Protein: SYK
Lysine--tRNA ligase (EC 2.7.7.-) (EC 6.1.1.6) (Lysyl-tRNA synthetase) (LysRS)

Gene: SYK, KARS1
Organism: Homo sapiens
Interactions: 224
UniProt ID: Q15046

Gene Ontology (top 5):
GO:0000049 - tRNA binding
GO:0002276 - basophil activation involved in immune response
GO:0002863 - positive regulation of inflammatory response to antigenic stimulus
GO:0003877 - ATP:ADP adenylyltransferase activity
GO:0004824 - lysine-tRNA ligase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1026271

AIMP2
Aminoacyl tRNA synthase complex-interacting multifunctional protein 2

20

4

Small-scale

0.990

High

1065515

SYK
Lysine--tRNA ligase

3

13

Small-scale

0.872

High

541365

SYDC
Aspartate--tRNA ligase, cytoplasmic

2

12

High-throughput

0.811

High

430959

SYEP
Bifunctional glutamate/proline--tRNA ligase

5

18

Small-scale

0.716

High

445410

RSSA
Small ribosomal subunit protein uS2

3

6

Small-scale

0.691

High

346827

MYC
Myc proto-oncogene protein

4

4

High-throughput

0.672

High

1019401

AIMP1
Aminoacyl tRNA synthase complex-interacting multifunctional protein 1

3

7

Small-scale

0.662

High

1065535

SDCG8
Serologically defined colon cancer antigen 8

3

4

Small-scale

0.662

High

58231

SYTC2
Threonine--tRNA ligase 2, cytoplasmic

2

8

High-throughput

0.628

High

201596

MCA3
Eukaryotic translation elongation factor 1 epsilon-1

2

9

High-throughput

0.628

High

783040

SYIC
Isoleucine--tRNA ligase, cytoplasmic

2

9

High-throughput

0.628

High

814452

SYQ
Glutamine--tRNA ligase

2

11

High-throughput

0.628

High

867707

SYRC
Arginine--tRNA ligase, cytoplasmic

2

2

High-throughput

0.628

High

880116

SYMC
Methionine--tRNA ligase, cytoplasmic

2

9

High-throughput

0.628

High

1065588

SYLC
Leucine--tRNA ligase, cytoplasmic

2

12

High-throughput

0.628

High

1065529

SYDM
Aspartate--tRNA ligase, mitochondrial

1

12

Small-scale

0.621

High

651248

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

3

High-throughput

0.618

High

227492

PRKN
E3 ubiquitin-protein ligase parkin

2

8

High-throughput

0.584

High

592262

RAB5A
Ras-related protein Rab-5A

2

1

High-throughput

0.571

High

205412

TGON2
Trans-Golgi network integral membrane protein 2

2

0

High-throughput

0.563

High

658949

MK01
Mitogen-activated protein kinase 1

1

1

Small-scale

0.561

High

1065572

ACE2
Angiotensin-converting enzyme 2

2

0

High-throughput

0.559

High

720507

RFA3
Replication protein A 14 kDa subunit

1

3

High-throughput

0.553

High

522994

SRC
Proto-oncogene tyrosine-protein kinase Src

2

0

High-throughput

0.547

High

1065563

OTUB1
Ubiquitin thioesterase OTUB1

2

0

High-throughput

0.547

High

644042

EF1G
Elongation factor 1-gamma

1

6

High-throughput

0.541

High

792986

LIS1
Platelet-activating factor acetylhydrolase IB subunit beta

1

7

High-throughput

0.541

High

132866

SDCB1
Syntenin-1

1

1

High-throughput

0.536

High

363157

FINC
Fibronectin

1

2

High-throughput

0.536

High

845923

RB27A
Ras-related protein Rab-27A

1

1

High-throughput

0.536

High

883914

SYJ2B
Synaptojanin-2-binding protein

1

1

High-throughput

0.536

High

907924

RS16
Small ribosomal subunit protein uS9

1

1

High-throughput

0.536

High

1040989

CUL1
Cullin-1

1

7

High-throughput

0.536

High

1062349

CND2
Condensin complex subunit 2

1

1

High-throughput

0.536

High

1065520

PKN2
Serine/threonine-protein kinase N2

1

2

High-throughput

0.536

High

1065557

CSN5
COP9 signalosome complex subunit 5

1

5

High-throughput

0.536

High

1065568

HCD2
3-hydroxyacyl-CoA dehydrogenase type-2

1

3

High-throughput

0.536

High

277837

DYSF
Dysferlin

1

0

High-throughput

0.518

High

518358

ADT3
ADP/ATP translocase 3

1

0

High-throughput

0.518

High

177894

TMPS2
Transmembrane protease serine 2

1

2

High-throughput

0.515

High

328852

TOP3B
DNA topoisomerase 3-beta-1

1

1

High-throughput

0.515

High

429894

CATL1
Procathepsin L

1

2

High-throughput

0.515

High

525936

IFM1
Interferon-induced transmembrane protein 1

1

1

High-throughput

0.515

High

779441

CCNF
Cyclin-F

1

3

High-throughput

0.515

High

965674

IFM3
Interferon-induced transmembrane protein 3

1

1

High-throughput

0.515

High

1065551

CLC4D
C-type lectin domain family 4 member D

1

2

High-throughput

0.515

High

1065595

CLC4E
C-type lectin domain family 4 member E

1

2

High-throughput

0.515

High

336498

SODC
Superoxide dismutase [Cu-Zn]

