Protein: CRKL
Crk-like protein

Gene: CRKL
Organism: Homo sapiens
Interactions: 208
UniProt ID: P46109

Gene Ontology (top 5):
GO:0001558 - regulation of cell growth
GO:0001568 - blood vessel development
GO:0001655 - urogenital system development
GO:0001764 - neuron migration
GO:0001783 - B cell apoptotic process

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

337389

ABL1
Tyrosine-protein kinase ABL1

13

20

Small-scale

0.983

High

338102

EGFR
Epidermal growth factor receptor

6

20

Small-scale

0.942

High

655266

P85A
Phosphatidylinositol 3-kinase regulatory subunit alpha

6

20

Small-scale

0.931

High

802892

DOK1
Docking protein 1

5

20

Small-scale

0.928

High

802811

BCAR1
Breast cancer anti-estrogen resistance protein 1

5

20

Small-scale

0.915

High

802843

CASL
Enhancer of filamentation 1

4

20

Small-scale

0.893

High

802837

GAB1
GRB2-associated-binding protein 1

4

20

Small-scale

0.886

High

802826

SOS1
Son of sevenless homolog 1

4

20

High-throughput

0.881

High

786590

STA5A
Signal transducer and activator of transcription 5A

3

4

Small-scale

0.870

High

506542

BCR
Breakpoint cluster region protein

3

20

Small-scale

0.864

High

581156

EPOR
Erythropoietin receptor

3

20

Small-scale

0.857

High

802920

GAB2
GRB2-associated-binding protein 2

3

20

Small-scale

0.854

High

181818

SOCS1
Suppressor of cytokine signaling 1

3

20

Small-scale

0.834

High

802829

ARHG5
Rho guanine nucleotide exchange factor 5

3

20

High-throughput

0.821

High

802803

CRKL
Crk-like protein

2

20

Small-scale

0.812

High

802842

DOCK1
Dedicator of cytokinesis protein 1

2

20

High-throughput

0.811

High

802866

PRAG1
Inactive tyrosine-protein kinase PRAG1

2

10

High-throughput

0.811

High

802906

DOCK5
Dedicator of cytokinesis protein 5

2

18

High-throughput

0.811

High

129238

P85B
Phosphatidylinositol 3-kinase regulatory subunit beta

2

20

Small-scale

0.806

High

802823

PTN11
Tyrosine-protein phosphatase non-receptor type 11

2

20

Small-scale

0.806

High

433280

YES
Tyrosine-protein kinase Yes

2

20

High-throughput

0.783

High

802808

BLK
Tyrosine-protein kinase Blk

2

20

High-throughput

0.783

High

802854

TENS2
Tensin-2

4

9

High-throughput

0.778

High

383685

ERBB2
Receptor tyrosine-protein kinase erbB-2

2

20

High-throughput

0.778

High

610289

CBL
E3 ubiquitin-protein ligase CBL

38

20

Small-scale

0.770

High

499248

KIT
Mast/stem cell growth factor receptor Kit

2

20

Small-scale

0.768

High

802840

RPGF1
Rap guanine nucleotide exchange factor 1

16

20

Small-scale

0.762

High

663966

PTN4
Tyrosine-protein phosphatase non-receptor type 4

2

20

High-throughput

0.754

High

802851

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

2

9

High-throughput

0.737

High

802885

SH3K1
SH3 domain-containing kinase-binding protein 1

2

20

High-throughput

0.737

High

64671

RHG32
Rho GTPase-activating protein 32

1

20

Small-scale

0.724

High

796524

KSYK
Tyrosine-protein kinase SYK

1

20

Small-scale

0.724

High

802882

SHIP1
Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1

1

20

Small-scale

0.724

High

557065

PGFRA
Platelet-derived growth factor receptor alpha

1

20

Small-scale

0.715

High

299104

SASH1
SAM and SH3 domain-containing protein 1

1

2

Small-scale

0.713

High

802883

M4K1
Mitogen-activated protein kinase kinase kinase kinase 1

4

20

Small-scale

0.702

High

63070

RHG42
Rho GTPase-activating protein 42

1

20

High-throughput

0.691

High

787358

PK3CB
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform

1

16

High-throughput

