Protein: KAT2A
Histone acetyltransferase KAT2A (EC 2.3.1.48) (General control of amino acid synthesis protein 5-like 2) (Histone acetyltransferase GCN5) (hGCN5) (Histone glutaryltransferase KAT2A) (EC 2.3.1.-) (Histone succinyltransferase KAT2A) (EC 2.3.1.-) (Lysine acetyltransferase 2A) (STAF97)

Gene: KAT2A
Organism: Homo sapiens
Interactions: 178
UniProt ID: Q92830

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000123 - histone acetyltransferase complex
GO:0000124 - SAGA complex
GO:0001701 - in utero embryonic development
GO:0001756 - somitogenesis

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

266398

TAD2A
Transcriptional adapter 2-alpha

10

20

Small-scale

0.972

High

903408

WDR5
WD repeat-containing protein 5

6

20

Small-scale

0.943

High

1271449

CSR2B
Cysteine-rich protein 2-binding protein

6

7

Small-scale

0.935

High

267783

TAF5L
TAF5-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 5L

5

20

Small-scale

0.912

High

1223165

ZZZ3
ZZ-type zinc finger-containing protein 3

5

3

Small-scale

0.909

High

1198565

TAD2B
Transcriptional adapter 2-beta

3

20

High-throughput

0.827

High

274368

WDHD1
WD repeat and HMG-box DNA-binding protein 1

2

20

Small-scale

0.819

High

1271433

KAT2A
Histone acetyltransferase KAT2A

2

19

Small-scale

0.757

High

1271440

SGF29
SAGA-associated factor 29

10

3

Small-scale

0.755

High

1271469

UBP22
Ubiquitin carboxyl-terminal hydrolase 22

11

15

Small-scale

0.754

High

1271474

TRRAP
Transformation/transcription domain-associated protein

11

19

Small-scale

0.752

High

1062106

AT7L3
Ataxin-7-like protein 3

10

4

Small-scale

0.752

High

347492

MYC
Myc proto-oncogene protein

8

20

Small-scale

0.750

High

173983

ATX7
Ataxin-7

9

15

Small-scale

0.748

High

266494

SUPT3
Transcription initiation protein SPT3 homolog

9

6

Small-scale

0.747

High

267675

TADA3
Transcriptional adapter 3

8

7

Small-scale

0.747

High

1083685

TAF9
Transcription initiation factor TFIID subunit 9

7

13

Small-scale

0.739

High

1271434

KAT2B
Histone acetyltransferase KAT2B

2

18

Small-scale

0.737

High

1271473

MED16
Mediator of RNA polymerase II transcription subunit 16

2

2

Small-scale

0.737

High

1021630

TAF10
Transcription initiation factor TFIID subunit 10

7

12

Small-scale

0.735

High

1271456

MBIP1
MAP3K12-binding inhibitory protein 1

6

4

Small-scale

0.730

High

917688

H4
Histone H4

6

20

Small-scale

0.728

High

935069

H31
Histone H3.1

6

20

Small-scale

0.728

High

1243301

SP20H
Transcription factor SPT20 homolog

6

4

Small-scale

0.726

High

1271459

DTL
Denticleless protein homolog

1

19

Small-scale

0.724

High

1271478

TAF6L
TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L

5

14

High-throughput

0.714

High

1271438

TADA1
Transcriptional adapter 1

5

3

High-throughput

0.709

High

796239

MAGAA
Melanoma-associated antigen 10

4

11

High-throughput

0.699

High

963658

E2F1
Transcription factor E2F1

5

12

Small-scale

0.699

High

1271445

PYGO2
Pygopus homolog 2

1

0

Small-scale

0.687

High

966179

NC2B
Protein Dr1

4

11

Small-scale

0.686

High

1073090

SF3B3
Splicing factor 3B subunit 3

4

14

High-throughput

0.686

High

297923

ST65G
STAGA complex 65 subunit gamma

4

1

Small-scale

0.676

High

1271451

TAF9B
Transcription initiation factor TFIID subunit 9B

4

13

Small-scale

0.676

High

1271466

YETS2
YEATS domain-containing protein 2

4

18

Small-scale

0.676

High

1082067

TAF12
Transcription initiation factor TFIID subunit 12

3

8

High-throughput

0.667

High

1271452

ENY2
Transcription and mRNA export factor ENY2

3

5

Small-scale

0.656

High

486817

MYB
Transcriptional activator Myb

1

8

Small-scale

0.647

High

1271467

FZR1
Fizzy-related protein homolog

1

20

High-throughput

0.647

High

387226

P53
Cellular tumor antigen p53

