Protein: RPGF6
Rap guanine nucleotide exchange factor 6 (PDZ domain-containing guanine nucleotide exchange factor 2) (PDZ-GEF2) (RA-GEF-2)

Gene: RPGF6, RAPGEF6
Organism: Homo sapiens
Interactions: 70
UniProt ID: Q8TEU7

Gene Ontology (top 5):
GO:0005085 - guanyl-nucleotide exchange factor activity
GO:0005813 - centrosome
GO:0005829 - cytosol
GO:0005886 - plasma membrane
GO:0007265 - Ras protein signal transduction

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

160679

AURKA
Aurora kinase A

3

5

High-throughput

0.861

High

350385

RASK
GTPase KRas

3

20

High-throughput

0.827

High

331397

APBA3
Amyloid-beta A4 precursor protein-binding family A member 3

2

3

High-throughput

0.811

High

1020197

PTN13
Tyrosine-protein phosphatase non-receptor type 13

2

9

Small-scale

0.799

High

486041

RAP2A
Ras-related protein Rap-2a

2

20

Small-scale

0.799

High

348818

RASN
GTPase NRas

2

20

High-throughput

0.754

High

1256802

RPGF2
Rap guanine nucleotide exchange factor 2

1

3

High-throughput

0.665

High

808794

YAP1
Transcriptional coactivator YAP1

3

13

Small-scale

0.656

High

156099

RASM
Ras-related protein M-Ras

1

20

Small-scale

0.647

High

919653

RAP1A
Ras-related protein Rap-1A

1

20

Small-scale

0.647

High

904905

1433G
14-3-3 protein gamma

2

20

High-throughput

0.635

High

982316

1433F
14-3-3 protein eta

2

20

High-throughput

0.635

High

683569

1433B
14-3-3 protein beta/alpha

2

20

High-throughput

0.628

High

909851

1433E
14-3-3 protein epsilon

2

3

High-throughput

0.628

High

232945

PHLP1
PH domain leucine-rich repeat-containing protein phosphatase 1

1

2

High-throughput

0.618

High

349519

RASH
GTPase HRas

1

20

High-throughput

0.618

High

374588

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

9

High-throughput

0.618

High

835467

GSK3A
Glycogen synthase kinase-3 alpha

1

3

High-throughput

0.618

High

835900

GSK3B
Glycogen synthase kinase-3 beta

1

4

High-throughput

0.618

High

915859

RHOB
Rho-related GTP-binding protein RhoB

1

11

High-throughput

0.618

High

1256789

PARD3
Partitioning defective 3 homolog

1

10

High-throughput

0.618

High

1256792

SNX27
Sorting nexin-27

1

13

High-throughput

0.618

High

1256797

PKHA4
Pleckstrin homology domain-containing family A member 4

1

3

High-throughput

0.618

High

1256799

ZO2
Tight junction protein ZO-2

1

1

High-throughput

0.618

High

397050

PAI2
Plasminogen activator inhibitor 2

2

0

High-throughput

0.602

High

1256793

MAGI1
Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1

1

9

High-throughput

0.575

High

225007

ZNRD2
Protein ZNRD2

2

1

High-throughput

0.574

High

1170959

TRI67
Tripartite motif-containing protein 67

1

3

High-throughput

0.553

High

647134

1433T
14-3-3 protein theta

1

20

High-throughput

0.536

High

871694

HSP72
Heat shock-related 70 kDa protein 2

1

3

High-throughput

0.536

High

927336

1433Z
14-3-3 protein zeta/delta

1

20

High-throughput

0.536

High

323921

BAG2
BAG family molecular chaperone regulator 2

1

0

High-throughput

0.513

High

364997

FRIL
Ferritin light chain

1

0

High-throughput

0.513

High

660638

GRN
Progranulin

1

0

High-throughput

0.513

High

1256794

DUS16
Dual specificity protein phosphatase 16

1

0

High-throughput

0.513

High

808200

NEDD4
E3 ubiquitin-protein ligase NEDD4

1

4

High-throughput

0.501

High

62235

SWAHB
Ankyrin repeat domain-containing protein SOWAHB

1

6

High-throughput

0.489

High

796143

MAGA9
Melanoma-associated antigen 9

1

1

High-throughput

0.489

High

163044

XPO1
Exportin-1

1

2

High-throughput

0.479

High

504457

HSP7C
Heat shock cognate 71 kDa protein

1

3

High-throughput

0.479

High

684227

1433S
14-3-3 protein sigma

1

20

High-throughput

0.479

High

779790

CCNF
Cyclin-F

1

1

High-throughput

0.479

High

1081543

NTRK3
NT-3 growth factor receptor

1

4

High-throughput

0.479

High

1220072

KIBRA
Protein KIBRA

1

15

Small-scale

0.479

High

1238042

CE120
Centrosomal protein of 120 kDa

1

4

High-throughput

0.479

High

1256790

GOGA1
Golgin subfamily A member 1

1

1

High-throughput

0.479

High

1256795

WWTR1
WW domain-containing transcription regulator protein 1

1

13

High-throughput

0.479

High

1256796

WWP1
NEDD4-like E3 ubiquitin-protein ligase WWP1

1

4

Small-scale

0.479

High

1256800

ZRAN1
Ubiquitin thioesterase ZRANB1

1

2

High-throughput

0.479

High

409175

K2C8
Keratin, type II cytoskeletal 8

1

0

High-throughput

0.458

High

430277

PROF1
Profilin-1

1

0

High-throughput

0.458

High

484382

SCHI1
Schwannomin-interacting protein 1

1

0

High-throughput

0.458

High

921357

RBX1
E3 ubiquitin-protein ligase RBX1

1

0

High-throughput

0.458

High

974940

CAV1
Caveolin-1

1

0

High-throughput

0.458

High

1038568

HDAC1
Histone deacetylase 1

1

0

High-throughput

0.458

High

1084114

OCLN
Occludin

1

0

High-throughput

0.458

High

1200516

NAA40
N-alpha-acetyltransferase 40

1

0

High-throughput

0.458

High

502356

BIP
Endoplasmic reticulum chaperone BiP

1

2

High-throughput

0.445

High

232370

KDM1A
Lysine-specific histone demethylase 1A

1

1

High-throughput

0.437

High

553266

RFA2
Replication protein A 32 kDa subunit

1

2

High-throughput

0.437

High

575507

EGR1
Early growth response protein 1

1

1

High-throughput

0.437

High

651770

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

2

High-throughput

0.437

High

720992

RFA3
Replication protein A 14 kDa subunit

1

1

High-throughput

0.437

High

1026487

RFA4
Replication protein A 30 kDa subunit

1

2

High-throughput

0.437

High

1256791

PF21A
PHD finger protein 21A

1

2

High-throughput

0.437

High

56688

PIPSL
Putative PIP5K1A and PSMD4-like protein

1

0

High-throughput

0.426

High

1256798

EGLN3
Prolyl hydroxylase EGLN3

1

0

High-throughput

0.426

High

834538

TIG1
Retinoic acid receptor responder protein 1

1

0

High-throughput

0.279

Low

928642

DYLT1
Dynein light chain Tctex-type 1

1

0

High-throughput

0.249

Low

1256801

RCOR1
REST corepressor 1

1

0

High-throughput

0.249

Low


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Last updated: 15 Jul 2024