Protein: DDX46
Probable ATP-dependent RNA helicase DDX46 (EC 3.6.4.13) (DEAD box protein 46) (PRP5 homolog)

Gene: DDX46
Organism: Homo sapiens
Interactions: 166
UniProt ID: Q7L014

Gene Ontology (top 5):
GO:0000398 - mRNA splicing, via spliceosome
GO:0001650 - fibrillar center
GO:0003723 - RNA binding
GO:0003724 - RNA helicase activity
GO:0005524 - ATP binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

942748

SRPK2
SRSF protein kinase 2

5

11

High-throughput

0.723

High

263695

PR40A
Pre-mRNA-processing factor 40 homolog A

3

15

High-throughput

0.660

High

911676

RUXE
Small nuclear ribonucleoprotein E

2

1

High-throughput

0.628

High

1157328

JMJD6
Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6

2

5

High-throughput

0.628

High

1183373

ANR50
Ankyrin repeat domain-containing protein 50

1

1

High-throughput

0.618

High

587616

NFKB1
Nuclear factor NF-kappa-B p105 subunit

1

7

High-throughput

0.618

High

684835

STIP1
Stress-induced-phosphoprotein 1

1

6

High-throughput

0.618

High

801904

RECQ1
ATP-dependent DNA helicase Q1

1

14

High-throughput

0.618

High

917490

H4
Histone H4

1

4

High-throughput

0.618

High

944841

RED1
Double-stranded RNA-specific editase 1

1

9

High-throughput

0.618

High

1018549

CHD3
Chromodomain-helicase-DNA-binding protein 3

1

10

High-throughput

0.618

High

1055407

DHX8
ATP-dependent RNA helicase DHX8

1

8

High-throughput

0.618

High

1059692

CHD4
Chromodomain-helicase-DNA-binding protein 4

1

10

High-throughput

0.618

High

1159164

PRP8
Pre-mRNA-processing-splicing factor 8

1

3

High-throughput

0.618

High

1183354

DDX23
Probable ATP-dependent RNA helicase DDX23

1

17

High-throughput

0.618

High

1183374

HECD1
E3 ubiquitin-protein ligase HECTD1

1

9

High-throughput

0.618

High

453852

RU2A
U2 small nuclear ribonucleoprotein A'

