Protein: SPB3
Serpin B3 (Protein T4-A) (Squamous cell carcinoma antigen 1) (SCCA-1)

Gene: SPB3, SERPINB3
Organism: Homo sapiens
Interactions: 203
UniProt ID: P29508

Gene Ontology (top 5):
GO:0001618 - virus receptor activity
GO:0002020 - protease binding
GO:0004867 - serine-type endopeptidase inhibitor activity
GO:0004869 - cysteine-type endopeptidase inhibitor activity
GO:0005576 - extracellular region

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

667928

SPB4
Serpin B4

4

5

High-throughput

0.895

High

668050

SCN3B
Sodium channel regulatory subunit beta-3

1

2

High-throughput

0.691

High

563811

ZSC20
Zinc finger and SCAN domain-containing protein 20

3

2

High-throughput

0.667

High

667963

GPR18
N-arachidonyl glycine receptor

3

11

High-throughput

0.667

High

667964

KI3S1
Killer cell immunoglobulin-like receptor 3DS1

3

7

High-throughput

0.667

High

667996

ASCC1
Activating signal cointegrator 1 complex subunit 1

3

1

High-throughput

0.667

High

668012

SUSD3
Sushi domain-containing protein 3

3

1

High-throughput

0.667

High

668065

SHLB1
Endophilin-B1

3

2

High-throughput

0.667

High

351521

ANF
Natriuretic peptides A

2

1

High-throughput

0.628

High

365156

FRIH
Ferritin heavy chain

2

5

High-throughput

0.628

High

667969

ZIC1
Zinc finger protein ZIC 1

2

7

High-throughput

0.628

High

668011

RM38
Large ribosomal subunit protein mL38

2

2

High-throughput

0.628

High

668014

CDK15
Cyclin-dependent kinase 15

2

7

High-throughput

0.628

High

668024

RBM24
RNA-binding protein 24

2

3

High-throughput

0.628

High

668034

ACAD9
Complex I assembly factor ACAD9, mitochondrial

2

3

High-throughput

0.628

High

668035

DDX31
ATP-dependent DNA helicase DDX31

2

5

High-throughput

0.628

High

429829

CATL1
Procathepsin L

2

2

Small-scale

0.619

High

427049

CATD
Cathepsin D

1

1

High-throughput

0.618

High

629093

ZA2G
Zinc-alpha-2-glycoprotein

1

2

High-throughput

0.618

High

667923

SPB5
Serpin B5

1

5

High-throughput

0.618

High

668055

PD1L1
Programmed cell death 1 ligand 1

1

1

High-throughput

0.618

High

667976

MYOME
Myomegalin

2

6

High-throughput

0.611

High

668062

DD19B
ATP-dependent RNA helicase DDX19B

2

9

High-throughput

0.611

High

668021

PHAF1
Phagosome assembly factor 1

3

2

High-throughput

0.609

High

346014

MYC
Myc proto-oncogene protein

2

6

High-throughput

0.584

