Protein: ICLN
Methylosome subunit pICln (Chloride channel, nucleotide sensitive 1A) (Chloride conductance regulatory protein ICln) (I(Cln)) (Chloride ion current inducer protein) (ClCI) (Reticulocyte pICln)

Gene: ICLN, CLNS1A
Organism: Homo sapiens
Interactions: 155
UniProt ID: P54105

Gene Ontology (top 5):
GO:0000387 - spliceosomal snRNP assembly
GO:0003723 - RNA binding
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005681 - spliceosomal complex

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

926165

SMD3
Small nuclear ribonucleoprotein Sm D3

10

11

Small-scale

0.980

High

926163

SMD1
Small nuclear ribonucleoprotein Sm D1

8

10

Small-scale

0.979

High

926164

SMD2
Small nuclear ribonucleoprotein Sm D2

8

2

Small-scale

0.976

High

926162

LSM6
U6 snRNA-associated Sm-like protein LSm6

8

8

High-throughput

0.974

High

574186

RSMB
Small nuclear ribonucleoprotein-associated proteins B and B'

7

3

Small-scale

0.968

High

926160

RUXG
Small nuclear ribonucleoprotein G

6

11

Small-scale

0.958

High

926249

LSM2
U6 snRNA-associated Sm-like protein LSm2

6

11

High-throughput

0.953

High

926159

RUXF
Small nuclear ribonucleoprotein F

5

8

Small-scale

0.942

High

926158

RUXE
Small nuclear ribonucleoprotein E

5

2

Small-scale

0.939

High

926161

LSM3
U6 snRNA-associated Sm-like protein LSm3

5

6

High-throughput

0.935

High

926167

RSMN
Small nuclear ribonucleoprotein-associated protein N

2

3

High-throughput

0.811

High

926252

LSM4
U6 snRNA-associated Sm-like protein LSm4

2

10

High-throughput

0.811

High

162515

ANM5
Protein arginine N-methyltransferase 5

9

1

Small-scale

0.759

High

926214

LSM10
U7 snRNA-associated Sm-like protein LSm10

1

11

Small-scale

0.724

High

926235

GAR1
H/ACA ribonucleoprotein complex subunit 1

5

0

High-throughput

0.691

High

926222

MEP50
Methylosome protein WDR77

5

0

Small-scale

0.689

High

217410

E41L2
Band 4.1-like protein 2

3

6

High-throughput

0.675

High

320548

FARP2
FERM, ARHGEF and pleckstrin domain-containing protein 2

3

6

High-throughput

0.675

High

926248

E41L3
Band 4.1-like protein 3

3

6

High-throughput

0.675

High

211292

RFOX2
RNA binding protein fox-1 homolog 2

3

2

High-throughput

0.667

High

586595

RS2
Small ribosomal subunit protein uS5

3

0

High-throughput

0.638

High

926223

RIOK1
Serine/threonine-protein kinase RIO1

3

0

High-throughput

0.638

High

538914

EPB41
Protein 4.1

2

7

High-throughput

0.631

High

926224

E41L1
Band 4.1-like protein 1

2

6

High-throughput

0.628

High

178003

LSM1
U6 snRNA-associated Sm-like protein LSm1

1

8

High-throughput

0.618

High

926169

LSM11
U7 snRNA-associated Sm-like protein LSm11

2

0

Small-scale

0.612

High

926193

FRMD7
FERM domain-containing protein 7

2

6

High-throughput

0.606

High

926154

RL15
Large ribosomal subunit protein eL15

2

0

High-throughput

0.602

High

926176

CIRBP
Cold-inducible RNA-binding protein

2

0

High-throughput

0.602

High

926231

COPRS
Coordinator of PRMT5 and differentiation stimulator

2

0

High-throughput

0.602

High

71563

RUXGL
Putative small nuclear ribonucleoprotein G-like protein 15

1

11

High-throughput

0.575

High

926198

NFE4
Transcription factor NF-E4

2

0

Small-scale

0.569

High

411642

NTRK1
High affinity nerve growth factor receptor

2

0

High-throughput

0.559

High

249732

DOK2
Docking protein 2

2

0

High-throughput

0.547

High

631139

RAB5A
Ras-related protein Rab-5A

2

0

High-throughput

0.547

High

702329

ELK4
ETS domain-containing protein Elk-4

2

0

High-throughput

0.547

High

470425

ITA2B
Integrin alpha-IIb

1

0

Small-scale

0.537

High

729198

HNRH1
Heterogeneous nuclear ribonucleoprotein H

1

1

High-throughput

0.536

High

908903

NEK4
Serine/threonine-protein kinase Nek4

1

1

High-throughput

0.536

High

926151

HNRH2
Heterogeneous nuclear ribonucleoprotein H2

1

1

High-throughput

0.536

High

926180

NUMA1
Nuclear mitotic apparatus protein 1

1

1

High-throughput

0.536

High

926181

SMN
Survival motor neuron protein

1

1

High-throughput

0.536

High

926207

DP13B
