Protein: MCM6
DNA replication licensing factor MCM6 (EC 3.6.4.12) (p105MCM)

Gene: MCM6
Organism: Homo sapiens
Interactions: 224
UniProt ID: Q14566

Gene Ontology (top 5):
GO:0000727 - double-strand break repair via break-induced replication
GO:0000781 - chromosome, telomeric region
GO:0003697 - single-stranded DNA binding
GO:0005524 - ATP binding
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

832459

MCM2
DNA replication licensing factor MCM2

16

20

Small-scale

0.986

High

708441

MCM4
DNA replication licensing factor MCM4

10

19

Small-scale

0.971

High

708906

MCM7
DNA replication licensing factor MCM7

9

19

Small-scale

0.971

High

627264

MCM3
DNA replication licensing factor MCM3

7

20

Small-scale

0.967

High

1055633

CDT1
DNA replication factor Cdt1

6

7

Small-scale

0.952

High

1055553

MCM6
DNA replication licensing factor MCM6

5

20

Small-scale

0.928

High

708644

MCM5
DNA replication licensing factor MCM5

5

20

Small-scale

0.915

High

264202

CDC45
Cell division control protein 45 homolog

3

18

Small-scale

0.828

High

1055585

MCM10
Protein MCM10 homolog

7

14

High-throughput

0.753

High

1055618

MCMBP
Mini-chromosome maintenance complex-binding protein

6

19

Small-scale

0.746

High

1055640

ASF1B
Histone chaperone ASF1B

5

11

Small-scale

0.714

High

996670

SSRP1
FACT complex subunit SSRP1

4

13

Small-scale

0.697

High

917263

H4
Histone H4

4

8

Small-scale

0.694

High

983124

UBE3A
Ubiquitin-protein ligase E3A

3

6

Small-scale

0.692

High

1055666

ORC6
Origin recognition complex subunit 6

1

4

High-throughput

0.692

High

1055598

ING5
Inhibitor of growth protein 5

3

3

Small-scale

0.669

High

555462

H2AX
Histone H2AX

3

20

High-throughput

0.667

High

1055605

H2B1A
Histone H2B type 1-A

3

20

High-throughput

0.667

High

1055662

ASF1A
Histone chaperone ASF1A

3

11

Small-scale

0.667

High

861754

PLK1
Serine/threonine-protein kinase PLK1

3

10

Small-scale

0.656

High

934761

H31
Histone H3.1

3

20

High-throughput

0.656

High

1055611

TONSL
Tonsoku-like protein

3

10

Small-scale

0.656

High

244436

BRD4
Bromodomain-containing protein 4

3

9

High-throughput

0.640

High

346783

MYC
Myc proto-oncogene protein

3

7

High-throughput

0.640

High

1029420

TIF1B
Transcription intermediary factor 1-beta

2

17

Small-scale

0.624

High

217802

ORC4
Origin recognition complex subunit 4

1

20

Small-scale

0.621

High

1055617

PSF3
DNA replication complex GINS protein PSF3

1

10

Small-scale

0.621

High

1055616

SLD5
DNA replication complex GINS protein SLD5

1

17

Small-scale

0.618

High

1055654

MCM8
DNA helicase MCM8

1

20

Small-scale

0.618

High

391697

H2A1B
Histone H2A type 1-B/E

2

20

High-throughput

0.611

High

1055614

SPI2B
Spindlin-2B

2

3

High-throughput

0.611

High

125886

CDC7
Cell division cycle 7-related protein kinase

2

20

Small-scale

0.602

High

1055650

DBF4A
Protein DBF4 homolog A

2

6

Small-scale

0.602

High

1055554

SMC1A
Structural maintenance of chromosomes protein 1A

2

13

Small-scale

0.601

High

651202

RFA1
Replication protein A 70 kDa DNA-binding subunit

2

8

Small-scale

0.586

High

790779

CDN2A
Cyclin-dependent kinase inhibitor 2A

1

7

Small-scale

0.586

High

227454

PRKN
E3 ubiquitin-protein ligase parkin

2

10

High-throughput

0.584

High

294831

RECQ4
ATP-dependent DNA helicase Q4

2

14

Small-scale

0.584

High

552725

RFA2
Replication protein A 32 kDa subunit

2

6

Small-scale

0.584

High

779410

CCNF
Cyclin-F

2

12

High-throughput

0.584

High

998707

EP300
Histone acetyltransferase p300

2

12

High-throughput

0.584

High

1055630

SPRTN
DNA-dependent metalloprotease SPRTN

2

5

Small-scale

0.584

High

1055572

ESCO2
N-acetyltransferase ESCO2

1

7

Small-scale

0.573

High

441285

RU2B
U2 small nuclear ribonucleoprotein B''

