Protein: ERBB4
Receptor tyrosine-protein kinase erbB-4 (EC 2.7.10.1) (Proto-oncogene-like protein c-ErbB-4) (Tyrosine kinase-type cell surface receptor HER4) (p180erbB4) [Cleaved into: ERBB4 intracellular domain (4ICD) (E4ICD) (s80HER4)]

Gene: ERBB4
Organism: Homo sapiens
Interactions: 182
UniProt ID: Q15303

Gene Ontology (top 5):
GO:0000976 - transcription cis-regulatory region binding
GO:0001755 - neural crest cell migration
GO:0001934 - positive regulation of protein phosphorylation
GO:0004713 - protein tyrosine kinase activity
GO:0004714 - transmembrane receptor protein tyrosine kinase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

383821

ERBB2
Receptor tyrosine-protein kinase erbB-2

8

19

Small-scale

0.960

High

338460

EGFR
Epidermal growth factor receptor

6

20

Small-scale

0.943

High

1070966

ERBB4
Receptor tyrosine-protein kinase erbB-4

5

19

Small-scale

0.930

High

666116

SHC1
SHC-transforming protein 1

5

20

Small-scale

0.916

High

942346

DLG4
Disks large homolog 4

4

17

Small-scale

0.903

High

924589

GRB2
Growth factor receptor-bound protein 2

4

20

Small-scale

0.884

High

985960

PTN11
Tyrosine-protein phosphatase non-receptor type 11

3

20

Small-scale

0.872

High

1070999

LRIG1
Leucine-rich repeats and immunoglobulin-like domains protein 1

3

20

Small-scale

0.871

High

601925

ERBB3
Receptor tyrosine-protein kinase erbB-3

3

18

Small-scale

0.829

High

786612

STA5A
Signal transducer and activator of transcription 5A

3

20

Small-scale

0.827

High

665895

PTN6
Tyrosine-protein phosphatase non-receptor type 6

2

20

High-throughput

0.817

High

618088

COF1
Cofilin-1

3

5

High-throughput

0.814

High

970267

NRG1
Pro-neuregulin-1, membrane-bound isoform

2

18

Small-scale

0.792

High

129295

P85B
Phosphatidylinositol 3-kinase regulatory subunit beta

2

20

Small-scale

0.789

High

337480

ABL1
Tyrosine-protein kinase ABL1

2

19

High-throughput

0.778

High

596404

RASA1
Ras GTPase-activating protein 1

2

20

High-throughput

0.778

High

789067

ABL2
Tyrosine-protein kinase ABL2

2

19

High-throughput

0.778

High

796580

KSYK
Tyrosine-protein kinase SYK

2

20

High-throughput

0.778

High

209056

NCK2
Cytoplasmic protein NCK2

2

20

Small-scale

0.768

High

557701

NCK1
SH2/SH3 adapter protein NCK1

2

20

Small-scale

0.768

High

802607

CRK
Adapter molecule crk

2

20

Small-scale

0.768

High

1021496

DLG1
Disks large homolog 1

2

17

Small-scale

0.754

High

923826

FKB1A
Peptidyl-prolyl cis-trans isomerase FKBP1A

2

9

High-throughput

0.743

High

1071001

LRRC7
Leucine-rich repeat-containing protein 7

2

20

High-throughput

0.743

High

1070970

NTRK2
BDNF/NT-3 growth factors receptor

1

20

Small-scale

0.724

High

1070977

LRIG3
Leucine-rich repeats and immunoglobulin-like domains protein 3

1

20

Small-scale

0.724

High

808627

YAP1
Transcriptional coactivator YAP1

5

20

Small-scale

0.720

High

412202

FYN
Tyrosine-protein kinase Fyn

1

20

Small-scale

0.713

High

1071023

WWOX
WW domain-containing oxidoreductase

5

1

Small-scale

0.704

High

146927

PTPRT
Receptor-type tyrosine-protein phosphatase T

1

20

High-throughput

0.698

High

719339

PTN7
Tyrosine-protein phosphatase non-receptor type 7

1

20

High-throughput

0.698

High

983487

PTN12
Tyrosine-protein phosphatase non-receptor type 12

1

20

High-throughput

0.698

High

1069844

PTPRR
Receptor-type tyrosine-protein phosphatase R

1

20

High-throughput

0.698

High

1070998

ITCH
E3 ubiquitin-protein ligase Itchy homolog

2

20

Small-scale

0.667

High

1033874

SNTB2
Beta-2-syntrophin

1

20

Small-scale

0.656

High

1070968

DLG2
Disks large homolog 2

1

14

Small-scale

0.656

High

1070994

DLG3
Disks large homolog 3

1

15

Small-scale

0.656

High

1071024

HDAC6
Histone deacetylase 6

3

8

Small-scale

0.653

High

1070971

PTN21
Tyrosine-protein phosphatase non-receptor type 21

1

20

Small-scale

0.648

High