DCC-interacting protein 13-beta

1

1

High-throughput

0.536

High

926208

GEMI5
Gem-associated protein 5

1

2

High-throughput

0.536

High

926210

DDX1
ATP-dependent RNA helicase DDX1

1

1

High-throughput

0.536

High

926221

VRK1
Serine/threonine-protein kinase VRK1

1

1

High-throughput

0.536

High

926226

AGO3
Protein argonaute-3

1

1

High-throughput

0.536

High

926230

WDR6
tRNA

1

2

High-throughput

0.536

High

926234

RFOX1
RNA binding protein fox-1 homolog 1

1

2

High-throughput

0.536

High

926239

DDX20
Probable ATP-dependent RNA helicase DDX20

1

3

High-throughput

0.536

High

926251

MTCL1
Microtubule cross-linking factor 1

1

1

High-throughput

0.536

High

926168

CSK21
Casein kinase II subunit alpha

1

0

High-throughput

0.527

High

136065

PLK4
Serine/threonine-protein kinase PLK4

1

0

High-throughput

0.513

High

250517

HNRPQ
Heterogeneous nuclear ribonucleoprotein Q

1

0

High-throughput

0.513

High

278837

PEX14
Peroxisomal membrane protein PEX14

1

0

High-throughput

0.513

High

344901

WIZ
Protein Wiz

1

0

High-throughput

0.513

High

389181

FINC
Fibronectin

1

0

High-throughput

0.513

High

732494

ARRB2
Beta-arrestin-2

1

0

High-throughput

0.513

High

926152

GEMI4
Gem-associated protein 4

1

0

High-throughput

0.513

High

926174

G3BP1
Ras GTPase-activating protein-binding protein 1

1

0

High-throughput

0.513

High

926183

TSR1
Pre-rRNA-processing protein TSR1 homolog

1

0

High-throughput

0.513

High

926196

CSN6
COP9 signalosome complex subunit 6

1

0

High-throughput

0.513

High

926197

KDM3B
Lysine-specific demethylase 3B

1

0

High-throughput

0.513

High

926199

THOC4
THO complex subunit 4

1

0

High-throughput

0.513

High

926204

LRC47
Leucine-rich repeat-containing protein 47

1

0

High-throughput

0.513

High

926205

EIF1A
Probable RNA-binding protein EIF1AD

1

0

High-throughput

0.513

High

926206

FA98A
Protein FAM98A

1

0

High-throughput

0.513

High

926213

FGF11
Fibroblast growth factor 11

1

0

High-throughput

0.513

High

926242

NOB1
RNA-binding protein NOB1

1

0

High-throughput

0.513

High

926244

WDR3
WD repeat-containing protein 3

1

0

High-throughput

0.513

High

926246

RTRAF
RNA transcription, translation and transport factor protein

1

0

High-throughput

0.513

High

926247

CDYL
Chromodomain Y-like protein

1

0

High-throughput

0.513

High

926157

1433E
14-3-3 protein epsilon

1

0

Small-scale

0.493

High

507718

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

0

High-throughput

0.480

High

315326

RECQ4
ATP-dependent DNA helicase Q4

1

1

High-throughput

0.479

High

543109

UBL4A
Ubiquitin-like protein 4A

1

1

High-throughput

0.479

High

683979

PTN3
Tyrosine-protein phosphatase non-receptor type 3

1

6

High-throughput

0.479

High

807326

IF4A3
Eukaryotic initiation factor 4A-III

1

1

High-throughput

0.479

High

926188

RC3H1
Roquin-1

1

1

High-throughput

0.479

High

926189

RN123
E3 ubiquitin-protein ligase RNF123

1

1

High-throughput

0.479

High

926192

TRI67
Tripartite motif-containing protein 67

1

1

High-throughput

0.479

High

926202

VRK3
Serine/threonine-protein kinase VRK3

1

1

High-throughput

0.479

High

926220

ANM1
Protein arginine N-methyltransferase 1

1

1

High-throughput

0.479

High

926227

RC3H2
Roquin-2

1

2

High-throughput

0.479

High

194071

R113A
E3 ubiquitin-protein ligase RNF113A

1

0

High-throughput

0.458

High

212938

HS12A
Heat shock 70 kDa protein 12A

1

0

High-throughput

0.458

High

241187

PRKN
E3 ubiquitin-protein ligase parkin

1

0

High-throughput

0.458

High

257398

PAGE4
P antigen family member 4

1

0

High-throughput

0.458

High

259676

BRD4
Bromodomain-containing protein 4

1

0

High-throughput

0.458

High

319562

UFL1
E3 UFM1-protein ligase 1

1

0

High-throughput

0.458

High

349015

LATS1
Serine/threonine-protein kinase LATS1

1

0

High-throughput

0.458

High

349891

SNAI1
Zinc finger protein SNAI1

1

0

High-throughput

0.458

High

376770

TGFB1
Transforming growth factor beta-1 proprotein [Cleaved into: Latency-associated peptide