1

6

High-throughput

0.573

High

154187

CHK1
Serine/threonine-protein kinase Chk1

1

5

Small-scale

0.561

High

1055597

ATRIP
ATR-interacting protein

1

4

Small-scale

0.561

High

581730

VCAM1
Vascular cell adhesion protein 1

2

8

High-throughput

0.549

High

1055608

ZBTB9
Zinc finger and BTB domain-containing protein 9

1

0

High-throughput

0.549

High

388444

HSPB1
Heat shock protein beta-1

1

3

High-throughput

0.541

High

637418

PSA1
Proteasome subunit alpha type-1

1

2

High-throughput

0.541

High

788030

AF9
Protein AF-9

1

1

High-throughput

0.541

High

943789

CCNA1
Cyclin-A1

1

5

High-throughput

0.536

High

274220

STK16
Serine/threonine-protein kinase 16

1

10

High-throughput

0.536

High

336495

SODC
Superoxide dismutase [Cu-Zn]

1

4

High-throughput

0.536

High

338436

EGFR
Epidermal growth factor receptor

1

8

Small-scale

0.536

High

426640

H10
Histone H1.0

1

3

High-throughput

0.536

High

452775

DLDH
Dihydrolipoyl dehydrogenase, mitochondrial

1

3

High-throughput

0.536

High

455440

PARP1
Poly [ADP-ribose] polymerase 1

1

10

High-throughput

0.536

High

470019

H2AZ
Histone H2A.Z

1

20

High-throughput

0.536

High

508526

TOP1
DNA topoisomerase 1

1

7

High-throughput

0.536

High

529120

CFTR
Cystic fibrosis transmembrane conductance regulator

1

4

High-throughput

0.536

High

535843

MIF
Macrophage migration inhibitory factor

1

3

High-throughput

0.536

High

564898

HMGA1
High mobility group protein HMG-I/HMG-Y

1

3

High-throughput

0.536

High

801141

KI67
Proliferation marker protein Ki-67

1

9

High-throughput

0.536

High

948787

HMGN5
High mobility group nucleosome-binding domain-containing protein 5

1

3

High-throughput

0.536

High

952336

H33
Histone H3.3

1

20

High-throughput

0.536

High

1041575

CUL3
Cullin-3

1

9

High-throughput

0.536

High

1055556

NUMA1
Nuclear mitotic apparatus protein 1

1

15

High-throughput

0.536

High

1055566

H2B2E
Histone H2B type 2-E

1

20

High-throughput

0.536

High

1055606

SGK3
Serine/threonine-protein kinase Sgk3

1

3

High-throughput

0.536

High

1055627

FOXQ1
Forkhead box protein Q1

1

8

High-throughput

0.536

High

1055632

NUCKS
Nuclear ubiquitous casein and cyclin-dependent kinase substrate 1

1

2

High-throughput

0.536

High

1055653

TRPS1
Zinc finger transcription factor Trps1

1

1

High-throughput

0.536

High

1055663

LMBL1
Lethal(3)malignant brain tumor-like protein 1

1

5

Small-scale

0.536

High

1055622

SCNM1
Sodium channel modifier 1

1

0

High-throughput

0.518

High

1055582

UBP49
Ubiquitin carboxyl-terminal hydrolase 49

1

5

High-throughput

0.515

High

1055602

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

1

6

High-throughput

0.515

High

267155

GEMI
Geminin

1

0

High-throughput

0.513

High

1019495

ILF2
Interleukin enhancer-binding factor 2

1

8

Small-scale

0.500

High

1055620

TIPIN
TIMELESS-interacting protein

1

7

Small-scale

0.500

High

1055648

I36RA
Interleukin-36 receptor antagonist protein

1

1

High-throughput

0.494

High

363148

FINC
Fibronectin

1

6

High-throughput

0.489

High

677965

SDHA
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial

1

2

High-throughput

0.489

High

949017

HTRA4
Serine protease HTRA4

1

1

High-throughput

0.489

High

1033381

ORC1
Origin recognition complex subunit 1

1

20

Small-scale

0.481

High

1033413

ORC2
Origin recognition complex subunit 2

1

7

Small-scale

0.481

High

59409

SBNO1
Protein strawberry notch homolog 1

1

2

High-throughput

0.479

High

170364

TIF1A
Transcription intermediary factor 1-alpha

1

15

Small-scale

0.479

High

203686

SUV91
Histone-lysine N-methyltransferase SUV39H1

1

2

High-throughput

0.479

High

209988

PRC1
Protein regulator of cytokinesis 1

1

4

High-throughput

