Protein: HP1
Heterochromatin protein 1 (HP1) (Non-histone chromosomal protein C1A9 antigen)

Gene: HP1, Su(var)205
Organism: Drosophila melanogaster
Interactions: 131
UniProt ID: P05205

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000182 - rDNA binding
GO:0000278 - mitotic cell cycle
GO:0000723 - telomere maintenance
GO:0000775 - chromosome, centromeric region

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

398994

SUV39
Histone-lysine N-methyltransferase Su(var)3-9

8

20

Small-scale

0.969

High

398977

HP1
Heterochromatin protein 1

4

20

Small-scale

0.873

High

399023

ATRX
Transcriptional regulator ATRX homolog

3

20

Small-scale

0.870

High

399056

SUUR
Protein suppressor of underreplication

3

0

Small-scale

0.810

High

356064

H3
Histone H3

14

20

Small-scale

0.763

High

399033

Q9VCU6
Heterochromatin protein 1c

2

20

Small-scale

0.754

High

399074

Q9W396
FI06908p

2

20

Small-scale

0.754

High

399020

CAV
Telomere-binding protein cav

9

2

Small-scale

0.752

High

399021

Q95RV3
LD09786p

6

1

Small-scale

0.730

High

54583

A1Z9S6

5

10

Small-scale

0.720

High

399038

Q9VEF0
LD33778p

4

20

Small-scale

0.690

High

399051

Q9VQ58
FI15207p1

1

1

Small-scale

0.647

High

399070

Q9W1H0
HL01030p

1

20

Small-scale

0.647

High

399046

PIWI
Protein piwi

3

0

Small-scale

0.646

High

116079

M9PHL2
Heterochromatin protein 5, isoform C

3

4

Small-scale

0.642

High

399011

Q86CW5
Hmr

3

1

Small-scale

0.640

High

399075

Q9W3D1
Chromatin assembly factor 1, p180 subunit

3

15

Small-scale

0.640

High

399044

MCM10
Protein MCM10 homolog

3

0

Small-scale

0.625

High

398998

STAT
Signal transducer and transcription activator

2

1

Small-scale

0.624

High

398984

SUV37
Protein suppressor of variegation 3-7

3

2

Small-scale

0.623

High

399054

Q9VSC4
FI16703p1

2

3

Small-scale

0.619

High

68987

A8WHL4
Bonus, isoform B

1

20

Small-scale

0.618

High

398986

PC
Polycomb group protein Pc

1

20

Small-scale

0.618

High

399029

Q9V9T4
ATP-dependent chromatin assembly factor large subunit

1

20

Small-scale

0.618

High

399034

Q9VDK5
Bonus, isoform A

1

20

Small-scale

0.618

High

399045

Q9VKB3
tRNA

1

15

Small-scale

0.618

High

399052

Q9VR09
Heterochromatin protein 6

1

14

Small-scale

0.618

High

399015

Q8IQ92
FI01426p

2

3

Small-scale

0.614

High

399025

KDM4A
Probable lysine-specific demethylase 4A

2

3

Small-scale

0.611

High

398991

EZ
Histone-lysine N-methyltransferase E(z)

