Protein: IQGA2
Ras GTPase-activating-like protein IQGAP2

Gene: IQGA2, IQGAP2
Organism: Homo sapiens
Interactions: 96
UniProt ID: Q13576

Gene Ontology (top 5):
GO:0003779 - actin binding
GO:0005095 - GTPase inhibitor activity
GO:0005096 - GTPase activator activity
GO:0005516 - calmodulin binding
GO:0005547 - phosphatidylinositol-3,4,5-trisphosphate binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

893981

CDC42
Cell division control protein 42 homolog

7

20

Small-scale

0.963

High

925259

RAC1
Ras-related C3 botulinum toxin substrate 1

5

20

Small-scale

0.931

High

1040052

CAB45
45 kDa calcium-binding protein

3

18

High-throughput

0.861

High

892356

RAC3
Ras-related C3 botulinum toxin substrate 3

2

20

High-throughput

0.789

High

950977

RHOG
Rho-related GTP-binding protein RhoG

2

20

Small-scale

0.768

High

350149

RASK
GTPase KRas

2

20

High-throughput

0.754

High

159570

ML12B
Myosin regulatory light chain 12B

1

20

High-throughput

0.691

High

380776

S100B
Protein S100-B

1

5

High-throughput

0.691

High

648499

CALL3
Calmodulin-like protein 3

1

15

High-throughput

0.691

High

795628

MAGA1
Melanoma-associated antigen 1

3

4

High-throughput

0.667

High

1040063

SUCB1
Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial

2

1

High-throughput

0.628

High

433751

LYN
Tyrosine-protein kinase Lyn

1

19

High-throughput

0.618

High

564517

RHOQ
Rho-related GTP-binding protein RhoQ

1

20

High-throughput

0.618

High

891748

ACTB
Actin, cytoplasmic 1

1

15

High-throughput

0.618

High

915658

RHOB
Rho-related GTP-binding protein RhoB

1

20

High-throughput

0.618

High

1040022

RAB35
Ras-related protein Rab-35

1

17

High-throughput

0.618

High

1040030

TRI67
Tripartite motif-containing protein 67

1

20

High-throughput

0.618

High

1040058

RHOJ
Rho-related GTP-binding protein RhoJ

1

20

High-throughput

0.618

High

346724

MYC
Myc proto-oncogene protein

2

7

High-throughput

0.611

High

391391

GNAI2
Guanine nucleotide-binding protein G(i) subunit alpha-2

2

11

High-throughput

0.611

High

1040044

DTBP1
Dysbindin

2

2

High-throughput

0.611

High

912890

ARF6
ADP-ribosylation factor 6

2

9

High-throughput

0.584

High

672115

2AAA
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform

1

4

High-throughput

0.536

High

734930

MP2K2
Dual specificity mitogen-activated protein kinase kinase 2

1

17

High-throughput

0.536

High

812741

MSS4
Guanine nucleotide exchange factor MSS4

1

1

High-throughput

0.536

High

848366

IRAK1
Interleukin-1 receptor-associated kinase 1

1

2

High-throughput

0.536

High

891518

MYL6
Myosin light polypeptide 6

1

20

High-throughput

0.536

High

1040028

DRC8
Dynein regulatory complex protein 8

1

20

High-throughput

0.536

High

1040033

ZNG1B
Zinc-regulated GTPase metalloprotein activator 1B

1

2

High-throughput

0.536

High

1040039

M4K1
Mitogen-activated protein kinase kinase kinase kinase 1

1

15

High-throughput

0.536

High

1040041

TRI52
E3 ubiquitin-protein ligase TRIM52

1

8

High-throughput

0.536

High

1040043

ARRD3
Arrestin domain-containing protein 3

1

3

High-throughput

0.536

High

1040046

KKCC2
Calcium/calmodulin-dependent protein kinase kinase 2

1

7

High-throughput

0.536

High

1040048

M3K14
Mitogen-activated protein kinase kinase kinase 14

1

18

High-throughput

0.536

High

1040053

ZNG1A
Zinc-regulated GTPase metalloprotein activator 1A

1

2

High-throughput

0.536

High

1040060

LATS2
Serine/threonine-protein kinase LATS2

1

8

High-throughput

0.536

High

1040066

HSPB8
Heat shock protein beta-8

1

4

High-throughput

0.536

High

779373

CCNF
Cyclin-F

1

4

High-throughput

0.515

High

978746

TF65
Transcription factor p65

1

3

High-throughput

0.515

High

380290

HG2A
HLA class II histocompatibility antigen gamma chain

1

0

High-throughput

0.513

High

1040025

ASIC2
Acid-sensing ion channel 2

1

0

High-throughput

0.513

High

1040035

MIER2
Mesoderm induction early response protein 2

1

0

High-throughput

0.513

High

1040055

B2L14
Apoptosis facilitator Bcl-2-like protein 14

1

0

High-throughput

0.513

High

1040054

UBAC1
Ubiquitin-associated domain-containing protein 1

1

0

High-throughput

0.493

High

71117

HNRC2
Heterogeneous nuclear ribonucleoprotein C-like 2

1

4

High-throughput

0.489

High

796075

