Protein: MAX
Protein max (Class D basic helix-loop-helix protein 4) (bHLHd4) (Myc-associated factor X)

Gene: MAX
Organism: Homo sapiens
Interactions: 219
UniProt ID: P61244

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000785 - chromatin
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001227 - DNA-binding transcription repressor activity, RNA polymerase II-specific
GO:0003677 - DNA binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

346390

MYC
Myc proto-oncogene protein

67

18

Small-scale

0.997

High

840202

MXI1
Max-interacting protein 1

14

20

Small-scale

0.985

High

898108

MAD1
Max dimerization protein 1

16

18

Small-scale

0.984

High

379188

MYCN
N-myc proto-oncogene protein

15

17

Small-scale

0.983

High

898186

MAD3
Max dimerization protein 3

9

18

Small-scale

0.972

High

898182

MNT
Max-binding protein MNT

7

19

Small-scale

0.969

High

898122

MAD4
Max dimerization protein 4

7

19

Small-scale

0.965

High

898153

MGAP
MAX gene-associated protein

6

6

High-throughput

0.955

High

898090

MAX
Protein max

7

18

Small-scale

0.953

High

519709

MYCL
Protein L-Myc

4

18

Small-scale

0.893

High

898224

TRRAP
Transformation/transcription domain-associated protein

7

14

Small-scale

0.747

High

898188

PCGF6
Polycomb group RING finger protein 6

7

16

Small-scale

0.746

High

898119

TFDP1
Transcription factor Dp-1

5

3

Small-scale

0.723

High

898169

LMBL2
Lethal(3)malignant brain tumor-like protein 2

5

7

Small-scale

0.723

High

265624

E2F6
Transcription factor E2F6

5

10

Small-scale

0.718

High

898175

EP400
E1A-binding protein p400

5

20

Small-scale

0.718

High

898178

RING2
E3 ubiquitin-protein ligase RING2

5

20

Small-scale

0.718

High

898126

TWST1
Twist-related protein 1

1

12

High-throughput

0.691

High

898145

FOXR2
Forkhead box protein R2

3

13

High-throughput

0.675

High

898111

EP300
Histone acetyltransferase p300

3

20

Small-scale

0.670

High

898154

YAF2
YY1-associated factor 2

3

4

Small-scale

0.667

High

898156

RYBP
RING1 and YY1-binding protein

3

4

Small-scale

0.667

High

898177

SIN3A
Paired amphipathic helix protein Sin3a

3

12

Small-scale

0.667

High

898132

HIF1A
Hypoxia-inducible factor 1-alpha

1

8

Small-scale

0.665

High

898184

EPAS1
Endothelial PAS domain-containing protein 1

1

8

Small-scale

0.665

High

317425

YETS4
YEATS domain-containing protein 4

3

5

Small-scale

0.656

High

898091

WDR5
WD repeat-containing protein 5

3

20

High-throughput

0.656

High

898110

RING1
E3 ubiquitin-protein ligase RING1

3

17

Small-scale

0.656

High

898114

CBX3
Chromobox protein homolog 3

3

14

Small-scale

0.656

High

898167

KAT5
Histone acetyltransferase KAT5

3

8

Small-scale

0.656

High

898206

DMAP1
DNA methyltransferase 1-associated protein 1

3

4

Small-scale

0.656

High

898192

BRD8
Bromodomain-containing protein 8

3

20

Small-scale

0.640

High

782324

KDM5C
Lysine-specific demethylase 5C

2

3

Small-scale

0.628

High

898100

CBX1
Chromobox protein homolog 1

2

14

High-throughput

0.628

High

898173

REXO5
RNA exonuclease 5

2

11

High-throughput

0.628

High

898191

SP130
Histone deacetylase complex subunit SAP130

2

11

High-throughput

0.628

High

