Protein: UBE3C
Ubiquitin-protein ligase E3C (EC 2.3.2.26) (HECT-type ubiquitin transferase E3C) (Homologous to E6AP carboxyl terminus homologous protein 2) (HectH2) (RTA-associated ubiquitin ligase) (RAUL)

Gene: UBE3C
Organism: Homo sapiens
Interactions: 187
UniProt ID: Q15386

Gene Ontology (top 5):
GO:0000209 - protein polyubiquitination
GO:0000502 - proteasome complex
GO:0006511 - ubiquitin-dependent protein catabolic process
GO:0035519 - protein K29-linked ubiquitination
GO:0061630 - ubiquitin protein ligase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

849334

UB2D1
Ubiquitin-conjugating enzyme E2 D1

7

20

Small-scale

0.964

High

1072676

UBE3C
Ubiquitin-protein ligase E3C

7

16

Small-scale

0.959

High

932518

UB2L3
Ubiquitin-conjugating enzyme E2 L3

6

20

Small-scale

0.942

High

919732

UB2D2
Ubiquitin-conjugating enzyme E2 D2

4

20

Small-scale

0.888

High

475799

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

6

20

Small-scale

0.841

High

895796

UB2D3
Ubiquitin-conjugating enzyme E2 D3

2

20

Small-scale

0.778

High

983132

UBE3A
Ubiquitin-protein ligase E3A

2

15

Small-scale

0.737

High

1027661

PSMD2
26S proteasome non-ATPase regulatory subunit 2

4

9

Small-scale

0.692

High

130900

PSDE
26S proteasome non-ATPase regulatory subunit 14

4

15

Small-scale

0.676

High

893554

SEM1
26S proteasome complex subunit SEM1

3

3

Small-scale

0.650

High

908588

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

20

High-throughput

0.618

High

1072733

HECD1
E3 ubiquitin-protein ligase HECTD1

1

18

High-throughput

0.618

High

874103

PSMD4
26S proteasome non-ATPase regulatory subunit 4

2

9

High-throughput

0.611

High

1062812

PSMD6
26S proteasome non-ATPase regulatory subunit 6

2

11

Small-scale

0.611

High

246352

SCN2B
Sodium channel subunit beta-2

3

1

High-throughput

0.609

High

907040

PRS8
26S proteasome regulatory subunit 8

2

18

Small-scale

0.595

High

1072722

BIRC6
Baculoviral IAP repeat-containing protein 6

1

20

Small-scale

0.579

High

994887

GOGA2
Golgin subfamily A member 2

2

7

High-throughput

0.578

High

58439

F234B
Protein FAM234B

2

1

High-throughput

0.574

High

1072736

VSIG4
V-set and immunoglobulin domain-containing protein 4

2

4

High-throughput

0.558

High

1072687

DDI2
Protein DDI1 homolog 2

1

16

High-throughput

0.553

High

121770

PSD11
26S proteasome non-ATPase regulatory subunit 11

1

9

High-throughput

0.536

High

122021

PSD12
26S proteasome non-ATPase regulatory subunit 12

1

7

High-throughput

0.536

High

198635

PSMD3
26S proteasome non-ATPase regulatory subunit 3

1

2

High-throughput

0.536

High

572962

PRS6A
26S proteasome regulatory subunit 6A

1

19

High-throughput

0.536

High

594535

PSB1
Proteasome subunit beta type-1

1

20

High-throughput

0.536

High

637427

PSA1
Proteasome subunit alpha type-1

1

16

High-throughput

0.536

High

656235