2

4

High-throughput

0.611

High

1041888

CUL3
Cullin-3

2

17

High-throughput

0.611

High

1183377

LC7L2
Putative RNA-binding protein Luc7-like 2

2

0

High-throughput

0.585

High

227864

PRKN
E3 ubiquitin-protein ligase parkin

2

9

High-throughput

0.584

High

1073683

SF3A2
Splicing factor 3A subunit 2

2

5

Small-scale

0.584

High

369889

ESR1
Estrogen receptor

2

20

High-throughput

0.571

High

408638

KPCB
Protein kinase C beta type

2

3

High-throughput

0.571

High

1069853

PTPRR
Receptor-type tyrosine-protein phosphatase R

2

2

High-throughput

0.571

High

738773

SPB5
Serpin B5

2

2

High-throughput

0.558

High

1170540

TRI67
Tripartite motif-containing protein 67

1

10

High-throughput

0.553

High

574374

RL35A
Large ribosomal subunit protein eL33

1

1

High-throughput

0.536

High

686564

OTX2
Homeobox protein OTX2

1

2

High-throughput

0.536

High

822071

KC1A
Casein kinase I isoform alpha

1

3

High-throughput

0.536

High

824645

MAPK2
MAP kinase-activated protein kinase 2

1

2

High-throughput

0.536

High

928122

SUMO1
Small ubiquitin-related modifier 1

1

5

High-throughput

0.536

High

1045613

NOG2
Nucleolar GTP-binding protein 2

1

2

High-throughput

0.536

High

1070527

RNPS1
RNA-binding protein with serine-rich domain 1

1

14

High-throughput

0.536

High

1084312

SRSF7
Serine/arginine-rich splicing factor 7

1

13

High-throughput

0.536

High

1127024

MTUS2
Microtubule-associated tumor suppressor candidate 2

1

1

High-throughput

0.536

High

1183339

EZH1
Histone-lysine N-methyltransferase EZH1

1

7

High-throughput

0.536

High

1183347

SRPK1
SRSF protein kinase 1

1

10

High-throughput

0.536

High

1183350

RBM4B
RNA-binding protein 4B

1

11

High-throughput

0.536

High

1183362

MET14
N6-adenosine-methyltransferase non-catalytic subunit

1

6

High-throughput

0.536

High

1183370

PUF60
Poly(U)-binding-splicing factor PUF60

1

7

High-throughput

0.536

High

58761

FUCM
Fucose mutarotase

1

0

High-throughput

0.513

High

887569

APC15
Anaphase-promoting complex subunit 15

1

0

High-throughput

0.513

High

951870

SERF2
Small EDRK-rich factor 2

1

0

High-throughput

0.513

High

958470

CYC
Cytochrome c

1

0

High-throughput

0.513

High

1029262

MD2L1
Mitotic spindle assembly checkpoint protein MAD2A

1

0

High-throughput

0.513

High

1068213

PEA15
Astrocytic phosphoprotein PEA-15

1

0

High-throughput

0.513

High

1110396

KR197
Keratin-associated protein 19-7

1

0

High-throughput

0.513

High

1183335

SNR27
U4/U6.U5 small nuclear ribonucleoprotein 27 kDa protein

1

0

High-throughput

0.513

High

1183352

TCAL7
Transcription elongation factor A protein-like 7

1

0

High-throughput

0.513

High

1183353

H2AJ
Histone H2A.J

1

0

High-throughput

0.513

High

1183375

TPX2
Targeting protein for Xklp2

1

0

High-throughput

0.513

High

1183378

MB212
Protein mab-21-like 2

1

0

High-throughput

0.513

High

120956

APBB1
Amyloid beta precursor protein binding family B member 1

1

2

High-throughput

0.501

High

1101879

ZN181
Zinc finger protein 181

1

0

High-throughput

0.493

High

650117

CO8A1
Collagen alpha-1(VIII) chain

1

1

High-throughput

0.489

High

122842

MEN1
Menin

1

3

High-throughput

0.479

High

148978

CTRO
Citron Rho-interacting kinase

1

9

High-throughput

0.479

High

210091

PRC1
Protein regulator of cytokinesis 1

1

2

High-throughput

0.479

High

233518

NUPR1
Nuclear protein 1

1

5

High-throughput

0.479

High

244599

BRD4
Bromodomain-containing protein 4

1

6

High-throughput

0.479

High

255885

OBSL1
Obscurin-like protein 1

1

4

High-throughput

0.479

High

268767

SF3B1
Splicing factor 3B subunit 1

1

4

High-throughput

0.479

High

298611

UFL1
E3 UFM1-protein ligase 1

1

3

High-throughput

0.479

High

304227

UBR5
E3 ubiquitin-protein ligase UBR5

1

8

High-throughput

0.479

High

308823

KI20A
Kinesin-like protein KIF20A

1

10

High-throughput

0.479

High

313307

CD2B2
CD2 antigen cytoplasmic tail-binding protein 2

1

2

High-throughput

0.479

High

319893

HERC2
E3 ubiquitin-protein ligase HERC2

1

8

High-throughput

0.479

High

331834

NSD2
