Protein: ORC5
Origin recognition complex subunit 5

Gene: ORC5
Organism: Homo sapiens
Interactions: 84
UniProt ID: O43913

Gene Ontology (top 5):
GO:0000166 - nucleotide binding
GO:0000781 - chromosome, telomeric region
GO:0000785 - chromatin
GO:0000808 - origin recognition complex
GO:0003688 - DNA replication origin binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

217258

ORC2
Origin recognition complex subunit 2

12

18

Small-scale

0.982

High

217257

ORC1
Origin recognition complex subunit 1

7

19

Small-scale

0.966

High

217213

ORC4
Origin recognition complex subunit 4

7

19

Small-scale

0.953

High

217282

ORC3
Origin recognition complex subunit 3

6

18

Small-scale

0.945

High

217230

MCM3
DNA replication licensing factor MCM3

2

20

Small-scale

0.793

High

217242

MCM2
DNA replication licensing factor MCM2

2

20

Small-scale

0.793

High

217212

ORC5
Origin recognition complex subunit 5

2

18

Small-scale

0.767

High

217287

ORC6
Origin recognition complex subunit 6

2

9

Small-scale

0.754

High

217235

MCM5
DNA replication licensing factor MCM5

1

20

High-throughput

0.692

High

217275

CDC6
Cell division control protein 6 homolog

1

19

High-throughput

0.692

High

217234

MCM4
DNA replication licensing factor MCM4

1

20

Small-scale

0.621

High

217236

MCM7
DNA replication licensing factor MCM7

1

20

Small-scale

0.621

High

217284

LRWD1
Leucine-rich repeat and WD repeat-containing protein 1

2

3

Small-scale

0.611

High

217217

SCN2B
Sodium channel subunit beta-2

3

2

High-throughput

0.609

High

217229

DPEP1
Dipeptidase 1

2

0

High-throughput

0.602

High

217274

CDC5L
Cell division cycle 5-like protein

2

4

High-throughput

0.595

High

217215

PRKN
E3 ubiquitin-protein ligase parkin

2

7

High-throughput

0.584

High

217227

LAMP2
Lysosome-associated membrane glycoprotein 2

2

3

High-throughput

0.574

High

217238

APJ
Apelin receptor

2

2

High-throughput

0.574

High

217239

VIPR2
Vasoactive intestinal polypeptide receptor 2

2

1

High-throughput

0.574

High

217260

I13R2
Interleukin-13 receptor subunit alpha-2

2

2

High-throughput

0.574

High

217263

C3AR
C3a anaphylatoxin chemotactic receptor

2

3

High-throughput

0.574

High

217224

ESR1
Estrogen receptor

2

6

High-throughput

0.571

High

217246

H4
Histone H4

2

8

High-throughput

0.563

High

217267

OBI1
ORC ubiquitin ligase 1

1

1

Small-scale

0.561

High

217261

NONO
Non-POU domain-containing octamer-binding protein

1

3

High-throughput

0.541

High

125828

CDC7
Cell division cycle 7-related protein kinase

1

7

High-throughput

0.536

High

217218

CDC45
Cell division control protein 45 homolog

1

1

High-throughput

0.536

High

71038

HNRC2
Heterogeneous nuclear ribonucleoprotein C-like 2

1

1

High-throughput

0.536

High

217273

TCPQM
T-complex protein 1 subunit theta-like 2

1

2

High-throughput

0.536

High

163674

AT2A1
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1

1

0

High-throughput

0.513

High

217223

GLPA
Glycophorin-A

1

0

High-throughput

0.513

High

217219

UBP2
Ubiquitin carboxyl-terminal hydrolase 2

1

1

Small-scale

0.501

High

217240

CDN2A
Cyclin-dependent kinase inhibitor 2A

1

2

High-throughput

0.501

High

217285

MD2L2
Mitotic spindle assembly checkpoint protein MAD2B

1

0

High-throughput

0.493

High

155865

TR10C
Tumor necrosis factor receptor superfamily member 10C

1

7

High-throughput

0.489

High

217233

CD80
T-lymphocyte activation antigen CD80

1

2

High-throughput

0.489

High

217244

CXCR4
C-X-C chemokine receptor type 4

1

2

High-throughput

0.489

High

217228

RFA2
Replication protein A 32 kDa subunit