145979

SH2B2
SH2B adapter protein 2

1

20

High-throughput

0.647

High

146629

SOCS2
Suppressor of cytokine signaling 2

1

20

High-throughput

0.647

High

147427

SOCS3
Suppressor of cytokine signaling 3

1

20

High-throughput

0.647

High

147522

SOCS6
Suppressor of cytokine signaling 6

1

20

High-throughput

0.647

High

155844

SH21B
SH2 domain-containing protein 1B

1

20

High-throughput

0.647

High

176447

SHIP2
Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2

1

11

High-throughput

0.647

High

181866

SOCS1
Suppressor of cytokine signaling 1

1

20

High-throughput

0.647

High

243143

SH21A
SH2 domain-containing protein 1A

1

20

High-throughput

0.647

High

256853

SOCS5
Suppressor of cytokine signaling 5

1

20

High-throughput

0.647

High

275197

GRAP2
GRB2-related adapter protein 2

1

20

High-throughput

0.647

High

275573

BCAR3
Breast cancer anti-estrogen resistance protein 3

1

20

High-throughput

0.647

High

411729

LCK
Tyrosine-protein kinase Lck

1

20

High-throughput

0.647

High

426961

FES
Tyrosine-protein kinase Fes/Fps

1

20

High-throughput

0.647

High

433359

YES
Tyrosine-protein kinase Yes

1

20

High-throughput

0.647

High

433770

LYN
Tyrosine-protein kinase Lyn

1

20

High-throughput

0.647

High

1071000

HSH2D
Hematopoietic SH2 domain-containing protein

1

20

High-throughput

0.647

High

442833

HCK
Tyrosine-protein kinase HCK

1

20

High-throughput

0.647

High

454834

FGR
Tyrosine-protein kinase Fgr

1

20

High-throughput

0.647

High

522997

SRC
Proto-oncogene tyrosine-protein kinase Src

1

20

High-throughput

0.647

High

548711

VAV
Proto-oncogene vav

1

20

High-throughput

0.647

High

562648

PLCG2
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2

1

17

High-throughput

0.647

High

581010

PLCG1
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1

1

20

High-throughput

0.647

High

655377

P85A
Phosphatidylinositol 3-kinase regulatory subunit alpha

1

20

High-throughput

0.647

High

788965

MATK
Megakaryocyte-associated tyrosine-protein kinase

1

20

High-throughput

0.647

High

788994

TEC
Tyrosine-protein kinase Tec

1

20

High-throughput

0.647

High

789023

TXK
Tyrosine-protein kinase TXK

1

20

High-throughput

0.647

High

796471

ZAP70
Tyrosine-protein kinase ZAP-70

1

20

High-throughput

0.647

High

846473

BLK
Tyrosine-protein kinase Blk

1

20

High-throughput

0.647

High

855797

VAV2
Guanine nucleotide exchange factor VAV2

1

20

High-throughput

0.647

High

940669

3BP2
SH3 domain-binding protein 2

1

15

High-throughput

0.647

High

957124

SHC2
SHC-transforming protein 2

1

20

High-throughput

0.647

High

996562

ITK
Tyrosine-protein kinase ITK/TSK

1

20

High-throughput

0.647

High

1024132

LCP2
Lymphocyte cytosolic protein 2

1

20

High-throughput

0.647

High

1028470

SLAP1
Src-like-adapter

1

20

High-throughput

0.647

High

1031667

GRB10
Growth factor receptor-bound protein 10

1

20

High-throughput

0.647

High

1046403

PTK6
Protein-tyrosine kinase 6

1

20

High-throughput

0.647

High

1054054

GRB7
Growth factor receptor-bound protein 7

1

20

High-throughput

0.647

High

1070967

SHB
SH2 domain-containing adapter protein B

1

20

High-throughput

0.647

High

1070974

TENS2
Tensin-2

1

20

High-throughput

0.647

High

1070975

TENS3
Tensin-3

1

20

High-throughput

0.647

High

1070976

SHC4
SHC-transforming protein 4

1

20

High-throughput

0.647

High

1070979

ANS1B
Ankyrin repeat and sterile alpha motif domain-containing protein 1B

1

18

High-throughput

0.647

High

1070981

TENS4
Tensin-4

1

20

High-throughput

0.647

High

1070984

SH2D3
SH2 domain-containing protein 3C

1

20

High-throughput

0.647

High

1070990

SHC3
SHC-transforming protein 3

1

20

High-throughput

0.647

High

1070991

P55G
Phosphatidylinositol 3-kinase regulatory subunit gamma

1

20

High-throughput

0.647

High

1070992

ANS1A
Ankyrin repeat and SAM domain-containing protein 1A