831169

CEBPA
CCAAT/enhancer-binding protein alpha

2

20

Small-scale

0.624

High

898098

CSK21
Casein kinase II subunit alpha

2

13

Small-scale

0.619

High

126114

BMAL1
Basic helix-loop-helix ARNT-like protein 1

1

8

High-throughput

0.618

High

181507

CLOCK
Circadian locomoter output cycles protein kaput

1

8

High-throughput

0.618

High

607801

USF1
Upstream stimulatory factor 1

1

18

Small-scale

0.618

High

898109

MBTD1
MBT domain-containing protein 1

2

7

Small-scale

0.611

High

898127

VPS72
Vacuolar protein sorting-associated protein 72 homolog

2

2

Small-scale

0.611

High

898135

EPC2
Enhancer of polycomb homolog 2

2

7

Small-scale

0.611

High

898193

EPC1
Enhancer of polycomb homolog 1

2

7

Small-scale

0.611

High

898210

ING3
Inhibitor of growth protein 3

2

8

Small-scale

0.611

High

898218

FBW1B
F-box/WD repeat-containing protein 11

2

20

High-throughput

0.611

High

898221

RUVB2
RuvB-like 2

2

9

Small-scale

0.611

High

898196

PKHF2
Pleckstrin homology domain-containing family F member 2

3

4

High-throughput

0.609

High

898165

KAT2A
Histone acetyltransferase KAT2A

2

20

Small-scale

0.584

High

898214

ZRAN1
Ubiquitin thioesterase ZRANB1

2

5

High-throughput

0.584

High

365179

FRIH
Ferritin heavy chain

1

6

High-throughput

0.578

High

898116

BFSP2
Phakinin

2

14

High-throughput

0.574

High

898194

UN45A
Protein unc-45 homolog A

2

10

High-throughput

0.573

High

296287

UBP1
Ubiquitin carboxyl-terminal hydrolase 1

1

13

Small-scale

0.561

High

658476

TEAD1
Transcriptional enhancer factor TEF-1

1

2

Small-scale

0.561

High

726694

FUS
RNA-binding protein FUS

1

20

High-throughput

0.561

High

794224

MSH2
DNA mismatch repair protein Msh2

1

3

Small-scale

0.561

High

898146

TBA1A
Tubulin alpha-1A chain

1

12

High-throughput

0.561

High

898217

DNM3L
DNA

1

3

Small-scale

0.561

High

260819

H2AY
Core histone macro-H2A.1

1

10

High-throughput

0.554

High

403612

AP2A
Transcription factor AP-2-alpha

1

4

High-throughput

0.554

High

669326

EF1D
Elongation factor 1-delta

1

2

High-throughput

0.554

High

836699

DNLI3
DNA ligase 3

1

3

High-throughput

0.554

High

847994

MECP2
Methyl-CpG-binding protein 2

1

11

High-throughput

0.554

High

898105

FOXK2
Forkhead box protein K2

1

9

High-throughput

0.554

High

898152

VRK3
Serine/threonine-protein kinase VRK3

1

10

High-throughput

0.554

High

898158

SNIP1
Smad nuclear-interacting protein 1

1

4

Small-scale

0.552

High

898157

BANP
Protein BANP

1

0

High-throughput

0.549

High

600115

TAF1
Transcription initiation factor TFIID subunit 1

1

20

High-throughput

0.541

High

764615

CUX1
Homeobox protein cut-like 1

1

11

High-throughput

0.541

High

898166

CSN5
COP9 signalosome complex subunit 5

1

6

High-throughput

0.541

High

898199

PKHA5
Pleckstrin homology domain-containing family A member 5

1

10

High-throughput

0.541

High

898208

TXLNG
Gamma-taxilin

1

15

High-throughput

0.541

High

898213

CLIP2
CAP-Gly domain-containing linker protein 2

1

9

High-throughput

0.541

High

129731

AGRIN
Agrin [Cleaved into: Agrin N-terminal 110 kDa subunit; Agrin C-terminal 110 kDa subunit; Agrin C-terminal 90 kDa fragment