PSA5
Proteasome subunit alpha type-5

1

17

High-throughput

0.536

High

656604

PSB6
Proteasome subunit beta type-6

1

20

High-throughput

0.536

High

730268

PRS7
26S proteasome regulatory subunit 7

1

16

High-throughput

0.536

High

798672

PRS6B
26S proteasome regulatory subunit 6B

1

13

High-throughput

0.536

High

831995

PSB3
Proteasome subunit beta type-3

1

19

High-throughput

0.536

High

832107

PSB2
Proteasome subunit beta type-2

1

20

High-throughput

0.536

High

893675

PSA6
Proteasome subunit alpha type-6

1

20

High-throughput

0.536

High

913273

PRS10
26S proteasome regulatory subunit 10B

1

18

High-throughput

0.536

High

1072708

PSB7
Proteasome subunit beta type-7

1

13

High-throughput

0.536

High

1072709

PSMD1
26S proteasome non-ATPase regulatory subunit 1

1

9

High-throughput

0.536

High

1072734

PSD13
26S proteasome non-ATPase regulatory subunit 13

1

5

High-throughput

0.536

High

1072696

PK3C3
Phosphatidylinositol 3-kinase catalytic subunit type 3

1

1

Small-scale

0.528

High

296032

MTA2
Metastasis-associated protein MTA2

1

5

High-throughput

0.494

High

1072732

TLK1
Serine/threonine-protein kinase tousled-like 1

1

19

High-throughput

0.494

High

538553

CCNB1
G2/mitotic-specific cyclin-B1

1

1

Small-scale

0.489

High

59755

KLRG2
Killer cell lectin-like receptor subfamily G member 2

1

2

High-throughput

0.489

High

172003

GP182
G-protein coupled receptor 182

1

8

High-throughput

0.489

High

274223

STK16
Serine/threonine-protein kinase 16

1

4

High-throughput

0.489

High

310646

VAPB
Vesicle-associated membrane protein-associated protein B/C

1

2

High-throughput

0.489

High

314641

PARN
Poly(A)-specific ribonuclease PARN

1

1

High-throughput

0.489

High

346850

MYC
Myc proto-oncogene protein

1

10

High-throughput

0.489

High

354837

DQA1
HLA class II histocompatibility antigen, DQ alpha 1 chain

1

2

High-throughput

0.489

High

380301

HG2A
HLA class II histocompatibility antigen gamma chain

1

1

High-throughput

0.489

High

488232

HLAC
HLA class I histocompatibility antigen, C alpha chain

1

1

High-throughput

0.489

High

529156

CFTR
Cystic fibrosis transmembrane conductance regulator

1

6

High-throughput

0.489

High

595532

GRAH
Granzyme H

1

7

High-throughput

0.489

High

600578

EPHA1
Ephrin type-A receptor 1

1

8

High-throughput

0.489

High

655175

IL1R2
Interleukin-1 receptor type 2

1

5

High-throughput

0.489

High

679346

KAP3
cAMP-dependent protein kinase type II-beta regulatory subunit

1

4

High-throughput

0.489

High

1047934

KCC1A
Calcium/calmodulin-dependent protein kinase type 1

1

6

High-throughput

0.489

High

1061378

PSME4
Proteasome activator complex subunit 4

1

1

High-throughput

0.489

High

1067497

P2RY6
P2Y purinoceptor 6

1

8

High-throughput

0.489

High

1072678

NTRK3
NT-3 growth factor receptor

1

17

High-throughput

0.489