Histone-lysine N-methyltransferase NSD2

1

7

Small-scale

0.479

High

360083

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

11

High-throughput

0.479

High

374432

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

4

High-throughput

0.479

High

379540

MYCN
N-myc proto-oncogene protein

1

9

High-throughput

0.479

High

385053

NTRK1
High affinity nerve growth factor receptor

1

5

High-throughput

0.479

High

386983

P53
Cellular tumor antigen p53

1

3

High-throughput

0.479

High

431995

HS90A
Heat shock protein HSP 90-alpha

1

3

High-throughput

0.479

High

438299

HS90B
Heat shock protein HSP 90-beta

1

3

High-throughput

0.479

High

487546

ANDR
Androgen receptor

1

18

High-throughput

0.479

High

504292

HSP7C
Heat shock cognate 71 kDa protein

1

3

High-throughput

0.479

High

523840

XRCC6
X-ray repair cross-complementing protein 6

1

5

High-throughput

0.479

High

547572

FOLR1
Folate receptor alpha

1

1

High-throughput

0.479

High

553027

RFA2
Replication protein A 32 kDa subunit

1

7

High-throughput

0.479

High

569832

CEBPB
CCAAT/enhancer-binding protein beta

1

8

High-throughput

0.479

High

612992

TCEA1
Transcription elongation factor A protein 1

1

1

High-throughput

0.479

High

651530

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

4

High-throughput

0.479

High

668780

PML
Protein PML

1

11

High-throughput

0.479

High

720771

RFA3
Replication protein A 14 kDa subunit

1

4

High-throughput

0.479

High

771463

PSB10
Proteasome subunit beta type-10

1

1

High-throughput

0.479

High

785981

LAP2B
Lamina-associated polypeptide 2, isoforms beta/gamma

1

3

High-throughput

0.479

High

808722

YAP1
Transcriptional coactivator YAP1

1

14

High-throughput

0.479

High

824132

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

11

High-throughput

0.479

High

827963

UB2R1
Ubiquitin-conjugating enzyme E2 R1

1

2

High-throughput

0.479

High

892448

RAC3
Ras-related C3 botulinum toxin substrate 3

1

1

High-throughput

0.479

High

897761

ABCE1
ATP-binding cassette sub-family E member 1

1

1

High-throughput

0.479

High

903327

WDR5
WD repeat-containing protein 5

1

9

High-throughput

0.479

High

908734

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

4

High-throughput

0.479

High

932223

ACTC
Actin, alpha cardiac muscle 1

1

3

High-throughput

0.479

High

998835

EP300
Histone acetyltransferase p300

1

9

High-throughput

0.479

High

1016205

FOXO1
Forkhead box protein O1

1

6

High-throughput

0.479

High

1019000

TP53B
TP53-binding protein 1

1

3

High-throughput

0.479

High

1024366

UBP4
Ubiquitin carboxyl-terminal hydrolase 4

1

7

High-throughput

0.479

High

1039642

SNW1
SNW domain-containing protein 1

1

5

High-throughput

0.479

High

1061478

CUL7
Cullin-7

1

7

High-throughput

0.479

High

1063904

TNIP1
TNFAIP3-interacting protein 1

1

16

High-throughput

0.479

High

1066308

KIF14
Kinesin-like protein KIF14

1

4

High-throughput

0.479

High

1116344

LARP7
La-related protein 7

1

17

High-throughput

0.479

High

1136142

RC3H1
Roquin-1

1

4

High-throughput

0.479

High

1148646

VIR
Protein virilizer homolog

1

2

High-throughput

0.479

High

1163722

RICTR
Rapamycin-insensitive companion of mTOR

1

2

High-throughput

0.479

High

1183324

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

2

High-throughput

0.479

High

1183325

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

7

High-throughput

0.479

High

1183326

NAA40
N-alpha-acetyltransferase 40

1

4

High-throughput

0.479

High

1183327

ZCH18
Zinc finger CCCH domain-containing protein 18

1

6

High-throughput

0.479

High

1183329

SMC5
Structural maintenance of chromosomes protein 5

1

5

High-throughput

0.479

High

1183330

SLX4
Structure-specific endonuclease subunit SLX4

1

6

High-throughput

0.479

High

1183334

DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

4

High-throughput

0.479

High

1183338

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

6

High-throughput

0.479

High

1183340

RBP56
TATA-binding protein-associated factor 2N

1

13

High-throughput

