Protein: ZC3H3
Zinc finger CCCH domain-containing protein 3 (Smad-interacting CPSF-like factor)

Gene: ZC3H3
Organism: Homo sapiens
Interactions: 226
UniProt ID: Q8IXZ2

Gene Ontology (top 5):
GO:0003677 - DNA binding
GO:0005634 - nucleus
GO:0005847 - mRNA cleavage and polyadenylation specificity factor complex
GO:0031124 - mRNA 3'-end processing
GO:0032927 - positive regulation of activin receptor signaling pathway

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1221460

PABP3
Polyadenylate-binding protein 3

3

1

High-throughput

0.861

High

1221409

ZC3H8
Zinc finger CCCH domain-containing protein 8

2

2

High-throughput

0.789

High

789482

RBM34
RNA-binding protein 34

3

9

High-throughput

0.770

High

1221479

RBM28
RNA-binding protein 28

3

4

High-throughput

0.770

High

1221513

RBM19
Probable RNA-binding protein 19

3

4

High-throughput

0.770

High

1221480

PK1IP
p21-activated protein kinase-interacting protein 1

2

1

High-throughput

0.705

High

432803

HNRPC
Heterogeneous nuclear ribonucleoproteins C1/C2

1

5

High-throughput

0.691

High

992837

SRSF1
Serine/arginine-rich splicing factor 1

1

10

High-throughput

0.691

High

1164129

WDR74
WD repeat-containing protein 74

1

1

High-throughput

0.691

High

1221501

SET1B
Histone-lysine N-methyltransferase SETD1B

1

4

High-throughput

0.691

High

1221507

RBMX2
RNA-binding motif protein, X-linked 2

1

7

High-throughput

0.691

High

242508

DKC1
H/ACA ribonucleoprotein complex subunit DKC1

3

1

High-throughput

0.667

High

257653

ANR17
Ankyrin repeat domain-containing protein 17

3

3

High-throughput

0.667

High

559812

H12
Histone H1.2

3

5

High-throughput

0.667

High

922620

RL10A
Large ribosomal subunit protein uL1

3

3

High-throughput

0.667

High

971257

H11
Histone H1.1

3

5

High-throughput

0.667

High

1045624

NOG2
Nucleolar GTP-binding protein 2

3

2

High-throughput

0.667

High

1073222

PUM3
Pumilio homolog 3

3

1

High-throughput

0.667

High

1145684

LAR1B
La-related protein 1B

3

5

High-throughput

0.667

High

1216220

H2A2B
Histone H2A type 2-B

3

4

High-throughput

0.667

High

1221422

RENT1
Regulator of nonsense transcripts 1

3

2

High-throughput

0.667

High

1221456

GTPB4
GTP-binding protein 4

3

2

High-throughput

0.667

High

1221467

MOV10
Helicase MOV-10

3

2

High-throughput

0.667

High

1221472

SSF1
Suppressor of SWI4 1 homolog

3

1

High-throughput

0.667

High

395138

A4
Amyloid-beta precursor protein

3

0

High-throughput

0.642

High

149994

CTDS2
Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 2

3

0

High-throughput

0.638

High

827056

RM19
Large ribosomal subunit protein bL19m

3

0

High-throughput

0.638

High

1221437

RAB3I
Rab-3A-interacting protein

3

0

High-throughput

0.638

High

1221466

NMNA1
Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1

3

0

High-throughput

0.638

High

1221469

NGRN
Neugrin

3

0

High-throughput

0.638

High

1221490

ZNF70
Zinc finger protein 70

3

0

High-throughput

0.638

High

1221481

TRM1
tRNA

1

0

High-throughput

0.631

High

1221461

IKZF5
Zinc finger protein Pegasus

2

2

High-throughput

0.628

High

1221423

RL36L
Ribosomal protein eL42-like

3

0

High-throughput

0.628

High

1028724

SRSF5
Serine/arginine-rich splicing factor 5

1

9

High-throughput