3

20

Small-scale

0.646

High

569928

CEBPB
CCAAT/enhancer-binding protein beta

2

20

Small-scale

0.639

High

1076181

MED1
Mediator of RNA polymerase II transcription subunit 1

3

19

Small-scale

0.633

High

978833

TF65
Transcription factor p65

2

12

Small-scale

0.629

High

1271448

IKZF5
Zinc finger protein Pegasus

2

16

High-throughput

0.628

High

1082309

DDB1
DNA damage-binding protein 1

2

14

Small-scale

0.624

High

826324

CDK8
Cyclin-dependent kinase 8

2

19

Small-scale

0.621

High

244733

BRD4
Bromodomain-containing protein 4

1

18

High-throughput

0.618

High

772087

VHL
von Hippel-Lindau disease tumor suppressor

1

4

High-throughput

0.618

High

943875

RAE1L
mRNA export factor RAE1

1

20

High-throughput

0.618

High

1139024

TAF3
Transcription initiation factor TFIID subunit 3

1

20

Small-scale

0.618

High

1271472

WDR37
WD repeat-containing protein 37

1

20

High-throughput

0.618

High

1086256

H31T
Histone H3.1t

2

20

Small-scale

0.613

High

1271447

SF3B5
Splicing factor 3B subunit 5

2

2

High-throughput

0.611

High

551561

TFE2
Transcription factor E2-alpha

2

11

Small-scale

0.602

High

1087072

H2A2C
Histone H2A type 2-C

2

20

Small-scale

0.602

High

1087311

H2B2E
Histone H2B type 2-E

2

20

Small-scale

0.602

High

1271435

MED12
Mediator of RNA polymerase II transcription subunit 12

2

20

Small-scale

0.601

High

717254

CTNB1
Catenin beta-1

2

20

Small-scale

0.595

High

898165

MAX
Protein max

2

20

Small-scale

0.584

High

1271439

SIR1
NAD-dependent protein deacetylase sirtuin-1

2

15

Small-scale

0.584

High

651852

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

9

Small-scale

0.578

High

311826

TACC2
Transforming acidic coiled-coil-containing protein 2

1

20

Small-scale

0.573

High

523913

XRCC6
X-ray repair cross-complementing protein 6

1

16

Small-scale

0.573

High

370140

ESR1
Estrogen receptor

2

20

High-throughput

0.571

High

1271457

MED17
Mediator of RNA polymerase II transcription subunit 17

2

2

Small-scale

0.571

High

740567

PPARG
Peroxisome proliferator-activated receptor gamma

2

20

Small-scale

0.563

High

501075

IRF1
Interferon regulatory factor 1

1

12

Small-scale

0.561

High

773082

PBX1
Pre-B-cell leukemia transcription factor 1

1

2

Small-scale

0.561

High

1041421

CUL2
Cullin-2

1

20

Small-scale

0.561

High

1069456

TEBP
Prostaglandin E synthase 3

1

3

Small-scale

0.561

High

1235528

COMD1
COMM domain-containing protein 1

1

1

Small-scale

0.561

High

555569

H2AX
Histone H2AX

1

20

Small-scale

0.536

High

639037

S100P
Protein S100-P

1

6

High-throughput

0.536

High

796150

MAGA9
Melanoma-associated antigen 9

1

11

High-throughput

0.536

High

853673

IMA5
Importin subunit alpha-5

1

12

High-throughput

0.536

High

913031

ARF6
ADP-ribosylation factor 6

1

2

High-throughput

0.536

High

1029293

MD2L1
Mitotic spindle assembly checkpoint protein MAD2A

1

4

High-throughput

0.536

High

1271453

DPOE4
DNA polymerase epsilon subunit 4

1

5

High-throughput

0.536

High

1231009

BATF2
Basic leucine zipper transcriptional factor ATF-like 2

1

0

High-throughput

0.518

High

229455

SMCA5
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5

1

20

High-throughput

0.515

High

974632

MECOM
Histone-lysine N-methyltransferase MECOM

1

16

High-throughput

0.515

High

1271471

CARD8
Caspase recruitment domain-containing protein 8

1

0

High-throughput

0.513

High

671485

ECHM
Enoyl-CoA hydratase, mitochondrial

1

6

Small-scale

0.512

High

946009

DHI2
11-beta-hydroxysteroid dehydrogenase type 2

1

1

Small-scale

0.512

High

1271458

AATF
Protein AATF

1

4

Small-scale

0.506

High

197785

CRX
Cone-rod homeobox protein

1

20

Small-scale

0.501

High

264076

TACC1
Transforming acidic coiled-coil-containing protein 1