0.691

High

789044

ABL2
Tyrosine-protein kinase ABL2

1

20

High-throughput

0.691

High

802827

SOS2
Son of sevenless homolog 2

1

20

High-throughput

0.691

High

802877

ASAP3
Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 3

1

20

High-throughput

0.691

High

802918

ASAP1
Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1

1

20

High-throughput

0.691

High

572596

VGFR1
Vascular endothelial growth factor receptor 1

1

20

Small-scale

0.665

High

802924

M4K5
Mitogen-activated protein kinase kinase kinase kinase 5

3

20

Small-scale

0.664

High

802834

CBLB
E3 ubiquitin-protein ligase CBL-B

3

20

Small-scale

0.660

High

802822

NOTC2
Neurogenic locus notch homolog protein 2

1

5

High-throughput

0.656

High

802907

PKHA1
Pleckstrin homology domain-containing family A member 1

1

20

High-throughput

0.656

High

802897

UBL5
Ubiquitin-like protein 5

1

0

High-throughput

0.656

High

802875

RIN3
Ras and Rab interactor 3

3

20

High-throughput

0.654

High

601845

ERBB3
Receptor tyrosine-protein kinase erbB-3

1

20

High-throughput

0.647

High

738174

FLT3
Receptor-type tyrosine-protein kinase FLT3

1

20

Small-scale

0.647

High

802871

ABI1
Abl interactor 1

1

20

Small-scale

0.647

High

802917

KDIS
Kinase D-interacting substrate of 220 kDa

1

4

Small-scale

0.647

High

802806

PAXI
Paxillin

2

20

Small-scale

0.629

High

802836

IFIT5
Interferon-induced protein with tetratricopeptide repeats 5

2

6

High-throughput

0.628

High

802858

EDC4
Enhancer of mRNA-decapping protein 4

2

6

High-throughput

0.628

High

802887

EDC3
Enhancer of mRNA-decapping protein 3

2

1

High-throughput

0.628

High

802905

PEAK1
Inactive tyrosine-protein kinase PEAK1

2

20

High-throughput

0.628

High

802895

SHAN3
SH3 and multiple ankyrin repeat domains protein 3

1

16

High-throughput

0.621

High

148506

CTRO
Citron Rho-interacting kinase

1

6

High-throughput

0.618

High

226784

PRKN
E3 ubiquitin-protein ligase parkin

1

15

High-throughput

0.618

High

384452

NTRK1
High affinity nerve growth factor receptor

1

20

High-throughput

0.618

High

434155

RET
Proto-oncogene tyrosine-protein kinase receptor Ret

1

20

High-throughput

0.618

High

507902

FGFR1
Fibroblast growth factor receptor 1

1

20

Small-scale

0.618

High

607913

FGFR4
Fibroblast growth factor receptor 4

1

20

High-throughput

0.618

High

665168

EPHA2
Ephrin type-A receptor 2

1

20

High-throughput

0.618

High

665448

EPHA8
Ephrin type-A receptor 8

1

20

High-throughput

0.618

High

666037

SHC1
SHC-transforming protein 1

1

20

Small-scale

0.618

High

669141

TYK2
Non-receptor tyrosine-protein kinase TYK2

1

20

Small-scale

0.618

High

802809

STA5B
Signal transducer and activator of transcription 5B

1

4

Small-scale

0.618

High

802810

EPHA4
Ephrin type-A receptor 4

1

20

High-throughput

0.618

High

802812

PTEN
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

1

8

Small-scale

0.618

High

802818

GRB2
Growth factor receptor-bound protein 2

1

20

Small-scale

0.618

High

802828

ACK1
Activated CDC42 kinase 1

1

20

Small-scale

0.618

High

802847

ERBB4
Receptor tyrosine-protein kinase erbB-4

1

20

Small-scale

0.618

High

802878

BLNK
B-cell linker protein

1

20

Small-scale

0.618

High

802881

DOCK2
Dedicator of cytokinesis protein 2

1

17

Small-scale

0.618

High

802893

RHG09
Rho GTPase-activating protein 9

1

20

High-throughput

0.618

High

802915

UBQL2
Ubiquilin-2

1

8

High-throughput

0.618

High

802919

ALK
ALK tyrosine kinase receptor

1

20

High-throughput

0.618

High

787862

