Protein: CCNB1
G2/mitotic-specific cyclin-B1

Gene: CCNB1
Organism: Homo sapiens
Interactions: 216
UniProt ID: P14635

Gene Ontology (top 5):
GO:0000086 - G2/M transition of mitotic cell cycle
GO:0000922 - spindle pole
GO:0000940 - outer kinetochore
GO:0001701 - in utero embryonic development
GO:0005113 - patched binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

414711

CDK1
Cyclin-dependent kinase 1

55

20

Small-scale

0.996

High

538471

CDK2
Cyclin-dependent kinase 2

14

20

Small-scale

0.984

High

538522

CDK5
Cyclin-dependent kinase 5

9

20

High-throughput

0.976

High

538489

CDN1A
Cyclin-dependent kinase inhibitor 1

8

15

Small-scale

0.967

High

538492

CDN1B
Cyclin-dependent kinase inhibitor 1B

6

15

Small-scale

0.948

High

538598

PMYT1
Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase

5

16

Small-scale

0.936

High

538497

CDK7
Cyclin-dependent kinase 7

4

20

Small-scale

0.899

High

538479

WEE1
Wee1-like protein kinase

2

9

Small-scale

0.799

High

538496

CDN1C
Cyclin-dependent kinase inhibitor 1C

2

15

Small-scale

0.789

High

538521

CDK3
Cyclin-dependent kinase 3

2

20

Small-scale

0.789

High

538532

CDC20
Cell division cycle protein 20 homolog

34

20

Small-scale

0.770

High

538625

FZR1
Fizzy-related protein homolog

32

20

Small-scale

0.769

High

538491

CCNF
Cyclin-F

2

6

Small-scale

0.754

High

538478

CDC27
Cell division cycle protein 27 homolog

7

8

Small-scale

0.738

High

538483

CKS2
Cyclin-dependent kinases regulatory subunit 2

6

20

Small-scale

0.735

High

538525

H11
Histone H1.1

6

7

Small-scale

0.727

High

538505

CKS1
Cyclin-dependent kinases regulatory subunit 1

5

20

Small-scale

0.718

High

538500

CCNH
Cyclin-H

1

6

High-throughput

0.691

High

538556

PKN2
Serine/threonine-protein kinase N2

1

4

High-throughput

0.691

High

517031

PCNA
Proliferating cell nuclear antigen

3

1

Small-scale

0.667

High

538573

ZC3C1
Zinc finger C3HC-type protein 1

4

0

Small-scale

0.666

High

521701

CADH1
Cadherin-1

3

3

Small-scale

0.655

High

538480

MPIP1
M-phase inducer phosphatase 1

3

9

Small-scale

0.650

High

538528

FOXM1
Forkhead box protein M1

3

2

Small-scale

0.650

High

538545

ESPL1
Separin

4

0

Small-scale

0.649

High

538623

APC4
Anaphase-promoting complex subunit 4

3

2

Small-scale

0.640

High

538592

NACC1
Nucleus accumbens-associated protein 1

2

1

Small-scale

0.639

High

538597

GA2L1
GAS2-like protein 1

3

0

High-throughput

0.638

High

538542

PTC1
Protein patched homolog 1

3

0

Small-scale

0.636

High

538488

BRCA1
Breast cancer type 1 susceptibility protein

2

1

Small-scale

0.629

High

226419

PRKN
E3 ubiquitin-protein ligase parkin

2

3

Small-scale

0.624

High

538551

STK38
Serine/threonine-protein kinase 38

1

6

Small-scale

0.618

High

538575

VRK3
Serine/threonine-protein kinase VRK3

1

6

High-throughput

0.618

High

538589

TOPK
Lymphokine-activated killer T-cell-originated protein kinase

1

0

Small-scale

0.614

High

538498

FXR1
RNA-binding protein FXR1

2

1

High-throughput

0.611

High

538537

SKP2
S-phase kinase-associated protein 2

2

3

Small-scale

0.611

High

538587

SIR1
NAD-dependent protein deacetylase sirtuin-1

2

3

Small-scale

0.611

High

538632

MD1L1
Mitotic spindle assembly checkpoint protein MAD1

2

1

Small-scale

0.611

High

414150

RB
Retinoblastoma-associated protein

2

7

Small-scale

0.602

High

538465

H15
Histone H1.5

2

7

Small-scale

0.602

High

225836

KPRB
Phosphoribosyl pyrophosphate synthase-associated protein 2

2

0

High-throughput

0.602

High

538557