1

15

Small-scale

0.501

High

391824

H2A1B
Histone H2A type 1-B/E

1

20

Small-scale

0.501

High

536542

IRF2
Interferon regulatory factor 2

1

12

Small-scale

0.501

High

559199

H15
Histone H1.5

1

15

Small-scale

0.501

High

620399

GATA2
Endothelial transcription factor GATA-2

1

18

Small-scale

0.501

High

624600

CCNE1
G1/S-specific cyclin-E1

1

10

High-throughput

0.501

High

625533

CDK2
Cyclin-dependent kinase 2

1

10

Small-scale

0.501

High

673093

CCND2
G1/S-specific cyclin-D2

1

12

High-throughput

0.501

High

681961

AKT1
RAC-alpha serine/threonine-protein kinase

1

10

High-throughput

0.501

High

707701

H2B1B
Histone H2B type 1-B

1

20

Small-scale

0.501

High

719569

MERL
Merlin

1

10

High-throughput

0.501

High

742444

SYUA
Alpha-synuclein

1

2

High-throughput

0.501

High

790942

CDN2B
Cyclin-dependent kinase 4 inhibitor B

1

12

High-throughput

0.501

High

805451

MP2K3
Dual specificity mitogen-activated protein kinase kinase 3

1

10

High-throughput

0.501

High

930331

UBC9
SUMO-conjugating enzyme UBC9

1

17

Small-scale

0.501

High

944354

PRKDC
DNA-dependent protein kinase catalytic subunit

1

19

Small-scale

0.501

High

960224

CDK6
Cyclin-dependent kinase 6

1

9

High-throughput

0.501

High

1029212

GRM1
Metabotropic glutamate receptor 1

1

1

High-throughput

0.501

High

1079119

STK11
Serine/threonine-protein kinase STK11

1

3

High-throughput

0.501

High

1082604

MK14
Mitogen-activated protein kinase 14

1

11

High-throughput

0.501

High

1174615

H32
Histone H3.2

1

20

Small-scale

0.501

High

1267508

TSC1
Hamartin

1

20

High-throughput

0.501

High

1271442

H4G
Histone H4-like protein type G

1

20

Small-scale

0.501

High

1271454

LATS2
Serine/threonine-protein kinase LATS2

1

9

High-throughput

0.501

High

1271455

RASF1
Ras association domain-containing protein 1

1

3

High-throughput

0.501

High

1271476

TACC3
Transforming acidic coiled-coil-containing protein 3

1

11

Small-scale

0.501

High

1271477

EID1
EP300-interacting inhibitor of differentiation 1

1

1

Small-scale

0.501

High

986953

SUH
Recombining binding protein suppressor of hairless

1

4

Small-scale

0.481

High

1054175

BECN1
Beclin-1

1

0

High-throughput

0.480

High

124243

TAF4
Transcription initiation factor TFIID subunit 4

1

20

Small-scale

0.479

High

171424

SMAD9
Mothers against decapentaplegic homolog 9

1

20

Small-scale

0.479

High

201383

M3K7
Mitogen-activated protein kinase kinase kinase 7

1

1

Small-scale

0.479

High

236962

BUB1B
Mitotic checkpoint serine/threonine-protein kinase BUB1 beta

1

12

Small-scale

0.479

High

316952

KLF8
Krueppel-like factor 8

1

20

High-throughput

0.479

High

334257

LDHA
L-lactate dehydrogenase A chain

1

8

High-throughput

0.479

High

428343

TBB5
Tubulin beta chain

1

9

Small-scale

0.479

High

437647

MCR
Mineralocorticoid receptor

1

20

Small-scale

0.479

High

515484

CDK4
Cyclin-dependent kinase 4

1

10

Small-scale

0.479

High

525005

XRCC5
X-ray repair cross-complementing protein 5

1

16

Small-scale

0.479

High

546020

MYOD1
Myoblast determination protein 1

1

20

High-throughput

0.479

High

571820

XBP1
X-box-binding protein 1

1

3

Small-scale

0.479

High

632838

TYY1
Transcriptional repressor protein YY1

1

20

High-throughput

0.479

High

692168

ELF1
ETS-related transcription factor Elf-1

1

20

High-throughput

0.479

High

729147

K22E
Keratin, type II cytoskeletal 2 epidermal

1

1

High-throughput

0.479

High

738983

SRBP1
Sterol regulatory element-binding protein 1

1

20

Small-scale

0.479

High

776770

STAT3
Signal transducer and activator of transcription 3

1

13

Small-scale

0.479

High

782611

HNF4A
Hepatocyte nuclear factor 4-alpha

1

20

High-throughput

0.479

High

836260

TAF6