1

19

High-throughput

0.647

High

1071013

SLAP2
Src-like-adapter 2

1

20

High-throughput

0.647

High

1071018

SH22A
SH2 domain-containing protein 2A

1

20

High-throughput

0.647

High

1071020

SH2B1
SH2B adapter protein 1

1

20

High-throughput

0.647

High

1071026

VAV3
Guanine nucleotide exchange factor VAV3

1

20

High-throughput

0.647

High

1071027

STAP1
Signal-transducing adaptor protein 1

1

5

High-throughput

0.647

High

1071028

SH2B3
SH2B adapter protein 3

1

20

High-throughput

0.647

High

808132

NEDD4
E3 ubiquitin-protein ligase NEDD4

2

20

Small-scale

0.634

High

1071010

WWP1
NEDD4-like E3 ubiquitin-protein ligase WWP1

2

20

Small-scale

0.634

High

1017078

TROP
Trophinin

2

4

Small-scale

0.624

High

1070973

PTN20
Tyrosine-protein phosphatase non-receptor type 20

1

20

High-throughput

0.621

High

224717

KALRN
Kalirin

1

14

Small-scale

0.618

High

684051

1433S
14-3-3 protein sigma

1

20

High-throughput

0.618

High

802847

CRKL
Crk-like protein

1

20

Small-scale

0.618

High

849893

STA5B
Signal transducer and activator of transcription 5B

1

20

Small-scale

0.618

High

909589

1433E
14-3-3 protein epsilon

1

8

High-throughput

0.618

High

146660

NRG2
Pro-neuregulin-2, membrane-bound isoform

2

11

Small-scale

0.602

High

1071011

RNF41
E3 ubiquitin-protein ligase NRDP1

2

15

Small-scale

0.595

High

1071006

LRRC1
Leucine-rich repeat-containing protein 1

1

20

Small-scale

0.590

High

1071017

PTPRH
Receptor-type tyrosine-protein phosphatase H

1

20

High-throughput

0.590

High

1070997

SHD
SH2 domain-containing adapter protein D

1

20

High-throughput

0.579

High

1071015

TENS1
Tensin-1

1

20

High-throughput

0.579

High

431871

HS90A
Heat shock protein HSP 90-alpha

2

20

High-throughput

0.576

High

375949

ALDOA
Fructose-bisphosphate aldolase A

2

5

High-throughput

0.576

High

495533

THIO
Thioredoxin

2

16

High-throughput

0.576

High

670836

PRDX5
Peroxiredoxin-5, mitochondrial

2

2

High-throughput

0.576

High

891156

GBRL2
Gamma-aminobutyric acid receptor-associated protein-like 2

2

6

High-throughput

0.576

High

1070978

I2BP2
Interferon regulatory factor 2-binding protein 2

2

2

High-throughput

0.576

High

1070983

SIM20
Small integral membrane protein 20

2

2

High-throughput

0.576

High

1071008

TMG4
Transmembrane gamma-carboxyglutamic acid protein 4

2

3

High-throughput

0.576

High

1071014

TM134
Transmembrane protein 134

2

2

High-throughput

0.576

High

1071016

ZN532
Zinc finger protein 532

2

4

High-throughput

0.576

High

1071019

RTN4
Reticulon-4

2

11

High-throughput

0.576

High

1071030

PIN4
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 4

2

4

High-throughput

0.576

High

1071032

SELK
Selenoprotein K

2

2

High-throughput

0.576

High

1071033

TM14A
Transmembrane protein 14A

2

1

High-throughput

0.576

High

1046835

BYST
Bystin

1

0

Small-scale

0.561

High

1070993

AP2C
Transcription factor AP-2 gamma

1

2

Small-scale

0.561

High

1071021

TAB2
TGF-beta-activated kinase 1 and MAP3K7-binding protein 2

1

11

Small-scale

0.552

High

56532

PTPC1
Protein tyrosine phosphatase domain-containing protein 1

1

20

High-throughput

0.541

High

273436

PPM1B
Protein phosphatase 1B

1

10

High-throughput

0.541

High

673584

MPIP3
M-phase inducer phosphatase 3

1

3

High-throughput

0.541

High

728610

PPM1A
Protein phosphatase 1A

1

10

High-throughput

0.541

High

829448

PPM1F
Protein phosphatase 1F

1

20

High-throughput

0.541

High

1040904

MTMR2
Myotubularin-related protein 2

1

12

High-throughput

0.541

High

1070969

TAB1
TGF-beta-activated kinase 1 and MAP3K7-binding protein 1

1

11

High-throughput

0.541

High

1070972

DUS6
Dual specificity protein phosphatase 6

1

20

High-throughput

0.541

High

1070986

DUS18
Dual specificity protein phosphatase 18

1

20

High-throughput

0.541

High

1070989

