Protein: SF3B6
Splicing factor 3B subunit 6 (Pre-mRNA branch site protein p14) (SF3b 14 kDa subunit) (SF3B14a) (Spliceosome-associated protein, 14-kDa) (Splicing factor 3b, subunit 6, 14kDa)

Gene: SF3B6
Organism: Homo sapiens
Interactions: 162
UniProt ID: Q9Y3B4

Gene Ontology (top 5):
GO:0000398 - mRNA splicing, via spliceosome
GO:0001825 - blastocyst formation
GO:0003723 - RNA binding
GO:0003729 - mRNA binding
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

268911

SF3B1
Splicing factor 3B subunit 1

9

4

Small-scale

0.973

High

453942

RU2A
U2 small nuclear ribonucleoprotein A'

3

8

High-throughput

0.861

High

1073194

SF3B3
Splicing factor 3B subunit 3

3

6

Small-scale

0.853

High

1073752

SF3A2
Splicing factor 3A subunit 2

3

9

Small-scale

0.847

High

441397

RU2B
U2 small nuclear ribonucleoprotein B''

2

19

High-throughput

0.811

High

1018884

SF3A3
Splicing factor 3A subunit 3

2

3

High-throughput

0.789

High

1034441

SF3B2
Splicing factor 3B subunit 2

2

4

High-throughput

0.789

High

1054696

RBM39
RNA-binding protein 39

2

18

High-throughput

0.789

High

1073656

SF3B4
Splicing factor 3B subunit 4

2

20

High-throughput

0.789

High

212191

HTSF1
17S U2 SnRNP complex component HTATSF1

1

20

High-throughput

0.691

High

213913

DYRK3
Dual specificity tyrosine-phosphorylation-regulated kinase 3

1

17

High-throughput

0.691

High

446848

SNRPA
U1 small nuclear ribonucleoprotein A

1

19

High-throughput

0.691

High

1077232

U2AFM
U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 2

1

6

High-throughput

0.691

High

1252788

ZCRB1
Zinc finger CCHC-type and RNA-binding motif-containing protein 1

1

18

High-throughput

0.691

High

1297434

RNPC3
RNA-binding region-containing protein 3

1

16

High-throughput

0.691

High

911774

RUXE
Small nuclear ribonucleoprotein E

3

4

High-throughput

0.675

High

1290972

CCD97
Coiled-coil domain-containing protein 97

3

2

High-throughput

0.675

High

1186280

PHF5A
PHD finger-like domain-containing protein 5A

3

2

Small-scale

0.670

High

1314751

SF3B5
Splicing factor 3B subunit 5

3

3

Small-scale

0.660

High

641990

U2AF2
Splicing factor U2AF 65 kDa subunit

1

20

Small-scale

0.647

High

348313

MYC
Myc proto-oncogene protein

3

15

High-throughput

0.640

High

1348145

PP4R2
Serine/threonine-protein phosphatase 4 regulatory subunit 2

2

1

High-throughput

0.635

High

325950

LATS1
Serine/threonine-protein kinase LATS1

1

3

High-throughput

0.618

High

375132

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

10

High-throughput

0.618

High

1018765

CHD3
Chromodomain-helicase-DNA-binding protein 3

1

12

High-throughput

0.618

High

1050306

IKKE
Inhibitor of nuclear factor kappa-B kinase subunit epsilon

1

5

High-throughput

0.618

High

1059959

CHD4
Chromodomain-helicase-DNA-binding protein 4

1

12

High-throughput

0.618

High

1116647

LARP7
La-related protein 7

1

19

High-throughput

0.618

High

1356421

TNIK
TRAF2 and NCK-interacting protein kinase

1

8

High-throughput

0.618

High

278894

DNJC8
DnaJ homolog subfamily C member 8

2

1

High-throughput

0.611

High

912134

RUXG
Small nuclear ribonucleoprotein G

2

20

High-throughput

0.611

High

1303882

CDC5L
Cell division cycle 5-like protein

2

7

High-throughput

0.611

High

780364

CCNF
Cyclin-F

2

7

High-throughput

0.601

High

1348010

MCM9
DNA helicase MCM9

2

5

Small-scale

0.584

High

1075780

SF01
Splicing factor 1

1

7

High-throughput

0.575

High

370777

ESR1
Estrogen receptor

2

20

High-throughput

0.571

High

1161730

TTC33
Tetratricopeptide repeat protein 33

2

4

High-throughput

0.558

High

1018204

M4K2
Mitogen-activated protein kinase kinase kinase kinase 2

1

9

High-throughput

0.553

High

581898

VCAM1
Vascular cell adhesion protein 1

2

6

High-throughput

0.549

High

448862

RU1C
U1 small nuclear ribonucleoprotein C

1

7

High-throughput

0.536

High

452926

DLDH
Dihydrolipoyl dehydrogenase, mitochondrial

1

1

High-throughput

0.536

High

539198

RSMB
Small nuclear ribonucleoprotein-associated proteins B and B'