Transcription initiation factor TFIID subunit 6

1

14

High-throughput

0.479

High

850957

HDGF
Hepatoma-derived growth factor

1

20

High-throughput

0.479

High

884214

KLF3
Krueppel-like factor 3

1

20

High-throughput

0.479

High

950236

SMAD3
Mothers against decapentaplegic homolog 3

1

20

Small-scale

0.479

High

952515

H33
Histone H3.3

1

20

Small-scale

0.479

High

1019052

TP53B
TP53-binding protein 1

1

13

High-throughput

0.479

High

1032541

CTBP1
C-terminal-binding protein 1

1

11

Small-scale

0.479

High

1043139

CUL4A
Cullin-4A

1

20

Small-scale

0.479

High

1049857

UBP2L
Ubiquitin-associated protein 2-like

1

20

Small-scale

0.479

High

1060343

NFIX
Nuclear factor 1 X-type

1

12

High-throughput

0.479

High

1072147

PCBP2
Poly(rC)-binding protein 2

1

16

High-throughput

0.479

High

1078607

SMAD2
Mothers against decapentaplegic homolog 2

1

20

Small-scale

0.479

High

1078736

SMAD1
Mothers against decapentaplegic homolog 1

1

20

Small-scale

0.479

High

1081345

E2F4
Transcription factor E2F4

1

12

Small-scale

0.479

High

1158985

EDC4
Enhancer of mRNA-decapping protein 4

1

20

High-throughput

0.479

High

1186149

PTF1A
Pancreas transcription factor 1 subunit alpha

1

19

Small-scale

0.479

High

1220751

SIR2
NAD-dependent protein deacetylase sirtuin-2

1

15

Small-scale

0.479

High

1254870

SP7
Transcription factor Sp7

1

20

High-throughput

0.479

High

1269279

ESR2
Estrogen receptor beta

1

20

High-throughput

0.479

High

1271436

LHX4
LIM/homeobox protein Lhx4

1

10

High-throughput

0.479

High

1271443

ELF4
ETS-related transcription factor Elf-4

1

20

High-throughput

0.479

High

1271444

SMAD5
Mothers against decapentaplegic homolog 5

1

20

Small-scale

0.479

High

1271460

HECW2
E3 ubiquitin-protein ligase HECW2

1

4

High-throughput

0.479

High

1271461

PRGC1
Peroxisome proliferator-activated receptor gamma coactivator 1-alpha

1

1

Small-scale

0.479

High

1271462

HDAC6
Histone deacetylase 6

1

20

High-throughput

0.479

High

1271468

JIP3
C-Jun-amino-terminal kinase-interacting protein 3

1

20

High-throughput

0.479

High

1271470

ZN148
Zinc finger protein 148

1

18

Small-scale

0.479

High

1271475

KLF12
Krueppel-like factor 12

1

20

High-throughput

0.479

High

548938

NDKA
Nucleoside diphosphate kinase A

1

0

Small-scale

0.458

High

886014

TIRAP
Toll/interleukin-1 receptor domain-containing adapter protein

1

0

Small-scale

0.458

High

1271441

ADAT3
Probable inactive tRNA-specific adenosine deaminase-like protein 3

1

0

High-throughput

0.458

High

56695

PIPSL
Putative PIP5K1A and PSMD4-like protein

1

11

High-throughput

0.445

High

225403

MED14
Mediator of RNA polymerase II transcription subunit 14

1

20

Small-scale

0.445

High

265348

MED24
Mediator of RNA polymerase II transcription subunit 24

1

4

Small-scale

0.445

High

1271437

FUBP1
Far upstream element-binding protein 1

1

20

Small-scale

0.445

High

1271463

MED13
Mediator of RNA polymerase II transcription subunit 13

1

3

Small-scale

0.445

High

1271465

MED23
Mediator of RNA polymerase II transcription subunit 23

1

5

Small-scale

0.445

High

1134033

AT7L2
Ataxin-7-like protein 2

1

9

High-throughput

0.437

High

1271464

AT7L1
Ataxin-7-like protein 1

1

17

High-throughput

0.437

High

120989

APBB1
Amyloid beta precursor protein binding family B member 1

1

0

High-throughput

0.426

High

831539

CEBPA
CCAAT/enhancer-binding protein alpha

1

20

High-throughput

0.408

High

1271450

PLAC1
Placenta-specific protein 1

2

0

High-throughput

0.328

High

708243

ERD22
ER lumen protein-retaining receptor 2

1

0

High-throughput

0.261

Low

1271446

TTYH2
Protein tweety homolog 2

1

0

High-throughput

0.261

Low


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Last updated: 15 Jul 2024