Protein: TBK1
Serine/threonine-protein kinase TBK1 (EC 2.7.11.1) (T2K) (TANK-binding kinase 1)

Gene: TBK1
Organism: Mus musculus
Interactions: 46
UniProt ID: Q9WUN2

Gene Ontology (top 5):
GO:0002218 - activation of innate immune response
GO:0002753 - cytoplasmic pattern recognition receptor signaling pathway
GO:0003676 - nucleic acid binding
GO:0004674 - protein serine/threonine kinase activity
GO:0005524 - ATP binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1376722

TBK1
Serine/threonine-protein kinase TBK1

2

17

Small-scale

0.834

High

936639

TANK
TRAF family member-associated NF-kappa-B activator

7

5

Small-scale

0.743

High

1111766

STING
Stimulator of interferon genes protein

7

6

Small-scale

0.740

High

1141450

TRAF3
TNF receptor-associated factor 3

7

20

Small-scale

0.736

High

1193566

TCAM1
TIR domain-containing adapter molecule 1

4

4

Small-scale

0.683

High

1225238

OPTN
Optineurin

3

20

Small-scale

0.664

High

1351628

AZI2
5-azacytidine-induced protein 2

3

5

Small-scale

0.656

High

1193400

MIB1
E3 ubiquitin-protein ligase MIB1

1

6

High-throughput

0.618

High

291483

IKKB
Inhibitor of nuclear factor kappa-B kinase subunit beta

1

18

Small-scale

0.618

High

682132

AKT1
RAC-alpha serine/threonine-protein kinase

1

20

Small-scale

0.618

High

710152

FAK1
Focal adhesion kinase 1

1

20

Small-scale

0.618

High

815746

KSYK
Tyrosine-protein kinase SYK

1

20

Small-scale

0.618

High

56999

TBKB1
TANK-binding kinase 1-binding protein 1

2

11

Small-scale

0.611

High

291823

NEMO
NF-kappa-B essential modulator

2

20

Small-scale

0.584

High

1163225

RIGI
Antiviral innate immune response receptor RIG-I

2

15

Small-scale

0.584

High

1351614

ZBP1
Z-DNA-binding protein 1

2

1

Small-scale

0.584

High

1376720

M3K14
Mitogen-activated protein kinase kinase kinase 14

1

20

Small-scale

0.575

High

936907

IRF3
Interferon regulatory factor 3

1

14

Small-scale

0.561

High

895598

RAB8B
Ras-related protein Rab-8B

1

6

Small-scale

0.553

High

1142915

FXR1
RNA-binding protein FXR1

1

3

High-throughput

0.536

High

1206535

RNF41
E3 ubiquitin-protein ligase NRDP1

1

20

Small-scale

0.528

High

547408

IRF1
Interferon regulatory factor 1

1

14

Small-scale

0.501

High

761845

TRAF2
TNF receptor-associated factor 2

1

20

Small-scale

0.501

High

880604

IRF5
Interferon regulatory factor 5

1

14

High-throughput

0.501

High

1237188

CIKS
E3 ubiquitin ligase TRAF3IP2

1

5

Small-scale

0.501

High

1143621

DDX3X
ATP-dependent RNA helicase DDX3X

1

9

Small-scale

0.500

High

420410

TNFA
Tumor necrosis factor

1

6

Small-scale

0.479

High

607583

MYD88
Myeloid differentiation primary response protein MyD88

1

6

Small-scale

0.479

High

672767

MSRE
Macrophage scavenger receptor types I and II

1

4

Small-scale

0.479

High

719321

PTN11
Tyrosine-protein phosphatase non-receptor type 11

1

11

Small-scale

0.479

High

841459

RN19A
E3 ubiquitin-protein ligase RNF19A

1

2

Small-scale

0.479

High

855345

STAT6
Signal transducer and transcription activator 6

1

3

Small-scale

0.479

High

956533

PP4C
Serine/threonine-protein phosphatase 4 catalytic subunit

1

20

Small-scale

0.479

High

1143608

TRI27
Zinc finger protein RFP

1

20

Small-scale

0.479

High

1206751

UBP1
Ubiquitin carboxyl-terminal hydrolase 1

1

7

Small-scale

0.479

High

1207842

A16L1
Autophagy-related protein 16-1

1

11

High-throughput

0.479

High

1257671

TRAIP
E3 ubiquitin-protein ligase TRAIP

1

18

Small-scale

0.479

High

1265643

EED
Polycomb protein EED

1

6

High-throughput

0.479

High

1307857

TLR3
Toll-like receptor 3

1

7

Small-scale

0.479

High

1322014

RN128
E3 ubiquitin-protein ligase RNF128

1

1

Small-scale

0.479

High

1351521

TLR4
Toll-like receptor 4

1

7

Small-scale

0.479

High

1265079

DDX41
Probable ATP-dependent RNA helicase DDX41

1

10

Small-scale

0.445

High

1351573

SRCN1
SRC kinase signaling inhibitor 1

1

1

High-throughput

0.445

High

1206499

WDR48
WD repeat-containing protein 48

1

9

Small-scale

0.437

High

1376723

ICOS
Inducible T-cell costimulator

1

1

Small-scale

0.407

High


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Last updated: 15 Jul 2024