LRRF1
Leucine-rich repeat flightless-interacting protein 1

2

0

High-throughput

0.602

High

538608

IKZF5
Zinc finger protein Pegasus

2

0

High-throughput

0.602

High

538610

NGB
Neuroglobin

2

0

High-throughput

0.602

High

538614

PARVA
Alpha-parvin

2

0

High-throughput

0.602

High

538475

RFA1
Replication protein A 70 kDa DNA-binding subunit

2

3

Small-scale

0.595

High

538502

UBP14
Ubiquitin carboxyl-terminal hydrolase 14

2

5

Small-scale

0.595

High

538585

KAT6A
Histone acetyltransferase KAT6A

2

0

High-throughput

0.585

High

322135

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

2

1

Small-scale

0.584

High

434916

SP1
Transcription factor Sp1

2

2

Small-scale

0.584

High

538481

MPIP2
M-phase inducer phosphatase 2

2

9

Small-scale

0.584

High

538503

TERA
Transitional endoplasmic reticulum ATPase

2

1

High-throughput

0.584

High

538561

OTU7B
OTU domain-containing protein 7B

1

1

Small-scale

0.578

High

538591

UHRF2
E3 ubiquitin-protein ligase UHRF2

1

1

Small-scale

0.578

High

538581

PTGR3
Prostaglandin reductase 3

2

1

High-throughput

0.574

High

538552

RBP1
RalA-binding protein 1

1

1

Small-scale

0.573

High

523490

XRCC6
X-ray repair cross-complementing protein 6

1

1

Small-scale

0.561

High

538518

PRKDC
DNA-dependent protein kinase catalytic subunit

1

1

Small-scale

0.561

High

538531

EP300
Histone acetyltransferase p300

1

6

Small-scale

0.561

High

538605

CDT1
DNA replication factor Cdt1

1

2

Small-scale

0.561

High

538606

TSYL2
Testis-specific Y-encoded-like protein 2

1

4

Small-scale

0.561

High

538628

UBP22
Ubiquitin carboxyl-terminal hydrolase 22

1

2

Small-scale

0.561

High

206718

B2L11
Bcl-2-like protein 11

2

0

Small-scale

0.559

High

538544

DCTN1
Dynactin subunit 1

2

0

High-throughput

0.559

High

271686

DEDD
Death effector domain-containing protein

1

1

Small-scale

0.554

High

538588

OTUB1
Ubiquitin thioesterase OTUB1

2

0

High-throughput

0.547

High

381776

G3P
Glyceraldehyde-3-phosphate dehydrogenase

1

0

Small-scale

0.537

High

538490

CUX1
Homeobox protein cut-like 1

1

2

Small-scale

0.536

High

259691

PDCD6
Programmed cell death protein 6

1

1

High-throughput

0.536

High

535316

GFAP
Glial fibrillary acidic protein

1

1

High-throughput

0.536

High

538474

STOM
Stomatin

1

1

High-throughput

0.536

High

538477

PRDX3
Thioredoxin-dependent peroxide reductase, mitochondrial

1

2

High-throughput

0.536

High

538516

SKP1
S-phase kinase-associated protein 1

1

3

High-throughput

0.536

High

538527

PRDX1
Peroxiredoxin-1

1

2

High-throughput

0.536

High

538529

RBL2
Retinoblastoma-like protein 2

1

7

High-throughput

0.536

High

538563

KLC3
Kinesin light chain 3

1

3

High-throughput

0.536

High

538596

CDC5L
Cell division cycle 5-like protein

1

2

High-throughput

0.536

High

262363

TULP3
Tubby-related protein 3

1

0

High-throughput

0.518

High

538495

TSC2
Tuberin

1

1

Small-scale

0.515

High

538506

UBE2K
Ubiquitin-conjugating enzyme E2 K

1

2

Small-scale

0.515

High

538584

TSC1
Hamartin

1

1

Small-scale

0.515

High

538569

UBE3D
E3 ubiquitin-protein ligase E3D

1

0

Small-scale

0.513

High

58214

SYTC2
Threonine--tRNA ligase 2, cytoplasmic

1

0

High-throughput

0.513

High

63990

SPDE4
Speedy protein E4

1

0

High-throughput

0.513

High

161496

S27A2
Long-chain fatty acid transport protein 2

1

0

High-throughput

0.513

High

204479

ARK72
Aflatoxin B1 aldehyde reductase member 2

1

0

High-throughput

0.513

High

535783

MIF
Macrophage migration inhibitory factor

