Protein: MAD
Protein mothers against dpp

Gene: MAD
Organism: Drosophila melanogaster
Interactions: 96
UniProt ID: P42003

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000977 - RNA polymerase II transcription regulatory region sequence-specific DNA binding
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001227 - DNA-binding transcription repressor activity, RNA polymerase II-specific

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

264546

O62609
Mothers against decapentaplegic homolog

6

19

Small-scale

0.941

High

837128

MAD
Protein mothers against dpp

3

20

Small-scale

0.849

High

837146

PANG2
Protein pangolin, isoform J

3

20

Small-scale

0.642

High

837154

Q95SI0
receptor protein serine/threonine kinase

3

20

Small-scale

0.640

High

837149

Q8T030
Mitogen-activated protein kinase

2

8

Small-scale

0.624

High

713654

ABDA
Homeobox protein abdominal-A

2

10

High-throughput

0.619

High

837139

YAP1
Transcriptional coactivator yorkie

2

20

Small-scale

0.601

High

837179

Q9VSD6
D-Importin 7/RanBP7

2

8

Small-scale

0.601

High

479023

ZEN1
Protein zerknuellt 1

2

17

Small-scale

0.600

High

837140

MAN1
Inner nuclear membrane protein Man1

2

14

Small-scale

0.586

High

837131

UBX
Homeotic protein ultrabithorax

2

17

High-throughput

0.584

High

837196

Q9W3Q1
GM14286p

1

4

Small-scale

0.561

High

837159

SMUF1
E3 ubiquitin-protein ligase Smurf1

2

20

High-throughput

0.560

High

54260

A1Z8F4
Schnurri, isoform D

1

6

Small-scale

0.552

High

837181

CDK8
Cyclin-dependent kinase 8

1

7

Small-scale

0.552

High

837189

Q9W022
GEO01508p1

2

3

High-throughput

0.550

High

633087

CNC
Segmentation protein cap'n'collar

1

14

High-throughput

0.541

High

715240

ETS3
DNA-binding protein D-ETS-3

1

4

High-throughput

0.541

High

837137

HR78
Nuclear hormone receptor HR78

1

12

High-throughput

0.541

High

837153

NFKB1
Nuclear factor NF-kappa-B p110 subunit

1

11

High-throughput

0.541

High

837163

Q9VDQ5
RE74560p

1

6

High-throughput

0.541

High

837166

SCM
Polycomb protein Scm

1

1

High-throughput

0.541

High

837168

Q9VHM4
Ranshi

1

7

High-throughput

0.541

High

837169

Q9VHR4
Uncharacterized protein

1

6

High-throughput

0.541

High

55220

A1Z995
Sequoia, isoform A

1

0

High-throughput

0.518

High

95204

E1JIH4
Uncharacterized protein, isoform D

1

0

High-throughput

0.518

High

837182

Q9VTE8
GEO08928p1

1

0

High-throughput

0.518

High

478784

BCD
Homeotic protein bicoid

1

12

High-throughput

0.508

High

597771

NUMB
Protein numb

1

2

High-throughput

0.508

High

786361

2ABA
Protein phosphatase PP2A 55 kDa regulatory subunit

1

1

High-throughput

0.508

High

837134

CPN
Calphotin

1

10

High-throughput

0.508

High

837156

Q9I7L0
LP01847p

1

1

High-throughput

0.508

High

837170

POLI
DNA polymerase iota

1

1

High-throughput

0.508

High

837176

BOWEL
Protein bowel

1

8

High-throughput

0.508

High

837190

SF3B3
Splicing factor 3B subunit 3

1

1

High-throughput

0.508

High

837191

REV1
DNA repair protein Rev1

1

1

High-throughput

0.508

High

837198

SUDX
E3 ubiquitin-protein ligase Su(dx)