0.618

High

1221414

ZCRB1
Zinc finger CCHC-type and RNA-binding motif-containing protein 1

1

7

High-throughput

0.618

High

1221454

MK67I
MKI67 FHA domain-interacting nucleolar phosphoprotein

1

8

High-throughput

0.618

High

1031384

PABP4
Polyadenylate-binding protein 4

1

1

High-throughput

0.618

High

1116378

LARP7
La-related protein 7

1

9

High-throughput

0.618

High

331843

NSD2
Histone-lysine N-methyltransferase NSD2

2

3

High-throughput

0.611

High

1221464

DDX31
ATP-dependent DNA helicase DDX31

2

4

High-throughput

0.611

High

216534

SAHH2
S-adenosylhomocysteine hydrolase-like protein 1

3

3

High-throughput

0.609

High

327488

TRUB2
Pseudouridylate synthase TRUB2, mitochondrial

3

2

High-throughput

0.609

High

738678

TNR3
Tumor necrosis factor receptor superfamily member 3

3

2

High-throughput

0.609

High

947608

RT05
Small ribosomal subunit protein uS5m

3

1

High-throughput

0.609

High

948631

RT09
Small ribosomal subunit protein uS9m

3

1

High-throughput

0.609

High

1162602

LARP1
La-related protein 1

3

5

High-throughput

0.609

High

1219778

ANKH1
Ankyrin repeat and KH domain-containing protein 1

3

3

High-throughput

0.609

High

1221408

ZCHC9
Zinc finger CCHC domain-containing protein 9

3

6

High-throughput

0.609

High

1221417

BRX1
Ribosome biogenesis protein BRX1 homolog

3

6

High-throughput

0.609

High

1221425

MTEF3
Transcription termination factor 3, mitochondrial

3

1

High-throughput

0.609

High

1221432

SAHH3
Adenosylhomocysteinase 3

3

3

High-throughput

0.609

High

1221451

RM13
Large ribosomal subunit protein uL13m

3

2

High-throughput

0.609

High

1221463

RPF2
Ribosome production factor 2 homolog

3

1

High-throughput

0.609

High

1221465

RPF1
Ribosome production factor 1

3

2

High-throughput

0.609

High

1221473

DDX21
Nucleolar RNA helicase 2

3

4

High-throughput

0.609

High

1221500

RL26L
Ribosomal protein uL24-like

3

3

High-throughput

0.599

High

273156

SURF6
Surfeit locus protein 6

2

0

High-throughput

0.585

High

899258

RL15
Large ribosomal subunit protein eL15

2

0

High-throughput

0.585

High

1152501

Q6ICH2
Apolipoprotein B mRNA editing enzyme catalytic subunit 3D

2

4

High-throughput

0.584

High

1158545

L2GL2
LLGL scribble cell polarity complex component 2

1

0

High-throughput

0.578

High

1221418

SREK1
Splicing regulatory glutamine/lysine-rich protein 1

1

0

High-throughput

0.578

High

271595

ERAL1
GTPase Era, mitochondrial

2

2

High-throughput

0.558

High

281326

RL1D1
Ribosomal L1 domain-containing protein 1

2

3

High-throughput

0.558

High

315388

NSA2
Ribosome biogenesis protein NSA2 homolog

2

1

High-throughput

0.558

High

947968

RT11
Small ribosomal subunit protein uS11m

2

1

High-throughput

0.558

High

1065828

RRS1
Ribosome biogenesis regulatory protein homolog

2

1

High-throughput

0.558

High

1221411

KRI1
Protein KRI1 homolog

2

1

High-throughput

0.558

High

1221458

DDX24
ATP-dependent RNA helicase DDX24

2

4

High-throughput

0.558

High

1221470

NOP10
H/ACA ribonucleoprotein complex subunit 3

2

1

High-throughput

0.558

High

1221487

NOP53
Ribosome biogenesis protein NOP53

2

2

High-throughput

0.558

High

1221508

RT02
Small ribosomal subunit protein uS2m

2

1

High-throughput

