Protein: EPHA4
Ephrin type-A receptor 4 (EC 2.7.10.1) (EPH-like kinase 8) (EK8) (hEK8) (Tyrosine-protein kinase TYRO1) (Tyrosine-protein kinase receptor SEK)

Gene: EPHA4
Organism: Homo sapiens
Interactions: 210
UniProt ID: P54764

Gene Ontology (top 5):
GO:0001540 - amyloid-beta binding
GO:0004672 - protein kinase activity
GO:0004713 - protein tyrosine kinase activity
GO:0005004 - GPI-linked ephrin receptor activity
GO:0005005 - transmembrane-ephrin receptor activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

872654

EFNB3
Ephrin-B3

4

20

Small-scale

0.902

High

856597

EFNA5
Ephrin-A5

4

20

Small-scale

0.893

High

872657

CEA21
Carcinoembryonic antigen-related cell adhesion molecule 21

3

9

High-throughput

0.861

High

872734

RIPK3
Receptor-interacting serine/threonine-protein kinase 3

3

15

High-throughput

0.861

High

856348

EFNA4
Ephrin-A4

3

20

Small-scale

0.853

High

872650

EPHA7
Ephrin type-A receptor 7

2

20

High-throughput

0.811

High

713776

RYK
Tyrosine-protein kinase RYK

2

20

Small-scale

0.789

High

595985

EFNA1
Ephrin-A1

2

20

Small-scale

0.768

High

217636

EFNA2
Ephrin-A2

1

20

Small-scale

0.761

High

856510

EFNB2
Ephrin-B2

1

20

Small-scale

0.761

High

350003

RASK
GTPase KRas

2

20

High-throughput

0.754

High

507926

FGFR1
Fibroblast growth factor receptor 1

2

20

Small-scale

0.754

High

412105

FYN
Tyrosine-protein kinase Fyn

2

19

Small-scale

0.743

High

655285

P85A
Phosphatidylinositol 3-kinase regulatory subunit alpha

2

20

High-throughput

0.743

High

789049

ABL2
Tyrosine-protein kinase ABL2

2

20

High-throughput

0.743

High

609225

FGFR3
Fibroblast growth factor receptor 3

1

19

Small-scale

0.740

High

59744

KLRG2
Killer cell lectin-like receptor subfamily G member 2

2

11

High-throughput

0.726

High

665568

EPHB2
Ephrin type-B receptor 2

1

18

High-throughput

0.715

High

872702

TBB2B
Tubulin beta-2B chain

4

10

High-throughput

0.696

High

560049

CTLA4
Cytotoxic T-lymphocyte protein 4

1

2

High-throughput

0.691

High

665385

EPHA3
Ephrin type-A receptor 3

1

18

High-throughput

0.691

High

580414

GNAZ
Guanine nucleotide-binding protein G(z) subunit alpha

3

6

High-throughput

0.667

High

522871

SRC
Proto-oncogene tyrosine-protein kinase Src

1

19

Small-scale

0.647

High

872624

EPHA4
Ephrin type-A receptor 4

1

19

Small-scale

0.647

High

872709

SLAP2
Src-like-adapter 2

1

20

Small-scale

0.647

High

872726

GPN3
GPN-loop GTPase 3

4

1

High-throughput

0.635

High

428109

TBB5
Tubulin beta chain

2

10

High-throughput

0.628

High

872686

HDA10
Polyamine deacetylase HDAC10

2

2

High-throughput

0.628

High

872692

GBP5
Guanylate-binding protein 5

2

2

High-throughput

0.628

High

872717

SYIM
Isoleucine--tRNA ligase, mitochondrial

2

4

High-throughput

0.628

High

872663

TENS3
Tensin-3

1

16

High-throughput

0.625

High

505713

UMPS
Uridine 5'-monophosphate synthase

2

1

High-throughput

0.621

High

383712

ERBB2
Receptor tyrosine-protein kinase erbB-2

1

20

Small-scale

0.621

High

381152

TBB4A
Tubulin beta-4A chain

2

10

High-throughput

0.618

High

129253

P85B
Phosphatidylinositol 3-kinase regulatory subunit beta

1

20

High-throughput

0.618

High

159179

CSKP
Peripheral plasma membrane protein CASK

1

15

High-throughput

0.618

High

209018

NCK2
Cytoplasmic protein NCK2

1

20

High-throughput

0.618

High

277037

STAM2
Signal transducing adapter molecule 2

1

20

High-throughput

0.618

High

302668

ARHGF
Rho guanine nucleotide exchange factor 15

1

19

Small-scale

0.618

High

324762

M4K4
Mitogen-activated protein kinase kinase kinase kinase 4

1

20

High-throughput

0.618

High

349222

RASH
GTPase HRas

1

20

High-throughput

0.618

High

433662

LYN
Tyrosine-protein kinase Lyn

1

19

High-throughput

0.618

High

588758

DPA1
HLA class II histocompatibility antigen, DP alpha 1 chain

1

12

High-throughput

0.618

High

601484

FGFR2
Fibroblast growth factor receptor 2

1

20

