Protein: SPB4
Serpin B4 (Leupin) (Peptidase inhibitor 11) (PI-11) (Squamous cell carcinoma antigen 2) (SCCA-2)

Gene: SPB4, SERPINB4
Organism: Homo sapiens
Interactions: 186
UniProt ID: P48594

Gene Ontology (top 5):
GO:0002020 - protease binding
GO:0004867 - serine-type endopeptidase inhibitor activity
GO:0005615 - extracellular space
GO:0005829 - cytosol
GO:0005886 - plasma membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

667928

SPB3
Serpin B3

4

5

High-throughput

0.895

High

588755

DPA1
HLA class II histocompatibility antigen, DP alpha 1 chain

3

1

High-throughput

0.861

High

820307

GPR18
N-arachidonyl glycine receptor

3

11

High-throughput

0.667

High

820308

KI3S1
Killer cell immunoglobulin-like receptor 3DS1

3

7

High-throughput

0.667

High

820364

SUSD3
Sushi domain-containing protein 3

3

1

High-throughput

0.667

High

820390

UD110
UDP-glucuronosyltransferase 1A10

3

3

High-throughput

0.667

High

439323

CATG
Cathepsin G

1

20

Small-scale

0.647

High

820338

EFNMT
eEF1A lysine and N-terminal methyltransferase

3

0

High-throughput

0.634

High

658605

HXD10
Homeobox protein Hox-D10

3

0

High-throughput

0.629

High

351525

ANF
Natriuretic peptides A

2

1

High-throughput

0.628

High

365168

FRIH
Ferritin heavy chain

2

5

High-throughput

0.628

High

714610

MPI
Mannose-6-phosphate isomerase

2

1

High-throughput

0.628

High

820339

CCYL1
Cyclin-Y-like protein 1

2

2

High-throughput

0.628

High

820362

RM38
Large ribosomal subunit protein mL38

2

2

High-throughput

0.628

High

820367

CDK15
Cyclin-dependent kinase 15

2

7

High-throughput

0.628

High

820379

PINK1
Serine/threonine-protein kinase PINK1, mitochondrial

2

6

High-throughput

0.628

High

820411

STA13
StAR-related lipid transfer protein 13

2

1

High-throughput

0.621

High

820305

ITA9
Integrin alpha-9

2

3

High-throughput

0.611

High

820322

MYOME
Myomegalin

2

6

High-throughput

0.611

High

563815

ZSC20
Zinc finger and SCAN domain-containing protein 20

3

2

High-throughput

0.609

High

820290

UCP2
Dicarboxylate carrier SLC25A8

3

5

High-throughput

0.609

High

820375

PHAF1
Phagosome assembly factor 1

3

2

High-throughput

0.609

High

820358

RNF25
E3 ubiquitin-protein ligase RNF25

2

0

High-throughput

0.602

High

820306

IL18
Interleukin-18

2

0

High-throughput

0.585

High

800720

MK08
Mitogen-activated protein kinase 8

1

3

Small-scale

0.578

High

820312

ZIC1
Zinc finger protein ZIC 1

2

7

High-throughput

0.574

High

820334

Z354C
Zinc finger protein 354C

2

1

High-throughput

0.574

High

820342

ASCC1
Activating signal cointegrator 1 complex subunit 1

2

1

High-throughput

0.574

High

820387

ACAD9
Complex I assembly factor ACAD9, mitochondrial

2

3

High-throughput

0.574

High

820392

SHCAF
SIN3-HDAC complex-associated factor

2

2

High-throughput

0.574

High

820396

TB22B
TBC1 domain family member 22B

2

7

High-throughput

0.574

High

820336

SLX4
Structure-specific endonuclease subunit SLX4

2

6

High-throughput

0.571

High

820402

DPOLL
DNA polymerase lambda

2

1

High-throughput

0.558

High

820405

DD19B
ATP-dependent RNA helicase DDX19B

2

9

High-throughput

0.558

High

125984

UPK1A
Uroplakin-1a

1

8

High-throughput

0.536

High

215810

G6PT1
Glucose-6-phosphate exchanger SLC37A4

1

4

High-throughput

0.536

High

239852

HCN1
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

1

5

High-throughput

0.536

High

274959

RENR
Renin receptor

1

6

High-throughput

0.536

High

277405

RASF9
Ras association domain-containing protein 9

1

3

High-throughput

0.536

High

320185

ERR2
Steroid hormone receptor ERR2

1

8

High-throughput

0.536

High

325087

AIFM1
Apoptosis-inducing factor 1, mitochondrial

1

2

High-throughput

0.536

High

328115

SG1D1
Secretoglobin family 1D member 1

1

4

High-throughput

0.536

High

329095

NUDT3
Diphosphoinositol polyphosphate phosphohydrolase 1

1

4

High-throughput

0.536

High

338114

EGFR
Epidermal growth factor receptor

1

4

High-throughput

0.536

High

369170

ESR1
Estrogen receptor

1

8

High-throughput

0.536

High

433287

YES
Tyrosine-protein kinase Yes

1

1

High-throughput

0.536

High

445940

NMB
Neuromedin-B [Cleaved into: Neuromedin-B-32; Neuromedin-B]