0.558

High

1020289

ELAV2
ELAV-like protein 2

1

4

High-throughput

0.553

High

230394

ZC3H1
Zinc finger C3H1 domain-containing protein

1

1

High-throughput

0.536

High

470447

H2A1
Histone H2A type 1

1

4

High-throughput

0.536

High

563489

ZNF22
Zinc finger protein 22

1

2

High-throughput

0.536

High

585501

E2AK2
Interferon-induced, double-stranded RNA-activated protein kinase

1

2

High-throughput

0.536

High

722260

RFC1
Replication factor C subunit 1

1

2

High-throughput

0.536

High

736573

RL4
Large ribosomal subunit protein uL4

1

1

High-throughput

0.536

High

913620

RL7A
Large ribosomal subunit protein eL8

1

2

High-throughput

0.536

High

916261

RL23A
Large ribosomal subunit protein uL23

1

1

High-throughput

0.536

High

924059

RS27A
Ubiquitin-ribosomal protein eS31 fusion protein

1

1

High-throughput

0.536

High

931264

YBOX1
Y-box-binding protein 1

1

6

High-throughput

0.536

High

980440

NOTC2
Neurogenic locus notch homolog protein 2

1

5

High-throughput

0.536

High

1027907

DDX10
Probable ATP-dependent RNA helicase DDX10

1

5

High-throughput

0.536

High

1057532

RRP1B
Ribosomal RNA processing protein 1 homolog B

1

1

High-throughput

0.536

High

1057968

RRP5
Protein RRP5 homolog

1

1

High-throughput

0.536

High

1169045

ZN574
Zinc finger protein 574

1

1

High-throughput

0.536

High

1183933

DHX30
ATP-dependent RNA helicase DHX30

1

2

High-throughput

0.536

High

1187660

ZCCHV
Zinc finger CCCH-type antiviral protein 1

1

3

High-throughput

0.536

High

1216939

ABC3F
DNA dC->dU-editing enzyme APOBEC-3F

1

4

High-throughput

0.536

High

1221416

DDX54
ATP-dependent RNA helicase DDX54

1

4

High-throughput

0.536

High

1221443

BUD13
BUD13 homolog

1

1

High-throughput

0.536

High

1221459

TSYL1
Testis-specific Y-encoded-like protein 1

1

1

High-throughput

0.536

High

1221474

ABC3C
DNA dC->dU-editing enzyme APOBEC-3C

1

4

High-throughput

0.536

High

1221483

AATF
Protein AATF

1

1

High-throughput

0.536

High

1221496

PURG
Purine-rich element-binding protein gamma

1

2

High-throughput

0.536

High

1221498

ABT1
Activator of basal transcription 1

1

1

High-throughput

0.536

High

172468

NKRF
NF-kappa-B-repressing factor

1

0

High-throughput

0.513

High

203146

P52K
52 kDa repressor of the inhibitor of the protein kinase

1

0

High-throughput

0.513

High

330206

PTTG1
Securin

1

0

High-throughput

0.513

High

642442

RL13
Large ribosomal subunit protein eL13

1

0

High-throughput

0.513

High

831000

CTCF
Transcriptional repressor CTCF

1

0

High-throughput

0.513

High

881226

CTBP2
C-terminal-binding protein 2

1

0

High-throughput

0.513

High

916684

RS6
Small ribosomal subunit protein eS6

1

0

High-throughput

0.513

High

920018

RS15
Small ribosomal subunit protein uS19

1

0

High-throughput

0.513

High

920247

RS24
Small ribosomal subunit protein eS24

1

0

High-throughput

0.513

High

967052

XPC
DNA repair protein complementing XP-C cells

1

0

High-throughput

0.513

High

1071735

TTF1
Transcription termination factor 1

1

0

High-throughput

0.513

High

1115542

GLYR1
Cytokine-like nuclear factor N-PAC

1

0

High-throughput

0.513

High

1162154

MDEAS
Mitotic deacetylase-associated SANT domain protein

1

0

High-throughput

0.513

