Protein: SMCR8
Guanine nucleotide exchange protein SMCR8 (Smith-Magenis syndrome chromosomal region candidate gene 8 protein)

Gene: SMCR8
Organism: Homo sapiens
Interactions: 129
UniProt ID: Q8TEV9

Gene Ontology (top 5):
GO:0000785 - chromatin
GO:0004860 - protein kinase inhibitor activity
GO:0005085 - guanyl-nucleotide exchange factor activity
GO:0005096 - GTPase activator activity
GO:0005654 - nucleoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1256811

CI072
Guanine nucleotide exchange factor C9orf72

8

1

Small-scale

0.977

High

518727

IMDH2
Inosine-5'-monophosphate dehydrogenase 2

3

1

High-throughput

0.667

High

359048

CRYAB
Alpha-crystallin B chain

3

0

High-throughput

0.638

High

596077

IMDH1
Inosine-5'-monophosphate dehydrogenase 1

2

1

High-throughput

0.628

High

1255626

RBCC1
RB1-inducible coiled-coil protein 1

2

0

High-throughput

0.585

High

262293

ULK1
Serine/threonine-protein kinase ULK1

2

0

Small-scale

0.561

High

845630

RAB9A
Ras-related protein Rab-9A

2

4

High-throughput

0.533

High

364998

FRIL
Ferritin light chain

1

0

High-throughput

0.513

High

1022951

CDC16
Cell division cycle protein 16 homolog

1

0

High-throughput

0.513

High

1126947

EFMT2
EEF1A lysine methyltransferase 2

1

0

High-throughput

0.513

High

1256818

DUS16
Dual specificity protein phosphatase 16

1

0

High-throughput

0.513

High

1256841

KCC2A
Calcium/calmodulin-dependent protein kinase type II subunit alpha

1

0

High-throughput

0.513

High

1256837

TBK1
Serine/threonine-protein kinase TBK1

1

1

Small-scale

0.501

High

1256838

FEM1B
Protein fem-1 homolog B

1

0

Small-scale

0.494

High

160941

RAB7L
Ras-related protein Rab-7L1

1

5

Small-scale

0.479

High

385220

NTRK1
High affinity nerve growth factor receptor

1

4

High-throughput

0.479

High

564625

RHOQ
Rho-related GTP-binding protein RhoQ

1

3

High-throughput

0.479

High

567189

CXA1
Gap junction alpha-1 protein

1

1

High-throughput

0.479

High

591639

RAB3B
Ras-related protein Rab-3B

1

3

High-throughput

0.479

High

592397

RAB5A
Ras-related protein Rab-5A

1

2

High-throughput

0.479

High

852567

RND2
Rho-related GTP-binding protein RhoN

1

4

High-throughput

0.479

High

894780

RAB8A
Ras-related protein Rab-8A

1

2

Small-scale

0.479

High

900725

RHOA
Transforming protein RhoA

1

1

High-throughput

0.479

High

901206

RND3
Rho-related GTP-binding protein RhoE

1

4

High-throughput

0.479

High

951181

RHOG
Rho-related GTP-binding protein RhoG

1

2

High-throughput

0.479

High

1017725

STX4
Syntaxin-4

1

1

High-throughput

0.479

High

1076679

RHOH
Rho-related GTP-binding protein RhoH

1

3

High-throughput

0.479

High

1256805

RAB24
Ras-related protein Rab-24

1

4

Small-scale

0.479

High

1256808

RB39B
Ras-related protein Rab-39B

1

4

Small-scale

0.479

High

1256822

RHOJ
Rho-related GTP-binding protein RhoJ

1

3

High-throughput

0.479

High

1256842

LAMP3
Lysosome-associated membrane glycoprotein 3

1

1

High-throughput

0.479

High

255177

ATG13
Autophagy-related protein 13

1

0

Small-scale

0.460

High

176621

FANCA
Fanconi anemia group A protein

1

0

Small-scale

0.458

High

205738

TGON2
Trans-Golgi network integral membrane protein 2

1

0

High-throughput

0.458

High

212948

STX6
Syntaxin-6

1

0

High-throughput

0.458

High

325289

AIFM1
Apoptosis-inducing factor 1, mitochondrial

1

0

High-throughput

0.458

High

377528

GCR
Glucocorticoid receptor

1

0

High-throughput

0.458

High

568741

KAPCA
cAMP-dependent protein kinase catalytic subunit alpha

1

0

High-throughput

0.458

High

573819

PTN1
Tyrosine-protein phosphatase non-receptor type 1

1

0

High-throughput

0.458

High

575802

VINC
Vinculin

1

0