EPS15
Epidermal growth factor receptor substrate 15

2

12

High-throughput

0.611

High

802890

ELMO2
Engulfment and cell motility protein 2

2

9

High-throughput

0.611

High

802923

MARF1
Meiosis regulator and mRNA stability factor 1

2

1

High-throughput

0.611

High

56516

PTPC1
Protein tyrosine phosphatase domain-containing protein 1

2

12

High-throughput

0.606

High

802815

PRS10
26S proteasome regulatory subunit 10B

2

4

High-throughput

0.606

High

165280

AREL1
Apoptosis-resistant E3 ubiquitin protein ligase 1

2

5

High-throughput

0.594

High

235054

DOK2
Docking protein 2

2

20

High-throughput

0.594

High

660426

GRN
Progranulin

2

2

High-throughput

0.594

High

411332

INSR
Insulin receptor

1

20

Small-scale

0.590

High

346177

MYC
Myc proto-oncogene protein

2

5

High-throughput

0.584

High

103875

G5E9C8
SOS Ras/Rac guanine nucleotide exchange factor 1

1

20

High-throughput

0.575

High

167748

FYB1
FYN-binding protein 1

1

17

Small-scale

0.575

High

802856

PKHA7
Pleckstrin homology domain-containing family A member 7

1

16

High-throughput

0.575

High

269125

DAB1
Disabled homolog 1

1

20

Small-scale

0.561

High

790644

WASP
Actin nucleation-promoting factor WAS

1

20

Small-scale

0.561

High

802864

UBP53
Inactive ubiquitin carboxyl-terminal hydrolase 53

2

10

High-throughput

0.553

High

802862

TRI67
Tripartite motif-containing protein 67

1

20

High-throughput

0.553

High

802902

PKHA4
Pleckstrin homology domain-containing family A member 4

1

20

High-throughput

0.553

High

802888

OTUB1
Ubiquitin thioesterase OTUB1

2

0

High-throughput

0.547

High

632637

TYY1
Transcriptional repressor protein YY1

1

5

High-throughput

0.541

High

802817

RL31
Large ribosomal subunit protein eL31

1

1

High-throughput

0.541

High

661034

CD34
Hematopoietic progenitor cell antigen CD34

1

0

Small-scale

0.537

High

617255

SP100
Nuclear autoantigen Sp-100

1

4

High-throughput

0.536

High

640359

DDX6
Probable ATP-dependent RNA helicase DDX6

1

9

High-throughput

0.536

High

802805

CAPZB
F-actin-capping protein subunit beta

1

4

High-throughput

0.536

High

802867

DCP2
m7GpppN-mRNA hydrolase

1

1

High-throughput

0.536

High

802880

ELMO1
Engulfment and cell motility protein 1

1

9

High-throughput

0.536

High

802909

DCP1A
mRNA-decapping enzyme 1A

1

7

High-throughput

0.536

High

802835

BIK
Bcl-2-interacting killer

1

0

High-throughput

0.518

High

802884

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

1

7

High-throughput

0.515

High

376438

APOB
Apolipoprotein B-100

1

0

High-throughput

0.513

High

802819

PRR3
Proline-rich protein 3

1

0

High-throughput

0.513

High

802831

TRAP1
Heat shock protein 75 kDa, mitochondrial

1

0

High-throughput

0.513

High

802853

GORAB
RAB6-interacting golgin

1

0

High-throughput

0.513

High

802913

IMPCT
Protein IMPACT

1

0

High-throughput

0.513

High

802925

TELO2
Telomere length regulation protein TEL2 homolog

1

0

High-throughput

0.513

High

170045

PLS1
Phospholipid scramblase 1

1

1

High-throughput

0.508

High

172646

LAMA5
Laminin subunit alpha-5

1

6

High-throughput

0.508

High

151734

IRS4
Insulin receptor substrate 4

1

15

Small-scale

0.501

High

311054

MPZL1
Myelin protein zero-like protein 1

1

5

High-throughput

0.489

High

802830

PNRC1
Proline-rich nuclear receptor coactivator 1

1

1

High-throughput

0.489

High

802855

MSL1
Male-specific lethal 1 homolog

1

0

High-throughput

0.486

High

802825

KHDR1
KH domain-containing, RNA-binding, signal transduction-associated protein 1