Small-scale

0.618

High

607929

FGFR4
Fibroblast growth factor receptor 4

1

20

Small-scale

0.618

High

665185

EPHA2
Ephrin type-A receptor 2

1

19

High-throughput

0.618

High

666049

SHC1
SHC-transforming protein 1

1

20

High-throughput

0.618

High

802810

CRKL
Crk-like protein

1

20

High-throughput

0.618

High

872630

GRB2
Growth factor receptor-bound protein 2

1

20

High-throughput

0.618

High

872634

NOTC2
Neurogenic locus notch homolog protein 2

1

10

High-throughput

0.618

High

872635

PTN11
Tyrosine-protein phosphatase non-receptor type 11

1

20

High-throughput

0.618

High

872638

PTN13
Tyrosine-protein phosphatase non-receptor type 13

1

20

High-throughput

0.618

High

872639

DLG1
Disks large homolog 1

1

16

High-throughput

0.618

High

872642

GAB1
GRB2-associated-binding protein 1

1

20

High-throughput

0.618

High

872667

RHOU
Rho-related GTP-binding protein RhoU

1

20

High-throughput

0.618

High

872674

UNC5B
Netrin receptor UNC5B

1

12

High-throughput

0.618

High

872675

NGEF
Ephexin-1

1

20

Small-scale

0.618

High

872679

PARD3
Partitioning defective 3 homolog

1

20

High-throughput

0.618

High

872687

FERM2
Fermitin family homolog 2

1

5

High-throughput

0.618

High

872694

ERBIN
Erbin

1

20

High-throughput

0.618

High

872712

PKHA1
Pleckstrin homology domain-containing family A member 1

1

20

High-throughput

0.618

High

872713

GOPC
Golgi-associated PDZ and coiled-coil motif-containing protein

1

20

High-throughput

0.618

High

872714

WDR6
tRNA

1

17

High-throughput

0.618

High

872718

LIN7C
Protein lin-7 homolog C

1

20

High-throughput

0.618

High

872725

BI2L1
BAR/IMD domain-containing adapter protein 2-like 1

1

14

High-throughput

0.618

High

872729

FZR1
Fizzy-related protein homolog

1

5

Small-scale

0.618

High

872730

PACN2
Protein kinase C and casein kinase substrate in neurons protein 2

1

10

High-throughput

0.618

High

237798

TSN3
Tetraspanin-3

3

7

High-throughput

0.609

High

872681

TB22A
TBC1 domain family member 22A

3

5

High-throughput

0.609

High

721952

RFC4
Replication factor C subunit 4

2

0

High-throughput

0.602

High

196420

SI1L1
Signal-induced proliferation-associated 1-like protein 1

1

5

High-throughput

0.590

High

305100

RIMB1
Peripheral-type benzodiazepine receptor-associated protein 1

1

7

High-throughput

0.590

High

562635

PLCG2
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2

1

11

High-throughput

0.590

High

580965

PLCG1
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1

1

12

High-throughput

0.590

High

592813

NR1D1
Nuclear receptor subfamily 1 group D member 1

1

8

High-throughput

0.590

High

596384

RASA1
Ras GTPase-activating protein 1

1

20

High-throughput

0.590

High

849879

STA5B
Signal transducer and activator of transcription 5B

1

12

High-throughput

0.590

High

855777

VAV2
Guanine nucleotide exchange factor VAV2

1

20

High-throughput

0.590

High

872640

GRB10
Growth factor receptor-bound protein 10

1

20

High-throughput

0.590

High

872649

NR1D2
Nuclear receptor subfamily 1 group D member 2

1

10

High-throughput

0.590

High

872666

KCC1B
Calcium/calmodulin-dependent protein kinase type 1B

1

5

High-throughput

0.590

High

872669

MAGI2
Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2

1

20

High-throughput

0.590

High

872678

LNX1
E3 ubiquitin-protein ligase LNX

1

20

High-throughput

0.590

High

872680

FRS2
Fibroblast growth factor receptor substrate 2

2

10

Small-scale

0.584

High

872643

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

14

High-throughput

0.575

High

398430

CP1A2
Cytochrome P450 1A2

2

16

High-throughput

0.574

High

872641

OS9
Protein OS-9

2

3

High-throughput

0.574

High

872683

CBPA5
Carboxypeptidase A5

2

6

High-throughput

0.574

High

872699

F118B
Protein FAM118B

2

1

High-throughput

0.574

High

872724

RSP14
Radial spoke head 14 homolog

2

20

High-throughput

0.574

High

872697

RNF5