High

667925

MK08
Mitogen-activated protein kinase 8

1

3

Small-scale

0.578

High

667934

UCP2
Dicarboxylate carrier SLC25A8

2

5

High-throughput

0.574

High

668046

TB22B
TBC1 domain family member 22B

2

7

High-throughput

0.574

High

668002

ARH40
Rho guanine nucleotide exchange factor 40

2

2

High-throughput

0.571

High

63634

RASFA
Ras association domain-containing protein 10

1

2

High-throughput

0.536

High

125976

UPK1A
Uroplakin-1a

1

8

High-throughput

0.536

High

128709

RTCA
RNA 3'-terminal phosphate cyclase

1

2

High-throughput

0.536

High

174364

FANCG
Fanconi anemia group G protein

1

2

High-throughput

0.536

High

209315

TSN6
Tetraspanin-6

1

5

High-throughput

0.536

High

213888

DYRK3
Dual specificity tyrosine-phosphorylation-regulated kinase 3

1

4

High-throughput

0.536

High

215806

G6PT1
Glucose-6-phosphate exchanger SLC37A4

1

4

High-throughput

0.536

High

217447

AIRE
Autoimmune regulator

1

8

High-throughput

0.536

High

236885

BUB1B
Mitotic checkpoint serine/threonine-protein kinase BUB1 beta

1

4

High-throughput

0.536

High

239801

HCN1
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

1

5

High-throughput

0.536

High

270766

FOXH1
Forkhead box protein H1

1

5

High-throughput

0.536

High

274941

RENR
Renin receptor

1

6

High-throughput

0.536

High

277402

RASF9
Ras association domain-containing protein 9

1

3

High-throughput

0.536

High

305367

ZFPL1
Zinc finger protein-like 1

1

1

High-throughput

0.536

High

325046

AIFM1
Apoptosis-inducing factor 1, mitochondrial

1

2

High-throughput

0.536

High

328109

SG1D1
Secretoglobin family 1D member 1

1

4

High-throughput

0.536

High

329089

NUDT3
Diphosphoinositol polyphosphate phosphohydrolase 1

1

4

High-throughput

0.536

High

445938

NMB
Neuromedin-B [Cleaved into: Neuromedin-B-32; Neuromedin-B]

1

1

High-throughput

0.536

High

507542

PIM1
Serine/threonine-protein kinase pim-1

1

3

High-throughput

0.536

High

518259

ADT3
ADP/ATP translocase 3

1

3

High-throughput

0.536

High

521221

SKI
Ski oncogene

1

2

High-throughput

0.536

High

528609

CFTR
Cystic fibrosis transmembrane conductance regulator

1

7

High-throughput

0.536

High

565876

AATC
Aspartate aminotransferase, cytoplasmic

1

8

High-throughput

0.536

High

584554

ERCC3
General transcription and DNA repair factor IIH helicase/translocase subunit XPB