1

1

High-throughput

0.515

High

255153

ATG13
Autophagy-related protein 13

1

0

High-throughput

0.513

High

1050955

ICT1
Large ribosomal subunit protein mL62

1

0

High-throughput

0.513

High

1065544

PDZD8
PDZ domain-containing protein 8

1

0

High-throughput

0.513

High

1065550

PSPC1
Paraspeckle component 1

1

0

High-throughput

0.513

High

1065577

MED4
Mediator of RNA polymerase II transcription subunit 4

1

0

High-throughput

0.513

High

1065593

MED23
Mediator of RNA polymerase II transcription subunit 23

1

0

High-throughput

0.513

High

1065601

MB212
Protein mab-21-like 2

1

0

High-throughput

0.513

High

381994

G3P
Glyceraldehyde-3-phosphate dehydrogenase

1

2

High-throughput

0.508

High

443528

VIME
Vimentin

1

1

High-throughput

0.508

High

1065553

P55G
Phosphatidylinositol 3-kinase regulatory subunit gamma

1

4

High-throughput

0.508

High

174902

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

1

2

High-throughput

0.501

High

369633

ESR1
Estrogen receptor

1

4

Small-scale

0.501

High

433151

LAMB1
Laminin subunit beta-1

1

1

Small-scale

0.501

High

894025

CDC42
Cell division control protein 42 homolog

1

1

High-throughput

0.501

High

902594

SUMO2
Small ubiquitin-related modifier 2

1

4

High-throughput

0.501

High

648766

DPP4
Dipeptidyl peptidase 4

1

0

High-throughput

0.493

High

202891

EMC8
ER membrane protein complex subunit 8

1

3

High-throughput

0.489

High

1065540

CMTD1
Catechol O-methyltransferase domain-containing protein 1

1

1

High-throughput

0.489

High

1065598

EMC9
ER membrane protein complex subunit 9

1

3

High-throughput

0.489

High

118867

GTPB1
GTP-binding protein 1

1

10

High-throughput

0.479

High

125469

WWP2
NEDD4-like E3 ubiquitin-protein ligase WWP2

1

4

High-throughput

0.479

High

165851

KDM6B
Lysine-specific demethylase 6B

1

4

Small-scale

0.479

High

182759

R113A
E3 ubiquitin-protein ligase RNF113A

1

1

High-throughput

0.479

High

244460

BRD4
Bromodomain-containing protein 4

1

1

High-throughput

0.479

High

272564

OFD1
Centriole and centriolar satellite protein OFD1

1

2

High-throughput

0.479

High

294846

RECQ4
ATP-dependent DNA helicase Q4

1

2

High-throughput

0.479

High

298527

UFL1
E3 UFM1-protein ligase 1

1

2

High-throughput

0.479

High

303251

HEXI1
Protein HEXIM1

1

1

High-throughput

0.479

High

322653

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

2

High-throughput

0.479

High

374252

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

4

High-throughput

0.479

High

377331

GCR
Glucocorticoid receptor

1

4

Small-scale

0.479

High

384870

NTRK1
High affinity nerve growth factor receptor

1

6

High-throughput

0.479

High

417293

ENOA
Alpha-enolase

1

3

High-throughput

0.479

High

431227

CATB
Cathepsin B

1

3

High-throughput

0.479

High

440520

ODPA
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial

1

3

High-throughput

0.479

High

450883

F16P1
Fructose-1,6-bisphosphatase 1

1

1

High-throughput

0.479

High

487448

ANDR
Androgen receptor

1

4

Small-scale

0.479

High

504109

HSP7C
Heat shock cognate 71 kDa protein

1

1

High-throughput

0.479

High

508007

FGFR1
Fibroblast growth factor receptor 1

1

13

High-throughput

0.479

High

547065

EZRI
Ezrin

1

1

High-throughput

0.479

High

552767

RFA2
Replication protein A 32 kDa subunit

1

3

High-throughput

0.479

High

569747

CEBPB
CCAAT/enhancer-binding protein beta

1

4

High-throughput

0.479

High

572637

VGFR1
Vascular endothelial growth factor receptor 1

1

5

High-throughput

0.479

High

600574

EPHA1
Ephrin type-A receptor 1

1

5

High-throughput

0.479