1

1

High-throughput

0.536

High

506813

SPTB1
Spectrin beta chain, erythrocytic

1

1

High-throughput

0.536

High

565898

AATC
Aspartate aminotransferase, cytoplasmic

1

8

High-throughput

0.536

High

647845

MARK3
MAP/microtubule affinity-regulating kinase 3

1

1

High-throughput

0.536

High

671748

PDIA3
Protein disulfide-isomerase A3

1

2

High-throughput

0.536

High

673315

MIP
Lens fiber major intrinsic protein

1

1

High-throughput

0.536

High

686612

CCR1
C-C chemokine receptor type 1

1

7

High-throughput

0.536

High

687022

GRK4
G protein-coupled receptor kinase 4

1

3

High-throughput

0.536

High

782753

CSK
Tyrosine-protein kinase CSK

1

2

High-throughput

0.536

High

819526

PCP4
Calmodulin regulator protein PCP4

1

3

High-throughput

0.536

High

820285

GSK3B
Glycogen synthase kinase-3 beta

1

1

High-throughput

0.536

High

820287

BMX
Cytoplasmic tyrosine-protein kinase BMX

1

3

High-throughput

0.536

High

820288

MP2K6
Dual specificity mitogen-activated protein kinase kinase 6

1

4

High-throughput

0.536

High

820291

STX17
Syntaxin-17

1

10

High-throughput

0.536

High

820293

RB11A
Ras-related protein Rab-11A

1

3

High-throughput

0.536

High

820297

2ABB
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform

1

9

High-throughput

0.536

High

820298

GCYA1
Guanylate cyclase soluble subunit alpha-1

1

3

High-throughput

0.536

High

820301

FMOD
Fibromodulin

1

1

High-throughput

0.536

High

820304

CUL2
Cullin-2

1

6

High-throughput

0.536

High

820310

STK11
Serine/threonine-protein kinase STK11

1

4

High-throughput

0.536

High

820313

PKN2
Serine/threonine-protein kinase N2

1

8

High-throughput

0.536

High

820314

MK06
Mitogen-activated protein kinase 6

1

2

High-throughput

0.536

High

820343

FNDC5
Fibronectin type III domain-containing protein 5

1

6

High-throughput

0.536

High

820346

O13C3
Olfactory receptor 13C3

1

4

High-throughput

0.536

High

820347

MYBPP
MYCBP-associated protein

1

1

High-throughput

0.536

High

820350

ITLN2
Intelectin-2

1

2

High-throughput

0.536

High

820353

TANK
TRAF family member-associated NF-kappa-B activator

1

1

High-throughput

0.536

High

820354

CSN5
COP9 signalosome complex subunit 5

1

1

High-throughput

0.536

High

820355

CUL5
Cullin-5

1

6

High-throughput

0.536

High

820357

SIA7F
Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6

1

4

High-throughput

0.536

High

820366

FMNL2
Formin-like protein 2

1

1

High-throughput

0.536

High

820370

PFD5
Prefoldin subunit 5

1

1

High-throughput

0.536

High

820385

FBX44
F-box only protein 44

1

5

High-throughput

0.536

High

820394

MBNL1
Muscleblind-like protein 1

1

5

High-throughput

0.536

High

820397

KLH11
Kelch-like protein 11

1

6

High-throughput

0.536

High

820401

DKK2
Dickkopf-related protein 2

1

1

High-throughput

0.536

High

820408

MAST1
Microtubule-associated serine/threonine-protein kinase 1

1

1

High-throughput

0.536

High

820410

CHMP3
Charged multivesicular body protein 3

1

1

High-throughput

0.536

High

820412

RN115
E3 ubiquitin-protein ligase RNF115

1

6

High-throughput

0.536

High

820407

FBW1A
F-box/WD repeat-containing protein 1A

1

5

High-throughput

0.515

High

820294

X3CL1
Fractalkine

1

0

High-throughput

0.513

High

820296

DAB2
Disabled homolog 2

1

0

High-throughput

0.513

High

820315

INSC
Protein inscuteable homolog

1

0

High-throughput

0.513

High

820325

DESI1
Desumoylating isopeptidase 1

1

0

High-throughput

0.513

High

820373

RNZ2
Zinc phosphodiesterase ELAC protein 2

1

0

High-throughput

0.513

High

820384

LRRN3
Leucine-rich repeat neuronal protein 3

1

0

High-throughput

0.513

High

820391

GPN1
GPN-loop GTPase 1

1

0

High-throughput

0.513

High

51002

PL8L1
PLAC8-like protein 1

1

1

High-throughput

0.489

High

128718

RTCA
RNA 3'-terminal phosphate cyclase

1

2

High-throughput

0.489

High

209319

TSN6
Tetraspanin-6

1

5

High-throughput

0.489

High

217552

NDUS5
NADH dehydrogenase [ubiquinone] iron-sulfur protein 5

1

2

High-throughput

0.489

High

265312

MED24
Mediator of RNA polymerase II transcription subunit 24

1

1

High-throughput

0.489

High

303670

OR2A4
Olfactory receptor 2A4

1

13

High-throughput

0.489

High

305385

ZFPL1
Zinc finger protein-like 1

1

1

High-throughput

0.489

High

309377

MBD4
Methyl-CpG-binding domain protein 4

1

1

High-throughput

0.489

High

518285

ADT3
ADP/ATP translocase 3

1

3

High-throughput

0.489

High

521233

SKI
Ski oncogene

1

2

High-throughput

0.489

High

584566

ERCC3
General transcription and DNA repair factor IIH helicase/translocase subunit XPB