1

0

High-throughput

0.458

High

395748

ESR1
Estrogen receptor

1

0

High-throughput

0.458

High

534825

BIP
Endoplasmic reticulum chaperone BiP

1

0

High-throughput

0.458

High

540375

LAMP1
Lysosome-associated membrane glycoprotein 1

1

0

High-throughput

0.458

High

606492

CEBPB
CCAAT/enhancer-binding protein beta

1

0

High-throughput

0.458

High

659005

PTPRG
Receptor-type tyrosine-protein phosphatase gamma

1

0

High-throughput

0.458

High

674975

TNR6
Tumor necrosis factor receptor superfamily member 6

1

0

High-throughput

0.458

High

697411

DCK
Deoxycytidine kinase

1

0

Small-scale

0.458

High

766158

NOS2
Nitric oxide synthase, inducible

1

0

High-throughput

0.458

High

897179

CDK7
Cyclin-dependent kinase 7

1

0

High-throughput

0.458

High

926153

UBC12
NEDD8-conjugating enzyme Ubc12

1

0

High-throughput

0.458

High

926155

MGN
Protein mago nashi homolog

1

0

High-throughput

0.458

High

926156

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

0

High-throughput

0.458

High

926170

TF65
Transcription factor p65

1

0

High-throughput

0.458

High

926171

EP300
Histone acetyltransferase p300

1

0

High-throughput

0.458

High

926172

TP4A2
Protein tyrosine phosphatase type IVA 2

1

0

High-throughput

0.458

High

926173

CACO2
Calcium-binding and coiled-coil domain-containing protein 2

1

0

High-throughput

0.458

High

926175

CUL3
Cullin-3

1

0

High-throughput

0.458

High

926177

TRI14
Tripartite motif-containing protein 14

1

0

High-throughput

0.458

High

926179

GRM2
Metabotropic glutamate receptor 2

1

0

High-throughput

0.458

High

926182

DUS5
Dual specificity protein phosphatase 5

1

0

High-throughput

0.458

High

926184

LARP7
La-related protein 7

1

0

High-throughput

0.458

High

926185

PAN2
PAN2-PAN3 deadenylation complex catalytic subunit PAN2

1

0

High-throughput

0.458

High

926190

VIR
Protein virilizer homolog

1

0

High-throughput

0.458

High

926195

MEPCE
7SK snRNA methylphosphate capping enzyme

1

0

High-throughput

0.458

High

926209

NUDC2
NudC domain-containing protein 2

1

0

High-throughput

0.458

High

926211

TOPB1
DNA topoisomerase 2-binding protein 1

1

0

High-throughput

0.458

High

926212

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

0

High-throughput

0.458

High

926215

CDCA5
Sororin

1

0

High-throughput

0.458

High

926217

ALKB3
Alpha-ketoglutarate-dependent dioxygenase alkB homolog 3

1

0

Small-scale

0.458

High

926218

CIC
Protein capicua homolog

1

0

High-throughput

0.458

High

926219

CRBN
Protein cereblon

1

0

Small-scale

0.458

High

926228

NMRL1
NmrA-like family domain-containing protein 1