1

20

High-throughput

0.508

High

837199

MED15
Mediator of RNA polymerase II transcription subunit 15

1

20

High-throughput

0.508

High

263565

O61458
Mothers against decapentaplegic homolog

1

19

High-throughput

0.492

High

837130

UBCD2
Ubiquitin-conjugating enzyme E2-24 kDa

1

0

High-throughput

0.486

High

837155

CYCG
Cyclin G

1

0

High-throughput

0.486

High

837160

NPL4
Nuclear protein localization protein 4 homolog

1

0

High-throughput

0.486

High

837161

DAN
Protein distal antenna

1

0

High-throughput

0.486

High

837193

TAMO
Protein tamozhennic

1

0

High-throughput

0.486

High

122340

M9PIP2
Activating transcription factor 3, isoform B

1

20

High-throughput

0.481

High

393629

ANTP
Homeotic protein antennapedia

1

16

High-throughput

0.481

High

478940

ABDB
Homeobox protein abdominal-B

1

11

High-throughput

0.481

High

837151

Q8T0K8
GH25629p

1

1

High-throughput

0.481

High

837162

Q9VBZ6
GH14566p

1

1

High-throughput

0.481

High

837167

Q9VHF4
Doctor no, isoform B

1

1

High-throughput

0.481

High

54933

A1Z913
Vismay, isoform B

1

11

Small-scale

0.479

High

62837

A4V4L0
Transducer of ERBB2, isoform E

1

12

Small-scale

0.479

High

121979

M9PH39
histone acetyltransferase

1

16

Small-scale

0.479

High

616508

ARM
Armadillo segment polarity protein

1

6

Small-scale

0.479

High

837129

PNR
GATA-binding factor A

1

8

Small-scale

0.479

High

837133

IF4A
Eukaryotic initiation factor 4A

1

11

Small-scale

0.479

High

837141

Q7KF43
LD16058p

1

1

Small-scale

0.479

High

837143

SCRIB
Protein lap4

1

10

Small-scale

0.479

High

837158

SEC13
Protein SEC13 homolog

1

3

Small-scale

0.479

High

837177

CNEP1
CTD nuclear envelope phosphatase 1 homolog

1

5

Small-scale

0.479

High

837178

FOXF
Forkhead box protein biniou

1

15

Small-scale

0.479

High

837142

LIS1
Lissencephaly-1 homolog

1

5

Small-scale

0.470

High

53559

A1Z813
Secretory 24AB, isoform A

1

1

High-throughput

0.464

High

837138

VPS18
Vacuolar protein sorting-associated protein 18 homolog

1

2

High-throughput

0.464

High

837195

Q9W221
MIP04282p

1

1

High-throughput

0.464

High

68650

A8JNU1
adenylate cyclase

1

0

High-throughput

0.460

High

837135

Y3427
Uncharacterized protein CG43427

1

0

High-throughput

0.460

High

837157

RAB5
Ras-related protein Rab5

1

0

Small-scale

0.458

High

837132

PANG1
Protein pangolin, isoforms A/H/I/S

1

20

High-throughput

0.457

High

837197

ATF3
Activating transcription factor 3

1

19

High-throughput

0.457

High

837183

Q9VUH7
triacylglycerol lipase

1

1

High-throughput

0.445

High

837144

Q7KU90
Liquid facets, isoform B

1

3

High-throughput

0.439

High

837194

Q9W219
GEO12575p1

1

3

High-throughput

0.439

High

837147

Q8MSZ0
GM16166p

1

1

High-throughput

0.417

High

837148

Q8MZI0
GM14040p

1

1

High-throughput

0.417

High

837150

Q8T0I6
GH27912p

1

1

High-throughput

0.417

High

837152

Q8WQ62
AN1-type zinc finger protein 6

1

1

High-throughput

0.417

High

144548

O01368
histone acetyltransferase

1

20

High-throughput

0.381

High

837136

Q24107
Transcription factor

1

7

High-throughput

0.381

High

55991

BL1S1
Biogenesis of lysosome-related organelles complex 1 subunit 1

1

0

High-throughput

0.282

High

837164

Q9VEY5
MICOS complex subunit

1

0

High-throughput

0.265

Low

837165

Q9VFL9
FI07901p

1

0

High-throughput

0.265

Low

837171

Q9VI39
AT17667p

1

0

High-throughput

0.265

Low

837172

COG5
Conserved oligomeric Golgi complex subunit 5

1

0

High-throughput

0.265

Low

837174

POLZ2
DNA polymerase zeta subunit 2

1

0

High-throughput

0.265

Low

837175

Q9VPE6
LD43096p

1

0

High-throughput

0.265

Low

837180

Q9VSP8
IP10051p

1

0

High-throughput

0.265

Low

837184

Q9VVP8
FI02818p

1

0

High-throughput

0.265

Low

837185

Q9VWQ7
Coactosin-like protein

1

0

High-throughput

0.265

Low

837186

Q9VY61
Uncharacterized protein, isoform A

1

0

High-throughput

0.265

Low

837187

Q9VYA4
Ribonuclease H2 subunit B

1

0

High-throughput

0.265

Low

837192

Q9W191
Ionotropic receptor 60a

1

0

High-throughput

0.265

Low

837173

Q9VN63
LD28447p

1

0

High-throughput

0.249

Low

837188

Q9VZ02
RE11532p

1

0

High-throughput

0.249

Low

837145

Q86BB6
FI05373p

1

0

High-throughput

0.238

Low


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Last updated: 11Aug2025