1

6

High-throughput

0.489

High

624410

CCNC
Cyclin-C

1

6

High-throughput

0.489

High

801019

KI67
Proliferation marker protein Ki-67

1

1

High-throughput

0.489

High

820284

PTSS1
Phosphatidylserine synthase 1

1

2

High-throughput

0.489

High

820286

ASCL1
Achaete-scute homolog 1

1

4

High-throughput

0.489

High

820289

NDST2
Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 2

1

1

High-throughput

0.489

High

820292

DSCR6
Protein ripply3

1

7

High-throughput

0.489

High

820295

SSBP2
Single-stranded DNA-binding protein 2

1

5

High-throughput

0.489

High

820299

EF1A2
Elongation factor 1-alpha 2

1

3

High-throughput

0.489

High

820300

GABPA
GA-binding protein alpha chain

1

5

High-throughput

0.489

High

820302

ZN154
Zinc finger protein 154

1

2

High-throughput

0.489

High

820316

ZN674
Zinc finger protein 674

1

2

High-throughput

0.489

High

820317

CR021
UPF0711 protein C18orf21

1

6

High-throughput

0.489

High

820319

LRC10
Leucine-rich repeat-containing protein 10

1

4

High-throughput

0.489

High

820320

EMC4
ER membrane protein complex subunit 4

1

3

High-throughput

0.489

High

820323

UBE2U
Ubiquitin-conjugating enzyme E2 U

1

5

High-throughput

0.489

High

820326

DPPA4
Developmental pluripotency-associated protein 4

1

1

High-throughput

0.489

High

820327

APTX
Aprataxin

1

3

High-throughput

0.489

High

820328

ZN550
Zinc finger protein 550

1

3

High-throughput

0.489

High

820329

NEK8
Serine/threonine-protein kinase Nek8

1

4

High-throughput

0.489

High

820330

MOGT3
2-acylglycerol O-acyltransferase 3

1

7

High-throughput

0.489

High

820331

BPHL
Valacyclovir hydrolase

1

1

High-throughput

0.489

High

820332

COA5
Cytochrome c oxidase assembly factor 5

1

2

High-throughput

0.489

High

820335

CERS3
Ceramide synthase 3

1

2

High-throughput

0.489

High

820337

NRSN1
Neurensin-1

1

1

High-throughput

0.489

High

820340

PDILT
Protein disulfide-isomerase-like protein of the testis

1

4

High-throughput

0.489

High

820341

FRMD1
FERM domain-containing protein 1

1

3

High-throughput

0.489

High

820345

ANKK1
Ankyrin repeat and protein kinase domain-containing protein 1

1

5

High-throughput

0.489

High

820348

STK35
Serine/threonine-protein kinase 35

1

1

High-throughput

0.489

High

820349

RHBL4
Rhomboid-related protein 4

1

4

High-throughput

0.489

High

820356

PIGT
GPI transamidase component PIG-T

1

4

High-throughput

0.489

High

820360

SARAF
Store-operated calcium entry-associated regulatory factor

1

8

High-throughput

0.489

High

820365

F227B
Protein FAM227B

1

3

High-throughput

0.489

High

820368

TEFM
Transcription elongation factor, mitochondrial

1

4

High-throughput

0.489

High

820369

FCRL5
Fc receptor-like protein 5

1

1

High-throughput

0.489

High

820371

PLCA
1-acyl-sn-glycerol-3-phosphate acyltransferase alpha

1

6

High-throughput

0.489

High

820372

TREX2
Three prime repair exonuclease 2

1

2

High-throughput

0.489

High

820374

SH23A
SH2 domain-containing protein 3A

1

9

High-throughput

0.489

High

820376

MMTA2
Multiple myeloma tumor-associated protein 2

1

5

High-throughput

0.489

High

820378

FUND2
FUN14 domain-containing protein 2

1

2

High-throughput

0.489

High

820380

SRRT
Serrate RNA effector molecule homolog

1

5

High-throughput

0.489

High

820386

