Protein: NGEF
Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor)

Gene: NGEF
Organism: Homo sapiens
Interactions: 87
UniProt ID: Q8N5V2

Gene Ontology (top 5):
GO:0005085 - guanyl-nucleotide exchange factor activity
GO:0005829 - cytosol
GO:0007399 - nervous system development
GO:0016020 - membrane
GO:0030154 - cell differentiation

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

900690

RHOA
Transforming protein RhoA

3

20

Small-scale

0.834

High

784042

KPCI
Protein kinase C iota type

2

14

High-throughput

0.811

High

984514

KPCD
Protein kinase C delta type

2

12

High-throughput

0.811

High

442854

HCK
Tyrosine-protein kinase HCK

2

18

High-throughput

0.767

High

243148

SH21A
SH2 domain-containing protein 1A

2

20

High-throughput

0.743

High

1235264

FEM1A
Protein fem-1 homolog A

1

4

High-throughput

0.691

High

349481

RASH
GTPase HRas

1

13

High-throughput

0.665

High

785556

ACTY
Beta-centractin

2

4

High-throughput

0.628

High

1235275

ARP10
Actin-related protein 10

2

3

High-throughput

0.628

High

47711

S12A8
Solute carrier family 12 member 8

2

1

High-throughput

0.621

High

841811

CDK9
Cyclin-dependent kinase 9

1

6

High-throughput

0.618

High

863485

COPA
Coatomer subunit alpha

1

3

High-throughput

0.618

High

872675

EPHA4
Ephrin type-A receptor 4

1

20

Small-scale

0.618

High

894213

CDC42
Cell division control protein 42 homolog

1

20

Small-scale

0.618

High

925436

RAC1
Ras-related C3 botulinum toxin substrate 1

1

20

Small-scale

0.618

High

1235251

NUP43
Nucleoporin Nup43

1

9

High-throughput

0.618

High

231623

KIF1B
Kinesin-like protein KIF1B

1

10

High-throughput

0.594

High

609419

FGFR3
Fibroblast growth factor receptor 3

1

20

High-throughput

0.594

High

915832

RHOB
Rho-related GTP-binding protein RhoB

1

20

Small-scale

0.590

High

149680

COPE
Coatomer subunit epsilon

2

3

High-throughput

0.571

High

942006

IF4G2
Eukaryotic translation initiation factor 4 gamma 2

2

3

High-throughput

0.571

High

1235252

NUP35
Nucleoporin NUP35

2

2

High-throughput

0.571

High

1170814

TRI67
Tripartite motif-containing protein 67

1

20

High-throughput

0.553

High

176820

EIF3D
Eukaryotic translation initiation factor 3 subunit D

2

0

High-throughput

0.547

High

735994

ATPG
ATP synthase subunit gamma, mitochondrial

1

3

High-throughput

0.541

High

1235283

HCFC2
Host cell factor 2

1

4

High-throughput

0.536

High

1235254

DEP1B
DEP domain-containing protein 1B

2

9

High-throughput

0.521

High

388591

HSPB1
Heat shock protein beta-1

1

4

High-throughput

0.515

High

413994

GELS
Gelsolin

1

5

High-throughput

0.515

High

1166632

LRRN1
Leucine-rich repeat neuronal protein 1

1

0

High-throughput

0.513

High

1235253

NEUA
N-acylneuraminate cytidylyltransferase

1

0

High-throughput

0.513

High

214989

CPSF5
Cleavage and polyadenylation specificity factor subunit 5

1

1

High-throughput

0.508

High

152311

ADA10
Disintegrin and metalloproteinase domain-containing protein 10

1

8

Small-scale

0.501

High

1235256

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

1

7

High-throughput

0.501

High

1235260

SMO
Protein smoothened

1

1

High-throughput

0.494

High

1235266

TRI55
Tripartite motif-containing protein 55

1

20

High-throughput

0.494

High

660619

GRN
Progranulin

1

0

High-throughput

0.493

High

791764

HD
Huntingtin

1

0

High-throughput

0.493

High

212161

HTSF1
17S U2 SnRNP complex component HTATSF1

1

8

High-throughput

0.489

High

1235263

GORS1
Golgi reassembly-stacking protein 1

1

1

High-throughput

0.489

High

1235268

TAF1D
TATA box-binding protein-associated factor RNA polymerase I subunit D

1

0

High-throughput

0.486

High

198669

PSMD3
26S proteasome non-ATPase regulatory subunit 3