1

18

High-throughput

0.481

High

802869

PHC2
Polyhomeotic-like protein 2

1

14

High-throughput

0.481

High

802872

LTBP4
Latent-transforming growth factor beta-binding protein 4

1

8

High-throughput

0.481

High

802874

LIPB2
Liprin-beta-2

1

9

High-throughput

0.481

High

802894

WAC
WW domain-containing adapter protein with coiled-coil

1

7

High-throughput

0.481

High

802904

GARE1
GRB2-associated and regulator of MAPK protein 1

1

9

High-throughput

0.481

High

165825

KDM6B
Lysine-specific demethylase 6B

1

8

Small-scale

0.479

High

232036

KDM1A
Lysine-specific histone demethylase 1A

1

5

High-throughput

0.479

High

294497

RECQ4
ATP-dependent DNA helicase Q4

1

6

High-throughput

0.479

High

308487

KI20A
Kinesin-like protein KIF20A

1

11

High-throughput

0.479

High

322305

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

5

High-throughput

0.479

High

324268

BAG3
BAG family molecular chaperone regulator 3

1

4

High-throughput

0.479

High

324759

M4K4
Mitogen-activated protein kinase kinase kinase kinase 4

1

20

High-throughput

0.479

High

328763

TOP3B
DNA topoisomerase 3-beta-1

1

3

High-throughput

0.479

High

359742

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

20

High-throughput

0.479

High

403818

ITB1
Integrin beta-1

1

8

Small-scale

0.479

High

503633

HSP7C
Heat shock cognate 71 kDa protein

1

11

High-throughput

0.479

High

519329

FCGR1
High affinity immunoglobulin gamma Fc receptor I

1

20

Small-scale

0.479

High

521791

CADH1
Cadherin-1

1

15

High-throughput

0.479

High

523581

XRCC6
X-ray repair cross-complementing protein 6

1

4

High-throughput

0.479

High

525862

IFM1
Interferon-induced transmembrane protein 1

1

3

High-throughput

0.479

High

552166

RFA2
Replication protein A 32 kDa subunit

1

7

High-throughput

0.479

High

589564

CD33
Myeloid cell surface antigen CD33

1

8

Small-scale

0.479

High

650604

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

8

High-throughput

0.479

High

719908

RFA3
Replication protein A 14 kDa subunit

1

4

High-throughput

0.479

High

781605

ETV6
Transcription factor ETV6

1

5

Small-scale

0.479

High

800717

MK08
Mitogen-activated protein kinase 8

1

4

Small-scale

0.479

High

802804

YAP1
Transcriptional coactivator YAP1

1

9

High-throughput

0.479

High

802807

MCM2
DNA replication licensing factor MCM2

1

4

High-throughput

0.479

High

802813

UBC12
NEDD8-conjugating enzyme Ubc12

1

1

High-throughput

0.479

High

802814

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

6

High-throughput

0.479

High

802816

RB11A
Ras-related protein Rab-11A

1

9

High-throughput

0.479

High

802820

IFM3
Interferon-induced transmembrane protein 3

1

3

High-throughput

0.479

High

802821

KIF23
Kinesin-like protein KIF23

1

9

High-throughput

0.479

High

802832

UBP4
Ubiquitin carboxyl-terminal hydrolase 4

1

6

High-throughput

0.479

High

802833

RFA4
Replication protein A 30 kDa subunit

1

7

High-throughput

0.479

High

802838

BIRC3
Baculoviral IAP repeat-containing protein 3

1

4

High-throughput

0.479

High

802839

HDAC1
Histone deacetylase 1

1

2

High-throughput

0.479

High

802845

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

2

High-throughput

0.479

High

802846

KIF14
Kinesin-like protein KIF14

1

9

High-throughput

0.479

High

802849

ODFP2
Outer dense fiber protein 2

1

7

High-throughput

0.479

High

802852

CE170
Centrosomal protein of 170 kDa

1

19

High-throughput

0.479

High

802865

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

4

