Protein: LEO1
RNA polymerase-associated protein LEO1 (Replicative senescence down-regulated leo1-like protein)

Gene: LEO1
Organism: Homo sapiens
Interactions: 111
UniProt ID: Q8WVC0

Gene Ontology (top 5):
GO:0001650 - fibrillar center
GO:0001711 - endodermal cell fate commitment
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005813 - centrosome

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1237136

PAF1
RNA polymerase II-associated factor 1 homolog

14

9

Small-scale

0.984

High

1158288

CDC73
Parafibromin

14

2

Small-scale

0.760

High

1160947

CTR9
RNA polymerase-associated protein CTR9 homolog

9

5

Small-scale

0.751

High

1261239

SKI8
Superkiller complex protein 8

6

5

Small-scale

0.732

High

1051993

ELOA1
Elongin-A

3

2

Small-scale

0.656

High

1261230

RTF1
RNA polymerase-associated protein RTF1 homolog

3

2

Small-scale

0.650

High

612999

TCEA1
Transcription elongation factor A protein 1

2

2

Small-scale

0.643

High

124025

SPT5H
Transcription elongation factor SPT5

2

2

High-throughput

0.628

High

489177

H14
Histone H1.4

2

2

High-throughput

0.628

High

274708

TCEA3
Transcription elongation factor A protein 3

2

4

High-throughput

0.606

High

624971

RPB1
DNA-directed RNA polymerase II subunit RPB1

2

2

Small-scale

0.585

High

665930

PTN6
Tyrosine-protein phosphatase non-receptor type 6

2

1

Small-scale

0.584

High

737943

PP1G
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit

2

1

High-throughput

0.584

High

1161644

GASP3
G protein-coupled receptor associated sorting protein 3

2

0

High-throughput

0.580

High

934345

CSK21
Casein kinase II subunit alpha

1

1

High-throughput

0.569

High

559860

H12
Histone H1.2

1

2

Small-scale

0.561

High

850755

BMX
Cytoplasmic tyrosine-protein kinase BMX

2

0

High-throughput

0.547

High

508628

TOP1
DNA topoisomerase 1

1

1

High-throughput

0.536

High

583527

RPB3
DNA-directed RNA polymerase II subunit RPB3

1

2

High-throughput

0.536

High

818296

SOX2
Transcription factor SOX-2

1

2

High-throughput

0.536

High

851855

UB2E1
Ubiquitin-conjugating enzyme E2 E1

1

2

Small-scale

0.536

High

891924

ACTB
Actin, cytoplasmic 1

1

1

High-throughput

0.536

High

906043

PP1A
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit

1

1

High-throughput

0.536

High

943141

KC1G2
Casein kinase I isoform gamma-2

1

2

High-throughput

0.536

High

975292

KMT2A
Histone-lysine N-methyltransferase 2A

1

1

Small-scale

0.536

High

996790

SSRP1
FACT complex subunit SSRP1

1

3

High-throughput

0.536

High

1045641

NOG2
Nucleolar GTP-binding protein 2

1

2

High-throughput

0.536

High

1087291

H2B2E
Histone H2B type 2-E

1

1

High-throughput

0.536

High

1121358

SETMR
Histone-lysine N-methyltransferase SETMAR

1

1

High-throughput

0.536

High

1261231

TOP1M
DNA topoisomerase I, mitochondrial

1

1

High-throughput

0.536

High

1261237

UBXN6
UBX domain-containing protein 6

1

1

High-throughput

0.536

High

1261249

RUVB2
RuvB-like 2

1

5

High-throughput

0.536

High

1043990

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

0

High-throughput

0.518

High

50444

SYCE3
Synaptonemal complex central element protein 3

1

0

High-throughput

0.513

High

146844

CDKA1
Cyclin-dependent kinase 2-associated protein 1

1

0

High-throughput

0.513

High

312945

SLU7
Pre-mRNA-splicing factor SLU7

1

0

High-throughput

0.513

High

446715

SNRPA
U1 small nuclear ribonucleoprotein A

1

0

High-throughput

0.513

High

448752

RU1C
U1 small nuclear ribonucleoprotein C

1

0

High-throughput

0.513

High

539071

RSMB
Small nuclear ribonucleoprotein-associated proteins B and B'