0.479

High

1183343

SPDLY
Protein Spindly

1

1

High-throughput

0.479

High

1183344

AURKB
Aurora kinase B

1

8

High-throughput

0.479

High

1183346

ZN363
RING finger and CHY zinc finger domain-containing protein 1

1

2

High-throughput

0.479

High

1183348

CDC5L
Cell division cycle 5-like protein

1

4

High-throughput

0.479

High

1183349

NECD
Necdin

1

6

High-throughput

0.479

High

1183356

IN80B
INO80 complex subunit B

1

2

High-throughput

0.479

High

1183358

TXNIP
Thioredoxin-interacting protein

1

2

Small-scale

0.479

High

1183359

CHM4B
Charged multivesicular body protein 4b

1

7

High-throughput

0.479

High

1183361

ECT2
Protein ECT2

1

5

High-throughput

0.479

High

1183363

BRD7
Bromodomain-containing protein 7

1

11

High-throughput

0.479

High

1183364

ANLN
Anillin

1

3

High-throughput

0.479

High

1183365

SIR7
NAD-dependent protein deacetylase sirtuin-7

1

2

High-throughput

0.479

High

1183369

ZRAN1
Ubiquitin thioesterase ZRANB1

1

7

High-throughput

0.479

High

1183371

AGO2
Protein argonaute-2

1

7

High-throughput

0.479

High

1183372

AGO1
Protein argonaute-1

1

7

High-throughput

0.479

High

1183376

AAR2
Protein AAR2 homolog

1

3

High-throughput

0.479

High

1183379

HEY1
Hairy/enhancer-of-split related with YRPW motif protein 1

1

1

Small-scale

0.479

High

176223

PPM1G
Protein phosphatase 1G

1

0

High-throughput

0.458

High

1183328

DYH10
Dynein axonemal heavy chain 10

1

0

High-throughput

0.458

High

1183332

FBX22
F-box only protein 22

1

0

High-throughput

0.458

High

402186

JUN
Transcription factor Jun

1

10

High-throughput

0.445

High

497225

TAU
Microtubule-associated protein tau

1

8

High-throughput

0.445

High

717959

BMI1
Polycomb complex protein BMI-1

1

4

High-throughput

0.445

High

853930

NCBP2
Nuclear cap-binding protein subunit 2

1

15

High-throughput

0.445

High

1057517

RRP1B
Ribosomal RNA processing protein 1 homolog B

1

4

High-throughput

0.445

High

1183357

ZDHC5
Palmitoyltransferase ZDHHC5

1

1

High-throughput

0.445

High

1183367

HIF1N
Hypoxia-inducible factor 1-alpha inhibitor

1

5

High-throughput

0.445

High

225643

PCDH7
Protocadherin-7

1

1

High-throughput

0.437

High

1062553

EMC2
ER membrane protein complex subunit 2

1

3

High-throughput

0.437

High

1173976

UBP53
Inactive ubiquitin carboxyl-terminal hydrolase 53

1

9

Small-scale

0.437

High

1183337

YLAT2
Y+L amino acid transporter 2

1

1

High-throughput

0.437

High

1183345

DDRGK
DDRGK domain-containing protein 1

1

3

High-throughput

0.437

High

1183355

ACE2
Angiotensin-converting enzyme 2

1

3

High-throughput

0.437

High

1183360

PKHA4
Pleckstrin homology domain-containing family A member 4

1

16

High-throughput

0.437

High

1183333

ARK74
Aflatoxin B1 aldehyde reductase member 4

1

0

High-throughput

0.426

High

159658

QCR10
Cytochrome b-c1 complex subunit 10

1

0

High-throughput

0.279

Low

456170

IFI6
Interferon alpha-inducible protein 6

1

0

High-throughput

0.279

Low

642831

3BHS2
3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2

1

0

High-throughput

0.279

Low

1022721

MALL
MAL-like protein

1

0

High-throughput

0.279

Low

1023599

GAGE5
G antigen 5

1

0

High-throughput

0.279

Low

1138408

CP141
Cilia- and flagella-associated protein 141

1

0

High-throughput

0.279

Low

1183331

CT197
Putative uncharacterized protein encoded by LINC02910

1

0

High-throughput

0.279

Low

1183336

JPH3
Junctophilin-3

1

0

High-throughput

0.279

Low

1183341

I27L1
Interferon alpha-inducible protein 27-like protein 1

1

0

High-throughput

0.279

Low

1183342

ERLEC
Endoplasmic reticulum lectin 1

1

0

High-throughput

0.279

Low

1183366

TM14B
Transmembrane protein 14B

1

0

High-throughput

0.279

Low

1183368

PEN2
Gamma-secretase subunit PEN-2

1

0

High-throughput

0.279

Low

1183380

SPCS1
Signal peptidase complex subunit 1

1

0

High-throughput

0.279

Low

1183351

CCD77
Coiled-coil domain-containing protein 77

1

0

High-throughput

0.269

Low

1146108

DCA15
DDB1- and CUL4-associated factor 15

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024