0.479

High

217480

AIRE
Autoimmune regulator

1

20

Small-scale

0.479

High

241525

H2B1K
Histone H2B type 1-K

1

20

High-throughput

0.479

High

324403

BAG3
BAG family molecular chaperone regulator 3

1

4

High-throughput

0.479

High

326637

SNAI1
Zinc finger protein SNAI1

1

3

High-throughput

0.479

High

359940

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

11

High-throughput

0.479

High

384840

NTRK1
High affinity nerve growth factor receptor

1

7

High-throughput

0.479

High

386729

P53
Cellular tumor antigen p53

1

5

High-throughput

0.479

High

506588

BCR
Breakpoint cluster region protein

1

9

High-throughput

0.479

High

569727

CEBPB
CCAAT/enhancer-binding protein beta

1

10

High-throughput

0.479

High

575433

EGR1
Early growth response protein 1

1

1

High-throughput

0.479

High

599669

TNAP3
Tumor necrosis factor alpha-induced protein 3

1

6

High-throughput

0.479

High

617550

CRCM
Colorectal mutant cancer protein

1

12

High-throughput

0.479

High

622458

CCND1
G1/S-specific cyclin-D1

1

9

Small-scale

0.479

High

625435

CDK2
Cyclin-dependent kinase 2

1

10

High-throughput

0.479

High

637880

PSA3
Proteasome subunit alpha type-3

1

2

Small-scale

0.479

High

684720

STIP1
Stress-induced-phosphoprotein 1

1

7

High-throughput

0.479

High

707629

H2B1B
Histone H2B type 1-B

1

20

High-throughput

0.479

High

718857

PHB1
Prohibitin 1

1

7

High-throughput

0.479

High

720463

RFA3
Replication protein A 14 kDa subunit

1

5

High-throughput

0.479

High

749497

BRCA1
Breast cancer type 1 susceptibility protein

1

9

High-throughput

0.479

High

802437

ATRX
Transcriptional regulator ATRX

1

12

Small-scale

0.479

High

824004

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

5

High-throughput

0.479

High

827937

UB2R1
Ubiquitin-conjugating enzyme E2 R1

1

7

High-throughput

0.479

High

835755

GSK3B
Glycogen synthase kinase-3 beta

1

10

High-throughput

0.479

High

838832

EMD
Emerin

1

2

Small-scale

0.479

High

869816

PMS1
PMS1 protein homolog 1

1

2

High-throughput

0.479

High

896088

UBC12
NEDD8-conjugating enzyme Ubc12

1

8

High-throughput

0.479

High

908536

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

10

High-throughput

0.479

High

961112

HSF1
Heat shock factor protein 1

1

4

High-throughput

0.479

High

989529

SOX4
Transcription factor SOX-4

1

10

High-throughput

0.479

High

1018955

TP53B
TP53-binding protein 1

1

6

High-throughput

0.479

High

1021107

FOXC1
Forkhead box protein C1

1

7

High-throughput

0.479

High

1034852

FKBP5
Peptidyl-prolyl cis-trans isomerase FKBP5

1

13

High-throughput

0.479

High

1035732

BIRC3
Baculoviral IAP repeat-containing protein 3

1

5

High-throughput

0.479

High

1049025

TRI14
Tripartite motif-containing protein 14

1

5

High-throughput

0.479

High

1054311

RBM39
RNA-binding protein 39

1

9

High-throughput

0.479

High

1055555

CHD4
Chromodomain-helicase-DNA-binding protein 4

1

5

High-throughput

0.479

High

1055558

TNIP1
TNFAIP3-interacting protein 1

1

20

High-throughput

0.479

High

1055559

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

6

High-throughput

0.479

High

1055560

SF3A1
Splicing factor 3A subunit 1

1

8

High-throughput

0.479

High

1055563

EZH2
Histone-lysine N-methyltransferase EZH2

1

10

High-throughput

0.479

High

1055564

E2F4
Transcription factor E2F4

1

3

High-throughput

0.479

High

1055565

IF16
Gamma-interferon-inducible protein 16

1

4

High-throughput

0.479

High

1055569

ANR55
Ankyrin repeat domain-containing protein 55

1

9

High-throughput

0.479

High

1055573

ESCO1
N-acetyltransferase ESCO1

1

8

Small-scale

0.479

High

1055576

VIR
Protein virilizer homolog

1

5

High-throughput

0.479

High

1055579