1

0

High-throughput

0.513

High

686018

ARRB2
Beta-arrestin-2

1

0

High-throughput

0.513

High

726952

FUS
RNA-binding protein FUS

1

0

High-throughput

0.513

High

911911

RUXF
Small nuclear ribonucleoprotein F

1

0

High-throughput

0.513

High

913925

RPB7
DNA-directed RNA polymerase II subunit RPB7

1

0

High-throughput

0.513

High

951882

SERF2
Small EDRK-rich factor 2

1

0

High-throughput

0.513

High

1069449

TEBP
Prostaglandin E synthase 3

1

0

High-throughput

0.513

High

1084544

CPSF6
Cleavage and polyadenylation specificity factor subunit 6

1

0

High-throughput

0.513

High

1137935

RPRD2
Regulation of nuclear pre-mRNA domain-containing protein 2

1

0

High-throughput

0.513

High

1192591

PXK
PX domain-containing protein kinase-like protein

1

0

High-throughput

0.513

High

1261240

AGO4
Protein argonaute-4

1

0

High-throughput

0.513

High

1261242

ANLN
Anillin

1

0

High-throughput

0.513

High

1261248

COG5
Conserved oligomeric Golgi complex subunit 5

1

0

High-throughput

0.513

High

976484

ERCC6
DNA excision repair protein ERCC-6

1

7

High-throughput

0.501

High

717235

CTNB1
Catenin beta-1

1

0

Small-scale

0.493

High

975697

LMNB2
Lamin-B2

1

1

High-throughput

0.489

High

1261233

TCPQM
T-complex protein 1 subunit theta-like 2

1

1

High-throughput

0.489

High

163056

XPO1
Exportin-1

1

2

High-throughput

0.479

High

179744

RPA34
DNA-directed RNA polymerase I subunit RPA34

1

1

High-throughput

0.479

High

244698

BRD4
Bromodomain-containing protein 4

1

3

High-throughput

0.479

High

382089

G3P
Glyceraldehyde-3-phosphate dehydrogenase

1

1

Small-scale

0.479

High

455695

PARP1
Poly [ADP-ribose] polymerase 1

1

2

High-throughput

0.479

High

631524

BRD2
Bromodomain-containing protein 2

1

4

High-throughput

0.479

High

828318

CENPA
Histone H3-like centromeric protein A

1

2

High-throughput

0.479

High

908876

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

4

High-throughput

0.479

High

917652

H4
Histone H4

1

3

High-throughput

0.479

High

935030

H31
Histone H3.1

1

2

Small-scale

0.479

High

971287

H11
Histone H1.1

1

2

Small-scale

0.479

High

985998

PTN11
Tyrosine-protein phosphatase non-receptor type 11

1

1

Small-scale

0.479

High

998916

EP300
Histone acetyltransferase p300

1

2

High-throughput

0.479

High

1059757

CHD4
Chromodomain-helicase-DNA-binding protein 4

1

5

High-throughput

0.479

High

1065667

SETB1
Histone-lysine N-methyltransferase SETDB1

1

2

Small-scale

0.479

High

1116411

LARP7
La-related protein 7

1

2

High-throughput

0.479

High

1244396

NUP43
Nucleoporin Nup43

1

4

High-throughput

0.479

High

1261232

EHMT2
Histone-lysine N-methyltransferase EHMT2

1

3

Small-scale

0.479

High

1261236

MK67I
MKI67 FHA domain-interacting nucleolar phosphoprotein

1

2

High-throughput

0.479

High

1261238

RPA49
DNA-directed RNA polymerase I subunit RPA49

1

1

High-throughput

0.479

High

1261246

DNM3B
DNA

1

1

Small-scale

0.479

High

1261247

ZRAN1
Ubiquitin thioesterase ZRANB1

1

1

High-throughput

0.479

High

1261251

DNM3A
DNA

1

1

Small-scale

0.479

High

133585

NOP56
Nucleolar protein 56

1

0

High-throughput

0.458

High

387187

P53
Cellular tumor antigen p53

1

0

High-throughput

0.458

High

569900

CEBPB
CCAAT/enhancer-binding protein beta

1

0

High-throughput

0.458

High

750376

COIL
Coilin

1

0

High-throughput

0.458

High

887534

ELOF1
Transcription elongation factor 1 homolog

1

0

Small-scale

0.458

High

931762

CSK2B
Casein kinase II subunit beta

1

0

High-throughput

0.458

High

1064524

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

0

High-throughput

0.458

High

1072395

ELOB
Elongin-B

1

0

High-throughput

0.458

High

1261229

SMG7
Nonsense-mediated mRNA decay factor SMG7

1

0

High-throughput

0.458

High

1261234

DDX23
Probable ATP-dependent RNA helicase DDX23

1

0

High-throughput

0.458

High

1261235

DDA1
DET1- and DDB1-associated protein 1

1

0

High-throughput

0.458

High

1261243

RAD18
E3 ubiquitin-protein ligase RAD18

1

0

High-throughput

0.458

High

1261244

TE2IP
Telomeric repeat-binding factor 2-interacting protein 1

1

0

High-throughput

0.458

High

1261245

TLS1
Splicing factor C9orf78

1

0

High-throughput

0.458

High

1261250

ZN330
Zinc finger protein 330

1

0

High-throughput

0.458

High

829038

UBE2A
Ubiquitin-conjugating enzyme E2 A

1

3

Small-scale

0.445

High

927764

UBE2B
Ubiquitin-conjugating enzyme E2 B

1

3

Small-scale

0.445

High

1261241

CHD8
Chromodomain-helicase-DNA-binding protein 8

1

5

High-throughput

0.445

High

282979

CIAO1
Probable cytosolic iron-sulfur protein assembly protein CIAO1

1

1

High-throughput

0.437

High

385234

NTRK1
High affinity nerve growth factor receptor

1

4

High-throughput

0.437

High

932283

ACTC
Actin, alpha cardiac muscle 1

1

1

High-throughput

0.437

High

1170985

TRI67
Tripartite motif-containing protein 67

1

1

High-throughput

0.437

High

295650

RMP
Unconventional prefoldin RPB5 interactor 1

1

0

Small-scale

0.426

High

989030

FMR1
Fragile X messenger ribonucleoprotein 1

1

0

High-throughput

0.426

High

124519

TULP2
Tubby-related protein 2

2

0

High-throughput

0.328

High

204507

ARK72
Aflatoxin B1 aldehyde reductase member 2

1

0

High-throughput

0.279

Low

828845

SRP09
Signal recognition particle 9 kDa protein

1

0

High-throughput

0.279

Low

1223307

CPNE9
Copine-9

1

0

High-throughput

0.279

Low

1238325

SYT2
Synaptotagmin-2

1

0

High-throughput

0.279

Low

362015

FIBG
Fibrinogen gamma chain

1

0

Small-scale

0.249

Low

390406

RPN1
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1

1

0

High-throughput

0.249

Low

778227

ECHA
Trifunctional enzyme subunit alpha, mitochondrial

1

0

High-throughput

0.249

Low

876022

ECHB
Trifunctional enzyme subunit beta, mitochondrial

1

0

High-throughput

0.249

Low


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Last updated: 15 Jul 2024