High

1162418

CC137
Coiled-coil domain-containing protein 137

1

0

High-throughput

0.513

High

1221429

THOC1
THO complex subunit 1

1

0

High-throughput

0.513

High

1221430

LTV1
Protein LTV1 homolog

1

0

High-throughput

0.513

High

1221434

ZN512
Zinc finger protein 512

1

0

High-throughput

0.513

High

1221436

F111A
Serine protease FAM111A

1

0

High-throughput

0.513

High

1221485

F120A
Constitutive coactivator of PPAR-gamma-like protein 1

1

0

High-throughput

0.513

High

1221493

PARP2
Poly [ADP-ribose] polymerase 2

1

0

High-throughput

0.513

High

322856

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

3

High-throughput

0.489

High

446413

RM03
Large ribosomal subunit protein uL3m

1

1

High-throughput

0.489

High

591370

TNR1B
Tumor necrosis factor receptor superfamily member 1B

1

1

High-throughput

0.489

High

803157

IF2M
Translation initiation factor IF-2, mitochondrial

1

1

High-throughput

0.489

High

1040607

KRR1
KRR1 small subunit processome component homolog

1

2

High-throughput

0.489

High

1150324

RL7L
Ribosomal protein uL30-like

1

1

High-throughput

0.489

High

1221431

DDX27
Probable ATP-dependent RNA helicase DDX27

1

5

High-throughput

0.489

High

1221440

DDX50
ATP-dependent RNA helicase DDX50

1

5

High-throughput

0.489

High

1221446

UTP23
rRNA-processing protein UTP23 homolog

1

1

High-throughput

0.489

High

1221447

NOC4L
Nucleolar complex protein 4 homolog

1

1

High-throughput

0.489

High

1221449

MAK16
Protein MAK16 homolog

1

1

High-throughput

0.489

High

1221462

YTDC2
3'-5' RNA helicase YTHDC2

1

3

High-throughput

0.489

High

1221476

STAU2
Double-stranded RNA-binding protein Staufen homolog 2

1

3

High-throughput

0.489

High

1221477

DDX28
Probable ATP-dependent RNA helicase DDX28

1

3

High-throughput

0.489

High

1221482

GAR1
H/ACA ribonucleoprotein complex subunit 1

1

1

High-throughput

0.489

High

1221497

PNMA2
Paraneoplastic antigen Ma2

1

1

High-throughput

0.489

High

1221499

EDAR
Tumor necrosis factor receptor superfamily member EDAR

1

2

High-throughput

0.489

High

1221512

RT18C
Small ribosomal subunit protein bS18m

1

1

High-throughput

0.489

High

318665

EYA4
Eyes absent homolog 4

1

3

High-throughput

0.479

High

631497

BRD2
Bromodomain-containing protein 2

1

5

High-throughput

0.479

High

773439

RL13A
Large ribosomal subunit protein uL13

1

2

High-throughput

0.479

High

960537

PURA
Transcriptional activator protein Pur-alpha

1

2

High-throughput

0.479

High

1221412

PAPD5
Terminal nucleotidyltransferase 4B

1

5

High-throughput

0.479

High

1221421

ESR2
Estrogen receptor beta

1

4

High-throughput

0.479

High

1221457

REXO4
RNA exonuclease 4

1

1

High-throughput

0.479

High

1221492

ZRAN1
Ubiquitin thioesterase ZRANB1

1

3

High-throughput

0.479

High

548819

HIS3
Histatin-3

1

0

Small-scale

0.458

High

760162

RL3
Large ribosomal subunit protein uL3

1

0

High-throughput

0.458

High

898382

RS3A
Small ribosomal subunit protein eS1

1

0

High-throughput

0.458

High

1221448

PINK1
Serine/threonine-protein kinase PINK1, mitochondrial

1

0

High-throughput

0.458

High

70171

B2CML4
Apolipoprotein B mRNA editing enzyme catalytic polypeptide-like 3DE

1

4

High-throughput

0.445

High

1221424