1

5

High-throughput

0.536

High

229350

SMCA5
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5

1

20

High-throughput

0.536

High

265180

SAP30
Histone deacetylase complex subunit SAP30

1

3

High-throughput

0.536

High

321743

WIZ
Protein Wiz

1

3

High-throughput

0.536

High

396216

ARGI1
Arginase-1

1

1

High-throughput

0.536

High

589816

TBP
TATA-box-binding protein

1

2

High-throughput

0.536

High

658645

SMCA1
Probable global transcription activator SNF2L1

1

20

High-throughput

0.536

High

801840

RECQ1
ATP-dependent DNA helicase Q1

1

13

High-throughput

0.536

High

817647

PI42A
Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha

1

5

High-throughput

0.536

High

898096

SKP1
S-phase kinase-associated protein 1

1

3

High-throughput

0.536

High

898099

PI42B
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta

1

5

High-throughput

0.536

High

898103

FOXK1
Forkhead box protein K1

1

12

High-throughput

0.536

High

898129

HSPB2
Heat shock protein beta-2

1

4

High-throughput

0.536

High

898133

ARI4B
AT-rich interactive domain-containing protein 4B

1

20

High-throughput

0.536

High

898137

BRM1L
Breast cancer metastasis-suppressor 1-like protein

1

7

High-throughput

0.536

High

898140

WBP2L
Postacrosomal sheath WW domain-binding protein

1

4

High-throughput

0.536

High

898144

FOXR1
Forkhead box protein R1

1

13

High-throughput

0.536

High

898147

SND1
Staphylococcal nuclease domain-containing protein 1

1

2

High-throughput

0.536

High

898160

PI42C
Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma

1

5

High-throughput

0.536

High

898164

HDAC2
Histone deacetylase 2

1

11

High-throughput

0.536

High

898195

SDS3
Sin3 histone deacetylase corepressor complex component SDS3

1

7

High-throughput

0.536

High

898197

WDR76
WD repeat-containing protein 76

1

20

High-throughput

0.536

High

898202

BRMS1
Breast cancer metastasis-suppressor 1

1

7

High-throughput

0.536

High

898207

BAZ1A
Bromodomain adjacent to zinc finger domain protein 1A

1

20

High-throughput

0.536

High

898225

MORC2
ATPase MORC2

1

1

High-throughput

0.536

High

579679

XRCC1
DNA repair protein XRCC1

1

0

High-throughput

0.530

High

898211

GABR1
Gamma-aminobutyric acid type B receptor subunit 1

1

1

High-throughput

0.528

High

898151

MF2L2
Probable guanine nucleotide exchange factor MCF2L2

2

12

High-throughput

0.521

High

737681

PP1G
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit

1

13

High-throughput

0.515

High

898092

PP1A
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit

1

13

High-throughput

0.515

High

898093

PP1B
Serine/threonine-protein phosphatase PP1-beta catalytic subunit

1

13

High-throughput

0.515

High

227041

PRKN
E3 ubiquitin-protein ligase parkin

1

4

High-throughput

0.515

High

231487

KIF1B
Kinesin-like protein KIF1B

1

7

High-throughput

0.515

High

388350

HSPB1
Heat shock protein beta-1

1

4

High-throughput

0.515

High

898223

RNF11
RING finger protein 11

1

5

High-throughput

0.515

High

552397

RFA2
Replication protein A 32 kDa subunit

1

0

High-throughput

0.513

High

229654

JIP4
C-Jun-amino-terminal kinase-interacting protein 4

1

7

Small-scale

0.512

High

790320

RL35
Large ribosomal subunit protein uL29

1

2

High-throughput

0.512

High

825151

RL34
Large ribosomal subunit protein eL34

1

2

High-throughput

0.512

High

898101

SMAD3
Mothers against decapentaplegic homolog 3

1

9

Small-scale

0.501

High

898113

ZBT17
Zinc finger and BTB domain-containing protein 17

1

4

Small-scale

0.501

High

898115

SMAD4
Mothers against decapentaplegic homolog 4

1

9

Small-scale

0.501

High

898190

PRD14
PR domain zinc finger protein 14

1

1

Small-scale

0.500

High

238162

PLIN3
Perilipin-3

1

1

High-throughput

0.494

High

898163

TCP1L
T-complex protein 10A homolog 1

1

0

High-throughput

0.493

High

281590

WFS1
Wolframin

1

0