High

609292

FGFR3
Fibroblast growth factor receptor 3

1

10

High-throughput

0.479

High

637252

CATS
Cathepsin S

1

2

High-throughput

0.479

High

666599

LTK
Leukocyte tyrosine kinase receptor

1

7

High-throughput

0.479

High

674434

UFO
Tyrosine-protein kinase receptor UFO

1

8

High-throughput

0.479

High

684737

STIP1
Stress-induced-phosphoprotein 1

1

5

High-throughput

0.479

High

718871

PHB1
Prohibitin 1

1

2

High-throughput

0.479

High

729282

VGFR3
Vascular endothelial growth factor receptor 3

1

5

High-throughput

0.479

High

738213

FLT3
Receptor-type tyrosine-protein kinase FLT3

1

5

High-throughput

0.479

High

749515

BRCA1
Breast cancer type 1 susceptibility protein

1

3

High-throughput

0.479

High

773375

RL13A
Large ribosomal subunit protein uL13

1

1

High-throughput

0.479

High

807729

MAP1B
Microtubule-associated protein 1B

1

1

High-throughput

0.479

High

813481

CAPZB
F-actin-capping protein subunit beta

1

3

High-throughput

0.479

High

818067

SOX2
Transcription factor SOX-2

1

1

High-throughput

0.479

High

832473

MCM2
DNA replication licensing factor MCM2

1

2

High-throughput

0.479

High

845492

RAB9A
Ras-related protein Rab-9A

1

1

High-throughput

0.479

High

868190

ATX3
Ataxin-3

1

1

High-throughput

0.479

High

874950

TERA
Transitional endoplasmic reticulum ATPase

1

1

High-throughput

0.479

High

897732

ABCE1
ATP-binding cassette sub-family E member 1

1

8

High-throughput

0.479

High

903238

WDR5
WD repeat-containing protein 5

1

5

High-throughput

0.479

High

908567

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

2

High-throughput

0.479

High

917296

H4
Histone H4

1

3

High-throughput

0.479

High

929206

RS21
Small ribosomal subunit protein eS21

1

1

High-throughput

0.479

High

959427

VIGLN
Vigilin

1

3

High-throughput

0.479

High

981877

RON
Macrophage-stimulating protein receptor

1

8

High-throughput

0.479

High

1018325

MERTK
Tyrosine-protein kinase Mer

1

7

High-throughput

0.479

High

1022099

NFX1
Transcriptional repressor NF-X1

1

2

High-throughput

0.479

High

1029445

TIF1B
Transcription intermediary factor 1-beta

1

3

High-throughput

0.479

High

1035758

BIRC3
Baculoviral IAP repeat-containing protein 3

1

2

High-throughput

0.479

High

1041603

CUL3
Cullin-3

1

7

High-throughput

0.479

High

1042995

CUL4A
Cullin-4A

1

7

High-throughput

0.479

High

1050198

IKKE
Inhibitor of nuclear factor kappa-B kinase subunit epsilon

1

1

High-throughput

0.479

High

1058209

UBP10
Ubiquitin carboxyl-terminal hydrolase 10

1

8

Small-scale

0.479

High

1063793

TNIP1
TNFAIP3-interacting protein 1

1

3

High-throughput

0.479

High

1064312

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

5

High-throughput

0.479

High

1065516

KIF14
Kinesin-like protein KIF14

1

2

High-throughput

0.479

High

1065517

PDK1
[Pyruvate dehydrogenase

1

2

High-throughput

0.479

High

1065521

IF16
Gamma-interferon-inducible protein 16

1

1

High-throughput

0.479

High

1065522

SYAM
Alanine--tRNA ligase, mitochondrial

1

2

High-throughput

0.479

High

1065525

RN123
E3 ubiquitin-protein ligase RNF123

1

2

High-throughput

0.479

High

1065526

VIR
Protein virilizer homolog

1

2

High-throughput

0.479

High

1065528

PRP8
Pre-mRNA-processing-splicing factor 8

1

1

High-throughput

0.479

High

1065530

LMBRL
Protein LMBR1L

1

1

High-throughput

0.479

High

1065531

LMTK1
Serine/threonine-protein kinase LMTK1

1

8

High-throughput

0.479

High

1065533

MOB3C
MOB kinase activator 3C

1

1

High-throughput

0.479

High

1065536

TM11B
Transmembrane protease serine 11B

1

2

High-throughput