ABC3D
DNA dC->dU-editing enzyme APOBEC-3D

1

4

High-throughput

0.445

High

802143

NOP2
Probable 28S rRNA

1

1

High-throughput

0.437

High

898668

RL26
Large ribosomal subunit protein uL24

1

3

High-throughput

0.437

High

1221489

HECW2
E3 ubiquitin-protein ligase HECW2

1

1

High-throughput

0.437

High

1221495

HERC5
E3 ISG15--protein ligase HERC5

1

2

High-throughput

0.437

High

92423

E9PDP5
Ankyrin repeat and KH domain containing 1

1

3

High-throughput

0.407

High

254721

PTCD1
Pentatricopeptide repeat-containing protein 1, mitochondrial

3

0

High-throughput

0.347

High

846160

RT29
Small ribosomal subunit protein mS29

3

0

High-throughput

0.347

High

922860

RL32
Large ribosomal subunit protein eL32

3

0

High-throughput

0.347

High

947262

RT10
Small ribosomal subunit protein uS10m

3

0

High-throughput

0.347

High

947432

RT35
Small ribosomal subunit protein mS35

3

0

High-throughput

0.347

High

1221426

MASU1
Mitochondrial assembly of ribosomal large subunit protein 1

3

0

High-throughput

0.347

High

1221428

PTCD3
Small ribosomal subunit protein mS39

3

0

High-throughput

0.347

High

1221484

FAKD2
FAST kinase domain-containing protein 2, mitochondrial

3

0

High-throughput

0.347

High

1221503

RT33
Small ribosomal subunit protein mS33

3

0

High-throughput

0.347

High

1221506

SYYM
Tyrosine--tRNA ligase, mitochondrial

3

0

High-throughput

0.347

High

224986

ZNRD2
Protein ZNRD2

2

0

High-throughput

0.328

High

1172848

NKAP1
Uncharacterized protein NKAPD1

2

0

High-throughput

0.328

High

1221410

TM102
Transmembrane protein 102

2

0

High-throughput

0.328

High

1221491

CCG5
Voltage-dependent calcium channel gamma-5 subunit

2

0

High-throughput

0.328

High

241038

RT14
Small ribosomal subunit protein uS14m

2

0

High-throughput

0.318

High

947093

RT25
Small ribosomal subunit protein mS25

2

0

High-throughput

0.318

High

948181

RT21
Small ribosomal subunit protein bS21m

2

0

High-throughput

0.318

High

1221407

SPB1
pre-rRNA 2'-O-ribose RNA methyltransferase FTSJ3

2

0

High-throughput

0.318

High

1221415

RM30
Large ribosomal subunit protein uL30m

2

0

High-throughput

0.318

High

1221420

RT31
Small ribosomal subunit protein mS31

2

0

High-throughput

0.318

High

1221427

RT24
Small ribosomal subunit protein uS3m

2

0

High-throughput

0.318

High

1221439

POP1
Ribonucleases P/MRP protein subunit POP1

2

0

High-throughput

0.318

High

1221441

RM34
Large ribosomal subunit protein bL34m

2

0

High-throughput

0.318

High

1221450

RM32
Large ribosomal subunit protein bL32m

2

0

High-throughput

0.318

High

1221452

RM09
Large ribosomal subunit protein bL9m

2

0

High-throughput

0.318

High

1221453

RM01
Large ribosomal subunit protein uL1m

2

0

High-throughput

0.318

High

1221455

RT26
Small ribosomal subunit protein mS26

2

0

High-throughput

0.318

High

1221475

RM17
Large ribosomal subunit protein bL17m

2

0

High-throughput

0.318

High

1221502

NIP7
60S ribosome subunit biogenesis protein NIP7 homolog

2

0

High-throughput

0.318

High

1221510

NOP16
Nucleolar protein 16

2

0

High-throughput

0.318

High

133182

MPP10
U3 small nucleolar ribonucleoprotein protein MPP10

1

0

High-throughput

0.279

Low

155183

KIF3C
Kinesin-like protein KIF3C