High-throughput

0.493

High

608856

SPR1B
Cornifin-B

1

1

High-throughput

0.489

High

898130

CCDC6
Coiled-coil domain-containing protein 6

1

10

High-throughput

0.489

High

898155

TXLNB
Beta-taxilin

1

11

High-throughput

0.489

High

898180

MTEF1
Transcription termination factor 1, mitochondrial

1

2

High-throughput

0.489

High

898185

DHB14
17-beta-hydroxysteroid dehydrogenase 14

1

3

High-throughput

0.489

High

898203

CHM1A
Charged multivesicular body protein 1a

1

4

High-throughput

0.489

High

118717

AIP
AH receptor-interacting protein

1

3

High-throughput

0.479

High

162570

XPO1
Exportin-1

1

10

High-throughput

0.479

High

199695

SNUT1
U4/U6.U5 tri-snRNP-associated protein 1

1

5

High-throughput

0.479

High

232080

KDM1A
Lysine-specific histone demethylase 1A

1

11

High-throughput

0.479

High

236732

CCNT1
Cyclin-T1

1

7

Small-scale

0.479

High

266474

SUPT3
Transcription initiation protein SPT3 homolog

1

1

Small-scale

0.479

High

267750

TAF5L
TAF5-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 5L

1

20

Small-scale

0.479

High

296438

ACL6B
Actin-like protein 6B

1

11

Small-scale

0.479

High

316839

KLF8
Krueppel-like factor 8

1

20

High-throughput

0.479

High

325676

LATS1
Serine/threonine-protein kinase LATS1

1

8

High-throughput

0.479

High

331481

ACL6A
Actin-like protein 6A

1

11

Small-scale

0.479

High

381157

TBB4A
Tubulin beta-4A chain

1

9

High-throughput

0.479

High

386422

P53
Cellular tumor antigen p53

1

4

High-throughput

0.479

High

401745

JUN
Transcription factor Jun

1

12

High-throughput

0.479

High

431713

HS90A
Heat shock protein HSP 90-alpha

1

10

High-throughput

0.479

High

438044

HS90B
Heat shock protein HSP 90-beta

1

10

High-throughput

0.479

High

507556

PIM1
Serine/threonine-protein kinase pim-1

1

7

Small-scale

0.479

High

518301

ADT3
ADP/ATP translocase 3

1

8

High-throughput

0.479

High

531103

EF2
Elongation factor 2

1

6

High-throughput

0.479

High

569493

CEBPB
CCAAT/enhancer-binding protein beta

1

18

High-throughput

0.479

High

575358

EGR1
Early growth response protein 1

1

7

High-throughput

0.479

High

609787

ROA2
Heterogeneous nuclear ribonucleoproteins A2/B1

1

17

High-throughput

0.479

High

632675

TYY1
Transcriptional repressor protein YY1

1

11

Small-scale

0.479

High

672066

2AAA
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform

1

7

Small-scale

0.479

High

672397

2AAB
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform

1

7

Small-scale

0.479

High

849175

PSMD7
26S proteasome non-ATPase regulatory subunit 7

1

6

High-throughput

0.479

High

862368

ACLY
ATP-citrate synthase

1

4

High-throughput

0.479

High

874214

DRG2
Developmentally-regulated GTP-binding protein 2

1

6

High-throughput

0.479

High

898094

PP2AB
Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform

1

10

Small-scale

0.479

High

898095

H4
Histone H4

1

9

High-throughput

0.479

High

898097

PP2AA
Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform

1

11

Small-scale

0.479

High

898102

H33
Histone H3.3

1

8

High-throughput

0.479

High

898104

HNRPU
Heterogeneous nuclear ribonucleoprotein U

1

14

Small-scale

0.479

High

898106

PFKAP
ATP-dependent 6-phosphofructokinase, platelet type

1

4

High-throughput

0.479

High

898107

PO5F1
POU domain, class 5, transcription factor 1

1

1

High-throughput

0.479

High

898112

FOXC1
Forkhead box protein C1

1

11

High-throughput

0.479

High

898117

KLF9
Krueppel-like factor 9

1

20

High-throughput

0.479

High

898118

GIT2
ARF GTPase-activating protein GIT2

1

10

High-throughput

0.479

High

898120

TFDP2
Transcription factor Dp-2

1

3

High-throughput

0.479

High

898124

MO4L2
Mortality factor 4-like protein 2

1

5

Small-scale

0.479

High

898125

ZNHI3
Zinc finger HIT domain-containing protein 3

1

1

Small-scale

0.479

High

898128

EZH2
Histone-lysine N-methyltransferase EZH2