High

1072682

PTPRN
Receptor-type tyrosine-protein phosphatase-like N

1

10

High-throughput

0.489

High

1072686

LRAD1
Low-density lipoprotein receptor class A domain-containing protein 1

1

1

High-throughput

0.489

High

1072692

DDX60
Probable ATP-dependent RNA helicase DDX60

1

10

High-throughput

0.489

High

1072693

XRN1
5'-3' exoribonuclease 1

1

3

High-throughput

0.489

High

1072695

ARRD4
Arrestin domain-containing protein 4

1

20

High-throughput

0.489

High

1072697

ARRD2
Arrestin domain-containing protein 2

1

20

High-throughput

0.489

High

1072700

CLC2B
C-type lectin domain family 2 member B

1

2

High-throughput

0.489

High

1072703

ARRD3
Arrestin domain-containing protein 3

1

20

High-throughput

0.489

High

1072705

RMXL1
RNA binding motif protein, X-linked-like-1

1

8

High-throughput

0.489

High

1072706

AURKB
Aurora kinase B

1

11

High-throughput

0.489

High

1072713

CNTP3
Contactin-associated protein-like 3

1

9

High-throughput

0.489

High

1072715

F234A
Protein FAM234A

1

1

High-throughput

0.489

High

1072717

TXNIP
Thioredoxin-interacting protein

1

20

High-throughput

0.489

High

1072723

LATS2
Serine/threonine-protein kinase LATS2

1

20

High-throughput

0.489

High

1072730

CLC2D
C-type lectin domain family 2 member D

1

2

High-throughput

0.489

High

1072739

GPR45
Probable G-protein coupled receptor 45

1

4

High-throughput

0.489

High

637692

PSA2
Proteasome subunit alpha type-2

1

20

Small-scale

0.479

High

656469

PSB4
Proteasome subunit beta type-4

1

20

High-throughput

0.479

High

1035770

BIRC3
Baculoviral IAP repeat-containing protein 3

1

4

High-throughput

0.479

High

1041632

CUL3
Cullin-3

1

8

High-throughput

0.479

High

1043362

CUL4B
Cullin-4B

1

8

High-throughput

0.479

High

1072677

ADRM1
Proteasomal ubiquitin receptor ADRM1

1

3

High-throughput

0.479

High

1072738

UCHL5
Ubiquitin carboxyl-terminal hydrolase isozyme L5

1

5

Small-scale

0.479

High

296915

LTN1
E3 ubiquitin-protein ligase listerin

1

0

High-throughput

0.458

High

1072691

SEML
Putative protein SEM1, isoform 2

1

0

High-throughput

0.458

High

1072724

RAD18
E3 ubiquitin-protein ligase RAD18

1

0

Small-scale

0.458

High

256752

CAND2
Cullin-associated NEDD8-dissociated protein 2

1

5

Small-scale

0.457

High

394749

A4
Amyloid-beta precursor protein

1

6

High-throughput

0.457

High

1017903

GRSF1
G-rich sequence factor 1

1

19

Small-scale

0.439

High

123606

PGRC1
Membrane-associated progesterone receptor component 1

1

1

Small-scale

0.437

High

224442

RAD21
Double-strand-break repair protein rad21 homolog

1

1

High-throughput

0.437

High

260562

TP4A3
Protein tyrosine phosphatase type IVA 3

1

13

High-throughput

0.437

High

338463

EGFR
Epidermal growth factor receptor

1

20

Small-scale

0.437

High

352107

INS
Insulin [Cleaved into: Insulin B chain; Insulin A chain]