High-throughput

0.458

High

654593

CALX
Calnexin

1

0

High-throughput

0.458

High

670128

MARCS
Myristoylated alanine-rich C-kinase substrate

1

0

High-throughput

0.458

High

786036

LAP2B
Lamina-associated polypeptide 2, isoforms beta/gamma

1

0

High-throughput

0.458

High

839007

EMD
Emerin

1

0

High-throughput

0.458

High

940505

CXAR
Coxsackievirus and adenovirus receptor

1

0

High-throughput

0.458

High

974941

CAV1
Caveolin-1

1

0

High-throughput

0.458

High

1036754

SQSTM
Sequestosome-1

1

0

Small-scale

0.458

High

1080733

ZYX
Zyxin

1

0

High-throughput

0.458

High

1135095

ACBD5
Acyl-CoA-binding domain-containing protein 5

1

0

High-throughput

0.458

High

1151999

LTOR1
Ragulator complex protein LAMTOR1

1

0

High-throughput

0.458

High

1190037

MAVS
Mitochondrial antiviral-signaling protein

1

0

High-throughput

0.458

High

1200517

NAA40
N-alpha-acetyltransferase 40

1

0

High-throughput

0.458

High

1240220

DHB11
Estradiol 17-beta-dehydrogenase 11

1

0

High-throughput

0.458

High

1256807

LRC59
Leucine-rich repeat-containing protein 59

1

0

High-throughput

0.458

High

1256812

MMS19
MMS19 nucleotide excision repair protein homolog

1

0

High-throughput

0.458

High

1256813

RMD3
Regulator of microtubule dynamics protein 3

1

0

High-throughput

0.458

High

1256815

PHB2
Prohibitin-2

1

0

High-throughput

0.458

High

1256819

LNP
Endoplasmic reticulum junction formation protein lunapark

1

0

High-throughput

0.458

High

1256825

PXMP2
Peroxisomal membrane protein 2

1

0

High-throughput

0.458

High

1256829

OTULL
Inactive ubiquitin thioesterase OTULINL

1

0

High-throughput

0.458

High

1256830

EXD2
Exonuclease 3'-5' domain-containing protein 2

1

0

High-throughput

0.458

High

1256839

CLC4E
C-type lectin domain family 4 member E

1

0

High-throughput

0.458

High

1256845

PTH2
Peptidyl-tRNA hydrolase 2, mitochondrial

1

0

High-throughput

0.458

High

1256824

WDR41
WD repeat-containing protein 41

1

1

Small-scale

0.445

High

178688

STX7
Syntaxin-7

1

1

High-throughput

0.437

High

434247

RET
Proto-oncogene tyrosine-protein kinase receptor Ret

1

3

High-throughput

0.437

High

508119

FGFR1
Fibroblast growth factor receptor 1

1

4

High-throughput

0.437

High

526003

IFM1
Interferon-induced transmembrane protein 1

1

1

High-throughput

0.437

High

527659

LAMP2
Lysosome-associated membrane glycoprotein 2

1

1

High-throughput

0.437

High

591948

RAB4A
Ras-related protein Rab-4A

1

1

High-throughput

0.437

High

608058

FGFR4
Fibroblast growth factor receptor 4

1

4

High-throughput

0.437

High

844645

RAB5C
Ras-related protein Rab-5C

1

2

High-throughput

0.437

High

845104

RAB7A
Ras-related protein Rab-7a

1

5

High-throughput

0.437

High

884549

RAB25
Ras-related protein Rab-25

1

1

High-throughput

0.437

High

914241

RB11A
Ras-related protein Rab-11A

1

1

High-throughput

0.437

High

965769

IFM3
Interferon-induced transmembrane protein 3

1

1

High-throughput

0.437

High

990571

CKAP4
Cytoskeleton-associated protein 4

1

1

High-throughput

0.437

High

1044503

RAB32
Ras-related protein Rab-32

1

5

Small-scale

0.437

High

1070319

RAB35
Ras-related protein Rab-35

1

3

High-throughput

0.437

High

1220604

MIRO2
Mitochondrial Rho GTPase 2

1

6

High-throughput

0.437

High

1230294

CXD3
Gap junction delta-3 protein

1

1

High-throughput

0.437

High

1256810

DNJC1
DnaJ homolog subfamily C member 1

1

3

High-throughput

0.437

High

1256820

DJC25
DnaJ homolog subfamily C member 25

1

2

High-throughput

0.437

High

1256834

MTCH1
Mitochondrial carrier homolog 1

1

1

High-throughput

0.437

High

1256836

SEC63
Translocation protein SEC63 homolog

1

1

High-throughput