1

9

High-throughput

0.536

High

595484

LMNB1
Lamin-B1

1

3

High-throughput

0.536

High

601415

VDAC1
Voltage-dependent anion-selective channel protein 1

1

3

High-throughput

0.536

High

739360

ODO2
Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial

1

1

High-throughput

0.536

High

828951

SRP09
Signal recognition particle 9 kDa protein

1

1

High-throughput

0.536

High

891016

PP4C
Serine/threonine-protein phosphatase 4 catalytic subunit

1

7

High-throughput

0.536

High

912003

RUXF
Small nuclear ribonucleoprotein F

1

14

High-throughput

0.536

High

912403

SMD1
Small nuclear ribonucleoprotein Sm D1

1

16

High-throughput

0.536

High

912597

SMD2
Small nuclear ribonucleoprotein Sm D2

1

5

High-throughput

0.536

High

1039960

SNW1
SNW domain-containing protein 1

1

5

High-throughput

0.536

High

1074275

SF3A1
Splicing factor 3A subunit 1

1

8

High-throughput

0.536

High

1149938

KDM4D
Lysine-specific demethylase 4D

1

1

High-throughput

0.536

High

1153067

P4R3A
Serine/threonine-protein phosphatase 4 regulatory subunit 3A

1

1

High-throughput

0.536

High

1183265

COX15
Heme A synthase COX15

1

2

High-throughput

0.536

High

1201790

ZCH18
Zinc finger CCCH domain-containing protein 18

1

20

High-throughput

0.536

High

1202204

CAND1
Cullin-associated NEDD8-dissociated protein 1

1

10

High-throughput

0.536

High

1204713

DDX42
ATP-dependent RNA helicase DDX42

1

11

High-throughput

0.536

High

1220012

SUGP1
SURP and G-patch domain-containing protein 1

1

5

High-throughput

0.536

High

1262142

PCNP
PEST proteolytic signal-containing nuclear protein

1

1

High-throughput

0.536

High

1305861

HCD2
3-hydroxyacyl-CoA dehydrogenase type-2

1

3

High-throughput

0.536

High

1314875

NADAP
Kanadaptin

1

10

High-throughput

0.536

High

1326495

SKI8
Superkiller complex protein 8

1

17

High-throughput

0.536

High

1334297

AGO3
Protein argonaute-3

1

9

High-throughput

0.536

High

602036

ERBB3
Receptor tyrosine-protein kinase erbB-3

2

4

High-throughput

0.526

High

1357455

RHG26
Rho GTPase-activating protein 26

2

3

High-throughput

0.521

High

331120

PAK4
Serine/threonine-protein kinase PAK 4

1

7

High-throughput

0.514

High

1130753

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

4

High-throughput

0.514

High

579761

XRCC1
DNA repair protein XRCC1

1

0

High-throughput

0.513

High

1152719

SNR48
U11/U12 small nuclear ribonucleoprotein 48 kDa protein

1

0

High-throughput

0.513

High

1313594

SNR25
U11/U12 small nuclear ribonucleoprotein 25 kDa protein

1

0

High-throughput

0.513

High

1314702

SCNM1
Sodium channel modifier 1

1

0

High-throughput

0.513

High

1377602

CTDP1
RNA polymerase II subunit A C-terminal domain phosphatase

1

0

High-throughput

0.513

High

128673

DNM1L
Dynamin-1-like protein

1

1

High-throughput

0.489

High

363362

FINC
Fibronectin

1

7

High-throughput

0.489

High

532255

P4HA1
Prolyl 4-hydroxylase subunit alpha-1

1

2

High-throughput

0.489

High

1238037

GPT11
G patch domain-containing protein 11

1

1

High-throughput

0.489

High

1333236

IFT22
Intraflagellar transport protein 22 homolog

1

2

High-throughput

0.489

High

736825

RL4
Large ribosomal subunit protein uL4

1

4

High-throughput

0.481

High

123114

MEN1
Menin

1

4

High-throughput

0.479

High

233703

NUPR1
Nuclear protein 1

1

6

High-throughput