1

0

High-throughput

0.279

Low

155694

TNF11
Tumor necrosis factor ligand superfamily member 11

1

0

High-throughput

0.279

Low

196128

RRP8
Ribosomal RNA-processing protein 8

1

0

High-throughput

0.279

Low

364965

FRIL
Ferritin light chain

1

0

High-throughput

0.279

Low

400595

RLA2
Large ribosomal subunit protein P2

1

0

High-throughput

0.279

Low

940715

NOP14
Nucleolar protein 14

1

0

High-throughput

0.279

Low

948094

RT15
Small ribosomal subunit protein uS15m

1

0

High-throughput

0.279

Low

948296

RT34
Small ribosomal subunit protein mS34

1

0

High-throughput

0.279

Low

948464

RT06
Small ribosomal subunit protein bS6m

1

0

High-throughput

0.279

Low

971499

RL18A
Large ribosomal subunit protein eL20

1

0

High-throughput

0.279

Low

995394

LG3BP
Galectin-3-binding protein

1

0

High-throughput

0.279

Low

997296

MZT1
Mitotic-spindle organizing protein 1

1

0

High-throughput

0.279

Low

1058119

BMS1
Ribosome biogenesis protein BMS1 homolog

1

0

High-throughput

0.279

Low

1198746

RM52
Large ribosomal subunit protein mL52

1

0

High-throughput

0.279

Low

1221413

G45IP
Large ribosomal subunit protein mL64

1

0

High-throughput

0.279

Low

1221419

RT27
Small ribosomal subunit protein mS27

1

0

High-throughput

0.279

Low

1221433

MR1L1
MORF4 family-associated protein 1-like 1

1

0

High-throughput

0.279

Low

1221435

TMM74
Transmembrane protein 74

1

0

High-throughput

0.279

Low

1221438

MTMR9
Myotubularin-related protein 9

1

0

High-throughput

0.279

Low

1221442

RT63
Large ribosomal subunit protein mL63

1

0

High-throughput

0.279

Low

1221444

CG050
Uncharacterized protein C7orf50

1

0

High-throughput

0.279

Low

1221468

E41L5
Band 4.1-like protein 5

1

0

High-throughput

0.279

Low

1221471

LUC7L
Putative RNA-binding protein Luc7-like 1

1

0

High-throughput

0.279

Low

1221478

SPS2L
SPATS2-like protein

1

0

High-throughput

0.279

Low

1221486

RM35
Large ribosomal subunit protein bL35m

1

0

High-throughput

0.279

Low

1221488

RM15
Large ribosomal subunit protein uL15m

1

0

High-throughput

0.279

Low

1221494

RLP24
Probable ribosome biogenesis protein RLP24

1

0

High-throughput

0.279

Low

1221504

NISCH
Nischarin

1

0

High-throughput

0.279

Low

1221505

RT07
Small ribosomal subunit protein uS7m

1

0

High-throughput

0.279

Low

1221509

RM11
Large ribosomal subunit protein uL11m

1

0

High-throughput

0.279

Low

1221511

RT16
Small ribosomal subunit protein bS16m

1

0

High-throughput

0.279

Low

1221514

RT18B
Small ribosomal subunit protein mS40

1

0

High-throughput

0.279

Low

72611

B4DEF8
Large ribosomal subunit protein mL45

1

0

High-throughput

0.249

Low

311949

SYFM
Phenylalanine--tRNA ligase, mitochondrial

1

0

High-throughput

0.249

Low

615788

GCSP
Glycine dehydrogenase

1

0

High-throughput

0.249

Low

946911

RT22
Small ribosomal subunit protein mS22

1

0

High-throughput

0.249

Low

1158456

RM14
Large ribosomal subunit protein uL14m

1

0

High-throughput

0.249

Low

1187896

RM21
Large ribosomal subunit protein bL21m

1

0

High-throughput

0.249

Low

1221445

LLPH
Protein LLP homolog

1

0

High-throughput

0.249

Low

56667

PIPSL
Putative PIP5K1A and PSMD4-like protein

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024