Protein: MUS81
Crossover junction endonuclease MUS81 (EC 3.1.22.-)

Gene: MUS81
Organism: Homo sapiens
Interactions: 53
UniProt ID: Q96NY9

Gene Ontology (top 5):
GO:0000712 - resolution of meiotic recombination intermediates
GO:0000727 - double-strand break repair via break-induced replication
GO:0003677 - DNA binding
GO:0004519 - endonuclease activity
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1284703

EME1
Crossover junction endonuclease EME1

17

3

Small-scale

0.986

High

1272210

XPF
DNA repair endonuclease XPF

2

1

High-throughput

0.811

High

1222526

SLX4
Structure-specific endonuclease subunit SLX4

23

2

Small-scale

0.767

High

434592

ERCC1
DNA excision repair protein ERCC-1

2

0

Small-scale

0.748

High

60017

EME2
Probable crossover junction endonuclease EME2

1

4

Small-scale

0.681

High

1298949

SLX1
Structure-specific endonuclease subunit SLX1

3

0

Small-scale

0.645

High

1298954

RRP44
Exosome complex exonuclease RRP44

2

1

High-throughput

0.628

High

902719

SUMO2
Small ubiquitin-related modifier 2

2

0

Small-scale

0.577

High

331326

CHK2
Serine/threonine-protein kinase Chk2

1

4

Small-scale

0.561

High

1298947

UHRF1
E3 ubiquitin-protein ligase UHRF1

1

1

Small-scale

0.561

High

295550

RECQ5
ATP-dependent DNA helicase Q5

1

0

Small-scale

0.537

High

1082339

DDB1
DNA damage-binding protein 1

1

0

Small-scale

0.537

High

625565

CDK2
Cyclin-dependent kinase 2

1

1

High-throughput

0.536

High

734997

MP2K2
Dual specificity mitogen-activated protein kinase kinase 2

1

1

High-throughput

0.536

High

764409

FEN1
Flap endonuclease 1

1

1

Small-scale

0.536

High

1076089

OASL
2'-5'-oligoadenylate synthase-like protein

1

1

High-throughput

0.536

High

180417

MAGB2
Melanoma-associated antigen B2

1

0

High-throughput

0.513

High

566456

KPCA
Protein kinase C alpha type

1

0

High-throughput

0.513

High

649675

RL10
Large ribosomal subunit protein uL16

1

0

High-throughput

0.513

High

805766

RL27A
Large ribosomal subunit protein uL15

1

0

High-throughput

0.513

High

962292

HNRPU
Heterogeneous nuclear ribonucleoprotein U

1

0

High-throughput

0.513

High

986014

PTN11
Tyrosine-protein phosphatase non-receptor type 11

1

0

High-throughput

0.513

High

1053424

GNA13
Guanine nucleotide-binding protein subunit alpha-13

1

0

High-throughput

0.513

High

1224872

FAM9B
Protein FAM9B

1

0

High-throughput

0.513

High

1298946

RBM14
RNA-binding protein 14

1

0

High-throughput

0.513

High

934407

CSK21
Casein kinase II subunit alpha

1

1

Small-scale

0.501

High

418559

NPM
Nucleophosmin

1

1

High-throughput

0.479

High

861896

PLK1
Serine/threonine-protein kinase PLK1

1

1

Small-scale

0.479

High

917769

H4
Histone H4

1

1

High-throughput

0.479

High

122947

MEN1
Menin

1

0

High-throughput

0.458

High

319977

HERC2
E3 ubiquitin-protein ligase HERC2

1

0

High-throughput

0.458

High

673291

WEE1
Wee1-like protein kinase

1

0

Small-scale

0.458

High

749786

BRCA1
Breast cancer type 1 susceptibility protein

1

0

High-throughput

0.458

High

918618

H2B1C
Histone H2B type 1-C/E/F/G/I

1

0

High-throughput

0.458

High

1019087

TP53B
TP53-binding protein 1

1

0

High-throughput

0.458

High

1074976

TERF2
Telomeric repeat-binding factor 2

1

0

Small-scale

0.458

High

1244125

SYNE1
Nesprin-1

1

0

High-throughput

0.458

High

1256341

DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

0

High-throughput

0.458

High

1260872

DCAF4
DDB1- and CUL4-associated factor 4

1

0

High-throughput

0.458

High

1270879

KAT6A
Histone acetyltransferase KAT6A

1

0

High-throughput

0.458

High

1298950

RIOK1
Serine/threonine-protein kinase RIO1

1

0

High-throughput

0.458

High

1298951

DCR1B
5' exonuclease Apollo

1

0

Small-scale

0.458

High

1298952

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.458

High

1298953

FBXL5
F-box/LRR-repeat protein 5

1

0

Small-scale

0.458

High

1298955

DCAF1
DDB1- and CUL4-associated factor 1

1

0

Small-scale

0.458

High

1298956

PIAS3
E3 SUMO-protein ligase PIAS3

1

0

Small-scale

0.458

High

1298948

SORT
Sortilin

1

1

High-throughput

0.437

High

365026

FRIL
Ferritin light chain

1

0

High-throughput

0.279

Low

648585

CALL3
Calmodulin-like protein 3

1

0

High-throughput

0.279

Low

661399

S10A2
Protein S100-A2

1

0

High-throughput

0.279

Low

905446

RRAS2
Ras-related protein R-Ras2

1

0

High-throughput

0.279

Low

1079407

VAMP3
Vesicle-associated membrane protein 3

1

0

High-throughput

0.279

Low

1139550

SLX4I
Protein SLX4IP

1

0

Small-scale

0.249

Low


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Last updated: 15 Jul 2024