0.479

High

268345

EED
Polycomb protein EED

1

20

High-throughput

0.479

High

278979

SPF30
Survival of motor neuron-related-splicing factor 30

1

5

High-throughput

0.479

High

298913

UFL1
E3 UFM1-protein ligase 1

1

5

High-throughput

0.479

High

303554

HEXI1
Protein HEXIM1

1

7

High-throughput

0.479

High

380050

MYCN
N-myc proto-oncogene protein

1

15

High-throughput

0.479

High

554122

RFA2
Replication protein A 32 kDa subunit

1

7

High-throughput

0.479

High

570212

CEBPB
CCAAT/enhancer-binding protein beta

1

9

High-throughput

0.479

High

587759

NFKB1
Nuclear factor NF-kappa-B p105 subunit

1

3

High-throughput

0.479

High

617717

CRCM
Colorectal mutant cancer protein

1

1

High-throughput

0.479

High

652681

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

5

High-throughput

0.479

High

719253

PHB1
Prohibitin 1

1

4

High-throughput

0.479

High

721850

RFA3
Replication protein A 14 kDa subunit

1

5

High-throughput

0.479

High

824569

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

8

High-throughput

0.479

High

877969

FOXA1
Hepatocyte nuclear factor 3-alpha

1

2

High-throughput

0.479

High

903629

WDR5
WD repeat-containing protein 5

1

16

High-throughput

0.479

High

909372

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

6

High-throughput

0.479

High

959785

VIGLN
Vigilin

1

20

High-throughput

0.479

High

962479

HNRPU
Heterogeneous nuclear ribonucleoprotein U

1

12

High-throughput

0.479

High

970087

KIF23
Kinesin-like protein KIF23

1

15

High-throughput

0.479

High

999241

EP300
Histone acetyltransferase p300

1

15

High-throughput

0.479

High

1022244

NFX1
Transcriptional repressor NF-X1

1

4

High-throughput

0.479

High

1043645

CUL4B
Cullin-4B

1

20

High-throughput

0.479

High

1049195

TRI14
Tripartite motif-containing protein 14

1

6

High-throughput

0.479

High

1063702

SUZ12
Polycomb protein SUZ12

1

4

High-throughput

0.479

High

1064878

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

7

High-throughput

0.479

High

1066921

KIF14
Kinesin-like protein KIF14

1

10

High-throughput

0.479

High

1119526

PAN2
PAN2-PAN3 deadenylation complex catalytic subunit PAN2

1

6

High-throughput

0.479

High

1148888

VIR
Protein virilizer homolog

1

2

High-throughput

0.479

High

1153982

IFIX
Pyrin and HIN domain-containing protein 1

1

6

High-throughput

0.479

High

1159353

PRP8
Pre-mRNA-processing-splicing factor 8

1

5

High-throughput

0.479

High

1174339

MOB3C
MOB kinase activator 3C

1

1

High-throughput

0.479

High

1189084

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

7

High-throughput

0.479

High

1251090

SNIP1
Smad nuclear-interacting protein 1

1

7

High-throughput

0.479

High

1256499

DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

4

High-throughput

0.479

High

1269999

ESR2
Estrogen receptor beta

1

20

High-throughput

0.479

High

1285597

PINX1
PIN2/TERF1-interacting telomerase inhibitor 1

1

3

High-throughput

0.479

High

1286504

DCPS
m7GpppX diphosphatase

1

2

High-throughput

0.479

High

1288405

SNR40
U5 small nuclear ribonucleoprotein 40 kDa protein

1

15

High-throughput

0.479

High

1301013

CIC
Protein capicua homolog

1

16

High-throughput

0.479

High

1315918

FACD2
Fanconi anemia group D2 protein

1

7

High-throughput

0.479

High

1319152

UBE2O
(E3-independent) E2 ubiquitin-conjugating enzyme

