homolog

1

0

Small-scale

0.561

High

851867

TRI11
E3 ubiquitin-protein ligase TRIM11

1

20

Small-scale

0.552

High

851810

M3K1
Mitogen-activated protein kinase kinase kinase 1

1

12

High-throughput

0.541

High

851833

MARH3
E3 ubiquitin-protein ligase MARCHF3

1

20

High-throughput

0.541

High

851834

CAPS2
Calcium-dependent secretion activator 2

1

6

High-throughput

0.541

High

851895

MKS1
Tectonic-like complex member MKS1

1

0

Small-scale

0.537

High

851392

NEK4
Serine/threonine-protein kinase Nek4

1

3

High-throughput

0.536

High

851797

SIK1
Serine/threonine-protein kinase SIK1

1

1

High-throughput

0.536

High

851825

CTR9
RNA polymerase-associated protein CTR9 homolog

1

2

Small-scale

0.536

High

851841

STK40
Serine/threonine-protein kinase 40

1

4

High-throughput

0.536

High

851855

LEO1
RNA polymerase-associated protein LEO1

1

2

Small-scale

0.536

High

851804

ID2
DNA-binding protein inhibitor ID-2

1

0

High-throughput

0.513

High

851862

CLUA1
Clusterin-associated protein 1

1

0

High-throughput

0.513

High

787874

EPS15
Epidermal growth factor receptor substrate 15

1

4

Small-scale

0.501

High

851805

TF65
Transcription factor p65

1

6

Small-scale

0.501

High

851815

UVSSA
UV-stimulated scaffold protein A

1

4

Small-scale

0.501

High

851823

JADE1
Protein Jade-1

1

1

Small-scale

0.501

High

851830

ASXL2
Putative Polycomb group protein ASXL2

1

2

Small-scale

0.501

High

851835

TRI69
E3 ubiquitin-protein ligase TRIM69

1

20

Small-scale

0.501

High

851878

BARD1
BRCA1-associated RING domain protein 1

1

11

Small-scale

0.501

High

851887

MARH7
E3 ubiquitin-protein ligase MARCHF7

1

17

Small-scale

0.501

High

851890

DPOLM
DNA-directed DNA/RNA polymerase mu

1

7

Small-scale

0.501

High

851894

MARH5
E3 ubiquitin-protein ligase MARCHF5

1

6

Small-scale

0.501

High

851897

MARH2
E3 ubiquitin-protein ligase MARCHF2

1

20

Small-scale

0.501

High

851900

HDAC6
Histone deacetylase 6

1

3

Small-scale

0.501

High

851902

DPOLL
DNA polymerase lambda

1

7

Small-scale

0.501

High

851906

FBX2
F-box only protein 2

1

3

Small-scale

0.501

High

851909

TRI33
E3 ubiquitin-protein ligase TRIM33

1

20

Small-scale

0.501

High

851911

FBX7
F-box only protein 7

1

3

High-throughput

0.501

High

135013

TRI38
E3 ubiquitin-protein ligase TRIM38

1

20

Small-scale

0.481

High

301691

TRI37
E3 ubiquitin-protein ligase TRIM37

1

20

Small-scale

0.481

High

536763

TRI27
Zinc finger protein RFP

1

20

Small-scale

0.481

High

851798

UFM1
Ubiquitin-fold modifier 1

1

5

High-throughput

0.481

High

851817

ZNG1E
Zinc-regulated GTPase metalloprotein activator 1E

1

1

High-throughput

0.481

High

851882

TRIM7
E3 ubiquitin-protein ligase TRIM7

1

20

Small-scale

0.481

High

244147

BRD4
Bromodomain-containing protein 4

1

7

High-throughput

0.479

High

260806

H2AY
Core histone macro-H2A.1

1

6

Small-scale

0.479

High

469975

H2AZ
Histone H2A.Z

1

6

Small-scale

0.479

High

532442

TCTP
Translationally-controlled tumor protein

1

4

High-throughput

0.479

High

683218

1433B
14-3-3 protein beta/alpha

1

1

Small-scale

0.479

High

823730

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

2

High-throughput

0.479

High

851814

NF2L2
Nuclear factor erythroid 2-related factor 2

1

3

Small-scale

0.479

High

851872

SNX27
Sorting nexin-27

1

2

High-throughput

0.479

High

851880

DDA1
DET1- and DDB1-associated protein 1

1

2

Small-scale

0.479

High

426607

H10
Histone H1.0

1

0

Small-scale

0.458

High

341425

FA12
Coagulation factor XII

1

5

Small-scale

0.457

High

851813

TRI29
Tripartite motif-containing protein 29

1

20

Small-scale

0.457

High

298298

UFL1
E3 UFM1-protein ligase 1

1

5

High-throughput

0.457

High

851816

ZNG1C
Zinc-regulated GTPase metalloprotein activator 1C

1

1

High-throughput

0.457

High

851842

ARRD1
Arrestin domain-containing protein 1

1

7

High-throughput

0.457

High

851892

ASF1B
Histone chaperone ASF1B

1

1

High-throughput

0.457

High

851818

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

6

High-throughput

0.445

High

851819

CE170
Centrosomal protein of 170 kDa

1

3

High-throughput

0.445

High

851884

PKHA4
Pleckstrin homology domain-containing family A member 4

1

8

High-throughput

0.437

High

46890

PNT87
Transcriptional regulator PINT87aa

1

0

Small-scale

0.426

High

450642

PAEP
Glycodelin

1

0

High-throughput

0.282

High

851873

ROBO3
Roundabout homolog 3

1

0

High-throughput

0.279

Low

851916

NDUB9
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9

1

0

High-throughput

0.238

Low


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Last updated: 15 Jul 2024