MMS22
Protein MMS22-like

1

3

Small-scale

0.479

High

1055581

PAXI1
PAX-interacting protein 1

1

1

High-throughput

0.479

High

1055583

MOB3C
MOB kinase activator 3C

1

6

High-throughput

0.479

High

1055586

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

4

High-throughput

0.479

High

1055587

FGD2
FYVE, RhoGEF and PH domain-containing protein 2

1

6

High-throughput

0.479

High

1055588

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

3

High-throughput

0.479

High

1055589

UBP37
Ubiquitin carboxyl-terminal hydrolase 37

1

12

Small-scale

0.479

High

1055590

SLX4
Structure-specific endonuclease subunit SLX4

1

7

High-throughput

0.479

High

1055592

SIR6
NAD-dependent protein deacylase sirtuin-6

1

14

High-throughput

0.479

High

1055594

UBP38
Ubiquitin carboxyl-terminal hydrolase 38

1

11

Small-scale

0.479

High

1055599

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

5

High-throughput

0.479

High

1055600

REQU
Zinc finger protein ubi-d4

1

15

High-throughput

0.479

High

1055601

CSN5
COP9 signalosome complex subunit 5

1

5

High-throughput

0.479

High

1055603

H2B1H
Histone H2B type 1-H

1

20

High-throughput

0.479

High

1055604

FBXW7
F-box/WD repeat-containing protein 7

1

6

High-throughput

0.479

High

1055609

ARMC5
Armadillo repeat-containing protein 5

1

10

High-throughput

0.479

High

1055613

BARD1
BRCA1-associated RING domain protein 1

1

10

High-throughput

0.479

High

1055615

RIOK1
Serine/threonine-protein kinase RIO1

1

3

High-throughput

0.479

High

1055619

DUS23
Dual specificity protein phosphatase 23

1

16

High-throughput

0.479

High

1055621

TRAIP
E3 ubiquitin-protein ligase TRAIP

1

18

Small-scale

0.479

High

1055623

PINK1
Serine/threonine-protein kinase PINK1, mitochondrial

1

8

High-throughput

0.479

High

1055624

FACD2
Fanconi anemia group D2 protein

1

10

Small-scale

0.479

High

1055629

UBE2O
(E3-independent) E2 ubiquitin-conjugating enzyme

1

6

High-throughput

0.479

High

1055631

CCDC8
Coiled-coil domain-containing protein 8

1

6

High-throughput

0.479

High

1055635

ECT2
Protein ECT2

1

10

High-throughput

0.479

High

1055636

PRD16
Histone-lysine N-methyltransferase PRDM16

1

2

High-throughput

0.479

High

1055637

MET14
N6-adenosine-methyltransferase non-catalytic subunit

1

3

High-throughput

0.479

High

1055638

SIR7
NAD-dependent protein deacetylase sirtuin-7

1

14

High-throughput

0.479

High

1055641

HIF1N
Hypoxia-inducible factor 1-alpha inhibitor

1

1

High-throughput

0.479

High

1055642

PP4R2
Serine/threonine-protein phosphatase 4 regulatory subunit 2

1

2

High-throughput

0.479

High

1055643

DONS
Protein downstream neighbor of Son

1

4

Small-scale

0.479

High

1055644

TLS1
Splicing factor C9orf78

1

2

High-throughput

0.479

High

1055645

PD1L1
Programmed cell death 1 ligand 1

1

3

Small-scale

0.479

High

1055647

EP15R
Epidermal growth factor receptor substrate 15-like 1

1

4

High-throughput

0.479

High

1055649

POLK
DNA polymerase kappa

1

1

Small-scale

0.479

High

1055651

ZRAN1
Ubiquitin thioesterase ZRANB1

1

8

High-throughput

0.479

High

1055652

UBQL2
Ubiquilin-2

1

9

High-throughput

0.479

High

1055655

TF3C4
General transcription factor 3C polypeptide 4

1

2

High-throughput

0.479

High

1055656

PPIE
Peptidyl-prolyl cis-trans isomerase E

1

2

High-throughput

0.479

High

1055657

TRI33
E3 ubiquitin-protein ligase TRIM33

1

16

High-throughput

0.479

High

1055658

SRRM2
Serine/arginine repetitive matrix protein 2

1

7

High-throughput

0.479

High

1055659

CD11A
Cyclin-dependent kinase 11A

1

11

High-throughput

0.479

High

1055660

SMC3
Structural maintenance of chromosomes protein 3

1

8

High-throughput

0.479

High

1055661

HDAC5
Histone deacetylase 5

1

15