ZDHC6
Palmitoyltransferase ZDHHC6

1

1

High-throughput

0.489

High

820389

COE2
Transcription factor COE2

1

5

High-throughput

0.489

High

820393

TSSP
Thymus-specific serine protease

1

5

High-throughput

0.489

High

820395

ST7
Suppressor of tumorigenicity 7 protein

1

1

High-throughput

0.489

High

820398

RM39
Large ribosomal subunit protein mL39

1

1

High-throughput

0.489

High

820399

PK2L2
Polycystin-2-like protein 2

1

2

High-throughput

0.489

High

820400

THA10
THAP domain-containing protein 10

1

1

High-throughput

0.489

High

820403

SMBT1
Scm-like with four MBT domains protein 1

1

1

High-throughput

0.489

High

820404

PHF11
PHD finger protein 11

1

8

High-throughput

0.489

High

820406

CD11A
Cyclin-dependent kinase 11A

1

1

High-throughput

0.489

High

820409

SSUH2
Protein SSUH2 homolog

1

8

High-throughput

0.489

High

820413

NPTN
Neuroplastin

1

1

High-throughput

0.489

High

396704

S10A8
Protein S100-A8

1

7

High-throughput

0.479

High

416382

S10A9
Protein S100-A9

1

9

High-throughput

0.479

High

678422

S10A7
Protein S100-A7

1

9

High-throughput

0.479

High

814918

LEG7
Galectin-7

1

3

High-throughput

0.479

High

820309

TNIP1
TNFAIP3-interacting protein 1

1

3

High-throughput

0.479

High

820352

ESR2
Estrogen receptor beta

1

8

High-throughput

0.479

High

820381

FACD2
Fanconi anemia group D2 protein

1

12

High-throughput

0.479

High

820311

USF2
Upstream stimulatory factor 2

1

7

High-throughput

0.470

High

608913

SPR2D
Small proline-rich protein 2D

1

0

High-throughput

0.458

High

820363

SIR1
NAD-dependent protein deacetylase sirtuin-1

1

0

Small-scale

0.458

High

820324

RNLS
Renalase

1

1

Small-scale

0.445

High

820383

GBRL1
Gamma-aminobutyric acid receptor-associated protein-like 1

1

5

High-throughput

0.445

High

346207

MYC
Myc proto-oncogene protein

1

7

High-throughput

0.437

High

569370

CEBPB
CCAAT/enhancer-binding protein beta

1

5

High-throughput

0.437

High

820382

DDX24
ATP-dependent RNA helicase DDX24

1

4

High-throughput

0.437

High

820414

SCC4
MAU2 chromatid cohesion factor homolog

1

1

High-throughput

0.437

High

92437

E9PDS3
Integrin subunit alpha 9

1

3

High-throughput

0.407

High

820321

Q5JQP4
DNA polymerase

1

1

High-throughput

0.407

High

820318

CCD92
Coiled-coil domain-containing protein 92

3

0

High-throughput

0.347

High

820377

YJU2
Splicing factor YJU2

3

0

High-throughput

0.347

High

595900

CP3A5
Cytochrome P450 3A5

2

0

High-throughput

0.328

High

820333

ZFAN4
AN1-type zinc finger protein 4

2

0

High-throughput

0.328

High

820351

PPM1E
Protein phosphatase 1E

2

0

High-throughput

0.328

High

820359

UPP
Uracil phosphoribosyltransferase homolog

2

0

High-throughput

0.328

High

472796

H2AB1
Histone H2A-Bbd type 1

1

0

High-throughput

0.279

Low

590553

PO3F3
POU domain, class 3, transcription factor 3

1

0

High-throughput

0.279

Low

820303

MMRN1
Multimerin-1

1

0

High-throughput

0.279

Low

820344

UBAC2
Ubiquitin-associated domain-containing protein 2

1

0

High-throughput

0.279

Low

820361

FWCH2
FLYWCH family member 2

1

0

High-throughput

0.279

Low

820388

L2HDH
L-2-hydroxyglutarate dehydrogenase, mitochondrial

1

0

High-throughput

0.279

Low


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Last updated: 15 Jul 2024