2

20

Small-scale

0.595

High

355220

H1
Histone H1

2

0

Small-scale

0.585

High

375636

RPB1
DNA-directed RNA polymerase II subunit RPB1

2

7

Small-scale

0.584

High

398995

RB87F
Heterogeneous nuclear ribonucleoprotein 87F

2

6

Small-scale

0.584

High

398997

SSRP1
FACT complex subunit Ssrp1

2

20

Small-scale

0.584

High

399003

SETB1
Histone-lysine N-methyltransferase eggless

2

20

Small-scale

0.584

High

399017

Q8MLV3
MADF domain-containing protein

2

2

Small-scale

0.584

High

399022

Q961B8
DNA helicase

2

13

Small-scale

0.584

High

399062

LSDA
Possible lysine-specific histone demethylase 1

2

6

Small-scale

0.584

High

399035

INO80
Chromatin-remodeling ATPase INO80

1

18

High-throughput

0.575

High

398999

ORC2
Origin recognition complex subunit 2

2

2

Small-scale

0.552

High

399041

DALMA
Protein dalmatian

1

1

Small-scale

0.552

High

81341

MODI
Protein modigliani

1

0

Small-scale

0.545

High

115700

M9PG80
Traffic jam, isoform C

1

1

High-throughput

0.541

High

247367

O61348
Bobby sox

1

15

High-throughput

0.541

High

399013

FRU
Sex determination protein fruitless

1

12

Small-scale

0.536

High

399031

Q9VCB8
Java no jive

1

10

Small-scale

0.536

High

115713

M9PG82
Enoyl-CoA hydratase, mitochondrial

2

8

Small-scale

0.535

High

399005

HPHP
HP1-HOAP-interacting protein

1

0

Small-scale

0.530

High

58918

A2VEF9
IP15561p

1

0

Small-scale

0.529

High

399047

Q9VL20
Ovaries absent, isoform A

1

0

Small-scale

0.529

High

185798

PAX6
Paired box protein Pax-6

1

1

High-throughput

0.508

High

399071

Q9W1T1
Large ribosomal subunit protein eL22

1

2

High-throughput

0.508

High

65994

A8JRE3
Without children, isoform B

1

20

Small-scale

0.501

High

90930

E1JJ76
Alhambra, isoform H

1

8

Small-scale

0.501

High

398987

ABDA
Homeobox protein abdominal-A

1

4

High-throughput

0.481

High

398996

UBX
Homeotic protein ultrabithorax

1

6

High-throughput

0.481

High

112858

M9NES5
Histone gene-specific epigenetic repressor in late S phase, isoform H

1

10

Small-scale

0.479

High

115785

M9PGH7
G9a, isoform B

1

20

Small-scale

0.479

High

398979

ROA1
Heterogeneous nuclear ribonucleoprotein A1

1

6

Small-scale

0.479

High

398981

H2AV
Histone H2A.v

1

20

Small-scale

0.479

High

398982

JRA
Transcription factor Jra

1

4

Small-scale

0.479

High

398989

RFC1
Replication factor C subunit 1

1

2

Small-scale

0.479

High

399000

ORC5
Origin recognition complex subunit 5

1

3

Small-scale

0.479

High

399004

Q7JRJ9
Inner centromere protein, isoform A

1

18

Small-scale

0.479

High

399007

Q7KN75
Dodeca-satellite-binding protein 1, isoform A

1

11

Small-scale

0.479

High

399008

ZMYD8
MYND-type zinc finger-containing chromatin reader Zmynd8

1

20

Small-scale

0.479

High

399009

NIPB
Nipped-B protein

1

3

Small-scale

0.479

High

399014

SLE
Protein slender lobes

1

15

Small-scale

0.479

High

399016

SPT16
FACT complex subunit spt16

1

2

Small-scale

0.479

High

399018

NSD
Nuclear receptor binding SET domain protein

1

20

Small-scale

0.479

High

399019

Q8SXI2
Craniofacial development protein 1

1

1

Small-scale

0.479

High

399024

SUZ12
Polycomb protein Su(z)12

1

6

Small-scale

0.479

High

399027

Q9V426
LD07162p

1

1

Small-scale

0.479

High

399030

Q9VBX3
Vig2, isoform B

1

1

Small-scale

0.479

High

399032

Q9VCD8
Structural maintenance of chromosomes protein

1

1

Small-scale

0.479

High

399036

Q9VE55
Qin

1

20

Small-scale

0.479

High

399037

MED17
Mediator of RNA polymerase II transcription subunit 17

1

1

Small-scale

0.479

High

399039

SCC4
MAU2 chromatid cohesion factor homolog

1

3

Small-scale

0.479

High

399040

EXOSX
Exosome complex component 10 homolog

1

2

Small-scale

0.479

High

399042

Q9VHJ3
Enhancer of variegation 3-9

1

