Protein: GLSK
Glutaminase kidney isoform, mitochondrial (GLS) (EC 3.5.1.2) (K-glutaminase) (L-glutamine amidohydrolase) [Cleaved into: Glutaminase kidney isoform, mitochondrial 68 kDa chain; Glutaminase kidney isoform, mitochondrial 65 kDa chain]

Gene: GLSK, GLS
Organism: Homo sapiens
Interactions: 193
UniProt ID: O94925

Gene Ontology (top 5):
GO:0001967 - suckling behavior
GO:0002087 - regulation of respiratory gaseous exchange by nervous system process
GO:0004359 - glutaminase activity
GO:0005739 - mitochondrion
GO:0005759 - mitochondrial matrix

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

300736

CDC42
Cell division control protein 42 homolog

2

20

High-throughput

0.768

High

300852

GLSL
Glutaminase liver isoform, mitochondrial

1

19

High-throughput

0.691

High

300701

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

16

High-throughput

0.665

High

300721

HMGCL
Hydroxymethylglutaryl-CoA lyase, mitochondrial

3

1

High-throughput

0.656

High

300692

GLSK
Glutaminase kidney isoform, mitochondrial

1

19

Small-scale

0.647

High

300839

SIR5
NAD-dependent protein deacylase sirtuin-5, mitochondrial

3

2

Small-scale

0.640

High

300782

RM43
Large ribosomal subunit protein mL43

3

0

High-throughput

0.638

High

300813

TR61B
tRNA

3

0

High-throughput

0.638

High

300766

MRM1
rRNA methyltransferase 1, mitochondrial

3

0

High-throughput

0.628

High

300844

COKA1

1

8

High-throughput

0.618

High

300734

PLK1
Serine/threonine-protein kinase PLK1

1

9

High-throughput

0.618

High

300737

RHOA
Transforming protein RhoA

1

20

High-throughput

0.618

High

300738

ARF6
ADP-ribosylation factor 6

1

1

High-throughput

0.618

High

300739

RHOG
Rho-related GTP-binding protein RhoG

1

18

High-throughput

0.618

High

300773

TBA1A
Tubulin alpha-1A chain

1

10

High-throughput

0.618

High

300775

RHOU
Rho-related GTP-binding protein RhoU

1

20

High-throughput

0.618

High

300776

DHX30
ATP-dependent RNA helicase DHX30

1

2

High-throughput

0.618

High

300786

PTPM1
Phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1

1

4

High-throughput

0.618

High

300834

DDX28
Probable ATP-dependent RNA helicase DDX28

1

4

High-throughput

0.618

High

300697

OTC
Ornithine transcarbamylase, mitochondrial

2

2

High-throughput

0.611

High

300699

TNFA
Tumor necrosis factor

3

1

High-throughput

0.609

High

258631

NDUS7
NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial

2

0

High-throughput

0.602

High

300829

ACAD9
Complex I assembly factor ACAD9, mitochondrial

2

0

High-throughput

0.585

High

226117

PRKN
E3 ubiquitin-protein ligase parkin

2

9

High-throughput

0.584

High

262658

CISY
Citrate synthase, mitochondrial

2

5

High-throughput

0.584

High

300695

AIFM1
Apoptosis-inducing factor 1, mitochondrial

2

4

High-throughput

0.584

High

300702

GCR
Glucocorticoid receptor

2

19

Small-scale

0.584

High

300747

GRSF1
G-rich sequence factor 1

2

6

High-throughput

0.584

High

300787

SNR27
U4/U6.U5 small nuclear ribonucleoprotein 27 kDa protein

2

1

High-throughput

0.574

High

300855

CFA45
Cilia- and flagella-associated protein 45

2

11

High-throughput

0.567

High

300708

COX41
Cytochrome c oxidase subunit 4 isoform 1, mitochondrial

2

0

High-throughput

0.559

High

300762

CLPP
ATP-dependent Clp protease proteolytic subunit, mitochondrial

2

0

High-throughput

0.559

High

300780

HSC20
Iron-sulfur cluster co-chaperone protein HscB

2

0

High-throughput

0.559

High

300850

NUFP1
FMR1-interacting protein NUFIP1

2

1

High-throughput

0.558

High

300772

TRI67
Tripartite motif-containing protein 67

1

20

High-throughput

0.553

High

300825

RHOJ
Rho-related GTP-binding protein RhoJ

1

20

High-throughput

0.553

High

300788

RSPH1
Radial spoke head 1 homolog

1

3

High-throughput

0.541

High

300700

FIBB
Fibrinogen beta chain [Cleaved into: Fibrinopeptide B; Fibrinogen beta chain]