1

6

High-throughput

0.536

High

624399

CCNC
Cyclin-C

1

6

High-throughput

0.536

High

667915

PDIA3
Protein disulfide-isomerase A3

1

2

High-throughput

0.536

High

667916

MIP
Lens fiber major intrinsic protein

1

1

High-throughput

0.536

High

667920

CCR1
C-C chemokine receptor type 1

1

7

High-throughput

0.536

High

667921

GRK4
G protein-coupled receptor kinase 4

1

2

High-throughput

0.536

High

667927

PCP4
Calmodulin regulator protein PCP4

1

3

High-throughput

0.536

High

667931

ASCL1
Achaete-scute homolog 1

1

4

High-throughput

0.536

High

667932

BMX
Cytoplasmic tyrosine-protein kinase BMX

1

3

High-throughput

0.536

High

667935

STX17
Syntaxin-17

1

10

High-throughput

0.536

High

667936

DSCR6
Protein ripply3

1

7

High-throughput

0.536

High

667937

CF298
Cilia- and flagella-associated protein 298

1

4

High-throughput

0.536

High

667941

RB11A
Ras-related protein Rab-11A

1

3

High-throughput

0.536

High

667943

SSBP2
Single-stranded DNA-binding protein 2

1

5

High-throughput

0.536

High

667944

2ABB
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform

1

9

High-throughput

0.536

High

667948

GCYA1
Guanylate cyclase soluble subunit alpha-1

1

3

High-throughput

0.536

High

667949

RASF7
Ras association domain-containing protein 7

1

3

High-throughput

0.536

High

667951

EF1A2
Elongation factor 1-alpha 2

1

3

High-throughput

0.536

High

667952

GABPA
GA-binding protein alpha chain

1

6

High-throughput

0.536

High

667953

FMOD
Fibromodulin

1

1

High-throughput

0.536

High

667955

ZN154
Zinc finger protein 154

1

2

High-throughput

0.536

High

667957

CUL2
Cullin-2

1

6

High-throughput

0.536

High

667958

ITA9
Integrin alpha-9

1

3

High-throughput

0.536

High

667967

STK11
Serine/threonine-protein kinase STK11

1

4

High-throughput

0.536

High

667970

ZYX
Zyxin

1

2

High-throughput

0.536

High

667971

PKN2
Serine/threonine-protein kinase N2

1

7

High-throughput

0.536

High

667973

LRC10
Leucine-rich repeat-containing protein 10

1

4

High-throughput

0.536

High

667979

JADE1
Protein Jade-1

1

1

High-throughput

0.536

High

667982

DPPA4
Developmental pluripotency-associated protein 4

1

1

High-throughput

0.536

High

667983

APTX
Aprataxin

1

3

High-throughput

0.536

High

667984

ZN550
Zinc finger protein 550

1

3

High-throughput

0.536

High

667985

NEK8
Serine/threonine-protein kinase Nek8

1

4

High-throughput

0.536

High

667991

AROS
Active regulator of SIRT1

1

2

High-throughput

0.536

High

667993

CDKL3
Cyclin-dependent kinase-like 3

1

3

High-throughput

0.536

High

667994

TEX14
Inactive serine/threonine-protein kinase TEX14

1

11

High-throughput

0.536

High

667997

FNDC5
Fibronectin type III domain-containing protein 5

1

6

High-throughput

0.536

High

667998

ANKK1
Ankyrin repeat and protein kinase domain-containing protein 1

1

5

High-throughput

0.536

High

667999

O13C3
Olfactory receptor 13C3

1

4

High-throughput

0.536

High

668004

ITLN2
Intelectin-2

1

2

High-throughput

0.536

High

668006

CSN5
COP9 signalosome complex subunit 5

1

1

High-throughput

0.536

High

668008

PIGT
GPI transamidase component PIG-T

1

4

High-throughput

0.536

High

668009

SIA7F
Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6

1

4

High-throughput

0.536

High

668019

TREX2
Three prime repair exonuclease 2

1

2

High-throughput

0.536

High

668022

MMTA2
Multiple myeloma tumor-associated protein 2

1

5

High-throughput

0.536

High

668023

FUND2
FUN14 domain-containing protein 2

1

2

High-throughput

0.536

High

668025

PINK1
Serine/threonine-protein kinase PINK1, mitochondrial

1

7

High-throughput

0.536

High

668026

SRRT
Serrate RNA effector molecule homolog

1

5

High-throughput

0.536

High

668032

FBX44
F-box only protein 44

1

6

High-throughput

0.536

High

668036

COE2