E3 ubiquitin-protein ligase RNF5

1

7

Small-scale

0.561

High

872736

NEMO
NF-kappa-B essential modulator

1

13

High-throughput

0.561

High

872684

ESR2
Estrogen receptor beta

1

12

High-throughput

0.553

High

253939

ADA11
Disintegrin and metalloproteinase domain-containing protein 11

1

20

High-throughput

0.536

High

276233

CIB2
Calcium and integrin-binding family member 2

1

4

High-throughput

0.536

High

341580

CFAB
Complement factor B

1

18

High-throughput

0.536

High

563876

NAGAB
Alpha-N-acetylgalactosaminidase

1

2

High-throughput

0.536

High

792754

EAA3
Excitatory amino acid transporter 3

1

7

High-throughput

0.536

High

872631

TBB4B
Tubulin beta-4B chain

1

10

High-throughput

0.536

High

872647

GNA13
Guanine nucleotide-binding protein subunit alpha-13

1

6

High-throughput

0.536

High

872655

CDC37
Hsp90 co-chaperone Cdc37

1

19

High-throughput

0.536

High

872658

NHLC3
NHL repeat-containing protein 3

1

1

High-throughput

0.536

High

872735

NUBP2
Cytosolic Fe-S cluster assembly factor NUBP2

1

0

High-throughput

0.513

High

214540

MYO1B
Unconventional myosin-Ib

1

13

High-throughput

0.500

High

268432

BAF
Barrier-to-autointegration factor

1

6

High-throughput

0.500

High

444699

GNAI3
Guanine nucleotide-binding protein G(i) subunit alpha-3

1

6

High-throughput

0.500

High

872629

RS29
Small ribosomal subunit protein uS14

1

1

High-throughput

0.500

High

872700

NTPCR
Cancer-related nucleoside-triphosphatase

1

8

High-throughput

0.500

High

872701

TBB6
Tubulin beta-6 chain

1

10

High-throughput

0.500

High

872703

PDIP3
Polymerase delta-interacting protein 3

1

4

High-throughput

0.500

High

872719

FANCI
Fanconi anemia group I protein

1

3

High-throughput

0.500

High

795939

MAGA8
Melanoma-associated antigen 8

1

4

High-throughput

0.489

High

872628

COPZ1
Coatomer subunit zeta-1

1

4

High-throughput

0.489

High

872637

LR74A
Leucine-rich repeat-containing protein 74A

1

20

High-throughput

0.489

High

872720

TMEM9
Proton-transporting V-type ATPase complex assembly regulator TMEM9

1

1

High-throughput

0.489

High

159938

HGS
Hepatocyte growth factor-regulated tyrosine kinase substrate

1

20

High-throughput

0.479

High

205216

TGON2
Trans-Golgi network integral membrane protein 2

1

12

High-throughput

0.479

High

216476

SAHH2
S-adenosylhomocysteine hydrolase-like protein 1

1

6

High-throughput

0.479

High

239093

CTND1
Catenin delta-1

1

20

High-throughput

0.479

High

280222

CBPD
Carboxypeptidase D

1

6

High-throughput

0.479

High

313518

ZFYV9
Zinc finger FYVE domain-containing protein 9

1

20

High-throughput

0.479

High

320284

SNP29
Synaptosomal-associated protein 29

1

4

High-throughput

0.479

High

431692

HS90A
Heat shock protein HSP 90-alpha

1

20

High-throughput

0.479

High

438029

HS90B
Heat shock protein HSP 90-beta

1

20

High-throughput

0.479

High

506944

LAMP1
Lysosome-associated membrane glycoprotein 1

1

9

High-throughput

0.479

High

542244

PLAK
Junction plakoglobin

1

20

High-throughput

0.479

High

566985

CXA1
Gap junction alpha-1 protein

1

14

High-throughput

0.479

High

580213

CADH2
Cadherin-2

1

19

High-throughput

0.479

High

580464

GNAT2
Guanine nucleotide-binding protein G(t) subunit alpha-2

1

6

High-throughput

0.479

High

640712

CTNA2
Catenin alpha-2

1

4

High-throughput

0.479

High

716635

CTNA1
Catenin alpha-1

1

4

High-throughput

0.479

High

833553

NUMB
Protein numb homolog

1

17

High-throughput

0.479

High

872625

S12A2
Solute carrier family 12 member 2

1

3

High-throughput

0.479

High

872632

DSC2
Desmocollin-2

1

20

High-throughput

0.479

High

872633

CAV1
Caveolin-1

1

10

High-throughput

0.479

High

872636

FCHO2
F-BAR domain only protein 2

1

8

High-throughput

0.479

High

872645

DSG2
Desmoglein-2

1

20

High-throughput

0.479

High

872646

FLOT2
Flotillin-2

1

13

High-throughput

0.479

High

872653

AAAT
Neutral amino acid transporter B(0)