1

1

High-throughput

0.536

High

300706

TAU
Microtubule-associated protein tau

1

14

High-throughput

0.536

High

300714

RL35A
Large ribosomal subunit protein eL33

1

1

High-throughput

0.536

High

300716

TGM1
Protein-glutamine gamma-glutamyltransferase K

1

1

High-throughput

0.536

High

300718

KAD4
Adenylate kinase 4, mitochondrial

1

2

High-throughput

0.536

High

300726

THIM
3-ketoacyl-CoA thiolase, mitochondrial

1

2

High-throughput

0.536

High

300740

SHC2
SHC-transforming protein 2

1

20

High-throughput

0.536

High

300761

TAZ
Tafazzin

1

1

High-throughput

0.536

High

300789

CUL5
Cullin-5

1

17

High-throughput

0.536

High

300808

NPS3B
Protein NipSnap homolog 3B

1

1

High-throughput

0.536

High

300847

NPS3A
Protein NipSnap homolog 3A

1

1

High-throughput

0.536

High

300853

MRM2
rRNA methyltransferase 2, mitochondrial

1

1

High-throughput

0.536

High

300698

MYC
Myc proto-oncogene protein

2

6

High-throughput

0.533

High

300845

KLH13
Kelch-like protein 13

1

4

High-throughput

0.515

High

300856

MTUS1
Microtubule-associated tumor suppressor 1

1

8

High-throughput

0.515

High

300717

CX7A1
Cytochrome c oxidase subunit 7A1, mitochondrial

1

0

High-throughput

0.513

High

300731

UCRI
Cytochrome b-c1 complex subunit Rieske, mitochondrial

1

0

High-throughput

0.513

High

300767

ACSM5
Acyl-coenzyme A synthetase ACSM5, mitochondrial

1

0

High-throughput

0.513

High

300771

FAHD1
Oxaloacetate decarboxylase, mitochondrial

1

0

High-throughput

0.513

High

300798

MASU1
Mitochondrial assembly of ribosomal large subunit protein 1

1

0

High-throughput

0.513

High

300819

GATA
Glutamyl-tRNA(Gln) amidotransferase subunit A, mitochondrial

1

0

High-throughput

0.513

High

300851

AMACR
Alpha-methylacyl-CoA racemase

1

0

High-throughput

0.513

High

300861

SYYM
Tyrosine--tRNA ligase, mitochondrial

1

0

High-throughput

0.513

High

300862

COQ4
Ubiquinone biosynthesis protein COQ4 homolog, mitochondrial

1

0

High-throughput

0.513

High

300865

RM42
Large ribosomal subunit protein mL42

1

0

High-throughput

0.513

High

174504

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

1

9

High-throughput

0.501

High

211337

PI15
Peptidase inhibitor 15

1

1

High-throughput

0.489

High

300711

ATF2
Cyclic AMP-dependent transcription factor ATF-2

1

5

High-throughput

0.489

High

300759

NAB2
NGFI-A-binding protein 2

1

2

High-throughput

0.489

High

300779

CDR2L
Cerebellar degeneration-related protein 2-like

1

1

High-throughput

0.489

High

300843

TMEM9
Proton-transporting V-type ATPase complex assembly regulator TMEM9

1

1

High-throughput

0.489

High

300859

LAMP3
Lysosome-associated membrane glycoprotein 3

1

5

High-throughput

0.489

High

300749

SNTA1
Alpha-1-syntrophin

1

11

Small-scale

0.481

High

59072

VWA8
von Willebrand factor A domain-containing protein 8

1

6

High-throughput

0.479

High

129626

AGRIN
Agrin [Cleaved into: Agrin N-terminal 110 kDa subunit; Agrin C-terminal 110 kDa subunit; Agrin C-terminal 90 kDa fragment