1

0

High-throughput

0.458

High

926229

SMUF1
E3 ubiquitin-protein ligase SMURF1

1

0

High-throughput

0.458

High

926232

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

1

0

High-throughput

0.458

High

926233

FBX6
F-box only protein 6

1

0

High-throughput

0.458

High

926237

KS6B2
Ribosomal protein S6 kinase beta-2

1

0

High-throughput

0.458

High

926238

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.458

High

926243

FZR1
Fizzy-related protein homolog

1

0

High-throughput

0.458

High

926250

WIPI4
WD repeat domain phosphoinositide-interacting protein 4

1

0

Small-scale

0.458

High

926178

IF4A2
Eukaryotic initiation factor 4A-II

1

1

High-throughput

0.457

High

46667

A0A2R8Y783
Erythrocyte membrane protein band 4.1

1

3

High-throughput

0.445

High

529410

TAU
Microtubule-associated protein tau

1

1

High-throughput

0.445

High

926191

PKHA7
Pleckstrin homology domain-containing family A member 7

1

1

High-throughput

0.445

High

926203

ULK2
Serine/threonine-protein kinase ULK2

1

1

High-throughput

0.445

High

926241

AGO2
Protein argonaute-2

1

1

High-throughput

0.445

High

294675

PR15A
Protein phosphatase 1 regulatory subunit 15A

1

0

High-throughput

0.426

High

926166

RS30
Ubiquitin-like FUBI-ribosomal protein eS30 fusion protein

1

0

High-throughput

0.426

High

926187

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

0

High-throughput

0.426

High

926194

NEK10
Serine/threonine-protein kinase Nek10

1

1

High-throughput

0.407

High

350285

DDAH2
Putative hydrolase DDAH2

3

0

High-throughput

0.347

High

615173

PACA
Pituitary adenylate cyclase-activating polypeptide

3

0

High-throughput

0.347

High

926186

FBLN7
Fibulin-7

2

0

High-throughput

0.318

High

926225

RDD1
Required for drug-induced death protein 1

1

0

High-throughput

0.279

Low

926236

F135A
Protein FAM135A

1

0

High-throughput

0.279

Low

926240

ZNHI2
Zinc finger HIT domain-containing protein 2

1

0

High-throughput

0.279

Low

926245

AGAP1
Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1

1

0

High-throughput

0.279

Low

276092

NIPS2
Protein NipSnap homolog 2

1

0

Small-scale

0.249

Low

293418

CD123
Translation initiation factor eIF2 assembly protein

1

0

High-throughput

0.249

Low

926200

TMM17
Transmembrane protein 17

1

0

High-throughput

0.249

Low

926201

GOLI
E3 ubiquitin-protein ligase RNF130

1

0

High-throughput

0.249

Low

87388

OSCRI
SCRIB overlapping open reading frame protein

1

0

High-throughput

0.232

Low

926216

MF14A
Hippocampus abundant transcript 1 protein

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025