Transcription factor COE2

1

5

High-throughput

0.536

High

668038

CLK4
Dual specificity protein kinase CLK4

1

4

High-throughput

0.536

High

668039

HES4
Transcription factor HES-4

1

4

High-throughput

0.536

High

668040

SHCAF
SIN3-HDAC complex-associated factor

1

2

High-throughput

0.536

High

668044

MBNL1
Muscleblind-like protein 1

1

5

High-throughput

0.536

High

668047

KLH11
Kelch-like protein 11

1

6

High-throughput

0.536

High

668058

DKK2
Dickkopf-related protein 2

1

1

High-throughput

0.536

High

668060

SMBT1
Scm-like with four MBT domains protein 1

1

1

High-throughput

0.536

High

668061

PHF11
PHD finger protein 11

1

8

High-throughput

0.536

High

668064

SSUH2
Protein SSUH2 homolog

1

8

High-throughput

0.536

High

668067

RN115
E3 ubiquitin-protein ligase RNF115

1

7

High-throughput

0.536

High

667968

USF2
Upstream stimulatory factor 2

1

6

High-throughput

0.515

High

668028

TRI55
Tripartite motif-containing protein 55

1

9

High-throughput

0.515

High

668048

IRAK4
Interleukin-1 receptor-associated kinase 4

1

0

High-throughput

0.513

High

637216

CATS
Cathepsin S

1

2

Small-scale

0.501

High

667924

CATK
Cathepsin K

1

2

Small-scale

0.501

High

667940

CDC42
Cell division control protein 42 homolog

1

3

High-throughput

0.501

High

668068

UCHL5
Ubiquitin carboxyl-terminal hydrolase isozyme L5

1

2

Small-scale

0.501

High

50999

PL8L1
PLAC8-like protein 1

1

1

High-throughput

0.489

High

303653

OR2A4
Olfactory receptor 2A4

1

13

High-throughput

0.489

High

312778

M3K6
Mitogen-activated protein kinase kinase kinase 6

1

2

High-throughput

0.489

High

667929

PTSS1
Phosphatidylserine synthase 1

1

2

High-throughput

0.489

High

667933

NDST2
Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 2

1

1

High-throughput

0.489

High

667972

CR021
UPF0711 protein C18orf21

1

6

High-throughput

0.489

High

667975

EMC4
ER membrane protein complex subunit 4

1

3

High-throughput

0.489

High

667977

UBE2U
Ubiquitin-conjugating enzyme E2 U

1

5

High-throughput

0.489

High

667980

MRM1
rRNA methyltransferase 1, mitochondrial

1

1

High-throughput

0.489

High

667988

MOGT3
2-acylglycerol O-acyltransferase 3

1

7

High-throughput

0.489

High

667989

BPHL
Valacyclovir hydrolase

1

1

High-throughput

0.489

High

667990

COA5
Cytochrome c oxidase assembly factor 5

1

2

High-throughput

0.489

High

667992

CERS3
Ceramide synthase 3

1

2

High-throughput

0.489

High

668001

RHBL4
Rhomboid-related protein 4

1

4

High-throughput

0.489

High

668010

SARAF
Store-operated calcium entry-associated regulatory factor

1

9

High-throughput

0.489

High

668013

F227B
Protein FAM227B

1

3

High-throughput

0.489

High

668015

TEFM
Transcription elongation factor, mitochondrial

1

4

High-throughput

0.489

High

668016

FCRL5
Fc receptor-like protein 5

1

1

High-throughput

0.489

High

668018

PLCA
1-acyl-sn-glycerol-3-phosphate acyltransferase alpha

1

7

High-throughput

0.489

High

668020

SH23A
SH2 domain-containing protein 3A

1

9

High-throughput

0.489

High

668030

S2532
Solute carrier family 25 member 32

1

6

High-throughput

0.489

High

668037

UD110
UDP-glucuronosyltransferase 1A10

1

3

High-throughput

0.489

High

668042

TSSP
Thymus-specific serine protease

1

5

High-throughput

0.489

High

668045

ST7
Suppressor of tumorigenicity 7 protein

1

1

High-throughput

0.489

High

668049

ST32B
Serine/threonine-protein kinase 32B

1

1

High-throughput

0.489

High

668052

RM39
Large ribosomal subunit protein mL39

1

1

High-throughput

0.489

High

668054

PK2L2
Polycystin-2-like protein 2

1

2

High-throughput

0.489

High

668069

NPTN
Neuroplastin

1

1

High-throughput

0.489

High

129704

AGRIN
Agrin [Cleaved into: Agrin N-terminal 110 kDa subunit; Agrin C-terminal 110 kDa subunit; Agrin C-terminal 90 kDa fragment

