Protein: FLNC
Filamin-C (FLN-C) (FLNc) (ABP-280-like protein) (ABP-L) (Actin-binding-like protein) (Filamin-2) (Gamma-filamin)

Gene: FLNC
Organism: Homo sapiens
Interactions: 185
UniProt ID: Q14315

Gene Ontology (top 5):
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0005856 - cytoskeleton
GO:0005886 - plasma membrane
GO:0005925 - focal adhesion

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1052874

FLNC
Filamin-C

1

16

Small-scale

0.716

High

1052875

MYPC2
Myosin-binding protein C, fast-type

1

20

High-throughput

0.698

High

199550

M3K13
Mitogen-activated protein kinase kinase kinase 13

1

6

High-throughput

0.691

High

1052947

MYOZ1
Myozenin-1

3

10

Small-scale

0.674

High

1052911

BACD1
BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 1

3

16

High-throughput

0.667

High

1031839

SGCG
Gamma-sarcoglycan

2

2

Small-scale

0.642

High

1052914

SGCD
Delta-sarcoglycan

2

2

Small-scale

0.642

High

227442

PRKN
E3 ubiquitin-protein ligase parkin

3

10

High-throughput

0.640

High

929152

GBG3

2

3

High-throughput

0.628

High

1052883

PKHO1
Pleckstrin homology domain-containing family O member 1

2

1

High-throughput

0.628

High

1052917

RAB8B
Ras-related protein Rab-8B

2

7

High-throughput

0.628

High

1052935

NUAK2
NUAK family SNF1-like kinase 2

2

6

High-throughput

0.628

High

1052956

HSPB7
Heat shock protein beta-7

2

18

High-throughput

0.628

High

1052893

XIRP1
Xin actin-binding repeat-containing protein 1

2

1

Small-scale

0.625

High

1052887

OTUD1
OTU domain-containing protein 1

4

8

Small-scale

0.623

High

1052932

TRI54
Tripartite motif-containing protein 54

2

20

Small-scale

0.620

High

261262

FLNB
Filamin-B

1

18

High-throughput

0.618

High

337473

ABL1
Tyrosine-protein kinase ABL1

1

12

High-throughput

0.618

High

363145

FINC
Fibronectin

1

20

High-throughput

0.618

High

412192

FYN
Tyrosine-protein kinase Fyn

1

13

High-throughput

0.618

High

598114

FLNA
Filamin-A

1

17

High-throughput

0.618

High

891763

ACTB
Actin, cytoplasmic 1

1

20

High-throughput

0.618

High

1045918

BACD2
BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2

2

18

High-throughput

0.611

High

1052906

NT5C
5'(3')-deoxyribonucleotidase, cytosolic type

2

0

High-throughput

0.602

High

1052877

MYPC3
Myosin-binding protein C, cardiac-type

1

20

Small-scale

0.590

High

346774

MYC
Myc proto-oncogene protein

2

14

High-throughput

0.584

High

1052891

RICTR
Rapamycin-insensitive companion of mTOR

2

5

High-throughput

0.584

High

1052959

FBW1B
F-box/WD repeat-containing protein 11

2

14

High-throughput

0.584

High

994634

DDR1
Epithelial discoidin domain-containing receptor 1

1

16

Small-scale

0.575

High

1037231

TBB3
Tubulin beta-3 chain

1

5

High-throughput

0.575

High

1052895

TBA1A
Tubulin alpha-1A chain

1

7

High-throughput

0.575

High

800982

MP2K4
Dual specificity mitogen-activated protein kinase kinase 4

1

12

Small-scale

0.573

High

1052889

FXL22
F-box and leucine-rich protein 22

1

3

Small-scale

0.573

High

182158

PDPK1
3-phosphoinositide-dependent protein kinase 1

2

3

High-throughput

0.571

High

529110

CFTR
Cystic fibrosis transmembrane conductance regulator

2

8

High-throughput

0.571

High

581728

VCAM1
Vascular cell adhesion protein 1

2

20

High-throughput

0.571

High

1021400

ANK3
Ankyrin-3

1

9

Small-scale

0.561

High

1052897

PHLB2
Pleckstrin homology-like domain family B member 2

1

20

Small-scale

0.561

High

176446

SHIP2
Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2

1

5

Small-scale

0.552

High

1052955

MYOTI
Myotilin

1

20

Small-scale

0.543

High

277835

DYSF
Dysferlin

1

5

High-throughput

0.541

High

417283

ENOA
Alpha-enolase

1

4

High-throughput

0.541

High

1052921

REPS1
RalBP1-associated Eps domain-containing protein 1

1

7

High-throughput

0.541

High

497015

TAU