High-throughput

0.479

High

802868

M4K3
Mitogen-activated protein kinase kinase kinase kinase 3

1

20

High-throughput

0.479

High

802870

SLX4
Structure-specific endonuclease subunit SLX4

1

6

High-throughput

0.479

High

802879

GBF1
Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1

1

3

High-throughput

0.479

High

802886

PF21A
PHD finger protein 21A

1

9

High-throughput

0.479

High

802889

BICD1
Protein bicaudal D homolog 1

1

7

High-throughput

0.479

High

802898

WWTR1
WW domain-containing transcription regulator protein 1

1

8

High-throughput

0.479

High

802901

CHM4B
Charged multivesicular body protein 4b

1

4

High-throughput

0.479

High

802903

EGLN3
Prolyl hydroxylase EGLN3

1

2

High-throughput

0.479

High

802910

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

1

1

Small-scale

0.479

High

802914

ZRAN1
Ubiquitin thioesterase ZRANB1

1

7

High-throughput

0.479

High

802916

RCOR1
REST corepressor 1

1

5

High-throughput

0.479

High

802921

NINL
Ninein-like protein

1

10

High-throughput

0.479

High

254231

MEGF6
Multiple epidermal growth factor-like domains protein 6

1

9

High-throughput

0.464

High

802824

AOXA
Aldehyde oxidase

1

0

High-throughput

0.460

High

92179

E9PAV9
G patch domain-containing protein 4

1

0

High-throughput

0.458

High

166217

GRRE1
Granule associated Rac and RHOG effector protein 1

1

0

High-throughput

0.458

High

802844

CUL7
Cullin-7

1

0

High-throughput

0.458

High

802848

CRY2
Cryptochrome-2

1

0

High-throughput

0.458

High

802859

PRP8
Pre-mRNA-processing-splicing factor 8

1

0

High-throughput

0.458

High

802857

Q6NSK7
RIN3 protein

1

20

High-throughput

0.457

High

802891

DCBD2
Discoidin, CUB and LCCL domain-containing protein 2

1

4

Small-scale

0.457

High

377978

PRIO
Major prion protein

1

4

High-throughput

0.445

High

401599

JUN
Transcription factor Jun

1

4

High-throughput

0.445

High

496517

TAU
Microtubule-associated protein tau

1

14

High-throughput

0.445

High

581523

VCAM1
Vascular cell adhesion protein 1

1

16

High-throughput

0.445

High

802850

Q5JVZ5
Engulfment and cell motility 2

1

9

High-throughput

0.445

High

802899

GBRL1
Gamma-aminobutyric acid receptor-associated protein-like 1

1

2

High-throughput

0.445

High

100573

APRIO
Alternative prion protein

1

4

High-throughput

0.437

High

318586

EYA4
Eyes absent homolog 4

1

3

High-throughput

0.437

High

802841

TRI14
Tripartite motif-containing protein 14

1

14

High-throughput

0.437

High

802861

PEAK3
Protein PEAK3

1

13

Small-scale

0.437

High

802896

ACE2
Angiotensin-converting enzyme 2

1

1

High-throughput

0.437

High

802908

GPVI
Platelet glycoprotein VI

1

4

Small-scale

0.437

High

802911

KBTB4
Kelch repeat and BTB domain-containing protein 4

1

4

High-throughput

0.437

High

802912

PIHD1
PIH1 domain-containing protein 1

1

1

High-throughput

0.437

High

802922

AAR2
Protein AAR2 homolog

1

1

High-throughput

0.437

High

484435

RPAC2
DNA-directed RNA polymerases I and III subunit RPAC2

1

1

High-throughput

0.417

High

802863

NEK10
Serine/threonine-protein kinase Nek10

1

9

High-throughput

0.407

High

802900

TM168
Transmembrane protein 168

2

0

High-throughput

0.310

High

802860

GDPP1
GDP-D-glucose phosphorylase 1

1

0

High-throughput

0.279

Low

802873

CO054
Putative uncharacterized protein encoded by LINC02915

1

0

High-throughput

0.279

Low

802876

C99L2
CD99 antigen-like protein 2

1

0

High-throughput

0.249

Low


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Last updated: 15 Jul 2024