1

1

High-throughput

0.437

High

369658

ESR1
Estrogen receptor

1

20

Small-scale

0.437

High

384887

NTRK1
High affinity nerve growth factor receptor

1

18

High-throughput

0.437

High

386782

P53
Cellular tumor antigen p53

1

17

Small-scale

0.437

High

423237

PDIA1
Protein disulfide-isomerase

1

12

Small-scale

0.437

High

443533

VIME
Vimentin

1

8

Small-scale

0.437

High

508543

TOP1
DNA topoisomerase 1

1

3

Small-scale

0.437

High

521548

ACTN1
Alpha-actinin-1

1

5

Small-scale

0.437

High

531161

EF2
Elongation factor 2

1

9

Small-scale

0.437

High

537913

KPYM
Pyruvate kinase PKM

1

8

Small-scale

0.437

High

538246

ENPL
Endoplasmin

1

15

Small-scale

0.437

High

541256

GBRA1
Gamma-aminobutyric acid receptor subunit alpha-1

1

2

High-throughput

0.437

High

552793

RFA2
Replication protein A 32 kDa subunit

1

5

High-throughput

0.437

High

570537

PTN2
Tyrosine-protein phosphatase non-receptor type 2

1

7

High-throughput

0.437

High

574209

BMP7
Bone morphogenetic protein 7

1

2

Small-scale

0.437

High

589198

ANXA7
Annexin A7

1

10

Small-scale

0.437

High

636935

ATPA
ATP synthase subunit alpha, mitochondrial

1

9

Small-scale

0.437

High

643516

PTBP1
Polypyrimidine tract-binding protein 1

1

9

Small-scale

0.437

High

651276

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

6

High-throughput

0.437

High

653600

CALR
Calreticulin

1

6

Small-scale

0.437

High

660852

PTPRM
Receptor-type tyrosine-protein phosphatase mu

1

4

High-throughput

0.437

High

671662

PEBP1
Phosphatidylethanolamine-binding protein 1

1

1

Small-scale

0.437

High

671821

PDIA3
Protein disulfide-isomerase A3

1

12

Small-scale

0.437

High

684748

STIP1
Stress-induced-phosphoprotein 1

1

13

High-throughput

0.437

High

724841

MYH9
Myosin-9

1

2

Small-scale

0.437

High

749520

BRCA1
Breast cancer type 1 susceptibility protein

1

4

High-throughput

0.437

High

779462

CCNF
Cyclin-F

1

7

High-throughput

0.437

High

795757

MAGA3
Melanoma-associated antigen 3

1

11

Small-scale

0.437

High

856535

EFNB2
Ephrin-B2

1

2

High-throughput

0.437

High

879803

TPTE
Putative tyrosine-protein phosphatase TPTE

1

13

High-throughput

0.437

High

881623

PEX3
Peroxisomal biogenesis factor 3

1

1

High-throughput

0.437

High

903949

HNRPK
Heterogeneous nuclear ribonucleoprotein K

1

18

Small-scale

0.437

High

932710

EF1A1
Elongation factor 1-alpha 1

1

6

Small-scale

0.437

High

965682

IFM3
Interferon-induced transmembrane protein 3

1

5

High-throughput

0.437

High

998736

EP300
Histone acetyltransferase p300

1

9

High-throughput

0.437

High

999587

AHNK
Neuroblast differentiation-associated protein AHNAK

1

6

Small-scale

0.437

High

1031865

MTA1
Metastasis-associated protein MTA1

1

5

Small-scale

0.437

High

1033271

DC1I2
Cytoplasmic dynein 1 intermediate chain 2

1

3

High-throughput

0.437

High

1035442

SMAD4
Mothers against decapentaplegic homolog 4

1

20

High-throughput

0.437

High

1051948

ELOA1
Elongin-A

1

3

Small-scale

0.437

High

1071873

PCBP1
Poly(rC)-binding protein 1

1

17

Small-scale

0.437

High

1072680

HIF1A
Hypoxia-inducible factor 1-alpha

1

5

High-throughput

0.437

High

1072681

PTPRO
Receptor-type tyrosine-protein phosphatase O

1

3

High-throughput

0.437

High

1072683

CL16A
Protein CLEC16A

1

1

High-throughput

0.437

High

1072684

ANR55
Ankyrin repeat domain-containing protein 55

1

8

High-throughput

0.437

High

1072688

MYOME
Myomegalin

1

8

High-throughput

0.437

High

1072690

TRI67
Tripartite motif-containing protein 67

1

14

High-throughput

0.437

High

1072699

RSAD2
S-adenosylmethionine-dependent nucleotide dehydratase RSAD2

1

1