1

1

High-throughput

0.479

High

1327164

SPRTN
DNA-dependent metalloprotease SPRTN

1

1

High-throughput

0.479

High

1349049

WWOX
WW domain-containing oxidoreductase

1

4

High-throughput

0.479

High

1354956

ZRAN1
Ubiquitin thioesterase ZRANB1

1

10

High-throughput

0.479

High

1377500

AAR2
Protein AAR2 homolog

1

2

High-throughput

0.479

High

1377601

AAKB1
5'-AMP-activated protein kinase subunit beta-1

1

1

High-throughput

0.479

High

1204244

ZFAN4
AN1-type zinc finger protein 4

1

10

High-throughput

0.470

High

128768

RTCA
RNA 3'-terminal phosphate cyclase

1

0

High-throughput

0.458

High

772215

VHL
von Hippel-Lindau disease tumor suppressor

1

0

High-throughput

0.458

High

868377

ATX3
Ataxin-3

1

0

High-throughput

0.458

High

899089

PSME3
Proteasome activator complex subunit 3

1

0

Small-scale

0.458

High

396097

A4
Amyloid-beta precursor protein

1

5

High-throughput

0.457

High

68470

RUXGL
Putative small nuclear ribonucleoprotein G-like protein 15

1

20

High-throughput

0.445

High

195581

DHX15
ATP-dependent RNA helicase DHX15

1

11

High-throughput

0.445

High

402662

JUN
Transcription factor Jun

1

10

High-throughput

0.445

High

497860

TAU
Microtubule-associated protein tau

1

11

High-throughput

0.445

High

1032704

CTBP1
C-terminal-binding protein 1

1

4

High-throughput

0.445

High

1318906

ZDHC5
Palmitoyltransferase ZDHHC5

1

2

High-throughput

0.445

High

1356720

AGO1
Protein argonaute-1

1

9

High-throughput

0.445

High

530772

ITA4
Integrin alpha-4

1

4

High-throughput

0.437

High

981937

RON
Macrophage-stimulating protein receptor

1

5

High-throughput

0.437

High

992525

SOS2
Son of sevenless homolog 2

1

2

High-throughput

0.437

High

1061703

CUL7
Cullin-7

1

9

High-throughput

0.437

High

1146990

A16L1
Autophagy-related protein 16-1

1

14

High-throughput

0.437

High

1172382

TRI67
Tripartite motif-containing protein 67

1

20

High-throughput

0.437

High

1235281

NGEF
Ephexin-1

1

13

High-throughput

0.437

High

1252256

TIP
T-cell immunomodulatory protein

1

3

High-throughput

0.437

High

1261455

NUDC2
NudC domain-containing protein 2

1

3

High-throughput

0.437

High

1286762

CHM4C
Charged multivesicular body protein 4c

1

9

High-throughput

0.437

High

1331696

PKHA4
Pleckstrin homology domain-containing family A member 4

1

17

High-throughput

0.437

High

1343400

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

1

5

High-throughput

0.437

High

1350010

RHG23
Rho GTPase-activating protein 23

1

6

High-throughput

0.437

High

1377603

PHLA3
Pleckstrin homology-like domain family A member 3

1

1

High-throughput

0.437

High

46897

PNT87
Transcriptional regulator PINT87aa

1

0

Small-scale

0.426

High

831834

CEBPA
CCAAT/enhancer-binding protein alpha

1

9

High-throughput

0.408

High

968671

TAGL
Transgelin

1

2

High-throughput

0.407

High

353160

IGJ
Immunoglobulin J chain

1

0

High-throughput

0.279

Low

847735

BAP31
B-cell receptor-associated protein 31

1

0

High-throughput

0.269

Low

894915

SPCS3
Signal peptidase complex subunit 3

1

0

High-throughput

0.249

Low

1101390

CL16A
Protein CLEC16A

1

0

High-throughput

0.249

Low

1285719

OTUL
Ubiquitin thioesterase otulin

1

0

Small-scale

0.249

Low


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Last updated: 15 Jul 2024