1

1

High-throughput

0.479

High

282541

RNF8
E3 ubiquitin-protein ligase RNF8

1

4

High-throughput

0.479

High

396687

S10A8
Protein S100-A8

1

7

High-throughput

0.479

High

416357

S10A9
Protein S100-A9

1

9

High-throughput

0.479

High

427457

ANXA2
Annexin A2

1

2

High-throughput

0.479

High

428557

INVO
Involucrin

1

1

High-throughput

0.479

High

503501

HSP7C
Heat shock cognate 71 kDa protein

1

5

High-throughput

0.479

High

569244

CEBPB
CCAAT/enhancer-binding protein beta

1

5

High-throughput

0.479

High

591267

TNR1B
Tumor necrosis factor receptor superfamily member 1B

1

1

High-throughput

0.479

High

637778

PSA3
Proteasome subunit alpha type-3

1

1

Small-scale

0.479

High

667917

S10A7
Protein S100-A7

1

9

High-throughput

0.479

High

667918

CASPE
Caspase-14

1

8

High-throughput

0.479

High

667919

1433S
14-3-3 protein sigma

1

3

High-throughput

0.479

High

667926

LEG7
Galectin-7

1

3

High-throughput

0.479

High

667930

MCM2
DNA replication licensing factor MCM2

1

6

High-throughput

0.479

High

667942

RNF4
E3 ubiquitin-protein ligase RNF4

1

1

Small-scale

0.479

High

667945

VIGLN
Vigilin

1

3

High-throughput

0.479

High

667946

HSF1
Heat shock factor protein 1

1

1

High-throughput

0.479

High

667947

EWS
RNA-binding protein EWS

1

3

High-throughput

0.479

High

667954

FOXO1
Forkhead box protein O1

1

4

High-throughput

0.479

High

667956

BIRC3
Baculoviral IAP repeat-containing protein 3

1

3

High-throughput

0.479

High

667959

PKP1
Plakophilin-1

1

3

High-throughput

0.479

High

667960

DX39B
Spliceosome RNA helicase DDX39B

1

2

High-throughput

0.479

High

667961

BLMH
Bleomycin hydrolase

1

2

High-throughput

0.479

High

667962

TRI25
E3 ubiquitin/ISG15 ligase TRIM25

1

10

High-throughput

0.479

High

667965

TNIP1
TNFAIP3-interacting protein 1

1

3

High-throughput

0.479

High

667981

TRI67
Tripartite motif-containing protein 67

1

9

High-throughput

0.479

High

667986

ZN598
E3 ubiquitin-protein ligase ZNF598

1

1

High-throughput

0.479

High

667987

PAQR2
Adiponectin receptor protein 2

1

1

Small-scale

0.479

High

667995

SLX4
Structure-specific endonuclease subunit SLX4

1

6

High-throughput

0.479

High

668000

LNX1
E3 ubiquitin-protein ligase LNX

1

1

Small-scale

0.479

High

668005

ESR2
Estrogen receptor beta

1

8

High-throughput

0.479

High

668007

KISSR
KiSS-1 receptor

1

8

Small-scale

0.479

High

668017

CIC
Protein capicua homolog

1

10

High-throughput

0.479

High

668027

FACD2
Fanconi anemia group D2 protein

1

12

High-throughput

0.479

High

668031

Q9H4D1
Protein kinase

1

5

High-throughput

0.479

High

668033

PKHA4
Pleckstrin homology domain-containing family A member 4

1

2

High-throughput

0.479

High

668041

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

1

1

High-throughput

0.479

High

668043

ANLN
Anillin

1

1

High-throughput

0.479

High

668053

WWOX
WW domain-containing oxidoreductase

1

2

High-throughput

0.479

High

668056

CALL5
Calmodulin-like protein 5

1

2

High-throughput

0.479

High

668059

ZRAN1
Ubiquitin thioesterase ZRANB1

1

4

High-throughput

0.479

High

668063

TRI33
E3 ubiquitin-protein ligase TRIM33

1

3

High-throughput

0.479

High

668070

SCC4
MAU2 chromatid cohesion factor homolog

1

1

High-throughput

0.479

High

667922

MERL
Merlin

1

0

High-throughput

0.458

High

667950

CREM
cAMP-responsive element modulator

1

0

Small-scale

0.458

High

667966

ELAV1
ELAV-like protein 1

1

0

Small-scale

0.458

High

668057

MARH2
E3 ubiquitin-protein ligase MARCHF2

1

0

High-throughput

0.458

High

668066

TRRAP
Transformation/transcription domain-associated protein

1

0

High-throughput

0.458

High

667938

RIPK4
Receptor-interacting serine/threonine-protein kinase 4

1

6

High-throughput

0.445

High

667939

GBRL2
Gamma-aminobutyric acid receptor-associated protein-like 2

1

5

High-throughput

0.445

High

667978

RNLS
Renalase

1

1

Small-scale

0.445

High

668029

GBRL1
Gamma-aminobutyric acid receptor-associated protein-like 1

1

5

High-throughput

0.445

High

668003

POF1B
Protein POF1B

1

1

High-throughput

0.437

High

668051

B3GN2
N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 2

1

1

High-throughput

0.437

High

667974

COQ5
2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial

1

0

High-throughput

0.279

Low

473244

F153B
Protein FAM153B

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024