Microtubule-associated protein tau

1

12

High-throughput

0.536

High

798658

PRS6B
26S proteasome regulatory subunit 6B

1

1

High-throughput

0.536

High

959210

S25A3
Solute carrier family 25 member 3

1

1

High-throughput

0.536

High

984582

CALD1
Caldesmon

1

20

High-throughput

0.536

High

1041565

CUL3
Cullin-3

1

15

High-throughput

0.536

High

1052878

IQCB1
IQ calmodulin-binding motif-containing protein 1

1

8

High-throughput

0.536

High

1052896

ANS1B
Ankyrin repeat and sterile alpha motif domain-containing protein 1B

1

18

High-throughput

0.536

High

1052905

ARRD2
Arrestin domain-containing protein 2

1

8

High-throughput

0.536

High

1052908

FBLI1
Filamin-binding LIM protein 1

1

20

High-throughput

0.536

High

1052913

RPGF5
Rap guanine nucleotide exchange factor 5

1

3

High-throughput

0.536

High

1052925

KKCC2
Calcium/calmodulin-dependent protein kinase kinase 2

1

5

High-throughput

0.536

High

1052936

P63
Tumor protein 63

1

5

Small-scale

0.536

High

1052941

PKHG2
Pleckstrin homology domain-containing family G member 2

1

17

High-throughput

0.536

High

1052942

PHAX
Phosphorylated adapter RNA export protein

1

1

High-throughput

0.536

High

1052953

SMOX
Spermine oxidase

1

2

High-throughput

0.536

High

1052960

NUDT5
ADP-sugar pyrophosphatase

1

2

High-throughput

0.536

High

1052966

WIPI2
WD repeat domain phosphoinositide-interacting protein 2

1

18

High-throughput

0.536

High

1052954

KCND2
Potassium voltage-gated channel subfamily D member 2

1

4

Small-scale

0.527

High

1052961

SYNP2
Synaptopodin-2

1

20

Small-scale

0.527

High

596276

FILA
Filaggrin

1

8

High-throughput

0.515

High

614321

PPIB
Peptidyl-prolyl cis-trans isomerase B

1

6

High-throughput

0.515

High

921845

RL30
Large ribosomal subunit protein eL30

1

2

High-throughput

0.515

High

966540

OTUD4
OTU domain-containing protein 4

1

6

High-throughput

0.515

High

1052884

H2B2F
Histone H2B type 2-F

1

15

High-throughput

0.515

High

1052909

RASF5
Ras association domain-containing protein 5

1

0

High-throughput

0.513

High

1052929

LRC61
Leucine-rich repeat-containing protein 61

1

0

High-throughput

0.513

High

1052881

HSPB2
Heat shock protein beta-2

1

15

High-throughput

0.508

High

1052919

TRI63
E3 ubiquitin-protein ligase TRIM63

1

20

High-throughput

0.508

High

60159

XIRP2
Xin actin-binding repeat-containing protein 2

1

1

Small-scale

0.501

High

595822

CAN3
Calpain-3

1

11

Small-scale

0.501

High

894003

CDC42
Cell division control protein 42 homolog

1

17

High-throughput

0.501

High

1052924

DOCK6
Dedicator of cytokinesis protein 6

1

0

High-throughput

0.493

High

131777

LAD1
Ladinin-1

1

13

High-throughput

0.489

High

1021054

FOXF1
Forkhead box protein F1

1

3

High-throughput

0.489

High

1052931

RTF2
Replication termination factor 2

1

1

High-throughput

0.489

High

1052945

TANC2
Protein TANC2

1

16

High-throughput

0.489

High

212414

AAKB2
5'-AMP-activated protein kinase subunit beta-2

1

6

Small-scale

0.481

High

1052880

KS6A2
Ribosomal protein S6 kinase alpha-2

1

3

High-throughput

0.481

High

1052933

TRI55
Tripartite motif-containing protein 55

1

20

High-throughput

0.481

High

1052939

WNK1
Serine/threonine-protein kinase WNK1

1

15

High-throughput

0.481

High

1052958

UBP25
Ubiquitin carboxyl-terminal hydrolase 25

1

8

Small-scale

0.481

High

119374

LEG9
Galectin-9

1

11

High-throughput

0.479

High

148807

CTRO
Citron Rho-interacting kinase

1

12

High-throughput

0.479

High

150705

DVL1
Segment polarity protein dishevelled homolog DVL-1

1

20

High-throughput

0.479

High

165978

PER2
Period circadian protein homolog 2

1

5

Small-scale

0.479

High

199115

SIAH2
E3 ubiquitin-protein ligase SIAH2

1

4

Small-scale

0.479

High

209983

PRC1
Protein regulator of cytokinesis 1

1

16

High-throughput

0.479

High