1

0

High-throughput

0.513

High

538501

MAT1
CDK-activating kinase assembly factor MAT1

1

0

High-throughput

0.513

High

538530

NCBP1
Nuclear cap-binding protein subunit 1

1

0

High-throughput

0.513

High

538540

SNW1
SNW domain-containing protein 1

1

0

High-throughput

0.513

High

538543

KEAP1
Kelch-like ECH-associated protein 1

1

0

High-throughput

0.513

High

538546

KIF22
Kinesin-like protein KIF22

1

0

High-throughput

0.513

High

538549

MD2BP
MAD2L1-binding protein

1

0

High-throughput

0.513

High

538560

TUT7
Terminal uridylyltransferase 7

1

0

High-throughput

0.513

High

538562

L2GL2
LLGL scribble cell polarity complex component 2

1

0

High-throughput

0.513

High

538567

CHSTF
Carbohydrate sulfotransferase 15

1

0

High-throughput

0.513

High

538572

CAND1
Cullin-associated NEDD8-dissociated protein 1

1

0

High-throughput

0.513

High

538586

ALKB8
Alkylated DNA repair protein alkB homolog 8

1

0

High-throughput

0.513

High

538619

HOP2
Homologous-pairing protein 2 homolog

1

0

High-throughput

0.513

High

538631

LRCH1
Leucine-rich repeat and calponin homology domain-containing protein 1

1

0

High-throughput

0.513

High

174599

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

1

6

High-throughput

0.501

High

175816

P73
Tumor protein p73

1

3

Small-scale

0.501

High

209634

PRC1
Protein regulator of cytokinesis 1

1

2

Small-scale

0.501

High

258861

GA45B
Growth arrest and DNA damage-inducible protein GADD45 beta

1

2

Small-scale

0.501

High

309831

GA45G
Growth arrest and DNA damage-inducible protein GADD45 gamma

1

2

Small-scale

0.501

High

456083

DPOLA
DNA polymerase alpha catalytic subunit

1

2

Small-scale

0.501

High

538463

UCHL3
Ubiquitin carboxyl-terminal hydrolase isozyme L3

1

1

Small-scale

0.501

High

538470

GA45A
Growth arrest and DNA damage-inducible protein GADD45 alpha

1

2

Small-scale

0.501

High

538476

ARI4A
AT-rich interactive domain-containing protein 4A

1

1

Small-scale

0.501

High

538482

MPIP3
M-phase inducer phosphatase 3

1

9

Small-scale

0.501

High

538487

TGFR2
TGF-beta receptor type-2

1

1

Small-scale

0.501

High

538493

UB2R1
Ubiquitin-conjugating enzyme E2 R1

1

2

Small-scale

0.501

High

538507

UBE2N
Ubiquitin-conjugating enzyme E2 N

1

1

Small-scale

0.501

High

538514

UB2D2
Ubiquitin-conjugating enzyme E2 D2

1

1

Small-scale

0.501

High

538520

XIAP
E3 ubiquitin-protein ligase XIAP

1

4

Small-scale

0.501

High

538538

SQSTM
Sequestosome-1

1

1

Small-scale

0.501

High

538599

CDC6
Cell division control protein 6 homolog

1

8

Small-scale

0.501

High

538617

APC11
Anaphase-promoting complex subunit 11

1

2

Small-scale

0.501

High

538622

HERC5
E3 ISG15--protein ligase HERC5

1

2

Small-scale

0.501

High

538602

DPY30
Protein dpy-30 homolog

1

0

High-throughput

0.493

High

538553

UBE3C
Ubiquitin-protein ligase E3C

1

1

Small-scale

0.489

High

283132

ZFAN5
AN1-type zinc finger protein 5

1

0

Small-scale

0.480

High

538517

CSK2B
Casein kinase II subunit beta

1

0

Small-scale

0.480

High

538519

BTG2
Protein BTG2

1

0

Small-scale

0.480

High

538533

TP53B
TP53-binding protein 1

1

0

Small-scale

0.480

High

538547

IMB1
Importin subunit beta-1

1

0

Small-scale

0.480

High

56502

PTPC1
Protein tyrosine phosphatase domain-containing protein 1

1

3

High-throughput

0.479

High

135205

E2F3
Transcription factor E2F3

1

9

Small-scale

0.479

High

162379

XPO1
Exportin-1

1

5

High-throughput

0.479

High

208241

DCX
Neuronal migration protein doublecortin

1

1

Small-scale