MAGA9
Melanoma-associated antigen 9

1

4

High-throughput

0.489

High

1040036

ABTB2
Ankyrin repeat and BTB/POZ domain-containing protein 2

1

8

High-throughput

0.489

High

1040047

TCPQM
T-complex protein 1 subunit theta-like 2

1

2

High-throughput

0.489

High

1040050

FOXB1
Forkhead box protein B1

1

5

High-throughput

0.489

High

1040056

UN93B
Protein unc-93 homolog B1

1

1

High-throughput

0.489

High

261997

PEX14
Peroxisomal membrane protein PEX14

1

1

Small-scale

0.484

High

129753

AGRIN
Agrin [Cleaved into: Agrin N-terminal 110 kDa subunit; Agrin C-terminal 110 kDa subunit; Agrin C-terminal 90 kDa fragment

1

1

High-throughput

0.479

High

374193

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

14

High-throughput

0.479

High

455410

PARP1
Poly [ADP-ribose] polymerase 1

1

10

High-throughput

0.479

High

560505

TSHR
Thyrotropin receptor

1

3

High-throughput

0.479

High

590902

BTF3
Transcription factor BTF3

1

2

High-throughput

0.479

High

742283

SYUA
Alpha-synuclein

1

1

High-throughput

0.479

High

874903

TERA
Transitional endoplasmic reticulum ATPase

1

5

Small-scale

0.479

High

974804

CAV1
Caveolin-1

1

6

High-throughput

0.479

High

1021395

ANK3
Ankyrin-3

1

4

High-throughput

0.479

High

1036552

SQSTM
Sequestosome-1

1

4

High-throughput

0.479

High

1040020

CUL3
Cullin-3

1

7

High-throughput

0.479

High

1040021

KIF14
Kinesin-like protein KIF14

1

13

High-throughput

0.479

High

1040023

IKBB
NF-kappa-B inhibitor beta

1

13

High-throughput

0.479

High

1040024

ZYX
Zyxin

1

6

High-throughput

0.479

High

1040026

OCLN
Occludin

1

3

High-throughput

0.479

High

1040027

CL16A
Protein CLEC16A

1

1

High-throughput

0.479

High

1040029

LTOR1
Ragulator complex protein LAMTOR1

1

4

High-throughput

0.479

High

1040038

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

3

High-throughput

0.479

High

1040040

CK052
Uncharacterized protein C11orf52

1

3

High-throughput

0.479

High

1040049

M3K3
Mitogen-activated protein kinase kinase kinase 3

1

11

High-throughput

0.479

High

1040051

GRWD1
Glutamate-rich WD repeat-containing protein 1

1

6

High-throughput

0.479

High

1040059

PKHA4
Pleckstrin homology domain-containing family A member 4

1

20

High-throughput

0.479

High

1040061

TLS1
Splicing factor C9orf78

1

1

High-throughput

0.479

High

1040065

ZRAN1
Ubiquitin thioesterase ZRANB1

1

6

High-throughput

0.479

High

1040068

UBQL1
Ubiquilin-1

1

1

High-throughput

0.479

High

559092

H15
Histone H1.5

1

2

High-throughput

0.470

High

1040062

WWOX
WW domain-containing oxidoreductase

1

0

High-throughput

0.458

High

1023038

STK4
Serine/threonine-protein kinase 4

1

10

High-throughput

0.445

High

1040057

MLP3A
Microtubule-associated proteins 1A/1B light chain 3A

1

2

High-throughput

0.445

High

352098

INS
Insulin [Cleaved into: Insulin B chain; Insulin A chain]

1

1

High-throughput

0.437

High

552668

RFA2
Replication protein A 32 kDa subunit

1

4

High-throughput

0.437

High

651143

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

3

High-throughput

0.437

High

720404

RFA3
Replication protein A 14 kDa subunit

1

5

High-throughput

0.437

High

1029393

TIF1B
Transcription intermediary factor 1-beta

1

11

High-throughput

0.437

High

1040031

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

4

High-throughput

0.437

High

1040032

ZCH18
Zinc finger CCCH domain-containing protein 18

1

6

High-throughput

0.437

High

1040034

S15A3
Solute carrier family 15 member 3

1

1

High-throughput

0.437

High

1040042

CLUA1
Clusterin-associated protein 1

1

3

High-throughput

0.437

High

1040067

HECD1
E3 ubiquitin-protein ligase HECTD1

1

11

High-throughput

0.437

High

1040037

GOLM1
Golgi membrane protein 1

1

0

Small-scale

0.426

High

1040064

UVRAG
UV radiation resistance-associated gene protein

1

0

High-throughput

0.426

High

99594

F5H1C8
Solute carrier family 15 member 3

1

1

High-throughput

0.407

High

1040069

CSAG2
Chondrosarcoma-associated gene 2/3 protein

1

2

High-throughput

0.407

High

1040045

CH076
Uncharacterized protein C8orf76

1

0

High-throughput

0.279

Low

47679

A0AUL9
ATG2A protein

1

0

High-throughput

0.232

Low


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Last updated: 15 Jul 2024