1

11

High-throughput

0.479

High

203843

HTRA2
Serine protease HTRA2, mitochondrial

1

1

High-throughput

0.479

High

264800

MPPB
Mitochondrial-processing peptidase subunit beta

1

4

High-throughput

0.479

High

269958

RF1M
Peptide chain release factor 1, mitochondrial

1

2

High-throughput

0.479

High

276767

SCO1
Protein SCO1 homolog, mitochondrial

1

5

High-throughput

0.479

High

300693

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

3

High-throughput

0.479

High

300694

BAG3
BAG family molecular chaperone regulator 3

1

3

Small-scale

0.479

High

300703

ODPA
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial

1

1

High-throughput

0.479

High

300707

CH60
60 kDa heat shock protein, mitochondrial

1

4

High-throughput

0.479

High

300715

RO52
E3 ubiquitin-protein ligase TRIM21

1

2

Small-scale

0.479

High

300722

LONM
Lon protease homolog, mitochondrial

1

5

High-throughput

0.479

High

300723

GRP75
Stress-70 protein, mitochondrial

1

15

High-throughput

0.479

High

300724

MDHM
Malate dehydrogenase, mitochondrial

1

2

High-throughput

0.479

High

300730

IF2M
Translation initiation factor IF-2, mitochondrial

1

3

High-throughput

0.479

High

300732

EFTU
Elongation factor Tu, mitochondrial

1

3

High-throughput

0.479

High

300741

TFAM
Transcription factor A, mitochondrial

1

6

High-throughput

0.479

High

300745

QOR
Quinone oxidoreductase

1

1

High-throughput

0.479

High

300746

MPPA
Mitochondrial-processing peptidase subunit alpha

1

5

High-throughput

0.479

High

300748

TRAP1
Heat shock protein 75 kDa, mitochondrial

1

4

High-throughput

0.479

High

300750

BIRC3
Baculoviral IAP repeat-containing protein 3

1

8

High-throughput

0.479

High

300751

AUHM
Methylglutaconyl-CoA hydratase, mitochondrial

1

6

High-throughput

0.479

High

300757

ELOB
Elongin-B

1

1

High-throughput

0.479

High

300760

EZH2
Histone-lysine N-methyltransferase EZH2

1

9

High-throughput

0.479

High

300764

SYAM
Alanine--tRNA ligase, mitochondrial

1

2

High-throughput

0.479

High

300768

RUSD3
Mitochondrial mRNA pseudouridine synthase RPUSD3

1

2

High-throughput

0.479

High

300777

FAKD5
FAST kinase domain-containing protein 5, mitochondrial

1

3

High-throughput

0.479

High

300778

ATCAY
Caytaxin

1

1

Small-scale

0.479

High

300784

MCU
Calcium uniporter protein, mitochondrial

1

1

High-throughput

0.479

High

300790

RRF2M
Ribosome-releasing factor 2, mitochondrial

1

2

High-throughput

0.479

High

300791

FAKD4
FAST kinase domain-containing protein 4

1

3

High-throughput

0.479

High

300792

MCUR1
Mitochondrial calcium uniporter regulator 1

1

2

High-throughput

0.479

High

300794

RUSD4
Pseudouridylate synthase RPUSD4, mitochondrial

1

2

High-throughput

0.479

High

300795

FMT
Methionyl-tRNA formyltransferase, mitochondrial

1

2

High-throughput

0.479

High

300797

MTEF3
Transcription termination factor 3, mitochondrial

1

1

High-throughput

0.479

High

300800

DNJA3
DnaJ homolog subfamily A member 3, mitochondrial

1

9

High-throughput

0.479

High

300802

IMP1L
Mitochondrial inner membrane protease subunit 1

1

2

High-throughput

0.479

High

300804

EFGM
Elongation factor G, mitochondrial

1

2

High-throughput

0.479

High

300807

ATF6B
Cyclic AMP-dependent transcription factor ATF-6 beta

1

4

High-throughput

0.479

High

300817

SLIRP
SRA stem-loop-interacting RNA-binding protein, mitochondrial

1

7

High-throughput

0.479

High

300818

CC90B
Coiled-coil domain-containing protein 90B, mitochondrial

1

2

High-throughput

0.479

High

300823

PARL
