Protein: AIRE
Autoimmune regulator (Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein homolog) (APECED protein homolog)

Gene: AIRE
Organism: Mus musculus
Interactions: 50
UniProt ID: Q9Z0E3

Gene Ontology (top 5):
GO:0000977 - RNA polymerase II transcription regulatory region sequence-specific DNA binding
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001673 - male germ cell nucleus
GO:0001674 - female germ cell nucleus
GO:0002458 - peripheral T cell tolerance induction

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1378257

AIRE
Autoimmune regulator

1

18

Small-scale

0.665

High

59026

CHD6
Chromodomain-helicase-DNA-binding protein 6

1

20

Small-scale

0.575

High

665773

PABP1
Polyadenylate-binding protein 1

1

12

Small-scale

0.575

High

952212

SRSF3
Serine/arginine-rich splicing factor 3

1

20

Small-scale

0.575

High

1143315

SRSF2
Serine/arginine-rich splicing factor 2

1

14

Small-scale

0.575

High

1143848

TIF1B
Transcription intermediary factor 1-beta

1

20

Small-scale

0.575

High

1161053

SRSF1
Serine/arginine-rich splicing factor 1

1

20

Small-scale

0.575

High

1307859

TLR3
Toll-like receptor 3

1

8

Small-scale

0.479

High

83337

H2A1B
Histone H2A type 1-B

1

20

Small-scale

0.445

High

139958

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

4

Small-scale

0.445

High

193266

C1QBP
Complement component 1 Q subcomponent-binding protein, mitochondrial

1

1

Small-scale

0.445

High

444990

RPB1
DNA-directed RNA polymerase II subunit RPB1

1

6

Small-scale

0.445

High

503196

PARP1
Poly [ADP-ribose] polymerase 1

1

20

Small-scale

0.445

High

539749

LMNB1
Lamin-B1

1

20

Small-scale

0.445

High

572266

PCNA
Proliferating cell nuclear antigen

1

4

Small-scale

0.445

High

646106

RSMB
Small nuclear ribonucleoprotein-associated protein B

1

3

Small-scale

0.445

High

794356

MSH2
DNA mismatch repair protein Msh2

1

6

Small-scale

0.445

High

831956

MCM5
DNA replication licensing factor MCM5

1

20

Small-scale

0.445

High

869803

MSH6
DNA mismatch repair protein Msh6

1

9

Small-scale

0.445

High

912778

SMD3
Small nuclear ribonucleoprotein Sm D3

1

5

Small-scale

0.445

High

935466

H31
Histone H3.1

1

20

Small-scale

0.445

High

935888

RANB9
Ran-binding protein 9

1

20

Small-scale

0.445

High

936171

IMB1
Importin subunit beta-1

1

12

Small-scale

0.445

High

956200

MCM2
DNA replication licensing factor MCM2

1

20

Small-scale

0.445

High

956211

MCM6
DNA replication licensing factor MCM6

1

20

Small-scale

0.445

High

956217

PRKDC
DNA-dependent protein kinase catalytic subunit

1

9

Small-scale

0.445

High

964620

TOP2A
DNA topoisomerase 2-alpha

1

9

Small-scale

0.445

High

1119393

DDX17
Probable ATP-dependent RNA helicase DDX17

1

18

Small-scale

0.445

High

1142824

RAD21
Double-strand-break repair protein rad21 homolog

1

3

Small-scale

0.445

High

1143001

DDX5
Probable ATP-dependent RNA helicase DDX5

1

18

Small-scale

0.445

High

1160047

XPO1
Exportin-1

1

9

Small-scale

0.445

High

1169689

CAND1
Cullin-associated NEDD8-dissociated protein 1

1

11

Small-scale

0.445

High

1186662

MBB1A
Myb-binding protein 1A

1

5

Small-scale

0.445

High

1207416

GEMI5
Gem-associated protein 5

1

14

Small-scale

0.445

High

1208300

RPB2
DNA-directed RNA polymerase II subunit RPB2

1

2

Small-scale

0.445

High

1265307

SP16H
FACT complex subunit SPT16

1

5

Small-scale

0.445

High

1307860

NASP
Nuclear autoantigenic sperm protein

1

4

Small-scale

0.445

High

1321795

XPOT
Exportin-T

1

9

Small-scale

0.445

High

1321816

SMC1A
Structural maintenance of chromosomes protein 1A

1

20

Small-scale

0.445

High

1321831

SMC3
Structural maintenance of chromosomes protein 3

1

13

Small-scale

0.445

High

1322075

NOP56
Nucleolar protein 56

1

9

Small-scale

0.445

High

1322279

IPO7
Importin-7

1

10

Small-scale

0.445

High

1322337

RBP2
E3 SUMO-protein ligase RanBP2

1

7

Small-scale

0.445

High

1376695

RUVB2
RuvB-like 2

1

5

Small-scale

0.445

High

885979

TLR8
Toll-like receptor 8

1

8

Small-scale

0.437

High

1322281

TLR1
Toll-like receptor 1

1

2

Small-scale

0.437

High

1112708

Q3UHQ5
TOG domain-containing protein

1

7

Small-scale

0.407

High

1145472

H2B2B
Histone H2B type 2-B

1

20

Small-scale

0.407

High

1206732

NUP93
Nuclear pore complex protein Nup93

1

1

Small-scale

0.407

High


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Last updated: 15 Jul 2024