0.479

High

1065537

ZN598
E3 ubiquitin-protein ligase ZNF598

1

4

High-throughput

0.479

High

1065538

NAA40
N-alpha-acetyltransferase 40

1

1

High-throughput

0.479

High

1065541

LMTK2
Serine/threonine-protein kinase LMTK2

1

8

High-throughput

0.479

High

1065547

TIP
T-cell immunomodulatory protein

1

1

High-throughput

0.479

High

1065552

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

3

High-throughput

0.479

High

1065554

ESR2
Estrogen receptor beta

1

4

High-throughput

0.479

High

1065559

FBXW7
F-box/WD repeat-containing protein 7

1

5

High-throughput

0.479

High

1065561

ARMC5
Armadillo repeat-containing protein 5

1

4

High-throughput

0.479

High

1065562

CHM4C
Charged multivesicular body protein 4c

1

1

High-throughput

0.479

High

1065566

LMTK3
Serine/threonine-protein kinase LMTK3

1

12

High-throughput

0.479

High

1065569

ANM1
Protein arginine N-methyltransferase 1

1

4

High-throughput

0.479

High

1065574

PKHA4
Pleckstrin homology domain-containing family A member 4

1

5

High-throughput

0.479

High

1065578

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

1

1

High-throughput

0.479

High

1065579

ANLN
Anillin

1

2

High-throughput

0.479

High

1065580

SIR7
NAD-dependent protein deacetylase sirtuin-7

1

1

High-throughput

0.479

High

1065581

FBX6
F-box only protein 6

1

1

High-throughput

0.479

High

1065583

RAD18
E3 ubiquitin-protein ligase RAD18

1

1

High-throughput

0.479

High

1065589

HDAC6
Histone deacetylase 6

1

4

High-throughput

0.479

High

1065590

DUX4
Double homeobox protein 4

1

2

High-throughput

0.479

High

1065591

ZRAN1
Ubiquitin thioesterase ZRANB1

1

2

High-throughput

0.479

High

1065592

MKRN1
E3 ubiquitin-protein ligase makorin-1

1

1

High-throughput

0.479

High

1065596

FAF1
FAS-associated factor 1

1

1

High-throughput

0.479

High

1065599

LOXL2
Lysyl oxidase homolog 2

1

1

High-throughput

0.479

High

1045416

SPTN1
Spectrin alpha chain, non-erythrocytic 1

1

0

Small-scale

0.460

High

117408

BACH
Cytosolic acyl coenzyme A thioester hydrolase

1

0

High-throughput

0.458

High

155358

NRP1
Neuropilin-1

1

0

High-throughput

0.458

High

273433

PPM1B
Protein phosphatase 1B

1

0

High-throughput

0.458

High

364282

TFR1
Transferrin receptor protein 1

1

0

High-throughput

0.458

High

456870

FURIN
Furin

1

0

High-throughput

0.458

High

525509

COX41
Cytochrome c oxidase subunit 4 isoform 1, mitochondrial

1

0

High-throughput

0.458

High

637888

PSA3
Proteasome subunit alpha type-3

1

0

Small-scale

0.458

High

726210

BASI
Basigin

1

0

High-throughput

0.458

High

781368

BCL6
B-cell lymphoma 6 protein

1

0

High-throughput

0.458

High

847479

BAP31
B-cell receptor-associated protein 31

1

0

High-throughput

0.458

High

914079

RB11A
Ras-related protein Rab-11A

1

0

High-throughput

0.458

High

961124

HSF1
Heat shock factor protein 1

1

0

High-throughput

0.458

High

962786

MDM2
E3 ubiquitin-protein ligase Mdm2

1

0

Small-scale

0.458

High

980260

K1C17
Keratin, type I cytoskeletal 17

1

0

High-throughput

0.458

High

1065527

CDC73
Parafibromin

1

0

High-throughput

0.458

High

1065534

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

0

High-throughput

0.458

High

1065545

TNIP2
TNFAIP3-interacting protein 2

1

0

High-throughput

0.458

High

1065548

PI42C
Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma

1

0

High-throughput

0.458

High

1065549

SH3R2
E3 ubiquitin-protein ligase SH3RF2

1

0

Small-scale

0.458

High

1065555

TANK
TRAF family member-associated NF-kappa-B activator

1

0

High-throughput

0.458

High

1065558

H2B1H