Presenilin-associated rhomboid-like protein, mitochondrial

1

1

High-throughput

0.479

High

300824

MTRFR
Mitochondrial translation release factor in rescue

1

2

High-throughput

0.479

High

300826

MTG2
Mitochondrial ribosome-associated GTPase 2

1

4

High-throughput

0.479

High

300830

SFXN1
Sideroflexin-1

1

4

High-throughput

0.479

High

300831

NGRN
Neugrin

1

1

High-throughput

0.479

High

300832

ANLN
Anillin

1

2

High-throughput

0.479

High

300835

EXD2
Exonuclease 3'-5' domain-containing protein 2

1

2

High-throughput

0.479

High

300836

MCUB
Calcium uniporter regulatory subunit MCUb, mitochondrial

1

1

High-throughput

0.479

High

300840

FAKD2
FAST kinase domain-containing protein 2, mitochondrial

1

3

High-throughput

0.479

High

300841

TLS1
Splicing factor C9orf78

1

1

High-throughput

0.479

High

300848

RF1ML
Peptide chain release factor 1-like, mitochondrial

1

2

High-throughput

0.479

High

300849

ZRAN1
Ubiquitin thioesterase ZRANB1

1

10

High-throughput

0.479

High

300857

FZR1
Fizzy-related protein homolog

1

2

Small-scale

0.479

High

300858

APC10
Anaphase-promoting complex subunit 10

1

3

Small-scale

0.479

High

300770

PRP8
Pre-mRNA-processing-splicing factor 8

1

2

High-throughput

0.470

High

300846

ATX10
Ataxin-10

1

0

Small-scale

0.460

High

63264

MET15
12S rRNA N4-methylcytidine

1

0

High-throughput

0.458

High

127686

SAP18
Histone deacetylase complex subunit SAP18

1

0

High-throughput

0.458

High

258380

COQ9
Ubiquinone biosynthesis protein COQ9, mitochondrial

1

0

High-throughput

0.458

High

300696

TRUB2
Pseudouridylate synthase TRUB2, mitochondrial

1

0

High-throughput

0.458

High

300704

CISD3
CDGSH iron-sulfur domain-containing protein 3, mitochondrial

1

0

High-throughput

0.458

High

300705

COX8A
Cytochrome c oxidase subunit 8A, mitochondrial

1

0

High-throughput

0.458

High

300710

ETFA
Electron transfer flavoprotein subunit alpha, mitochondrial

1

0

High-throughput

0.458

High

300725

LPPRC
Leucine-rich PPR motif-containing protein, mitochondrial

1

0

High-throughput

0.458

High

300729

EFTS
Elongation factor Ts, mitochondrial

1

0

High-throughput

0.458

High

300743

SSBP
Single-stranded DNA-binding protein, mitochondrial

1

0

High-throughput

0.458

High

300744

C1QBP
Complement component 1 Q subcomponent-binding protein, mitochondrial

1

0

High-throughput

0.458

High

300752

ICT1
Large ribosomal subunit protein mL62

1

0

High-throughput

0.458

High

300753

NBR1
Next to BRCA1 gene 1 protein

1

0

High-throughput

0.458

High

300756

PDK1
[Pyruvate dehydrogenase

1

0

High-throughput

0.458

High

300758

SURF1
Surfeit locus protein 1

1

0

High-throughput

0.458

High

300763

OXLD1
Oxidoreductase-like domain-containing protein 1

1

0

High-throughput

0.458

High

300765

SYRM
Probable arginine--tRNA ligase, mitochondrial

1

0

High-throughput

0.458

High

300774

COX15
Heme A synthase COX15

1

0

High-throughput

0.458

High

300781

ETKMT
Electron transfer flavoprotein beta subunit lysine methyltransferase

1

0

High-throughput

0.458

High

300793

CHCH1
Small ribosomal subunit protein mS37

1

0

High-throughput

0.458

High

300796

RRFM
Ribosome-recycling factor, mitochondrial

1

0

High-throughput

0.458

High

300801

COX14
Cytochrome c oxidase assembly protein COX14

1

0

High-throughput

0.458

High

300803

TEFM
Transcription elongation factor, mitochondrial

1

0

High-throughput

0.458

High

300809

TACO1
Translational activator of cytochrome c oxidase 1

1

0

High-throughput

0.458

High

300811

MTG1