1

1

High-throughput

0.479

High

239173

CTND1
Catenin delta-1

1

14

High-throughput

0.479

High

381242

TBB4A
Tubulin beta-4A chain

1

6

High-throughput

0.479

High

422237

NFL
Neurofilament light polypeptide

1

19

High-throughput

0.479

High

614385

PPIB
Peptidyl-prolyl cis-trans isomerase B

1

7

High-throughput

0.479

High

737405

LONM
Lon protease homolog, mitochondrial

1

1

High-throughput

0.479

High

853375

IMA1
Importin subunit alpha-1

1

3

High-throughput

0.479

High

874542

XPO2
Exportin-2

1

4

High-throughput

0.479

High

1057316

SMC1A
Structural maintenance of chromosomes protein 1A

1

8

High-throughput

0.479

High

1201993

CAND1
Cullin-associated NEDD8-dissociated protein 1

1

7

High-throughput

0.479

High

1204670

DDX42
ATP-dependent RNA helicase DDX42

1

5

High-throughput

0.479

High

1235267

XRN2
5'-3' exoribonuclease 2

1

2

High-throughput

0.479

High

1235273

TOM22
Mitochondrial import receptor subunit TOM22 homolog

1

1

High-throughput

0.479

High

1235277

TPX2
Targeting protein for Xklp2

1

5

High-throughput

0.479

High

1235280

NOP58
Nucleolar protein 58

1

3

High-throughput

0.479

High

1235285

COPG1
Coatomer subunit gamma-1

1

10

High-throughput

0.479

High

1235257

TRI63
E3 ubiquitin-protein ligase TRIM63

1

20

High-throughput

0.439

High

703412

CSTF2
Cleavage stimulation factor subunit 2

1

7

High-throughput

0.437

High

839634

SERPH
Serpin H1

1

6

High-throughput

0.437

High

981331

SSBP
Single-stranded DNA-binding protein, mitochondrial

1

3

High-throughput

0.437

High

1047887

CIRBP
Cold-inducible RNA-binding protein

1

10

High-throughput

0.437

High

1124904

ZN326
DBIRD complex subunit ZNF326

1

3

High-throughput

0.437

High

1137534

RIF1
Telomere-associated protein RIF1

1

8

High-throughput

0.437

High

1235255

PSPC1
Paraspeckle component 1

1

9

High-throughput

0.437

High

1235259

RPR1A
Regulation of nuclear pre-mRNA domain-containing protein 1A

1

2

High-throughput

0.437

High

1235265

SF3B5
Splicing factor 3B subunit 5

1

3

High-throughput

0.437

High

1235274

MIC19
MICOS complex subunit MIC19

1

4

High-throughput

0.437

High

1235276

STML2
Stomatin-like protein 2, mitochondrial

1

3

High-throughput

0.437

High

1235278

UTP16
U3 small nucleolar RNA-associated protein NOL7

1

3

High-throughput

0.437

High

1235281

SF3B6
Splicing factor 3B subunit 6

1

13

High-throughput

0.437

High

1235272

MRS2
Magnesium transporter MRS2 homolog, mitochondrial

2

0

High-throughput

0.328

High

1086661

CLPP
ATP-dependent Clp protease proteolytic subunit, mitochondrial

2

0

High-throughput

0.298

High

1235258

LCOR
Ligand-dependent corepressor

1

0

High-throughput

0.282

High

281758

WFS1
Wolframin

1

0

High-throughput

0.268

Low

1235282

RNF11
RING finger protein 11

1

0

High-throughput

0.268

Low

1235284

Q9Y649
GW128

1

0

High-throughput

0.268

Low

1235261

CG025
UPF0415 protein C7orf25

1

0

High-throughput

0.265

Low

1235262

F118B
Protein FAM118B

1

0

High-throughput

0.265

Low

1235269

CH033
UPF0488 protein C8orf33

1

0

High-throughput

0.265

Low

1235271

RM44
Large ribosomal subunit protein mL44

1

0

High-throughput

0.265

Low

335142

DHE3
Glutamate dehydrogenase 1, mitochondrial

1

0

High-throughput

0.249

Low

674697

AMRP
Alpha-2-macroglobulin receptor-associated protein

1

0

High-throughput

0.249

Low

966261

TFAP4
Transcription factor AP-4

1

0

Small-scale

0.249

Low

1140489

MIC13
MICOS complex subunit MIC13

1

0

High-throughput

0.249

Low

1235270

SFXN1
Sideroflexin-1

1

0

High-throughput

0.249

Low

1235279

SSRG
Translocon-associated protein subunit gamma

1

0

High-throughput

0.249

Low


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Last updated: 15 Jul 2024