Histone H2B type 1-H

1

0

High-throughput

0.458

High

1065565

COX14
Cytochrome c oxidase assembly protein COX14

1

0

High-throughput

0.458

High

1065570

OVOL2
Transcription factor Ovo-like 2

1

0

Small-scale

0.458

High

1065571

PINK1
Serine/threonine-protein kinase PINK1, mitochondrial

1

0

High-throughput

0.458

High

1065575

SFXN1
Sideroflexin-1

1

0

High-throughput

0.458

High

1065576

PLRKT
Plasminogen receptor

1

0

High-throughput

0.458

High

1065582

TOM22
Mitochondrial import receptor subunit TOM22 homolog

1

0

High-throughput

0.458

High

1065584

PIHD1
PIH1 domain-containing protein 1

1

0

High-throughput

0.458

High

1065585

AKIP
Small ribosomal subunit protein mS38

1

0

High-throughput

0.458

High

1065586

PD1L1
Programmed cell death 1 ligand 1

1

0

High-throughput

0.458

High

240000

HCN1
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

1

1

High-throughput

0.445

High

402031

JUN
Transcription factor Jun

1

4

High-throughput

0.445

High

529138

CFTR
Cystic fibrosis transmembrane conductance regulator

1

5

High-throughput

0.445

High

891153

GBRL2
Gamma-aminobutyric acid receptor-associated protein-like 2

1

2

High-throughput

0.445

High

1065523

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

4

High-throughput

0.445

High

1065546

MSPD2
Motile sperm domain-containing protein 2

1

3

High-throughput

0.445

High

1065573

GBRL1
Gamma-aminobutyric acid receptor-associated protein-like 1

1

2

High-throughput

0.445

High

1065597

ST38L
Serine/threonine-protein kinase 38-like

1

2

High-throughput

0.445

High

207317

FRS3
Fibroblast growth factor receptor substrate 3

1

0

High-throughput

0.438

High

1065556

CELF1
CUGBP Elav-like family member 1

1

0

High-throughput

0.438

High

169465

BET1
BET1 homolog

1

2

High-throughput

0.437

High

824023

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

3

High-throughput

0.437

High

1062517

EMC2
ER membrane protein complex subunit 2

1

1

High-throughput

0.437

High

1065532

TRI67
Tripartite motif-containing protein 67

1

3

High-throughput

0.437

High

1065539

ZCH18
Zinc finger CCCH domain-containing protein 18

1

1

High-throughput

0.437

High

1065564

DDRGK
DDRGK domain-containing protein 1

1

1

High-throughput

0.437

High

1065587

RN181
E3 ubiquitin-protein ligase RNF181

1

1

High-throughput

0.437

High

1065594

HECD1
E3 ubiquitin-protein ligase HECTD1

1

4

High-throughput

0.437

High

1017130

SNF5
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1

1

0

High-throughput

0.426

High

1065518

NEDD8
NEDD8

1

0

Small-scale

0.426

High

1065567

SCN2A
Sodium channel protein type 2 subunit alpha

1

0

High-throughput

0.426

High

831340

CEBPA
CCAAT/enhancer-binding protein alpha

1

4

High-throughput

0.408

High

502895

CD37
Leukocyte antigen CD37

1

1

Small-scale

0.407

High

1065602

LRRF2
Leucine-rich repeat flightless-interacting protein 2

2

0

High-throughput

0.328

High

1065519

E2F4
Transcription factor E2F4

1

0

High-throughput

0.249

Low

1065524

CI114
Putative methyltransferase C9orf114

1

0

High-throughput

0.249

Low

1065542

EMC1
ER membrane protein complex subunit 1

1

0

High-throughput

0.249

Low

1065543

CA131
Uncharacterized protein C1orf131

1

0

High-throughput

0.249

Low

1065560

VP33A
Vacuolar protein sorting-associated protein 33A

1

0

High-throughput

0.249

Low

1065600

PPME1
Protein phosphatase methylesterase 1

1

0

Small-scale

0.249

Low

484451

RPAC2
DNA-directed RNA polymerases I and III subunit RPAC2

1

0

High-throughput

0.232

Low

968578

TAGL
Transgelin

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024