Small-scale

0.437

High

1072702

PTPRU
Receptor-type tyrosine-protein phosphatase U

1

4

High-throughput

0.437

High

1072704

FAF2
FAS-associated factor 2

1

10

High-throughput

0.437

High

1072710

TCPH
T-complex protein 1 subunit eta

1

14

Small-scale

0.437

High

1072711

GRWD1
Glutamate-rich WD repeat-containing protein 1

1

10

High-throughput

0.437

High

1072714

MLP3B
Microtubule-associated proteins 1A/1B light chain 3B

1

10

High-throughput

0.437

High

1072718

Q9H4D1
Protein kinase

1

6

High-throughput

0.437

High

1072719

ECT2
Protein ECT2

1

8

High-throughput

0.437

High

1072721

BRD7
Bromodomain-containing protein 7

1

5

High-throughput

0.437

High

1072725

PD1L1
Programmed cell death 1 ligand 1

1

7

High-throughput

0.437

High

1072729

ZRAN1
Ubiquitin thioesterase ZRANB1

1

8

High-throughput

0.437

High

1072731

HOOK1
Protein Hook homolog 1

1

8

High-throughput

0.437

High

92788

E9PS44
Interferon induced transmembrane protein 3

1

5

High-throughput

0.407

High

353938

IGHM
Immunoglobulin heavy constant mu

1

4

High-throughput

0.407

High

354456

HLAB
HLA class I histocompatibility antigen, B alpha chain

1

1

High-throughput

0.407

High

483932

CALM1
Calmodulin-1

1

14

High-throughput

0.407

High

484006

CALM2
Calmodulin-2

1

14

High-throughput

0.407

High

484130

CALM3
Calmodulin-3

1

14

High-throughput

0.407

High

1072685

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

11

High-throughput

0.407

High

1072698

DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

0

Small-scale

0.292

High

68058

HIDE1
Protein HIDE1

1

0

High-throughput

0.279

Low

131897

UPK2
Uroplakin-2

1

0

High-throughput

0.279

Low

362207

GLPA
Glycophorin-A

1

0

High-throughput

0.279

Low

454701

TACD2
Tumor-associated calcium signal transducer 2

1

0

High-throughput

0.279

Low

530244

ICAM2
Intercellular adhesion molecule 2

1

0

High-throughput

0.279

Low

686292

VIPR1
Vasoactive intestinal polypeptide receptor 1

1

0

High-throughput

0.279

Low

702225

CD70
CD70 antigen

1

0

High-throughput

0.279

Low

702348

TNFL8
Tumor necrosis factor ligand superfamily member 8

1

0

High-throughput

0.279

Low

771189

CD79B
B-cell antigen receptor complex-associated protein beta chain

1

0

High-throughput

0.279

Low

1072679

SGCA
Alpha-sarcoglycan

1

0

High-throughput

0.279

Low

1072689

BRID5
BRICHOS domain-containing protein 5

1

0

High-throughput

0.279

Low

1072694

LRC25
Leucine-rich repeat-containing protein 25

1

0

High-throughput

0.279

Low

1072707

OPALI
Opalin

1

0

High-throughput

0.279

Low

1072716

UN93B
Protein unc-93 homolog B1

1

0

High-throughput

0.279

Low

1072720

KT3K
Ketosamine-3-kinase

1

0

High-throughput

0.279

Low

1072726

TMEM9
Proton-transporting V-type ATPase complex assembly regulator TMEM9

1

0

High-throughput

0.279

Low

1072727

HCST
Hematopoietic cell signal transducer

1

0

High-throughput

0.279

Low

1072728

CCG4
Voltage-dependent calcium channel gamma-4 subunit

1

0

High-throughput

0.279

Low

1072735

TN13B
Tumor necrosis factor ligand superfamily member 13B

1

0

High-throughput

0.279

Low

1072737

PCDB3
Protocadherin beta-3

1

0

High-throughput

0.279

Low

1072740

KCMB2
Calcium-activated potassium channel subunit beta-2

1

0

High-throughput

0.279

Low

618269

BDNF
Brain-derived neurotrophic factor

1

0

High-throughput

0.268

Low

363798

ALBU
Albumin

1

0

Small-scale

0.249

Low

621250

RIR1
Ribonucleoside-diphosphate reductase large subunit

1

0

Small-scale

0.249

Low

1072701

FAM3C
Protein FAM3C

1

0

Small-scale

0.249

Low

1072712

MIC26
MICOS complex subunit MIC26

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024