Protein: SIN3
Paired amphipathic helix protein sin-3 (Histone deacetylase complex subunit sin-3) (Transcriptional corepressor sin-3)

Gene: SIN3, sin-3
Organism: Caenorhabditis elegans
Interactions: 139
UniProt ID: A5JYW9

Gene Ontology (top 5):
GO:0000118 - histone deacetylase complex
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000785 - chromatin
GO:0001708 - cell fate specification
GO:0003714 - transcription corepressor activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

60829

FOXO
Forkhead box protein O

1

2

High-throughput

0.508

High

60832

EYA1
Eyes absent homolog 1

1

1

High-throughput

0.508

High

60835

MAB3
Protein male abnormal 3

1

1

High-throughput

0.508

High

60852

NHR23
Nuclear hormone receptor family member nhr-23

1

4

High-throughput

0.508

High

60881

ZTF2
Zinc finger protein ztf-2

1

0

High-throughput

0.486

High

60798

SIN3
Paired amphipathic helix protein sin-3

1

3

High-throughput

0.479

High

60807

LE418
Protein let-418

1

12

High-throughput

0.479

High

60808

HCF1
Host cell factor homolog hcf-1

1

3

High-throughput

0.479

High

60810

G5ECH0
Histone deacetylase

1

20

High-throughput

0.479

High

60813

DCP66
Transcription factor dcp-66

1

5

High-throughput

0.479

High

60817

SWSN4
SWI/SNF chromatin remodeling complex core catalytic subunit swsn-4

1

17

High-throughput

0.479

High

60834

HDA1
Histone deacetylase 1

1

20

High-throughput

0.479

High

60850

TLK1
Serine/threonine-protein kinase tousled-like 1

1

1

High-throughput

0.479

High

60877

Q18241
Helicase ARIP4

1

5

High-throughput

0.479

High

60878

Q18605
PHD-type domain-containing protein

1

19

High-throughput

0.479

High

60880

Q19007
Nucleosome assembly protein 1-like 1

1

1

High-throughput

0.479

High

60891

Q21831
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1

1

2

High-throughput

0.479

High

60914

Q9N4N4
Actin-related protein 4

1

2

High-throughput

0.479

High

60932

HBL1
Hunchback-like protein

1

2

High-throughput

0.479

High

60876

FLH2
FLYWCH transcription factor 2

1

1

High-throughput

0.464

High

60879

MXL3
Protein mxl-3

1

19

High-throughput

0.464

High

60882

Q19496
Nuclear Hormone Receptor family

1

2

High-throughput

0.464

High

60916

Q9NAE4
BZIP domain-containing protein

1

5

High-throughput

0.464

High

60918

Q9TXN8
DM domain-containing protein

1

1

High-throughput

0.464

High

60885

MAB21
Protein male abnormal 21

1

0

Small-scale

0.460

High

60811

G5ECR1
Methyl-CpG binding protein 2/3 C-terminal domain-containing protein

1

0

High-throughput

0.458

High

60890

MEP1
MOG interacting and ectopic P-granules protein 1

1

0

High-throughput

0.458

High

60819

H2KYD4
C2H2-type domain-containing protein

1

3

High-throughput

0.451

High

60460

A5A8Q6
C2H2-type domain-containing protein

1

3

High-throughput

0.439

High

60802

D3YT85
DM domain-containing protein

1

1

High-throughput

0.439

High

47100

FPEB1
FLYWCH-type zinc finger-containing protein peb-1

1

0

High-throughput

0.438

High

60805

G5EBR7
exodeoxyribonuclease III

1

1

High-throughput

0.437

High

60816

G5EF11
E2F/DP family winged-helix DNA-binding domain-containing protein

1