1

7

High-throughput

0.479

High

872656

OCLN
Occludin

1

5

High-throughput

0.479

High

872661

F1711
Protein FAM171A1

1

9

High-throughput

0.479

High

872668

ZFY16
Zinc finger FYVE domain-containing protein 16

1

19

High-throughput

0.479

High

872670

LSR
Lipolysis-stimulated lipoprotein receptor

1

3

High-throughput

0.479

High

872671

CPNE8
Copine-8

1

5

High-throughput

0.479

High

872672

DEN6A
Protein DENND6A

1

1

High-throughput

0.479

High

872676

CNNM3
Metal transporter CNNM3

1

1

High-throughput

0.479

High

872677

VANG1
Vang-like protein 1

1

3

High-throughput

0.479

High

872685

US6NL
USP6 N-terminal-like protein

1

9

High-throughput

0.479

High

872688

CYFP2
Cytoplasmic FMR1-interacting protein 2

1

7

High-throughput

0.479

High

872695

NIBA2
Protein Niban 2

1

5

High-throughput

0.479

High

872696

PKP4
Plakophilin-4

1

20

High-throughput

0.479

High

872698

PKP2
Plakophilin-2

1

20

High-throughput

0.479

High

872704

ZDHC5
Palmitoyltransferase ZDHHC5

1

2

High-throughput

0.479

High

872706

S6A15
Sodium-dependent neutral amino acid transporter B(0)AT2

1

2

High-throughput

0.479

High

872716

TMPS4
Transmembrane protease serine 4

1

18

High-throughput

0.479

High

872721

DIP2B
Disco-interacting protein 2 homolog B

1

10

High-throughput

0.479

High

872723

TRM7
tRNA

1

7

High-throughput

0.479

High

872728

ANC2
Anaphase-promoting complex subunit 2

1

4

Small-scale

0.479

High

872731

BAIP2
BAR/IMD domain-containing adapter protein 2

1

14

High-throughput

0.479

High

872733

NISCH
Nischarin

1

20

High-throughput

0.479

High

364666

TRFL
Lactotransferrin

1

0

High-throughput

0.458

High

771852

VHL
von Hippel-Lindau disease tumor suppressor

1

0

Small-scale

0.458

High

872737

ZNT1
Proton-coupled zinc antiporter SLC30A1

1

0

High-throughput

0.458

High

117375

BACH
Cytosolic acyl coenzyme A thioester hydrolase

1

1

High-throughput

0.457

High

301699

TRI37
E3 ubiquitin-protein ligase TRIM37

1

13

High-throughput

0.457

High

582156

NUCL
Nucleolin

1

10

High-throughput

0.457

High

641352

PAX6
Paired box protein Pax-6

1

7

High-throughput

0.457

High

816677

GLRB
Glycine receptor subunit beta

1

1

High-throughput

0.457

High

872660

K1755
Uncharacterized protein KIAA1755

1

10

High-throughput

0.457

High

872691

OPALI
Opalin

1

1

High-throughput

0.457

High

872705

RHG39
Rho GTPase-activating protein 39

1

10

High-throughput

0.457

High

778087

ECHA
Trifunctional enzyme subunit alpha, mitochondrial

1

9

High-throughput

0.457

High

239879

HCN1
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

1

13

High-throughput

0.445

High

872644

CAC1C
Voltage-dependent L-type calcium channel subunit alpha-1C

1

11

High-throughput

0.445

High

872693

SYGP1
Ras/Rap GTPase-activating protein SynGAP

1