1

19

Small-scale

0.479

High

898131

TAF9
Transcription initiation factor TFIID subunit 9

1

4

Small-scale

0.479

High

898134

GRAP1
GRIP1-associated protein 1

1

9

High-throughput

0.479

High

898142

CAVN1
Caveolae-associated protein 1

1

2

High-throughput

0.479

High

898143

PKN3
Serine/threonine-protein kinase N3

1

4

High-throughput

0.479

High

898149

UBP37
Ubiquitin carboxyl-terminal hydrolase 37

1

13

Small-scale

0.479

High

898161

CCHCR
Coiled-coil alpha-helical rod protein 1

1

8

High-throughput

0.479

High

898162

SP7
Transcription factor Sp7

1

20

High-throughput

0.479

High

898168

FBXW7
F-box/WD repeat-containing protein 7

1

16

Small-scale

0.479

High

898170

PF21A
PHD finger protein 21A

1

15

High-throughput

0.479

High

898171

SPDLY
Protein Spindly

1

11

High-throughput

0.479

High

898176

RPR1A
Regulation of nuclear pre-mRNA domain-containing protein 1A

1

6

High-throughput

0.479

High

898179

MPP8
M-phase phosphoprotein 8

1

15

High-throughput

0.479

High

898181

FEV
Protein FEV

1

12

High-throughput

0.479

High

898187

KLF16
Krueppel-like factor 16

1

20

High-throughput

0.479

High

898189

NUF2
Kinetochore protein Nuf2

1

8

High-throughput

0.479

High

898198

EAF6
Chromatin modification-related protein MEAF6

1

3

Small-scale

0.479

High

898205

HM20A
High mobility group protein 20A

1

20

High-throughput

0.479

High

898209

MRGBP
MRG/MORF4L-binding protein

1

3

Small-scale

0.479

High

898212

MO4L1
Mortality factor 4-like protein 1

1

5

Small-scale

0.479

High

898216

RABX5
Rab5 GDP/GTP exchange factor

1

3

High-throughput

0.479

High

898219

RCOR1
REST corepressor 1

1

13

High-throughput

0.479

High

898220

HDAC5
Histone deacetylase 5

1

16

High-throughput

0.479

High

898222

RUVB1
RuvB-like 1

1

9

Small-scale

0.479

High

660453

GRN
Progranulin

1

2

High-throughput

0.470

High

893327

PRPS1
Ribose-phosphate pyrophosphokinase 1

1

2

High-throughput

0.470

High

122168

PSMD9
26S proteasome non-ATPase regulatory subunit 9

1

0

High-throughput

0.458

High

204309

MS18B
Protein Mis18-beta

1

0

High-throughput

0.458

High

262415

TULP3
Tubby-related protein 3

1

0

High-throughput

0.458

High

471571

TFPT
TCF3 fusion partner

1

0

High-throughput

0.458

High

898172

THA11
THAP domain-containing protein 11

1

0

High-throughput

0.458

High

898123

Q14901
Myc protein

1

0

Small-scale

0.438

High

299254

FARP2
FERM, ARHGEF and pleckstrin domain-containing protein 2

1

6

High-throughput

0.437

High

583309

HXK1
Hexokinase-1

1

2

High-throughput

0.437

High

898121

DYHC1
Cytoplasmic dynein 1 heavy chain 1

1

2

High-throughput

0.437

High

898136

CCD93
Coiled-coil domain-containing protein 93

1

5

High-throughput

0.437

High

898139

TBC9B
TBC1 domain family member 9B

1

5

High-throughput

0.437

High

898141

PHLB3
Pleckstrin homology-like domain family B member 3

1

14

High-throughput

0.437

High

898150

DZIP3
E3 ubiquitin-protein ligase DZIP3

1

4

High-throughput

0.437

High

898159

GOGA5
Golgin subfamily A member 5

1

12

High-throughput

0.437

High

898183

SEPT5
Septin-5

1

3

High-throughput

0.437

High

898204

TUFT1
Tuftelin

1

1

High-throughput

0.437

High

898200

GLOD4
Glyoxalase domain-containing protein 4

1

0

High-throughput

0.279

Low

47208

A0A6Q8PF08
Peripheral myelin protein 22

1

0

High-throughput

0.268

Low

81701

RBG10
Rab GTPase-activating protein 1-like, isoform 10

1

0

High-throughput

0.249

Low

898138

VPS53
Vacuolar protein sorting-associated protein 53 homolog

1

0

High-throughput

0.249

Low

898148

HAUS6
HAUS augmin-like complex subunit 6

1

0

High-throughput

0.249

Low

898174

VPS50
Syndetin

1

0

High-throughput

0.249

Low

898201

NCK5L
Nck-associated protein 5-like

1

0

High-throughput

0.249

Low

898215

GGT7
Glutathione hydrolase 7

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024