0.437

High

1256840

ALK
ALK tyrosine kinase receptor

1

3

High-throughput

0.437

High

1256846

MTCH2
Mitochondrial carrier homolog 2

1

1

High-throughput

0.437

High

56689

PIPSL
Putative PIP5K1A and PSMD4-like protein

1

0

High-throughput

0.426

High

225008

ZNRD2
Protein ZNRD2

2

0

High-throughput

0.328

High

796144

MAGA9
Melanoma-associated antigen 9

1

0

High-throughput

0.279

Low

1121836

KCP3
Keratinocyte-associated protein 3

1

0

High-throughput

0.279

Low

1205590

F90A1
Protein FAM90A1

1

0

High-throughput

0.279

Low

132542

RCAS1
Receptor-binding cancer antigen expressed on SiSo cells

1

0

High-throughput

0.249

Low

157621

MGST3
Glutathione S-transferase 3, mitochondrial

1

0

High-throughput

0.249

Low

262048

PEX14
Peroxisomal membrane protein PEX14

1

0

High-throughput

0.249

Low

273909

NU155
Nuclear pore complex protein Nup155

1

0

High-throughput

0.249

Low

304857

MFN2
Mitofusin-2

1

0

High-throughput

0.249

Low

305559

ZFPL1
Zinc finger protein-like 1

1

0

High-throughput

0.249

Low

391046

RPN2
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2

1

0

High-throughput

0.249

Low

456904

FURIN
Furin

1

0

High-throughput

0.249

Low

665503

EPHA8
Ephrin type-A receptor 8

1

0

High-throughput

0.249

Low

795211

SSRA
Translocon-associated protein subunit alpha

1

0

High-throughput

0.249

Low

825485

LMAN1
Protein ERGIC-53

1

0

High-throughput

0.249

Low

847574

BAP31
B-cell receptor-associated protein 31

1

0

High-throughput

0.249

Low

890291

SC61B
Protein transport protein Sec61 subunit beta

1

0

High-throughput

0.249

Low

961749

REEP5
Receptor expression-enhancing protein 5

1

0

High-throughput

0.249

Low

1040180

STIM1
Stromal interaction molecule 1

1

0

High-throughput

0.249

Low

1053095

FKBP8
Peptidyl-prolyl cis-trans isomerase FKBP8

1

0

High-throughput

0.249

Low

1072789

TOM20
Mitochondrial import receptor subunit TOM20 homolog

1

0

High-throughput

0.249

Low

1203787

TMM17
Transmembrane protein 17

1

0

High-throughput

0.249

Low

1237763

ARL10
ADP-ribosylation factor-like protein 10

1

0

High-throughput

0.249

Low

1256803

AKAP1
A-kinase anchor protein 1, mitochondrial

1

0

High-throughput

0.249

Low

1256804

GOGA1
Golgin subfamily A member 1

1

0

High-throughput

0.249

Low

1256806

S2546
Mitochondrial outer membrane protein SLC25A46

1

0

High-throughput

0.249

Low

1256809

COX14
Cytochrome c oxidase assembly protein COX14

1

0

High-throughput

0.249

Low

1256814

SEC62
Translocation protein SEC62

1

0

High-throughput

0.249

Low

1256816

GORS1
Golgi reassembly-stacking protein 1

1

0

High-throughput

0.249

Low

1256817

DERL1
Derlin-1

1

0

High-throughput

0.249

Low

1256821

3BHS7
3 beta-hydroxysteroid dehydrogenase type 7

1

0

High-throughput

0.249

Low

1256823

TMT1A
Thiol S-methyltransferase TMT1A

1

0

High-throughput

0.249

Low

1256826

ST7
Suppressor of tumorigenicity 7 protein

1

0

High-throughput

0.249

Low

1256827

TMPS4
Transmembrane protease serine 4

1

0

High-throughput

0.249

Low

1256828

TOM22
Mitochondrial import receptor subunit TOM22 homolog

1

0

High-throughput

0.249

Low

1256831

OCAD1
OCIA domain-containing protein 1

1

0

High-throughput

0.249

Low

1256832

MARH5
E3 ubiquitin-protein ligase MARCHF5

1

0

High-throughput

0.249

Low

1256833

ELOV5
Very long chain fatty acid elongase 5

1

0

High-throughput

0.249

Low

1256835

B3GA1
Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1

1

0

High-throughput

0.249

Low

1256843

DJC16
DnaJ homolog subfamily C member 16

1

0

High-throughput

0.249

Low

1256844

FIS1
Mitochondrial fission 1 protein

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024