Mitochondrial ribosome-associated GTPase 1

1

0

High-throughput

0.458

High

300812

TMM70
Transmembrane protein 70, mitochondrial

1

0

High-throughput

0.458

High

300814

HINT2
Adenosine 5'-monophosphoramidase HINT2

1

0

High-throughput

0.458

High

300815

RM04
Large ribosomal subunit protein uL4m

1

0

High-throughput

0.458

High

300816

RT26
Small ribosomal subunit protein mS26

1

0

High-throughput

0.458

High

300821

IF3M
Translation initiation factor IF-3, mitochondrial

1

0

High-throughput

0.458

High

300822

IPYR2
Inorganic pyrophosphatase 2, mitochondrial

1

0

High-throughput

0.458

High

300828

MET17
Ribosome assembly protein METTL17, mitochondrial

1

0

High-throughput

0.458

High

300837

RMND1
Required for meiotic nuclear division protein 1 homolog

1

0

High-throughput

0.458

High

300838

AKIP
Small ribosomal subunit protein mS38

1

0

High-throughput

0.458

High

300842

MRES1
Mitochondrial transcription rescue factor 1

1

0

High-throughput

0.458

High

300863

RM11
Large ribosomal subunit protein uL11m

1

0

High-throughput

0.458

High

69724

B1AK13
Hydroxymethylglutaryl-CoA lyase, mitochondrial

1

1

High-throughput

0.445

High

300709

CFTR
Cystic fibrosis transmembrane conductance regulator

1

1

High-throughput

0.445

High

300755

FAKD3
FAST kinase domain-containing protein 3, mitochondrial

1

3

Small-scale

0.445

High

300805

CK5P2
CDK5 regulatory subunit-associated protein 2

1

7

High-throughput

0.445

High

100332

APRIO
Alternative prion protein

1

2

High-throughput

0.437

High

300713

CEBPB
CCAAT/enhancer-binding protein beta

1

6

High-throughput

0.437

High

300719

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

2

High-throughput

0.437

High

300728

MAGA6
Melanoma-associated antigen 6

1

6

High-throughput

0.437

High

300733

MCM2
DNA replication licensing factor MCM2

1

7

High-throughput

0.437

High

300806

IMP2L
Mitochondrial inner membrane protease subunit 2

1

2

High-throughput

0.437

High

300827

PKHA4
Pleckstrin homology domain-containing family A member 4

1

18

High-throughput

0.437

High

300854

HDAC9
Histone deacetylase 9

1

6

Small-scale

0.437

High

300742

TAGL
Transgelin

1

7

High-throughput

0.407

High

300860

ITM2B
Integral membrane protein 2B

1

5

High-throughput

0.407

High

134717

CCL22
C-C motif chemokine 22

2

0

High-throughput

0.328

High

300735

YBEY
Endoribonuclease YbeY

2

0

High-throughput

0.328

High

300727

SSRB
Translocon-associated protein subunit beta

1

0

High-throughput

0.279

Low

300783

LRN4L
LRRN4 C-terminal-like protein

1

0

High-throughput

0.279

Low

300799

RT24
Small ribosomal subunit protein uS3m

1

0

High-throughput

0.279

Low

300820

TSN10
Tetraspanin-10

1

0

High-throughput

0.279

Low

300833

KISHB
Protein kish-B

1

0

High-throughput

0.279

Low

172952

RT12
Small ribosomal subunit protein uS12m

1

0

High-throughput

0.249

Low

300712

RFA2
Replication protein A 32 kDa subunit

1

0

High-throughput

0.249

Low

300720

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.249

Low

300754

HAPR1
HUWE1-associated protein modifying stress responses 1

1

0

Small-scale

0.249

Low

300769

CH082
UPF0598 protein C8orf82

1

0

High-throughput

0.249

Low

300785

SPT20
Spermatogenesis-associated protein 20

1

0

High-throughput

0.249

Low

300810

CQ080
Mitochondrial nucleoid-associated protein 1

1

0

High-throughput

0.249

Low

300864

DJC15
DnaJ homolog subfamily C member 15

1

0

High-throughput

0.249

Low


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Last updated: 15 Jul 2024