STYX
Serine/threonine/tyrosine-interacting protein

1

20

High-throughput

0.541

High

1071002

MTMR9
Myotubularin-related protein 9

1

12

High-throughput

0.541

High

1071007

DUS16
Dual specificity protein phosphatase 16

1

20

High-throughput

0.541

High

1071009

ILKAP
Integrin-linked kinase-associated serine/threonine phosphatase 2C

1

20

High-throughput

0.541

High

1071012

DUS21
Dual specificity protein phosphatase 21

1

20

High-throughput

0.541

High

1071029

MTMR6
Myotubularin-related protein 6

1

12

High-throughput

0.541

High

1071034

DUS10
Dual specificity protein phosphatase 10

1

20

High-throughput

0.541

High

642945

S10A4
Protein S100-A4

1

15

Small-scale

0.536

High

166123

SYNEM
Synemin

2

16

High-throughput

0.526

High

237891

AP180
Clathrin coat assembly protein AP180

2

14

High-throughput

0.526

High

1070995

TM230
Transmembrane protein 230

2

2

High-throughput

0.526

High

1070996

F241B
Protein FAM241B

2

2

High-throughput

0.526

High

1071022

TV23B
Golgi apparatus membrane protein TVP23 homolog B

2

3

High-throughput

0.526

High

1071025

ERG28
Ergosterol biosynthetic protein 28 homolog

2

2

High-throughput

0.526

High

1071031

TMA7
Translation machinery-associated protein 7

2

2

High-throughput

0.526

High

261514

NCOR1
Nuclear receptor corepressor 1

1

18

Small-scale

0.515

High

438189

HS90B
Heat shock protein HSP 90-beta

1

20

High-throughput

0.515

High

901365

CH10
10 kDa heat shock protein, mitochondrial

1

2

High-throughput

0.515

High

1071003

NUDC1
NudC domain-containing protein 1

1

0

High-throughput

0.513

High

304961

DUS14
Dual specificity protein phosphatase 14

1

20

High-throughput

0.494

High

1070988

DUS19
Dual specificity protein phosphatase 19

1

20

High-throughput

0.494

High

685170

S10AB
Protein S100-A11

1

15

High-throughput

0.481

High

1071005

MUC4
Mucin-4

1

20

Small-scale

0.481

High

159425

EREG
Proepiregulin [Cleaved into: Epiregulin

1

2

Small-scale

0.479

High

162768

XPO1
Exportin-1

1

18

Small-scale

0.479

High

164381

TRI66
Tripartite motif-containing protein 66

1

9

High-throughput

0.479

High

369651

ESR1
Estrogen receptor

1

14

Small-scale

0.479

High

386778

P53
Cellular tumor antigen p53

1

10

Small-scale

0.479

High

403648

AP2A
Transcription factor AP-2-alpha

1

2

Small-scale

0.479

High

554307

MUC1
Mucin-1

1

20

Small-scale

0.479

High

555145

CD44
CD44 antigen

1

5

Small-scale

0.479

High

567066

CXA1
Gap junction alpha-1 protein

1

13

High-throughput

0.479

High

610410

CBL
E3 ubiquitin-protein ligase CBL

1

20

Small-scale

0.479

High

777042

UBP8
Ubiquitin carboxyl-terminal hydrolase 8

1

10

Small-scale

0.479

High

962790

MDM2
E3 ubiquitin-protein ligase Mdm2

1

8

Small-scale

0.479

High

984266

NMDZ1
Glutamate receptor ionotropic, NMDA 1

1

10

Small-scale

0.479

High

1029449

TIF1B
Transcription intermediary factor 1-beta

1

5

Small-scale

0.479

High

1043000

CUL4A
Cullin-4A

1

12

High-throughput

0.479

High

1070980

MAGI2
Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2

1

20

Small-scale

0.479

High

1070982

PIAS4
E3 SUMO-protein ligase PIAS4

1

1

Small-scale

0.479

High

1070987

VANG1
Vang-like protein 1

1

3

Small-scale

0.479

High

1071004

HBEGF
Proheparin-binding EGF-like growth factor [Cleaved into: Heparin-binding EGF-like growth factor

1

19

Small-scale

0.479

High

1071035

PIAS3
E3 SUMO-protein ligase PIAS3

1

1

Small-scale

0.479

High

381999

G3P
Glyceraldehyde-3-phosphate dehydrogenase

1

4

High-throughput

0.457

High

893799

S10AA
Protein S100-A10

1

15

High-throughput

0.457

High

602259

CD9
CD9 antigen

1

6

High-throughput

0.445

High

1070985

GOLM1
Golgi membrane protein 1

1

1

Small-scale

0.445

High

1017047

TROAP
Tastin

1

0

Small-scale

0.279

Low


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Last updated: 15 Jul 2024