0.479

High

272482

OFD1
Centriole and centriolar satellite protein OFD1

1

2

High-throughput

0.479

High

294327

RECQ4
ATP-dependent DNA helicase Q4

1

3

High-throughput

0.479

High

299833

ERLN2
Erlin-2

1

2

Small-scale

0.479

High

301591

TRI37
E3 ubiquitin-protein ligase TRIM37

1

3

High-throughput

0.479

High

386020

P53
Cellular tumor antigen p53

1

3

Small-scale

0.479

High

456486

UCHL1
Ubiquitin carboxyl-terminal hydrolase isozyme L1

1

1

Small-scale

0.479

High

507825

FGFR1
Fibroblast growth factor receptor 1

1

1

High-throughput

0.479

High

538464

RFA2
Replication protein A 32 kDa subunit

1

3

High-throughput

0.479

High

538467

FLNA
Filamin-A

1

1

Small-scale

0.479

High

538468

RS3
Small ribosomal subunit protein uS3

1

1

High-throughput

0.479

High

538469

NFYA
Nuclear transcription factor Y subunit alpha

1

1

Small-scale

0.479

High

538472

NFYB
Nuclear transcription factor Y subunit beta

1

1

Small-scale

0.479

High

538484

RFA3
Replication protein A 14 kDa subunit

1

2

High-throughput

0.479

High

538485

PP1G
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit

1

8

High-throughput

0.479

High

538486

SRBP1
Sterol regulatory element-binding protein 1

1

1

Small-scale

0.479

High

538499

BRCA2
Breast cancer type 2 susceptibility protein

1

2

Small-scale

0.479

High

538504

PSA6
Proteasome subunit alpha type-6

1

2

Small-scale

0.479

High

538508

PP1A
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit

1

8

High-throughput

0.479

High

538509

PP1B
Serine/threonine-protein phosphatase PP1-beta catalytic subunit

1

8

High-throughput

0.479

High

538510

RS14
Small ribosomal subunit protein uS11

1

1

Small-scale

0.479

High

538513

H4
Histone H4

1

2

Small-scale

0.479

High

538515

RL40
Ubiquitin-ribosomal protein eL40 fusion protein

1

2

Small-scale

0.479

High

538523

SET
Protein SET

1

4

Small-scale

0.479

High

538534

TRAP1
Heat shock protein 75 kDa, mitochondrial

1

1

Small-scale

0.479

High

538535

CDC16
Cell division cycle protein 16 homolog

1

11

Small-scale

0.479

High

538536

TIF1B
Transcription intermediary factor 1-beta

1

5

Small-scale

0.479

High

538539

HDAC1
Histone deacetylase 1

1

1

Small-scale

0.479

High

538541

CUL3
Cullin-3

1

3

Small-scale

0.479

High

538548

NUMA1
Nuclear mitotic apparatus protein 1

1

1

Small-scale

0.479

High

538550

PCM1
Pericentriolar material 1 protein

1

1

High-throughput

0.479

High

538555

CCDC6
Coiled-coil domain-containing protein 6

1

2

Small-scale

0.479

High

538558

CE170
Centrosomal protein of 170 kDa

1

1

High-throughput

0.479

High

538565

TRI67
Tripartite motif-containing protein 67

1

3

High-throughput

0.479

High

538566

CE128
Centrosomal protein of 128 kDa

1

1

High-throughput

0.479

High

538571

UBP37
Ubiquitin carboxyl-terminal hydrolase 37

1

4

Small-scale

0.479

High

538574

DZIP3
E3 ubiquitin-protein ligase DZIP3

1

1

Small-scale

0.479

High

538577

CCAR1
Cell division cycle and apoptosis regulator protein 1

1

1

Small-scale

0.479

High

538580

NIN
Ninein

1

1

High-throughput

0.479

High

538595

RMD3
Regulator of microtubule dynamics protein 3

1

1

High-throughput

0.479

High

538600

GRWD1
Glutamate-rich WD repeat-containing protein 1

1

1

Small-scale

0.479

High

538607

PKHA4
Pleckstrin homology domain-containing family A member 4

1

1

High-throughput

0.479

High

538611

TRI36
E3 ubiquitin-protein ligase TRIM36

1

7

High-throughput

0.479

High

538612

SIR7
NAD-dependent protein deacetylase sirtuin-7

1

3

Small-scale