255772

OBSL1
Obscurin-like protein 1

1

20

High-throughput

0.479

High

278081

PIAS1
E3 SUMO-protein ligase PIAS1

1

7

High-throughput

0.479

High

308705

KI20A
Kinesin-like protein KIF20A

1

20

High-throughput

0.479

High

322619

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

6

High-throughput

0.479

High

418271

NPM
Nucleophosmin

1

4

High-throughput

0.479

High

502093

BIP
Endoplasmic reticulum chaperone BiP

1

15

High-throughput

0.479

High

504073

HSP7C
Heat shock cognate 71 kDa protein

1

8

High-throughput

0.479

High

557690

NCK1
SH2/SH3 adapter protein NCK1

1

20

High-throughput

0.479

High

567055

CXA1
Gap junction alpha-1 protein

1

8

Small-scale

0.479

High

581006

PLCG1
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1

1

6

High-throughput

0.479

High

625431

CDK2
Cyclin-dependent kinase 2

1

8

High-throughput

0.479

High

655367

P85A
Phosphatidylinositol 3-kinase regulatory subunit alpha

1

8

High-throughput

0.479

High

668680

PML
Protein PML

1

14

High-throughput

0.479

High

718853

PHB1
Prohibitin 1

1

6

High-throughput

0.479

High

749493

BRCA1
Breast cancer type 1 susceptibility protein

1

12

High-throughput

0.479

High

802599

CRK
Adapter molecule crk

1

20

High-throughput

0.479

High

813463

CAPZB
F-actin-capping protein subunit beta

1

5

High-throughput

0.479

High

832456

MCM2
DNA replication licensing factor MCM2

1

17

High-throughput

0.479

High

870803

UBP14
Ubiquitin carboxyl-terminal hydrolase 14

1

10

High-throughput

0.479

High

923684

PPIA
Peptidyl-prolyl cis-trans isomerase A

1

6

High-throughput

0.479

High

924572

GRB2
Growth factor receptor-bound protein 2

1

20

High-throughput

0.479

High

940896

RNF4
E3 ubiquitin-protein ligase RNF4

1

7

High-throughput

0.479

High

974560

MECOM
Histone-lysine N-methyltransferase MECOM

1

3

High-throughput

0.479

High

983484

PTN12
Tyrosine-protein phosphatase non-receptor type 12

1

3

High-throughput

0.479

High

983833

KPCZ
Protein kinase C zeta type

1

5

High-throughput

0.479

High

1042976

CUL4A
Cullin-4A

1

15

High-throughput

0.479

High

1043790

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

14

High-throughput

0.479

High

1052879

KIF14
Kinesin-like protein KIF14

1

9

High-throughput

0.479

High

1052890

CDC73
Parafibromin

1

6

High-throughput

0.479

High

1052892

FGD5
FYVE, RhoGEF and PH domain-containing protein 5

1

20

High-throughput

0.479

High

1052904

DTX3
Probable E3 ubiquitin-protein ligase DTX3

1

4

Small-scale

0.479

High

1052907

MYOZ3
Myozenin-3

1

10

Small-scale

0.479

High

1052910

SSH1
Protein phosphatase Slingshot homolog 1

1

4

High-throughput

0.479

High

1052912

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

7

High-throughput

0.479

High

1052918

IGSF8
Immunoglobulin superfamily member 8

1

20

High-throughput

0.479

High

1052920

CHM4C
Charged multivesicular body protein 4c

1

18

High-throughput

0.479

High

1052922

SPDLY
Protein Spindly

1

17

High-throughput

0.479

High

1052923

RNF31
E3 ubiquitin-protein ligase RNF31

1

7

High-throughput

0.479

High

1052927

ANM1
Protein arginine N-methyltransferase 1

1

6

High-throughput

0.479

High

1052928

MEP50
Methylosome protein WDR77

1

15

High-throughput

0.479

High

1052930

PINK1
Serine/threonine-protein kinase PINK1, mitochondrial

1

17

High-throughput

0.479

High

1052937

CHM4B
Charged multivesicular body protein 4b

1

18

High-throughput

0.479

High

1052940

PKHA4
Pleckstrin homology domain-containing family A member 4

1

20

High-throughput

0.479

High

1052943

ECT2
Protein ECT2

1

13

High-throughput

0.479

High

1052948

MYOZ2
Myozenin-2

1

10

Small-scale

0.479

High

1052949

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

1

2

High-throughput

0.479

High

1052950

ANLN
Anillin

1

9

High-throughput

0.479

High

1052951

SIR7