1

3

Small-scale

0.481

High

217256

CACO2
Calcium-binding and coiled-coil domain-containing protein 2

1

1

High-throughput

0.481

High

217269

TAXB1
Tax1-binding protein 1

1

2

High-throughput

0.481

High

217276

NIF3L
NIF3-like protein 1

1

1

High-throughput

0.481

High

217278

UBQL4
Ubiquilin-4

1

2

High-throughput

0.481

High

217283

DBF4A
Protein DBF4 homolog A

1

2

Small-scale

0.481

High

217245

PP1A
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit

1

0

Small-scale

0.480

High

217221

NFAC1
Nuclear factor of activated T-cells, cytoplasmic 1

1

2

High-throughput

0.479

High

217222

EGFR
Epidermal growth factor receptor

1

3

High-throughput

0.479

High

217231

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

2

High-throughput

0.479

High

217237

RFA3
Replication protein A 14 kDa subunit

1

2

High-throughput

0.479

High

217247

H2B1C
Histone H2B type 1-C/E/F/G/I

1

10

High-throughput

0.479

High

217249

H31
Histone H3.1

1

9

High-throughput

0.479

High

217250

RNF4
E3 ubiquitin-protein ligase RNF4

1

1

High-throughput

0.479

High

217252

H33
Histone H3.3

1

9

High-throughput

0.479

High

217259

SNW1
SNW domain-containing protein 1

1

2

High-throughput

0.479

High

217271

ESR2
Estrogen receptor beta

1

6

High-throughput

0.479

High

217272

CIC
Protein capicua homolog

1

3

High-throughput

0.479

High

217226

K1C18
Keratin, type I cytoskeletal 18

1

0

High-throughput

0.460

High

217266

DMRTA
Doublesex- and mab-3-related transcription factor A1

1

0

High-throughput

0.460

High

217216

NUPR1
Nuclear protein 1

1

0

High-throughput

0.458

High

217248

ACTC
Actin, alpha cardiac muscle 1

1

0

High-throughput

0.458

High

217262

KS6A1
Ribosomal protein S6 kinase alpha-1

1

0

High-throughput

0.458

High

217265

CL16A
Protein CLEC16A

1

0

High-throughput

0.458

High

217280

TLS1
Splicing factor C9orf78

1

0

High-throughput

0.458

High

217225

JUN
Transcription factor Jun

1

2

High-throughput

0.445

High

217255

DDR1
Epithelial discoidin domain-containing receptor 1

1

1

Small-scale

0.445

High

217243

LAMB2
Laminin subunit beta-2

1

3

High-throughput

0.439

High

217279

STAB1
Stabilin-1

1

1

High-throughput

0.439

High

217277

PKHA4
Pleckstrin homology domain-containing family A member 4

1

4

High-throughput

0.437

High

217214

PRKY
Putative serine/threonine-protein kinase PRKY

1

0

High-throughput

0.426

High

217241

CEBPA
CCAAT/enhancer-binding protein alpha

1

2

High-throughput

0.408

High

217264

H31T
Histone H3.1t

1

9

High-throughput

0.408

High

217220

LYPD3
Ly6/PLAUR domain-containing protein 3

3

0

High-throughput

0.347

High

217270

TM171
Transmembrane protein 171

3

0

High-throughput

0.347

High

58416

F234B
Protein FAM234B

2

0

High-throughput

0.328

High

217232

CD70
CD70 antigen

2

0

High-throughput

0.328

High

68034

HIDE1
Protein HIDE1

1

0

High-throughput

0.279

Low

196699

CYB5B
Cytochrome b5 type B

1

0

High-throughput

0.279

Low

217251

X3CL1
Fractalkine

1

0

High-throughput

0.279

Low

217253

TNR17
Tumor necrosis factor receptor superfamily member 17

1

0

High-throughput

0.279

Low

217254

VMAT2
Synaptic vesicular amine transporter

1

0

High-throughput

0.279

Low

217286

CC018
Uncharacterized protein C3orf18

1

0

High-throughput

0.279

Low

217268

TXD11
Thioredoxin domain-containing protein 11

1

0

High-throughput

0.251

Low

217281

SI1L2
Signal-induced proliferation-associated 1-like protein 2

1

0

High-throughput

0.251

Low


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Last updated: 15 Jul 2024