Protein: PRKN
E3 ubiquitin-protein ligase parkin (EC 2.3.2.31)

Gene: PRKN, park
Organism: Drosophila melanogaster
Interactions: 57
UniProt ID: Q7KTX7

Gene Ontology (top 5):
GO:0000151 - ubiquitin ligase complex
GO:0000209 - protein polyubiquitination
GO:0000266 - mitochondrial fission
GO:0000422 - autophagy of mitochondrion
GO:0001933 - negative regulation of protein phosphorylation

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1182248

PRKN
E3 ubiquitin-protein ligase parkin

2

18

Small-scale

0.768

High

1182262

Q9VEJ4
E2 ubiquitin-conjugating enzyme

2

20

High-throughput

0.767

High

1001801

PINK1
Serine/threonine-protein kinase Pink1, mitochondrial

2

15

Small-scale

0.754

High

1182250

MARF
Transmembrane GTPase Marf

3

5

Small-scale

0.657

High

1182271

Q9VUV7
E3 ubiquitin-protein ligase NRDP1

1

20

Small-scale

0.621

High

284377

ARI2
Potential E3 ubiquitin-protein ligase ariadne-2

1

19

Small-scale

0.618

High

715094

UBE2N
Ubiquitin-conjugating enzyme E2 N

1

20

Small-scale

0.618

High

1182251

Q86NK9
Histone deacetylase 6 isoform A

1

10

Small-scale

0.618

High

1182259

ARI1
E3 ubiquitin-protein ligase ariadne-1

1

17

Small-scale

0.618

High

1177069

Q7JRF1
RE48509p

2

1

High-throughput

0.594

High

1182261

ZFPL1
Zinc finger protein-like 1 homolog

2

2

High-throughput

0.594

High

1182272

Q9VVX6
Blocked early in transport 1, isoform A

2

1

High-throughput

0.594

High

677697

DLG1
Disks large 1 tumor suppressor protein

1

11

High-throughput

0.587

High

1182263

Q9VIL1
Transmembrane protein 230

2

0

High-throughput

0.569

High

1182266

Q9VPD4
Vesicle transport protein

2

0

High-throughput

0.569

High

1182258

Q8SYY7
RE27547p

2

6

High-throughput

0.542

High

1182268

Q9VQT8
Immune induced molecule 33, isoform A

2

6

High-throughput

0.542

High

1182249

Q7KUX3
Septin

1

11

Small-scale

0.512

High

1182255

CDIPT
CDP-diacylglycerol--inositol 3-phosphatidyltransferase

1

1

High-throughput

0.494

High

612400

DSX
Protein doublesex

1

0

High-throughput

0.486

High

54994

CLU
Protein clueless

1

10

Small-scale

0.479

High

776972

PNUT
Protein peanut

1

11

Small-scale

0.479

High

786235

SEPT1
Septin-1

1

11

Small-scale

0.479

High

820448

IF4E
Eukaryotic translation initiation factor 4E1

1

3

Small-scale

0.479

High

820837

PELO
Protein pelota

1

3

Small-scale

0.479

High

1182252

MIRO
Mitochondrial Rho GTPase

1

13

Small-scale

0.479

High

1182269

PARIS
Zinc finger protein Paris

1

12

Small-scale

0.479

High

1182270

ABCE1
Protein Pixie

1

3

Small-scale

0.479

High

55661

MED9
Mediator of RNA polymerase II transcription subunit 9

1

1

High-throughput

0.464

High

1180619

Q7KJA9
protein O-GlcNAc transferase

1

9

High-throughput

0.464

High

114148

HAKAI
E3 ubiquitin-protein ligase Hakai

1

2

High-throughput

0.457

High

1182254

Q8MLR2
Entomoglyceroporin 4, isoform C

1

2

High-throughput

0.451

High

1182265

Q9VMN4
Uncharacterized protein, isoform B

1

1

High-throughput

0.451

High

1182267

Q9VPN0
GH04039p

1

1

High-throughput

0.451

High

1182274

Q9W4B3
Visual system homeobox 2

1

4

High-throughput

0.451

High

65380

A8DYS6
IP17118p

1

1

High-throughput

0.439

High

78582

B6IDP6
FI06437p

1

1

High-throughput

0.439

High

87790

D1Z394
Entomoglyceroporin 4, isoform E

1

2

High-throughput

0.439

High

1182278

X2JDS9
Visual system homeobox 2

1

4

High-throughput

0.439

High

51644

A1Z6Q0
Klaroid, isoform D

1

1

Small-scale

0.437

High

53604

A1Z8Z3
Cuticular protein 49Ag

2

0

High-throughput

0.310

High

332941

U729
UPF0729 protein CG18508

2

0

High-throughput

0.310

High

1001060

Q0E985
RH74701p

2

0

High-throughput

0.310

High

1178555

Q7K087
GEO08225p1

2

0

High-throughput

0.310

High

1179300

Q7K2P1
Cuticular protein 50Cb

2

0

High-throughput

0.310

High

1182253

Q8IQ76
GEO12894p1

2

0

High-throughput

0.310

High

1182256

Q8SY76
RH45738p

2

0

High-throughput

0.310

High

1182257

Q8SYA4
Bomanin short 4

2

0

High-throughput

0.310

High

1182260

AQP
Aquaporin

2

0

High-throughput

0.310

High

1182264

Q9VLL8
Peritrophin-15a

2

0

High-throughput

0.310

High

1182273

TM14
Transmembrane protein 14 homolog

2

0

High-throughput

0.310

High

1182275

Q9W4B6
RE01432p

2

0

High-throughput

0.310

High

1182276

Q9W4S5
IP07779p

2

0

High-throughput

0.310

High

54609

A1Z9T6
Uncharacterized protein

1

0

High-throughput

0.265

Low

1177574

Q7JWN2
RE25177p

1

0

High-throughput

0.265

Low

1182277

Q9XTN4
Brinker

1

0

High-throughput

0.265

Low


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Last updated: 15 Jul 2024