NAD-dependent protein deacetylase sirtuin-7

1

9

High-throughput

0.479

High

1052952

RAD18
E3 ubiquitin-protein ligase RAD18

1

3

High-throughput

0.479

High

1052957

TES
Testin

1

20

High-throughput

0.479

High

1052962

CARD8
Caspase recruitment domain-containing protein 8

1

1

High-throughput

0.479

High

1052965

RPGF2
Rap guanine nucleotide exchange factor 2

1

3

High-throughput

0.479

High

329719

AGR2
Anterior gradient protein 2 homolog

1

7

High-throughput

0.470

High

391694

H2A1B
Histone H2A type 1-B/E

1

6

High-throughput

0.470

High

1052894

UBP53
Inactive ubiquitin carboxyl-terminal hydrolase 53

1

6

High-throughput

0.470

High

312757

TFIP8
Tumor necrosis factor alpha-induced protein 8

1

0

High-throughput

0.458

High

879521

BID
BH3-interacting domain death agonist

1

0

Small-scale

0.458

High

1052903

NAT8L
N-acetylaspartate synthetase

1

0

High-throughput

0.458

High

1052926

PI51A
Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha

1

0

High-throughput

0.458

High

166120

SYNEM
Synemin

1

11

Small-scale

0.457

High

626688

ADA1D
Alpha-1D adrenergic receptor

1

8

Small-scale

0.457

High

722936

ADA1A
Alpha-1A adrenergic receptor

1

8

Small-scale

0.457

High

723009

ADA1B
Alpha-1B adrenergic receptor

1

7

Small-scale

0.457

High

930213

UBC9
SUMO-conjugating enzyme UBC9

1

3

High-throughput

0.457

High

1052944

SMUF2
E3 ubiquitin-protein ligase SMURF2

1

12

High-throughput

0.457

High

378049

PRIO
Major prion protein

1

3

High-throughput

0.445

High

1052876

RRP1B
Ribosomal RNA processing protein 1 homolog B

1

10

High-throughput

0.445

High

1052885

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

7

High-throughput

0.445

High

1052900

KIBRA
Protein KIBRA

1

14

High-throughput

0.445

High

1052902

RYBP
RING1 and YY1-binding protein

1

4

High-throughput

0.445

High

1052934

MLP3B
Microtubule-associated proteins 1A/1B light chain 3B

1

16

High-throughput

0.445

High

1052938

MLP3A
Microtubule-associated proteins 1A/1B light chain 3A

1

16

High-throughput

0.445

High

1052964

SHLB1
Endophilin-B1

1

12

High-throughput

0.445

High

100761

APRIO
Alternative prion protein

1

3

High-throughput

0.437

High

552715

RFA2
Replication protein A 32 kDa subunit

1

8

High-throughput

0.437

High

651191

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

6

High-throughput

0.437

High

708641

MCM5
DNA replication licensing factor MCM5

1

16

High-throughput

0.437

High

720453

RFA3
Replication protein A 14 kDa subunit

1

5

High-throughput

0.437

High

1052882

FBX43
F-box only protein 43

1

2

Small-scale

0.437

High

1052898

MGDP1
Magnesium-dependent phosphatase 1

1

3

High-throughput

0.437

High

1052916

ATOH1
Transcription factor ATOH1

1

3

Small-scale

0.437

High

1052946

MET14
N6-adenosine-methyltransferase non-catalytic subunit

1

3

High-throughput

0.437

High

776318

MLH1
DNA mismatch repair protein Mlh1

1

1

Small-scale

0.417

High

47680

A0AUL9
ATG2A protein

1

1

High-throughput

0.407

High

401994

JUN
Transcription factor Jun

1

7

High-throughput

0.407

High

1052915

ESR2
Estrogen receptor beta

1

20

High-throughput

0.407

High

300479

FRYL
Protein furry homolog-like

2

0

High-throughput

0.328

High

66740

ERI2
ERI1 exoribonuclease 2

2

0

High-throughput

0.318

High

1052901

OFCC1
Orofacial cleft 1 candidate gene 1 protein

2

0

High-throughput

0.288

High

1052886

CF141
Uncharacterized protein C6orf141

1

0

High-throughput

0.279

Low

1052888

SPRY7
SPRY domain-containing protein 7

1

0

High-throughput

0.279

Low

1052899

MFN1
Mitofusin-1

1

0

High-throughput

0.279

Low

201119

PAX4
Paired box protein Pax-4

1

0

High-throughput

0.269

Low

1052963

SNX24
Sorting nexin-24

1

0

High-throughput

0.249

Low


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Last updated: 15 Jul 2024