High-throughput

0.479

High

1055664

UBP15
Ubiquitin carboxyl-terminal hydrolase 15

1

10

High-throughput

0.479

High

1055665

TRAF6
TNF receptor-associated factor 6

1

7

High-throughput

0.479

High

1055667

NS1BP
Influenza virus NS1A-binding protein

1

10

High-throughput

0.479

High

532527

TCTP
Translationally-controlled tumor protein

1

0

High-throughput

0.458

High

673403

MPIP1
M-phase inducer phosphatase 1

1

0

High-throughput

0.458

High

1021599

TAF10
Transcription initiation factor TFIID subunit 10

1

0

High-throughput

0.458

High

894009

CDC42
Cell division control protein 42 homolog

1

4

High-throughput

0.457

High

652851

APEX1
DNA repair nuclease/redox regulator APEX1

1

5

Small-scale

0.445

High

1055574

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

8

High-throughput

0.445

High

1055575

Q5T670
Protein MCM10 homolog

1

14

High-throughput

0.445

High

1055628

ZDHC5
Palmitoyltransferase ZDHHC5

1

3

High-throughput

0.445

High

120437

RHOD
Rho-related GTP-binding protein RhoD

1

5

High-throughput

0.437

High

229671

JIP4
C-Jun-amino-terminal kinase-interacting protein 4

1

15

High-throughput

0.437

High

255776

OBSL1
Obscurin-like protein 1

1

7

High-throughput

0.437

High

322626

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

12

High-throughput

0.437

High

354445

HLAB
HLA class I histocompatibility antigen, B alpha chain

1

3

High-throughput

0.437

High

530659

ITA4
Integrin alpha-4

1

5

High-throughput

0.437

High

852474

RND2
Rho-related GTP-binding protein RhoN

1

3

High-throughput

0.437

High

1021402

ANK3
Ankyrin-3

1

3

High-throughput

0.437

High

1055557

GAPD1
GTPase-activating protein and VPS9 domain-containing protein 1

1

4

High-throughput

0.437

High

1055561

RHOH
Rho-related GTP-binding protein RhoH

1

3

High-throughput

0.437

High

1055567

CL16A
Protein CLEC16A

1

1

High-throughput

0.437

High

1055570

DUS28
Dual specificity phosphatase 28

1

7

High-throughput

0.437

High

1055577

RICTR
Rapamycin-insensitive companion of mTOR

1

2

High-throughput

0.437

High

1055580

TRI67
Tripartite motif-containing protein 67

1

15

High-throughput

0.437

High

1055584

RHOU
Rho-related GTP-binding protein RhoU

1

5

High-throughput

0.437

High

1055591

RHG24
Rho GTPase-activating protein 24

1

10

High-throughput

0.437

High

1055593

KDF1
Keratinocyte differentiation factor 1

1

2

High-throughput

0.437

High

1055595

DUS19
Dual specificity protein phosphatase 19

1

7

High-throughput

0.437

High

1055596

DEP1B
DEP domain-containing protein 1B

1

7

High-throughput

0.437

High

1055607

ATG2B
Autophagy-related protein 2 homolog B

1

3

High-throughput

0.437

High

1055612

TNIP3
TNFAIP3-interacting protein 3

1

9

High-throughput

0.437

High

1055625

ACE2
Angiotensin-converting enzyme 2

1

1

High-throughput

0.437

High

1055626

RHBT2
Rho-related BTB domain-containing protein 2

1

4

High-throughput

0.437

High

1055634

PKHA4
Pleckstrin homology domain-containing family A member 4

1

15

High-throughput

0.437

High

1055639

DUS22
Dual specificity protein phosphatase 22

1

7

High-throughput

0.437

High

1055646

RELCH
RAB11-binding protein RELCH

1

2

High-throughput

0.437

High

1055610

OTUB1
Ubiquitin thioesterase OTUB1

1

0

High-throughput

0.426

High

841052

AP4A
Bis(5'-nucleosyl)-tetraphosphatase [asymmetrical]

1

0

High-throughput

0.299

High

1055568

F161A
Protein FAM161A

1

0

High-throughput

0.299

High

1055571

CTSRT
Cation channel sperm-associated targeting subunit tau

1

0

High-throughput

0.282

High

1055562

MARE1
Microtubule-associated protein RP/EB family member 1

1

0

High-throughput

0.279

Low

1055578

LMBRL
Protein LMBR1L

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024