0.479

High

538620

ZO2
Tight junction protein ZO-2

1

1

High-throughput

0.479

High

538621

ZRAN1
Ubiquitin thioesterase ZRANB1

1

1

High-throughput

0.479

High

538626

APC10
Anaphase-promoting complex subunit 10

1

1

Small-scale

0.479

High

538627

CC14A
Dual specificity protein phosphatase CDC14A

1

3

Small-scale

0.479

High

538629

EXO1
Exonuclease 1

1

7

Small-scale

0.479

High

538630

FBW1A
F-box/WD repeat-containing protein 1A

1

2

Small-scale

0.479

High

150842

DVL2
Segment polarity protein dishevelled homolog DVL-2

1

0

High-throughput

0.458

High

301174

RHBT3
Rho-related BTB domain-containing protein 3

1

0

Small-scale

0.458

High

538466

MGMT
Methylated-DNA--protein-cysteine methyltransferase

1

0

Small-scale

0.458

High

538473

DNMT1
DNA

1

0

Small-scale

0.458

High

538511

RS18
Small ribosomal subunit protein uS13

1

0

Small-scale

0.458

High

538512

RHOB
Rho-related GTP-binding protein RhoB

1

0

High-throughput

0.458

High

538526

TF65
Transcription factor p65

1

0

Small-scale

0.458

High

538554

EZH2
Histone-lysine N-methyltransferase EZH2

1

0

High-throughput

0.458

High

538559

CE162
Centrosomal protein of 162 kDa

1

0

High-throughput

0.458

High

538568

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

0

High-throughput

0.458

High

538570

CNTRL
Centriolin

1

0

High-throughput

0.458

High

538576

MFN1
Mitofusin-1

1

0

Small-scale

0.458

High

538578

SPICE
Spindle and centriole-associated protein 1

1

0

High-throughput

0.458

High

538579

RPTOR
Regulatory-associated protein of mTOR

1

0

Small-scale

0.458

High

538583

FBF1
Fas-binding factor 1

1

0

High-throughput

0.458

High

538593

CIC
Protein capicua homolog

1

0

High-throughput

0.458

High

538594

DCR1C
Protein artemis

1

0

Small-scale

0.458

High

538601

WAC
WW domain-containing adapter protein with coiled-coil

1

0

Small-scale

0.458

High

538603

MLP3B
Microtubule-associated proteins 1A/1B light chain 3B

1

0

High-throughput

0.458

High

538604

APC1
Anaphase-promoting complex subunit 1

1

0

Small-scale

0.458

High

538613

TREX1
Three-prime repair exonuclease 1

1

0

Small-scale

0.458

High

538615

MARH5
E3 ubiquitin-protein ligase MARCHF5

1

0

Small-scale

0.458

High

538616

BCLF1
Bcl-2-associated transcription factor 1

1

0

Small-scale

0.458

High

538618

TLS1
Splicing factor C9orf78

1

0

High-throughput

0.458

High

538624

JUPI1
Jupiter microtubule associated homolog 1

1

0

Small-scale

0.458

High

401345

JUN
Transcription factor Jun

1

1

High-throughput

0.445

High

434129

RET
Proto-oncogene tyrosine-protein kinase receptor Ret

1

2

High-throughput

0.437

High

538524

ROR2
Tyrosine-protein kinase transmembrane receptor ROR2

1

3

High-throughput

0.437

High

538564

LMBRL
Protein LMBR1L

1

1

High-throughput

0.437

High

127628

EF2K
Eukaryotic elongation factor 2 kinase

1

0

Small-scale

0.426

High

414559

PTMA
Prothymosin alpha [Cleaved into: Prothymosin alpha, N-terminally processed; Thymosin alpha-1]

1

0

Small-scale

0.426

High

92536

E9PJN9
Ribosomal protein S3

1

1

High-throughput

0.407

High

538494

CEBPA
CCAAT/enhancer-binding protein alpha

1

0

High-throughput

0.391

High

362580

C1QC
Complement C1q subcomponent subunit C

1

0

High-throughput

0.279

Low

538582

F110D
Protein FAM110D

1

0

High-throughput

0.279

Low

538590

DOCK7
Dedicator of cytokinesis protein 7

1

0

High-throughput

0.279

Low

538609

CIP1
E3 ubiquitin-protein ligase CCNB1IP1

1

0

Small-scale

0.265

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024