2

High-throughput

0.437

High

60818

G5EFX8
Not3 domain-containing protein

1

1

High-throughput

0.437

High

60823

H2L031
NOT2/NOT3/NOT5 C-terminal domain-containing protein

1

2

High-throughput

0.437

High

60843

ERGO1
Piwi-like protein ergo-1

1

1

High-throughput

0.437

High

60848

PSDE
26S proteasome non-ATPase regulatory subunit 14

1

1

High-throughput

0.437

High

60854

YKI5
Uncharacterized protein C01G6.5

1

2

High-throughput

0.437

High

60863

P91482
RING-type domain-containing protein

1

2

High-throughput

0.437

High

60864

P91494
Transcription termination factor 2

1

17

High-throughput

0.437

High

60874

WDR51
WD repeat-containing protein wdr-5.1

1

2

High-throughput

0.437

High

60884

Q19818
RING-type E3 ubiquitin transferase

1

2

High-throughput

0.437

High

60892

NUF2
Kinetochore protein Nuf2 homolog

1

1

High-throughput

0.437

High

60903

Q95Y97
Replication protein A C-terminal domain-containing protein

1

1

High-throughput

0.437

High

60911

PARP1
Poly [ADP-ribose] polymerase 1

1

1

High-throughput

0.437

High

60912

Q9N4H7
Coatomer subunit alpha

1

1

High-throughput

0.437

High

60923

SET26
Histone-lysine N-methyltransferase set-26

1

3

High-throughput

0.437

High

60931

FLH3
FLYWCH transcription factor 3

1

1

High-throughput

0.437

High

60846

O62159
DM domain-containing protein

1

1

High-throughput

0.417

High

60870

CEH62
Homeobox protein ceh-62

1

0

High-throughput

0.265

Low

60875

Q18056
BHLH domain-containing protein

1

0

High-throughput

0.265

Low

60921

Q9TZ37
FAR1 domain-containing protein

1

0

High-throughput

0.265

Low

60757

A5HWB1
CCR4-NOT transcription complex subunit 11

1

0

High-throughput

0.249

Low

60799

B1GRK6
Protein TALPID3

1

0

High-throughput

0.249

Low

60800

B9ZSG9
C2H2-type domain-containing protein

1

0

High-throughput

0.249

Low

60801

D3YT78
AF-9 ANC1 homology domain-containing protein

1

0

High-throughput

0.249

Low

60803

G2HK17
STING ER exit protein

1

0

High-throughput

0.249

Low

60804

G3MU54
Claspin

1

0

High-throughput

0.249

Low

60806

G5EBY3
Myosin-11

1

0

High-throughput

0.249

Low

60809

ZTF6
Zinc finger protein ztf-6

1

0

High-throughput

0.249

Low

60814

G5EE62
BEN domain-containing protein

1

0

High-throughput

0.249

Low

60815

G5EF02
PIP-1

1

0

High-throughput

0.249

Low

60820

H2KZ79
Ig-like domain-containing protein

1

0

High-throughput

0.249

Low

60821

H2KZH7
Retrotransposon gag protein

1

0

High-throughput

0.249

Low

60822

H2L025
RNA-directed RNA polymerase

1

0

High-throughput

0.249

Low

60824

H2L0E0
SET domain-containing protein

1

0

High-throughput

0.249

Low

60825

H2L2E3
DUF3452 domain-containing protein

1

0

High-throughput

0.249

Low

60826

RL4
Large ribosomal subunit protein uL4

1

0

High-throughput

0.249

Low

60827

O02074
HOOK domain-containing protein

1

0

High-throughput

0.249

Low

60828

P2R31
Serine/threonine-protein phosphatase 2A regulatory subunit rsa-1

1

0

High-throughput

0.249

Low

60830

O17149
Alcohol dehydrogenase transcription factor myb/sant-like protein

1

0

High-throughput

0.249

Low

60831

O17643
Isocitrate dehydrogenase [NADP]