20

Small-scale

0.479

High

399043

Q9VI63
AF10

1

9

Small-scale

0.479

High

399049

Q9VP12
Structural maintenance of chromosomes protein 5

1

10

Small-scale

0.479

High

399055

Q9VT61
Ciz1 zinc finger protein, isoform A

1

5

Small-scale

0.479

High

399058

Q9VTX7
Eyegone, isoform A

1

3

Small-scale

0.479

High

399064

Q9VYB1
Kinetochore protein NDC80

1

6

Small-scale

0.479

High

399076

Q9W3W6
Small ovary, isoform A

1

20

Small-scale

0.479

High

399077

Q9XYM5
LD27861p

1

2

Small-scale

0.479

High

399079

ORC6
Origin recognition complex subunit 6

1

2

Small-scale

0.479

High

399006

Q7K0W4
LD27203p

1

5

High-throughput

0.464

High

332161

O96689
FI11703p

1

0

Small-scale

0.458

High

398990

PEP
Zinc finger protein on ecdysone puffs

1

0

Small-scale

0.458

High

399002

Q2PE13
Activating transcription factor-2

1

0

Small-scale

0.458

High

399028

MED26
Mediator of RNA polymerase II transcription subunit 26

1

0

Small-scale

0.458

High

399048

BOREA
Borealin

1

0

Small-scale

0.458

High

399053

Q9VRN6
separase

1

0

Small-scale

0.458

High

399057

Q9VTT2
LD20590p

1

0

Small-scale

0.458

High

399059

VERR
Protein verrocchio

1

0

Small-scale

0.458

High

399072

RAD50
DNA repair protein RAD50

1

0

Small-scale

0.458

High

399078

Q9XYZ4
Double-strand break repair protein

1

0

Small-scale

0.458

High

399050

Q9VPB0
Enoyl-CoA hydratase, mitochondrial

1

8

High-throughput

0.457

High

399066

Q9VYY7
Heterochromatin protein 5, isoform B

1

4

High-throughput

0.457

High

398978

NOTCH
Neurogenic locus Notch protein [Cleaved into: Processed neurogenic locus Notch protein]

1

3

High-throughput

0.445

High

398983

ARM
Armadillo segment polarity protein

1

20

High-throughput

0.445

High

398985

MA205
205 kDa microtubule-associated protein

1

4

High-throughput

0.445

High

399010

Q7YU66
Structural maintenance of chromosomes protein 5

1

15

Small-scale

0.445

High

113068

M9NFI9
Spinophilin, isoform J

1

6

High-throughput

0.442

High

55997

A1ZBG4
Uncharacterized protein, isoform E

1

1

High-throughput

0.439

High

399001

IF2G
Eukaryotic translation initiation factor 2 subunit 3

1

4

High-throughput

0.439

High

399012

Q86P80
CAP, isoform K

1

5

Small-scale

0.437

High

399060

PYRG
CTP synthase

1

1

High-throughput

0.437

High

399063

Q9VWJ6
FI03615p

1

1

High-throughput

0.437

High

399073

Q9W2S2
Autophagy-related 8a, isoform A

1

2

High-throughput

0.437

High

399061

ATRIP
ATR-interacting protein mus304

1

0

Small-scale

0.426

High

56050

A1ZBG6
Uncharacterized protein, isoform C

1

1

High-throughput

0.417

High

398988

VATB
V-type proton ATPase subunit B

1

1

High-throughput

0.407

High

399068

Q9W0L7
ubiquitinyl hydrolase 1

1

6

High-throughput

0.407

High

54581

A1Z9S5
RE12383p

1

2

High-throughput

0.381

High

184159

ORC1
Origin recognition complex subunit 1

1

4

High-throughput

0.381

High

398980

CSK2A
Casein kinase II subunit alpha

1

10

High-throughput

0.381

High

398993

ARP6
Actin-related protein 6

1

1

High-throughput

0.381

High

398992

GRK
Protein gurken

1

0

High-throughput

0.282

High

399069

Q9W0Z5
LP09747p

1

0

Small-scale

0.269

Low

399026

Q9V3Y7
Uncharacterized protein, isoform A

1

0

High-throughput

0.265

Low

399065

Q9VYW6
Rhomboid-4

1

0

High-throughput

0.265

Low

116171

M9PHX2
Visgun, isoform E

1

0

High-throughput

0.253

Low

90650

E1JH24
Telomere ends associated, isoform D

1

0

Small-scale

0.249

Low

116446

M9PJA1
Uncharacterized protein, isoform F

1

0

Small-scale

0.249

Low

399067

Q9VZ00
FI19420p1

1

0

Small-scale

0.249

Low

399080

X2JD11
Uncharacterized protein, isoform C

1

0

Small-scale

0.249

Low

51788

GDS1
GTPase-GDP dissociation stimulator vimar

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024