16

High-throughput

0.445

High

872648

SLBP
Histone RNA hairpin-binding protein

1

0

High-throughput

0.438

High

872710

MB12B
Multivesicular body subunit 12B

1

0

High-throughput

0.438

High

872727

VATH
V-type proton ATPase subunit H

1

0

High-throughput

0.438

High

68152

F1712
Protein FAM171A2

1

9

High-throughput

0.437

High

169420

BET1
BET1 homolog

1

4

High-throughput

0.437

High

315534

SC24A
Protein transport protein Sec24A

1

20

High-throughput

0.437

High

315674

SC24B
Protein transport protein Sec24B

1

20

High-throughput

0.437

High

315808

AGRL2
Adhesion G protein-coupled receptor L2

1

7

High-throughput

0.437

High

363499

FETUA
Alpha-2-HS-glycoprotein

1

7

High-throughput

0.437

High

417698

G6PI
Glucose-6-phosphate isomerase

1

2

High-throughput

0.437

High

833058

ACOT2
Acyl-coenzyme A thioesterase 2, mitochondrial

1

6

High-throughput

0.437

High

872651

SC23A
Protein transport protein Sec23A

1

20

High-throughput

0.437

High

872652

SC23B
Protein transport protein Sec23B

1

20

High-throughput

0.437

High

872673

M21D2
Nucleotidyltransferase MB21D2

1

3

High-throughput

0.437

High

872682

BRK1
Protein BRICK1

1

3

High-throughput

0.437

High

872689

SAHH3
Adenosylhomocysteinase 3

1

6

High-throughput

0.437

High

872707

GCP60
Golgi resident protein GCP60

1

9

High-throughput

0.437

High

872711

GORS2
Golgi reassembly-stacking protein 2

1

8

High-throughput

0.437

High

872722

F135A
Protein FAM135A

1

4

High-throughput

0.437

High

872732

NCKP1
Nck-associated protein 1

1

2

High-throughput

0.437

High

872738

WASF2
Actin-binding protein WASF2

1

15

High-throughput

0.437

High

441972

RU17
U1 small nuclear ribonucleoprotein 70 kDa

1

12

High-throughput

0.417

High

872626

MFAP1
Microfibrillar-associated protein 1

1

1

High-throughput

0.417

High

872659

GASP1
G-protein coupled receptor-associated sorting protein 1

1

1

High-throughput

0.417

High

872662

JKIP3
Janus kinase and microtubule-interacting protein 3

1

11

High-throughput

0.417

High

872664

PLAG1
Zinc finger protein PLAG1

1

5

High-throughput

0.417

High

872690

ZN521
Zinc finger protein 521

1

4

High-throughput

0.417

High

872665

ARMC6
Armadillo repeat-containing protein 6

2

0

High-throughput

0.328

High

872715

MMP26
Matrix metalloproteinase-26

2

0

High-throughput

0.328

High

421531

FABPL
Fatty acid-binding protein, liver

2

0

High-throughput

0.324

High

648481

CALL3
Calmodulin-like protein 3

1

0

High-throughput

0.279

Low

872708

CENPH
Centromere protein H

1

0

High-throughput

0.279

Low

365304

STAT
Statherin

1

0

High-throughput

0.249

Low

872627

RPAB2
DNA-directed RNA polymerases I, II, and III subunit RPABC2

1

0

High-throughput

0.249

Low


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Last updated: 15 Jul 2024