1

0

High-throughput

0.249

Low

60833

O17687
Tetratricopeptide SHNi-TPR domain-containing protein

1

0

High-throughput

0.249

Low

60836

O44139
Chromo domain-containing protein

1

0

High-throughput

0.249

Low

60837

O44175
Replication factor C subunit 2

1

0

High-throughput

0.249

Low

60838

O44512
Cytochrome b-c1 complex subunit Rieske, mitochondrial

1

0

High-throughput

0.249

Low

60839

O45069
Queuosine 5'-phosphate N-glycosylase/hydrolase

1

0

High-throughput

0.249

Low

60840

O45548
Phosphoprotein

1

0

High-throughput

0.249

Low

60841

O45578
NR LBD domain-containing protein

1

0

High-throughput

0.249

Low

60842

O45950
C2H2-type domain-containing protein

1

0

High-throughput

0.249

Low

60844

IF4E3
Eukaryotic translation initiation factor 4E-3

1

0

High-throughput

0.249

Low

60845

LAP1
Protein lap1

1

0

High-throughput

0.249

Low

60847

SYQ
Probable glutamine--tRNA ligase

1

0

High-throughput

0.249

Low

60849

RPAP2
Putative RNA polymerase II subunit B1 CTD phosphatase rpap-2

1

0

High-throughput

0.249

Low

60851

KLE2
Condensin-2 complex subunit kle-2

1

0

High-throughput

0.249

Low

60853

KC1A
Casein kinase I isoform alpha

1

0

High-throughput

0.249

Low

60855

SUMV1
Protein sumv-1

1

0

High-throughput

0.249

Low

60856

RL6
Large ribosomal subunit protein eL6

1

0

High-throughput

0.249

Low

60857

CYP10
Peptidyl-prolyl cis-trans isomerase 10

1

0

High-throughput

0.249

Low

60858

P90786
Piwi-like protein 1

1

0

High-throughput

0.249

Low

60859

DPOD1
DNA polymerase delta catalytic subunit

1

0

High-throughput

0.249

Low

60860

DJ11
Glutathione-independent glyoxalase DJR-1.1

1

0

High-throughput

0.249

Low

60861

SPD5
Spindle-defective protein 5

1

0

High-throughput

0.249

Low

60862

P91350
Nuclear Pore complex Protein

1

0

High-throughput

0.249

Low

60865

YP68
Uncharacterized protein B0495.8

1

0

High-throughput

0.249

Low

60866

NOP1
Pseudocleavage protein nop-1

1

0

High-throughput

0.249

Low

60867

PCF11
Polyadenylation and cleavage factor homolog 11

1

0

High-throughput

0.249

Low

60868

YRS4
Uncharacterized protein T05H10.4

1

0

High-throughput

0.249

Low

60869

SLBP
Histone RNA hairpin-binding protein

1

0

High-throughput

0.249

Low

60871

SYLC
Leucine--tRNA ligase

1

0

High-throughput

0.249

Low

60872

Q10050
Mitochondrial ornithine transporter 1

1

0

High-throughput

0.249

Low

60873

Q17792
Homeobox domain-containing protein

1

0

High-throughput

0.249

Low

60883

Q19805
Non-structural maintenance of chromosomes element 4

1

0

High-throughput

0.249

Low

60886

SIP1
Stress-induced protein 1

1

0

High-throughput

0.249

Low

60887

MEGG1
Protein meg-1

1

0

High-throughput

0.249

Low

60888

Q21234
Integrase zinc-binding domain-containing protein

1

0

High-throughput

0.249

Low

60889

NOP56
Nucleolar protein 56

1

0

High-throughput

0.249

Low

60893

Q22047
TRansport of membrane to Cell Surface

1

0

High-throughput

0.249

Low

60894

Q22662
UBR-type domain-containing protein

1

0

High-throughput

0.249

Low

60895

TFDP1
Transcription factor dpl-1

1

0

High-throughput

0.249

Low

60896

Q23191
PUM-HD domain-containing protein

1

0

High-throughput

0.249

Low

60897

Q27GU1
Piwi domain-containing protein

1

0

High-throughput

0.249

Low

60898

Q564Z8
DUF2040 domain-containing protein

1

0

High-throughput

0.249

Low

60899

Q7KX00
nucleoside-diphosphate kinase

1

0

High-throughput

0.249

Low

60900

GLS1
Germline survival defective-1

1

0

High-throughput

0.249

Low

60901

Q93520
AAA domain-containing protein

1

0

High-throughput

0.249

Low

60902

PLP1
Transcriptional activator plp-1

1

0

High-throughput

0.249

Low

60904

Q965V4
Exportin-2

1

0

High-throughput

0.249

Low

60905

Q9BL15
tRNA

1

0

High-throughput

0.249

Low

60906

Q9BL64
Protein HGH1 homolog

1

0

High-throughput

0.249

Low

60907

Q9GYQ9
CCR4-NOT transcription complex subunit 4

1

0

High-throughput

0.249

Low

60908

Q9N3F7
C3H1-type domain-containing protein

1

0

High-throughput

0.249

Low

60909

CSN3
COP9 signalosome complex subunit 3

1

0

High-throughput

0.249

Low

60910

Q9N492
Peptidyl-prolyl cis-trans isomerase

1

0

High-throughput

0.249

Low

60913

RL10A
Large ribosomal subunit protein uL1

1

0

High-throughput

0.249

Low

60915

RPAB1
DNA-directed RNA polymerases I, II, and III subunit RPABC1

1

0

High-throughput

0.249

Low

60917

Q9TXM1
Uncharacterized protein

1

0

High-throughput

0.249

Low

60919

GAR1
Probable H/ACA ribonucleoprotein complex subunit 1-like protein

1

0

High-throughput

0.249

Low

60920

Q9TYL9
Coatomer subunit beta

1

0

High-throughput

0.249

Low

60922

Q9U229
Pyr_redox_2 domain-containing protein

1

0

High-throughput

0.249

Low

60924

Q9XUR4
F-box associated domain-containing protein

1

0

High-throughput

0.249

Low

60925

Q9XUW5
RNA helicase

1

0

High-throughput

0.249

Low

60926

RPB11
Probable DNA-directed RNA polymerase II subunit RPB11

1

0

High-throughput

0.249

Low

60927

Q9XVS2
RRM domain-containing protein

1

0

High-throughput

0.249

Low

60928

LS14H
Protein LSM14 homolog car-1

1

0

High-throughput

0.249

Low

60929

Q9XWG2
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2

1

0

High-throughput

0.249

Low

60930

Q9XWK6
C2H2-type domain-containing protein

1

0

High-throughput

0.249

Low

60812

JUN
Transcription factor jun-1

1

0

High-throughput

0.238

Low


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Last updated: 15 Jul 2024