Protein: SHC2
SHC-transforming protein 2 (Protein Sck) (SHC-transforming protein B) (Src homology 2 domain-containing-transforming protein C2) (SH2 domain protein C2)

Gene: SHC2
Organism: Homo sapiens
Interactions: 37
UniProt ID: P98077

Gene Ontology (top 5):
GO:0005829 - cytosol
GO:0005886 - plasma membrane
GO:0007169 - cell surface receptor protein tyrosine kinase signaling pathway
GO:0030971 - receptor tyrosine kinase binding
GO:0035556 - intracellular signal transduction

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

338278

EGFR
Epidermal growth factor receptor

4

20

Small-scale

0.882

High

729640

VGFR2
Vascular endothelial growth factor receptor 2

3

20

Small-scale

0.880

High

666069

SHC1
SHC-transforming protein 1

2

19

High-throughput

0.811

High

383740

ERBB2
Receptor tyrosine-protein kinase erbB-2

2

20

High-throughput

0.778

High

572619

VGFR1
Vascular endothelial growth factor receptor 1

2

20

Small-scale

0.754

High

441481

MET
Hepatocyte growth factor receptor

1

20

High-throughput

0.692

High

499256

KIT
Mast/stem cell growth factor receptor Kit

1

20

High-throughput

0.692

High

855787

VAV2
Guanine nucleotide exchange factor VAV2

1

20

High-throughput

0.691

High

601896

ERBB3
Receptor tyrosine-protein kinase erbB-3

1

20

High-throughput

0.647

High

957124

ERBB4
Receptor tyrosine-protein kinase erbB-4

1

20

High-throughput

0.647

High

924476

GRB2
Growth factor receptor-bound protein 2

1

20

Small-scale

0.618

High

300740

GLSK
Glutaminase kidney isoform, mitochondrial

1

20

High-throughput

0.536

High

321527

AP2A1
AP-2 complex subunit alpha-1

1

17

High-throughput

0.536

High

513565

PYC
Pyruvate carboxylase, mitochondrial

1

6

High-throughput

0.536

High

957123

AP1B1
AP-1 complex subunit beta-1

1

17

High-throughput

0.536

High

957128

PSMA8
Proteasome subunit alpha-type 8

1

3

High-throughput

0.536

High

957129

AP2M1
AP-2 complex subunit mu

1

8

High-throughput

0.536

High

957130

COQ8B
Atypical kinase COQ8B, mitochondrial

1

2

High-throughput

0.536

High

957136

ERRFI
ERBB receptor feedback inhibitor 1

1

18

High-throughput

0.536

High

59164

VWA8
von Willebrand factor A domain-containing protein 8

1

2

High-throughput

0.489

High

157317

BCKD
Branched-chain alpha-ketoacid dehydrogenase kinase

1

2

High-throughput

0.489

High

803096

IF2M
Translation initiation factor IF-2, mitochondrial

1

1

High-throughput

0.489

High

957125

SYAM
Alanine--tRNA ligase, mitochondrial

1

1

High-throughput

0.489

High

957127

SYDM
Aspartate--tRNA ligase, mitochondrial

1

5

High-throughput

0.489

High

957131

SYTM
Threonine--tRNA ligase, mitochondrial

1

3

High-throughput

0.489

High

957132

MTG2
Mitochondrial ribosome-associated GTPase 2

1

10

High-throughput

0.489

High

957133

RSAD1
Radical S-adenosyl methionine domain-containing protein 1, mitochondrial

1

1

High-throughput

0.489

High

957134

D39U1
Epimerase family protein SDR39U1

1

2

High-throughput

0.489

High

64693

RHG32
Rho GTPase-activating protein 32

1

20

Small-scale

0.479

High

957126

Q6NSK7
RIN3 protein

1

20

High-throughput

0.457

High

63341

MET15
12S rRNA N4-methylcytidine

1

0

High-throughput

0.279

Low

167221

MRPP3
Mitochondrial ribonuclease P catalytic subunit

1

0

High-throughput

0.279

Low

254683

PTCD1
Pentatricopeptide repeat-containing protein 1, mitochondrial

1

0

High-throughput

0.279

Low

276703

GATB
Glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial

1

0

High-throughput

0.279

Low

957122

CP24A
1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial

1

0

High-throughput

0.279

Low

957135

TMLH
Trimethyllysine dioxygenase, mitochondrial

1

0

High-throughput

0.279

Low

957137

SARDH
Sarcosine dehydrogenase, mitochondrial

1

0

High-throughput

0.279

Low


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Last updated: 15 Jul 2024